LOCUS       NM_001403817            8517 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus pericentriolar material 1 (Pcm1), transcript variant
            1, mRNA.
ACCESSION   NM_001403817 XM_006509298
VERSION     NM_001403817.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8517)
  AUTHORS   Sequeira,C., Wackerbarth,L.M., Pena,A., Sa-Pereira,M., Franco,C.A.
            and Gomes,E.R.
  TITLE     Myonuclear position and blood vessel organization during skeletal
            muscle postnatal development
  JOURNAL   Development 151 (19) (2024)
   PUBMED   39289869
REFERENCE   2  (bases 1 to 8517)
  AUTHORS   Van Wauwe,J., Mahy,A., Craps,S., Ekhteraei-Tousi,S., Vrancaert,P.,
            Kemps,H., Dheedene,W., Donate Puertas,R., Trenson,S.,
            Roderick,H.L., Beerens,M. and Luttun,A.
  TITLE     PRDM16 determines specification of ventricular cardiomyocytes by
            suppressing alternative cell fates
  JOURNAL   Life Sci Alliance 7 (12), e202402719 (2024)
   PUBMED   39304345
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8517)
  AUTHORS   Hashimoto,K., Ohira,M., Kodama,A., Kimoto,M., Inoue,M., Tone,S.,
            Usui,Y., Hanashima,A., Goto,T., Ogura,Y., Ujihara,Y. and Mohri,S.
  TITLE     Loss of connectin novex-3 leads to heart dysfunction associated
            with impaired cardiomyocyte proliferation and abnormal nuclear
            mechanics
  JOURNAL   Sci Rep 14 (1), 13727 (2024)
   PUBMED   38877142
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8517)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 8517)
  AUTHORS   Gan,P., Wang,Z., Morales,M.G., Zhang,Y., Bassel-Duby,R., Liu,N. and
            Olson,E.N.
  TITLE     RBPMS is an RNA-binding protein that mediates cardiomyocyte
            binucleation and cardiovascular development
  JOURNAL   Dev Cell 57 (8), 959-973 (2022)
   PUBMED   35472321
REFERENCE   6  (bases 1 to 8517)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 8517)
  AUTHORS   Dammermann,A. and Merdes,A.
  TITLE     Assembly of centrosomal proteins and microtubule organization
            depends on PCM-1
  JOURNAL   J Cell Biol 159 (2), 255-266 (2002)
   PUBMED   12403812
REFERENCE   8  (bases 1 to 8517)
  AUTHORS   Balczon,R., Simerly,C., Takahashi,D. and Schatten,G.
  TITLE     Arrest of cell cycle progression during first interphase in murine
            zygotes microinjected with anti-PCM-1 antibodies
  JOURNAL   Cell Motil Cytoskeleton 52 (3), 183-192 (2002)
   PUBMED   12112146
  REMARK    GeneRIF: results identify a novel role for PCM- 1 in cell cycle
            regulation, and indicate that PCM-1 must fulfill an essential
            function for cells to complete interphase
REFERENCE   9  (bases 1 to 8517)
  AUTHORS   Kubo,A., Sasaki,H., Yuba-Kubo,A., Tsukita,S. and Shiina,N.
  TITLE     Centriolar satellites: molecular characterization, ATP-dependent
            movement toward centrioles and possible involvement in ciliogenesis
  JOURNAL   J Cell Biol 147 (5), 969-980 (1999)
   PUBMED   10579718
  REMARK    Erratum:[J Cell Biol 1999 Dec 27;147(7):1585]
REFERENCE   10 (bases 1 to 8517)
  AUTHORS   Grewal,P.K., Bolland,D.J., Todd,L.C. and Hewitt,J.E.
  TITLE     High-resolution mapping of mouse chromosome 8 identifies an
            evolutionary chromosomal breakpoint
  JOURNAL   Mamm Genome 9 (8), 603-607 (1998)
   PUBMED   9680377
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC156554.13 and AC144926.6.
