LOCUS       NM_153594               3568 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus protein-L-isoaspartate (D-aspartate)
            O-methyltransferase domain containing 2 (Pcmtd2), transcript
            variant 1, mRNA.
ACCESSION   NM_153594
VERSION     NM_153594.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3568)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   2  (bases 1 to 3568)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845173.4, CJ149855.1, BC031360.1, CD774000.1 and BY477720.1.
            
            On Mar 28, 2014 this sequence version replaced NM_153594.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040385.1, AK088800.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL845173.4         146465-146469
            6-183               CJ149855.1         7-184
            184-2961            BC031360.1         1-2778
            2962-3566           CD774000.1         18-622              c
            3567-3568           BY477720.1         513-514
FEATURES             Location/Qualifiers
     source          1..3568
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.81 cM"
     gene            1..3568
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /note="protein-L-isoaspartate (D-aspartate)
                     O-methyltransferase domain containing 2"
                     /db_xref="GeneID:245867"
                     /db_xref="MGI:MGI:1923927"
     exon            1..131
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            132..315
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            316..646
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1419
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /note="isoform a is encoded by transcript variant 1;
                     protein-L-isoaspartate O-methyltransferase
                     domain-containing protein 2"
                     /codon_start=1
                     /product="protein-L-isoaspartate O-methyltransferase
                     domain-containing protein 2 isoform a"
                     /protein_id="NP_705822.1"
                     /db_xref="CCDS:CCDS17224.1"
                     /db_xref="GeneID:245867"
                     /db_xref="MGI:MGI:1923927"
                     /translation="MGGAVSAGEDNDELIDNLKEAQYIRTDLVEQAFRAIDRADYYLE
                     EFKENAYKDLAWKHGNIHLSAPCIYSEVMEALDLQPGLSFLNLGSGTGYLSSMVGLIL
                     GPFGVNHGVELHSDVTEYAKQKLDVFIRTSDSFDKFDFCEPSFVTGNCLEIAPDCCQY
                     DRVYCGAGVQKEHEEYMKNLLKVGGILVMPLEEKLTKITRTGPSAWETKKILAVSFAP
                     LVQPCRSESGQSRLVQLPPPAVRSLQDLARLAIRGSIKRAMRQEATRGGGLKNTPMFK
                     RRRVRRRRMETIVFLDKEVFASRISNPSDDTSCEDAEEDRREVAERTLQETKPEPPVN
                     FLRQRVLRLPLPDPLKYYLLYYREK"
     exon            647..749
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..921
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1045
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..3568
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3536..3541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3560
                     /gene="Pcmtd2"
                     /gene_synonym="5330414D10Rik"
                     /note="major polyA site"
ORIGIN      
        1 agttcaggta gagcccgcgc acgcgcagag gtagcagcgg atgtttacag cggctgaggt
       61 ccgtccgaag cgacagaagc gtctgaagaa ctgctctccg agactcaata cgggggctgc
      121 tgagcgccga ggttcttata taatccacgc tggcctggaa ctcacggaag atcaccttga
      181 actcctgagc aggagctgtt gagattcaga aagtctacta atcttttgtg gtttggtagt
      241 ctttccttca accgtttata tcagcatcac cagcttttaa gaaataaagc cattagtttg
      301 gaaaagtcac ccgagccttg cttggctgtg accttgaaca tgggcggtgc tgtgagtgct
      361 ggggaggaca acgatgagct cattgataac ttgaaggaag cccagtacat ccggacggac
      421 ttagtagagc aggctttccg cgctattgat cgagcagatt attatcttga agaatttaaa