            
            On Apr 5, 2022 this sequence version replaced XM_006509298.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223970.10567.1,
                                           SRR10223969.8201.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               AC156554.13        17473-17696         c
            225-339             AC156554.13        1326-1440           c
            340-585             AC144926.6         134983-135228       c
            586-855             AC144926.6         133713-133982       c
            856-1026            AC144926.6         131838-132008       c
            1027-1143           AC144926.6         131543-131659       c
            1144-1321           AC144926.6         125655-125832       c
            1322-1431           AC144926.6         122469-122578       c
            1432-1648           AC144926.6         120559-120775       c
            1649-1847           AC144926.6         118721-118919       c
            1848-2021           AC144926.6         117851-118024       c
            2022-2176           AC144926.6         117212-117366       c
            2177-2403           AC144926.6         116867-117093       c
            2404-2546           AC144926.6         113126-113268       c
            2547-2676           AC144926.6         112868-112997       c
            2677-2817           AC144926.6         110299-110439       c
            2818-3008           AC144926.6         109273-109463       c
            3009-3206           AC144926.6         106857-107054       c
            3207-3426           AC144926.6         105118-105337       c
            3427-3572           AC144926.6         104865-105010       c
            3573-3763           AC144926.6         104198-104388       c
            3764-3935           AC144926.6         102127-102298       c
            3936-4294           AC144926.6         99203-99561         c
            4295-4459           AC144926.6         88868-89032         c
            4460-4632           AC144926.6         83327-83499         c
            4633-4764           AC144926.6         82879-83010         c
            4765-4885           AC144926.6         80741-80861         c
            4886-5044           AC144926.6         79559-79717         c
            5045-5181           AC144926.6         79038-79174         c
            5182-5316           AC144926.6         76965-77099         c
            5317-5514           AC144926.6         70968-71165         c
            5515-5577           AC144926.6         68002-68064         c
            5578-5713           AC144926.6         67620-67755         c
            5714-5874           AC144926.6         67032-67192         c
            5875-5947           AC144926.6         65420-65492         c
            5948-6204           AC144926.6         63994-64250         c
            6205-6297           AC144926.6         62294-62386         c
            6298-6412           AC144926.6         62099-62213         c
            6413-8517           AC144926.6         58932-61036         c
FEATURES             Location/Qualifiers
     source          1..8517
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 23.89 cM"
     gene            1..8517
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /note="pericentriolar material 1"
                     /db_xref="GeneID:18536"
                     /db_xref="MGI:MGI:1277958"
     exon            1..224
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            225..339
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..6438
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pericentriolar material gene 1; pericentriolar material 1
                     protein; PCM-1; mPCM-1"
                     /codon_start=1
                     /product="pericentriolar material 1 protein isoform 1"
                     /protein_id="NP_001390746.1"
                     /db_xref="GeneID:18536"
                     /db_xref="MGI:MGI:1277958"
                     /translation="MATGGGPFEEVMHDQDLPNWSNDSVDDRLNNMEWGGQQKKANRS
                     SEKNKKKFGVASDKRVTNAISPESSPGVGRRRTKIPHTFPHSRYMTQMSVPEQAELEK
                     LKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDATASL
                     PKREMTTSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITK
                     ASSMREDLVEKNERSANVERLTHLIEHLKEQEKSYMKFLQKILARENEEEDVRTVDSA
                     VGSGSVAESTSLNADVQSEASDTTARDPQQEPMEETENLKKQHDLLKRMLQQQEQLRA
                     LQGRQAALLALQHKAEQAIAVMDDSVVTETTGSLSGVSITSELNEELNDLIQRFHNQL
                     RDSQPPAVPDNRRQAESLSLTREISQSRNPSVSEHLPDEKVQLFSKMRVLQEKKQKMD
                     KLLGELHNLRDQHLNNSSFVPSTSLQRSGDKRSSTVALSAPVGFASAVNGEANSLISS
                     VPCPATSLVSQNESENEGHLNPAEKLQKLNEVQKRLNELRELVHYYEQTSDMMTDAVN
                     ENTKDEETEESEYDSEHENSEPVTNIRNPQVASTWNEVNTNSNTQCGSNNRDGRPVNS
                     NCEINNRSAANIRALNMPPLDCRYNREGEQRLHVAHGEDEEEEVEEEGVSGASLSSRR
                     SSLVDEAPEDEEFEQKISRLMAAKEKLKQLQDLVAMVQDDDATQVVVPAASNLDDFYA
                     AEEDIKQNSNNARENSNKIDTGVNEKTREKFYEAKLQQQQRELKQLQEERKKLIEIQE
                     KIQAVQKACPDLQLSATSISSGPTKKYLPAITSTPTVNENDSSTSKCVIDPEDSSVVD
                     NELWSDMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETSSPVAISLRSDGSENLCT
                     PQQSRTEKTMATWGGSTQCALDEEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFPIYP
                     PSMNQNSYNVKETKTRWKSNRPVSADGNYRPLAKTRQQNISMQRQENLRWVSELSYIE
                     EKEQWQEQINQLKKQLDFSVNICQTLMQDQQTLSCLLQTLLTGPYSVLPSNVASPQVH
                     LIMHQLNQCYTQLTWQQNNVQRLKQMLTELMRQQNQHPEKPRSKERGSSASHPSSPNL
                     FCPFSFPTQPVNLFNLPGFTNFPSFAPGMNFSPLFPSNFGDFSQNVSTPTEQQQPLAQ
                     NPSGKTEYMAFPKPFESSSSLGAEKQRNQKQPEEEAENTKTPWLYDQEGGVEKPFFKT
                     GFTESVEKATNSNRKNQPDTSRRRRQFDEESLESFSSMPDPIDPTTVTKTFKTRKASA
                     QASLASKDKTPKSKSKKRNSTQLKSRVKNIGYESASVSSTCEPCKNRNRHSAQTEEPV
                     QAKLFSRKNHEQLEKIIKYSRSAEISSETGSDFSMFEALRDTIYSEVATLISQNESRP
                     HFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESDEREGENVKPVNSGTWVASNS
                     ELTPSESLVTTDDETFEKNFERETHKVSEQNDADNVSVMSVSSNFEPFATDDLGNTVI
                     HLDQALARMREYERMKTETESHSNMRCTCRVIEDEDGAAAAATVSNSEETPIIENHNS
                     PQPISDVSAVPCPRIDTQQLDRQIKAIMKEVIPFLKEHMDEVCSSQLLTSVRRMVLTL
                     TQQNDESKEFVKFFHKQLGSILQDSLAKFAGRKLKDCGEDLLVEISEVLFNELAFFKL
                     MQDLDNNSIAVKQRCKRKIEAAGVRQSYAKEAKRILEGDHGSPAGEIDDEDKDKDETE
                     TVKQTQTSEVYDAKGPKNVRSDVSDQEEDEESERCPVSINLSKAESQALTNYGSGEDE
                     NEDEEMEDFEESPVDIQTSLQANTETTEENEHDSQILQHDLEKTPESTNVPSDQEPTS
                     KNDQDSSPVKPCYLNILENEQQLNSATHKDSLTTTDSSKQPEPLPLPLAASETLVPRV
                     KEVKSAQETPESSLAGSPDTESPVLVNDYEAESGNISQKSDEEDFVKVEDLPLKLTVY