      481 gaaaatgcat acaaagactt ggcatggaaa catggaaata ttcatctctc agccccgtgc
      541 atctactcgg aggtgatgga ggctctggat ctgcagcctg ggctttcatt tctgaatttg
      601 ggcagtggta ctggctacct cagctccatg gtggggctca ttctaggtcc tttcggcgtg
      661 aaccacgggg tggagcttca ttcagatgtc actgagtacg cgaagcagaa actggatgtc
      721 ttcatcagaa ccagcgacag ctttgacaaa tttgacttct gtgaaccttc ctttgtaact
      781 ggaaattgcc tggagattgc tccagattgt tgtcagtatg atcgtgttta ttgtggggct
      841 ggtgtgcaga aagaacatga agagtacatg aaaaatcttc tcaaagttgg aggcatcctt
      901 gtcatgccct tggaagagaa gttgaccaag ataacacgca caggtccttc tgcttgggag
      961 acaaaaaaga ttctggctgt ttcctttgcc cctctggtcc agccttgccg ttcggaatca
     1021 ggacagtcca gacttgtcca gctaccacca ccagccgtgc gcagcctaca ggacctggcc
     1081 cggcttgcta tccgtggcag catcaagagg gctatgcgac aggaagccac aagaggaggt
     1141 ggcctgaaga acacacctat gtttaaaaga aggcgagtcc gtcgccgcag aatggagacc
     1201 attgtctttt tggacaaaga ggtttttgcc agtcgaattt ccaacccctc tgatgacacc
     1261 agctgtgagg atgcagagga ggatcggcgg gaagtggcag agaggacctt acaggagacc
     1321 aagcctgagc caccagtgaa cttccttcgt cagagggtat tgcgcctccc attgcctgat
     1381 cccctgaagt actacctgct gtattacagg gaaaagtgag ctgtgggaga gtgggaccag
     1441 gatacccaga ggaaactgct ggccaggtac atgtcttttc cctttcttgg ttcctgtctg
     1501 tgctctaaaa cttcccatgt aatggtgtga tttatttaag tacagtctaa caagaaactg
     1561 catagaatta ttttctttgg gggtggggtg ggatgtgcat ctttttggct ctactgtaac
     1621 ttgaactcat tgggaactgc atgatgtctg ctccttatag aggcaagctt tcacattgag
     1681 acttgaatta aatttgattg gatcctgtgt gaggcaaggg gcaagtctgt aaaggtgtga
     1741 cacaccacca cgcaaatttc atgtgatggt tctattgctg gcctctgact tttgcctttt
     1801 tctatgctca gaaaatcctc ccttatttaa atcaaactaa tcaaatatta tgtgaaataa
     1861 tcatccataa ttttttaaag aaaaagaaaa tgagatacag aaggaggaat aatgtataga
     1921 aatgccagat atccttcagg attttccaaa gactttcaag cagtcgatcc tcccctgatt
     1981 ccttctgatg ctttatagga accaccatca agtgatctct ttttctgaga ggaaaagttt
     2041 ttcctgaacc atcgcagtga ttcatgagtc agttctaagg tatctacatg agaattttcg
     2101 gtgcaggtgg agagactgca gtgtcacaga acgcccgcac ttcttgactt ctttggtcat
     2161 attagagtac caggtcatag atttttatct tttataattc tggagaaaaa aattgttagt
     2221 tttgtaagtt ttcttaagaa cagatatatg tattttaata gctccattgc attagagcag
     2281 tttaacttag tgacatgtga aatctgttat ctccaggcca taggtgttga gaactatcaa
     2341 gtttaaaaat aaagggggga ggggcaacct ttctgctgtc agagggaaag acttgaagtt
     2401 gcattgctga ttccaaaagc tggctcttaa aaaaattttt tttctagccc aaagaaaaga
     2461 atagtgttaa ttgttagtaa taagcccaag ttagagtact aatttaggat taagtactga
     2521 gatcttatga ttgactttta gtttagcctc acgtgacttg cagggagaaa tttgatagtt
     2581 ttgcgatttc tccatcttaa atgtgtattt tggttctttt tcttttttct tttttttaag
     2641 ttagttgaat catttttacc acacattata gtctgcatgt atagctggga aaatgtataa
     2701 taccctacat tataaatata atgtacactt acatgacttt aaatataagc tatttaaaga
     2761 aattcatagt tggttttact tgccttttaa ctccactttg ggcttctttt ctctcagaag
     2821 gaagtgcatg ctctaacttg acttgcaaac gtttgtcgtt tgcaggttgt tcttgatgtt
     2881 aactctgatt gttagctaga cttttgttac ctggaaaatt ttggacataa aattaaataa
     2941 atgatacctg tgaagtttgt atattaggtg gattgattga attttttcct gtaattgagt
     3001 atgggctaca ttttgaaaag ccacatttgc ctttatgctg gacttttaaa aaatgacaat
     3061 gcgtaagaca ttttcccttt atatgttaaa cttttcttag cattttgtat ttatatttta
     3121 tcactttgtg attttaaacc acaattcagt gaaatatagt tgtaacaagt gagaaataga
     3181 ttggccttta tcttatacta ccagggaaat tttaaatttt ctcataaaca ctttgctgcc
     3241 agaattcagt atataccaat ggtatataca ataatatccc acattctgtt ttcaggctaa
     3301 taaatgttaa tatagtctaa tgtttgtctt caggatctgt attgtaaaca aaatattgac
     3361 agtggctatg tttcaaggag tgagtatttt taaacacatg acttctgttg taagaatcaa
     3421 aggtgtacat aaaaatagat ttgtcaacat ggaacttaaa gttgaaaatc caagaaatta
     3481 gaaacactga ttttttttta atgaggtgaa acatatgggt aaacacaaat gaatcaataa
     3541 aatcgtgtta cgacattcta ttctcagt
//