                     SEEELRKKMIEEEQKNHLSGEICEMQTEELAGNSQILKEPETVGAQSI"
     exon            340..585
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            586..855
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1026
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1143
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1321
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1431
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1648
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1847
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2021
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2176
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2403
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2546
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2676
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2817
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2818..3008
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3206
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3207..3426
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3427..3572
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3573..3763
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..3935
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4294
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4295..4459
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4460..4632
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4633..4764
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4765..4885
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            4886..5044
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5045..5181
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5182..5316
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5317..5514
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5515..5577
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5578..5713
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5714..5874
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5875..5947
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            5948..6204
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6205..6297
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6298..6412
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            6413..8517
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6750..6755
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      6774
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /note="major polyA site"
     regulatory      6989..6994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      7008
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
     regulatory      8495..8500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
                     /note="hexamer: AATAAA"
     polyA_site      8517
                     /gene="Pcm1"
                     /gene_synonym="2600002H09Rik; 9430077F19Rik;
                     C030044G17Rik"
ORIGIN      
        1 actcttctcc caccacaatg aggtcctaag atggcggtgg ctgcggcggt tggcgcctag
       61 ttagctaatg tagagaaggc ggccattggg gctttgggca gtcgaggggg atttgtgggc
      121 ctcccttccg cggtcttgga ggaagaaccg ctgccggcgg cggctcctgg aggggcggcc
      181 gaccgccact cggcccttgg caggaggggc ggcttcgttt ccagagaatt aattaaaggc
      241 aacatggcca caggaggagg tccttttgaa gaagtcatgc atgatcagga cttaccaaac
      301 tggagcaatg acagtgtgga tgaccgactc aacaatatgg agtggggtgg ccaacagaag
      361 aaggccaata gatcatcaga aaagaataag aaaaagtttg gtgtagcaag tgataagagg
      421 gtaactaacg ctatttctcc ggagtcatcg ccaggagttg gaaggcgaag aacaaagatt
      481 ccacatacgt ttccacacag cagatatatg actcagatgt ctgttccaga gcaggcagaa
      541 ctagagaaac ttaaacagcg gataaacttc agtgatttag atcagagaag tattggaagt
      601 gattctcaag gtagagcaac agcggctaac aacaaacgtc agcttagtga aaaccgaaag
      661 cccttcaact ttttgcctat gcagattaat actaacaaga gcaaggatgc tactgcaagt
      721 cttccaaaga gagagatgac aacgtcagca cagtgcaaag agttgtttgc ttctgctcta
      781 agtaatgacc ttttgcaaaa ctgtcaagtc tctgaagaag atgggagagg ggagcctgca
      841 atggagagca gccagattgt aagcaggctt gttcaaatcc gtgactatat tactaaagct
      901 agttctatgc gagaagatct tgtagagaaa aatgaaagat ctgccaatgt tgagcgtctt
      961 actcatctaa tagagcatct taaagagcaa gaaaagtcat atatgaaatt tctccagaaa
     1021 atccttgcta gagaaaatga ggaggaggat gttcggactg tagactcagc tgtgggatct
     1081 ggttctgtag ctgagagcac atcgctaaac gcagatgtgc agtctgaggc ttcagatacc
     1141 acggccagag atcctcagca ggagcctatg gaagagacag aaaatttgaa gaaacaacat
     1201 gatttattaa aaagaatgtt acaacagcag gagcagctgc gagctctgca gggccgacag
     1261 gctgctcttc tagctttgca gcataaagca gagcaagcta tagctgtgat ggatgactct
     1321 gttgttacag aaactacagg aagcttatct ggagtcagca tcacatctga actaaatgaa
     1381 gaactgaatg atttaattca gcgtttccat aatcagcttc gtgattctca gcctccagct
     1441 gttccagaca acagaagaca ggcagaaagt ctttcattaa ctagagagat ttctcagagc
     1501 agaaatccct cagtttctga acatttacct gatgagaaag tacagctttt tagcaaaatg
     1561 agagtactac aggaaaagaa acagaaaatg gacaaattac ttggagaact tcataacctt
     1621 cgagatcagc atctgaacaa ctcatcattt gtgccttcaa cttctctcca aagaagtggg
     1681 gataagagaa gttcaactgt agctctctct gctcctgtgg gctttgcatc agctgtcaat
     1741 ggagaggcca atagtcttat ctcatctgtt ccctgtcctg ccacctctct agtttctcag
     1801 aatgagagtg aaaatgaagg tcatctaaat ccagctgaaa aactacagaa gttaaatgaa
     1861 gttcaaaaga gattgaatga actgagagaa ttagttcatt attatgaaca aacatcagat
     1921 atgatgacag atgctgtaaa tgaaaataca aaagatgaag aaactgaaga gtcagaatat
     1981 gattctgaac atgaaaattc tgaacctgtt actaacatta gaaatccaca ggtagcttct
     2041 acctggaatg aagtgaatac taacagtaat acacagtgtg gttctaacaa tagagatggg
     2101 agaccagtta attctaactg tgaaattaat aacagatctg ctgccaacat cagagctcta
     2161 aacatgcctc cattagactg tcgatacaat agagaaggag agcagaggtt gcatgtagca
     2221 catggagaag atgaggaaga agaagtagaa gaggaaggag tcagtggggc ttcattatct
     2281 agtcgtagga gcagtctggt cgatgaagca ccagaagatg aagaatttga acagaagatt
     2341 agtagactca tggctgcaaa agagaaactt aaacagctcc aagatcttgt tgctatggtg
     2401 caggatgatg atgcaactca agtggttgtc cctgctgcat caaatttgga tgatttctat
     2461 gcagcagaag aagatatcaa acaaaattcc aataatgcaa gagaaaattc taataaaata
     2521 gatactggag taaatgaaaa aacaagagag aaattttatg aggctaaact acagcagcaa
     2581 cagagagagc ttaaacaatt gcaggaggaa agaaagaaat tgattgaaat tcaagagaaa
     2641 attcaagcag tgcaaaaggc atgccctgac cttcagctct cagccactag tataagtagt
     2701 ggtcccacaa aaaaatatct accagctatt acttcaactc caactgttaa tgaaaatgac
     2761 agcagtacaa gcaagtgtgt tattgatcct gaagattctt cagtggtgga taatgagttg
     2821 tggtcagaca tgagaagaca tgaaatgtta agggaagagc tacggcagag aaggaagcaa
     2881 cttgaagctc taatggctga acaccagagg aggcaaggtc tagctgagac ctcatctcca
     2941 gtggctatat cattgagaag tgatggatct gagaacctgt gcactcctca gcaaagtaga
     3001 acagaaaaaa caatggcaac ttggggaggt tctactcagt gtgcattaga tgaagaagga
     3061 gatgaggatg gctatctttc agaaggaatt gttcgcacag atgaagaaga ggaggaggag
     3121 caggatgcca gttccaatga taacttccct atataccctc ctagcatgaa tcaaaattct
     3181 tacaatgtaa aggaaaccaa aaccaggtgg aagagcaatc gccctgtttc agcagatgga
     3241 aattaccgtc ctttagccaa gacaaggcag cagaatatca gcatgcaacg acaagaaaac
     3301 cttcgatggg tgtcagagct ctcttacata gaagagaagg agcagtggca agaacagatt
     3361 aatcagctaa agaaacaact cgatttcagt gtcaatattt gtcagactct gatgcaagac
     3421 caacagactt tatcttgttt gctgcagact cttctaacag gtccgtacag tgttctgcct
     3481 agtaatgtgg cgtcccctca agtgcacctt atcatgcatc agctgaacca atgctacaca
     3541 cagctaacat ggcagcagaa caatgtccag aggttaaaac aaatgctaac tgaacttatg
     3601 cgccaacaaa atcagcaccc agaaaagcct agaagcaaag aaagaggcag tagtgcgtca
     3661 cacccttctt ctcccaattt attttgccct ttcagctttc caacacagcc tgtaaatctg
     3721 tttaacctgc ctggatttac taactttcca tcatttgcac caggaatgaa tttcagccct
     3781 ttatttcctt ctaattttgg agatttttct cagaatgttt ctacacctac tgaacagcag
     3841 cagccattag ctcaaaatcc ttcagggaaa acagagtata tggcttttcc aaaacccttt
     3901 gaaagcagtt cttctcttgg agcagaaaag caaaggaatc agaaacagcc cgaagaggaa
     3961 gctgaaaaca ctaagacacc atggttatat gatcaagaag gtggagtaga aaaaccattt
     4021 ttcaagactg gatttacaga gtctgtagag aaagctacaa atagtaaccg caaaaatcaa
     4081 ccagatacaa gcaggagaag acgtcagttt gatgaagaat ccttggaaag ctttagcagt
     4141 atgcctgatc ctatagaccc aacaacagta actaaaacat ttaaaacaag aaaagcatct
     4201 gcccaggcca gcctggcctc taaggacaaa actcccaaat caaagagtaa gaagaggaat
     4261 tctactcagc tgaaaagtag agttaaaaat attgggtatg aaagtgccag tgtgtctagc
     4321 acatgtgaac cttgcaaaaa taggaacaga cattcagccc agactgaaga gcctgttcaa
     4381 gcaaaattat tcagcagaaa gaatcatgaa cagctggaaa aaataataaa atatagtagg
     4441 tctgcagaaa tatcttcaga gactggaagt gatttttcca tgtttgaagc tttacgggat
     4501 actatttatt ccgaagtggc tacattaatt tctcaaaatg agtctcgtcc acattttctt
     4561 attgaacttt tccatgagct gcagctactt aatacagact acttgagaca gagagcttta
     4621 tatgcattgc aggatatcgt atccagacac atttctgaaa gtgatgaaag agaaggagaa
     4681 aatgtaaagc ctgtgaactc tggcacttgg gtagcatcca attcagagct tactccgagt
     4741 gagagccttg ttactactga cgatgaaaca tttgagaaga actttgaaag agaaacacat
     4801 aaagtaagtg aacagaatga tgctgacaac gtgagtgtca tgtccgtatc ctccaacttt
     4861 gagccatttg caacagacga cttaggtaac actgtgattc acttggatca agcattagcc
     4921 agaatgagag agtatgagcg catgaagacc gagacagaaa gtcactcaaa tatgagatgc
     4981 acttgcaggg ttattgagga tgaagatggt gctgccgccg ctgccacagt cagtaattca
     5041 gaagaaactc ccattattga gaatcacaat tcaccacaac ctataagtga tgtttctgcc
     5101 gtcccctgtc ctagaattga tactcagcaa ctggaccgcc aaattaaagc aattatgaaa
     5161 gaagtcattc cttttttgaa ggagcacatg gatgaagtgt gttcgtctca gcttctcact
     5221 tcagtaagac gtatggtctt gacccttacc cagcagaatg atgagagcaa agagtttgtg
     5281 aagttctttc ataaacaact aggaagtata ttgcaggatt cactagcaaa atttgcaggc
     5341 agaaagctga aagactgtgg agaagatctt cttgtggaga tctctgaagt gttgtttaat
     5401 gaattggctt tctttaagct catgcaagac ttggataata atagcatagc tgttaaacag
     5461 aggtgcaaga ggaaaattga agcagctgga gtgaggcagt cttatgcaaa agaggccaaa
     5521 aggattcttg aaggagatca tggctcacct gctggagaga ttgatgatga agacaaagac
     5581 aaggatgaga ctgaaactgt taagcagact cagacttctg aggtatatga tgctaaaggt
     5641 cccaaaaatg taagatctga tgtttctgat caagaagaag atgaagaaag tgaacggtgt
     5701 ccagtgtcta ttaatctgtc taaagctgaa agtcaggctt taactaatta tggaagtgga
     5761 gaagatgaga atgaggatga agaaatggaa gactttgaag agagtcctgt ggacatccag
     5821 acttcacttc aggctaacac tgaaactaca gaagaaaatg aacatgacag tcagattctg
     5881 caacatgatc ttgaaaaaac accagaaagt acaaatgtac catcagacca agaaccaact
     5941 agtaagaatg atcaagacag ctctcctgtg aaaccttgtt atctcaatat cttggaaaat
     6001 gagcaacagt taaatagtgc tacccataag gactcgctta ctactactga ttcatctaaa
     6061 cagcctgagc ctctgccatt acccttggct gcaagtgaaa ccttagtgcc tagagtcaaa
     6121 gaagtgaagt ctgctcagga aacgcctgag agctctctgg ctggaagccc tgatactgaa
     6181 tctccagtgt tagtgaatga ctatgaagca gagtctggta acataagtca aaagtcggat
     6241 gaagaagact ttgtgaaagt tgaggatttg ccgctcaaac tgacagtcta ttcagaggaa
     6301 gagctaagga agaaaatgat agaagaagaa cagaaaaacc atttatctgg tgaaatatgt
     6361 gaaatgcaga cagaagaatt agctggaaat tctcagatac tgaaagaacc tgaaacagtg
     6421 ggagcccaga gtatatgaaa tgtcttcaga gactcatcta actctcttac atagtcagca
     6481 catttaaaaa aaagacacta aataaacatt tgctttgatc tgtataaaat gtaaattagt
     6541 ttgacactgc atttttgatg ggtgtgctaa tttctgccca tggcagttta aaacattaga
     6601 atctgaatcc tggacagatt caaaccttga cacactgtgg gatttttctt ttgctttttg
     6661 tcctgttttt tctttcttat gatcttgacc cccccctccc ccacccttca ttgtgacatt
     6721 tggtgtgtta actttaaaat gtagttttaa ataaagtttg aacttatctg taaagtatgc
     6781 ttttgggaaa tgttgttgaa ttctatgcag caaattgctg tttttgtaac aacactattc
     6841 agaaacagca gtggtcaaaa atttgagaaa ttcttatttc ctctaattct tatttattct
     6901 aaagctctgc cttagaccag tctttcaaat aatgttagtg ttgctgctgt taggtctgat
     6961 gttcttgtag ttcctgctct tgtgtgcgaa taaagcagat gaatctcagt ggtcttagaa
     7021 catgttaata actcagactg tatacacagt tcagacattg ttagtaacta gaatttaaca
     7081 ggattatcta ttagattaat atttttcaga atttaaaatg ttgcctcatt ctaaaaatta
     7141 aaaaaaaagc tttatatgta tttctgtaca gacaagtagc attctaatta attaaaaaaa
     7201 aaaaacaaac tctttcaagt taggataaat agaactaaat ttatgtaaca gaacactaag
     7261 atttttaatg cctatggaca aaacatgcct tttgagatga taatttaaaa ccaaagccta
     7321 atagttgttt ttgtgtgttt tgagagagaa gcaagttcaa gtgttaagaa cgtctctgtg
     7381 agtttttcat cactaagtaa accaactctt aaaaagtgct ttgccttctg agtctgtcta
     7441 cacttaccac ttcctataat attgcagagc cagttaacca tgaataatct gtcagtctta
     7501 gagatttata cttgaaaaag taatagtgtg aaggactaat tgttcattcc aagtatttgc
     7561 ttaaattttt aagtagttgt ctgtaatact ctataagaac ttatttggta ttcctttaaa
     7621 attttcactt gcagctgggc agtagtgaca cgcctttaat cccagcactc cagaggcaga
     7681 agctgtttga tcagagttcg aggccagcct tgtttacaga ttgaatccta ggacagctga
     7741 tgttacataa agaaaccata tctcaaaaac aaaataagat tctcacttac ttgatagctt
     7801 aatataaatg tccagtcagt aaataacaaa tgatggtttt ctctgaggac ttttgtattg
     7861 ttacttaatt taaactagga ccatatttct caaccttcat taaaatttgc aaaacttcta
     7921 atctagaatt tacccagctg gacggacttc agggacatta gaacagtaat ttatattata
     7981 tgtacaaaca agttgtgtat tttccaggcg caaaacaaga aactccattt taatcctcag
     8041 gccaggctta catagtgcag tgcgttgttc tccctccctt tcctgctttg tgtctttgca
     8101 tgcatacagt ggagggctgt atttgatgtt cgctactacc atagcatctg tgagctttat
     8161 caaactagtt tatttgactt atgtcctacc tgctatctcc aatttgttgt tttcatattt
     8221 tagtggataa tttagtttaa aatacccaga gattgggaac atgcaaccgt gtaacgtgat
     8281 ttttctagta agtatcgctc agaaggaagt tatagtattt ctgtttgtat taatttgtaa
     8341 gttaaaactt tggttagtaa gagaaaaaaa atcccaataa ataagctata actcttatgt
     8401 agttagagat aatgctacca taataaactg cccagactgt ggaggtactc tgtattttgt
     8461 aacattcact ttgggtaaat gctttttcat tgctaataaa tgtatatcat acattca
//
