LOCUS       NM_011044               2637 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus phosphoenolpyruvate carboxykinase 1, cytosolic (Pck1),
            mRNA.
ACCESSION   NM_011044
VERSION     NM_011044.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2637)
  AUTHORS   Deja,S., Fletcher,J.A., Kim,C.W., Kucejova,B., Fu,X., Mizerska,M.,
            Villegas,M., Pudelko-Malik,N., Browder,N., Inigo-Vollmer,M.,
            Menezes,C.J., Mishra,P., Berglund,E.D., Browning,J.D.,
            Thyfault,J.P., Young,J.D., Horton,J.D. and Burgess,S.C.
  TITLE     Hepatic malonyl-CoA synthesis restrains gluconeogenesis by
            suppressing fat oxidation, pyruvate carboxylation, and amino acid
            availability
  JOURNAL   Cell Metab 36 (5), 1088-1104 (2024)
   PUBMED   38447582
REFERENCE   2  (bases 1 to 2637)
  AUTHORS   Guo,C.G., Sun,R., Wang,X., Yuan,Y., Xu,Y., Li,S., Sun,X., Wang,J.,
            Hu,X., Guo,T., Chen,X.W., Xiao,R.P. and Zhang,X.
  TITLE     Intestinal SURF4 is essential for apolipoprotein transport and
            lipoprotein secretion
  JOURNAL   Mol Metab 79, 101847 (2024)
   PUBMED   38042368
REFERENCE   3  (bases 1 to 2637)
  AUTHORS   Hao,W., Chen,Z., Tang,J., Yang,R., Gao,W.Q. and Xu,H.
  TITLE     hnRNPA2B1 promotes the occurrence and progression of hepatocellular
            carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation
            manner
  JOURNAL   J Transl Med 21 (1), 861 (2023)
   PUBMED   38017546
  REMARK    GeneRIF: hnRNPA2B1 promotes the occurrence and progression of
            hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA
            methylation manner.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2637)
  AUTHORS   Oelkrug,R., Harder,L., Pedaran,M., Hoffmann,A., Kolms,B.,
            Inderhees,J., Gachkar,S., Resch,J., Johann,K., Johren,O., Krause,K.
            and Mittag,J.
  TITLE     Maternal thyroid hormone receptor beta activation in mice sparks
            brown fat thermogenesis in the offspring
  JOURNAL   Nat Commun 14 (1), 6742 (2023)
   PUBMED   37875497
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2637)
  AUTHORS   Onodera,T., Wang,M.Y., Rutkowski,J.M., Deja,S., Chen,S.,
            Balzer,M.S., Kim,D.S., Sun,X., An,Y.A., Field,B.C., Lee,C.,
            Matsuo,E.I., Mizerska,M., Sanjana,I., Fujiwara,N., Kusminski,C.M.,
            Gordillo,R., Gautron,L., Marciano,D.K., Hu,M.C., Burgess,S.C.,
            Susztak,K., Moe,O.W. and Scherer,P.E.
  TITLE     Endogenous renal adiponectin drives gluconeogenesis through
            enhancing pyruvate and fatty acid utilization
  JOURNAL   Nat Commun 14 (1), 6531 (2023)
   PUBMED   37848446
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2637)
  AUTHORS   Pilz,A.J., Willer,E., Povey,S. and Abbott,C.M.
  TITLE     The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and
            neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4)
            map to human chromosome 20, extending the known region of homology
            with mouse chromosome 2
  JOURNAL   Ann Hum Genet 56 (4), 289-293 (1992)
   PUBMED   1492743
REFERENCE   7  (bases 1 to 2637)
  AUTHORS   Nandan,S.D. and Beale,E.G.
  TITLE     Regulation of phosphoenolpyruvate carboxykinase mRNA in mouse
            liver, kidney, and fat tissues by fasting, diabetes, and insulin
  JOURNAL   Lab Anim Sci 42 (5), 473-477 (1992)
   PUBMED   1460846
REFERENCE   8  (bases 1 to 2637)
  AUTHORS   Nelson,K.K., Knopf,J.L. and Siracusa,L.D.
  TITLE     Localization of phospholipase C-gamma 1 to mouse chromosome 2
  JOURNAL   Mamm Genome 3 (10), 597-600 (1992)
   PUBMED   1358284
REFERENCE   9  (bases 1 to 2637)
  AUTHORS   Fulchignoni-Lataud,M.C., Szpirer,J., Levan,G. and Weiss,M.C.
  TITLE     Assignment of the rat genes coding for alpha 1-antitrypsin (PI),
            phosphoenolpyruvate carboxykinase (PEPCK), alcohol dehydrogenase
            (ADH), and fructose-1,6-bisphosphatase (FDP)
  JOURNAL   Mamm Genome 3 (1), 42-45 (1992)
   PUBMED   1316195
REFERENCE   10 (bases 1 to 2637)
  AUTHORS   Siracusa,L.D., Alvord,W.G., Bickmore,W.A., Jenkins,N.A. and
            Copeland,N.G.
  TITLE     Interspecific backcross mice show sex-specific differences in
            allelic inheritance
  JOURNAL   Genetics 128 (4), 813-821 (1991)
   PUBMED   1916246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL837509.11.
            
            On Apr 24, 2018 this sequence version replaced NM_011044.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149525.1, AK133496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AL837509.11        60056-60154
            100-364             AL837509.11        60331-60595
            365-546             AL837509.11        60918-61099
            547-750             AL837509.11        61684-61887
            751-938             AL837509.11        62160-62347
            939-1101            AL837509.11        62921-63083
            1102-1326           AL837509.11        63895-64119
            1327-1458           AL837509.11        64212-64343
            1459-1554           AL837509.11        64976-65071
            1555-2637           AL837509.11        65175-66257
FEATURES             Location/Qualifiers
     source          1..2637
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 95.79 cM"
     gene            1..2637
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /note="phosphoenolpyruvate carboxykinase 1, cytosolic"
                     /db_xref="GeneID:18534"
                     /db_xref="MGI:MGI:97501"
     exon            1..99
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     exon            100..364
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..2009
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /EC_number="4.1.1.32"
                     /note="phosphoenolpyruvate carboxykinase, cytosolic;
                     phosphoenolpyruvate carboxylase; serine-protein kinase
                     PCK1"
                     /codon_start=1
                     /product="phosphoenolpyruvate carboxykinase, cytosolic
                     [GTP]"
                     /protein_id="NP_035174.1"
                     /db_xref="CCDS:CCDS17141.1"
                     /db_xref="GeneID:18534"
                     /db_xref="MGI:MGI:97501"
                     /translation="MPPQLHNGLDFSAKVIQGSLDSLPQAVRKFVEGNAQLCQPEYIH
                     ICDGSEEEYGQLLAHMQEEGVIRKLKKYDNCWLALTDPRDVARIESKTVIITQEQRDT
                     VPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLAKIGIEL
                     TDSPYVVASMRIMTRMGISVLEALGDGEFIKCLHSVGCPLPLKKPLVNNWACNPELTL
                     IAHLPDRREIISFGSGYGGNSLLGKKCFALRIASRLAKEEGWLAEHMLILGITNPEGK
                     KKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGNLRAINPENGFFG
                     VAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLAPGVTITSWKNKEWR
                     PQDAEPCAHPNSRFCTPASQCPIIDPAWESPEGVPIEGIIFGGRRPEGVPLVYEALSW
                     QHGVFVGAAMRSEATAAAEHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAHRPAAKL
                     PKIFHVNWFRKDKDGKFLWPGFGENSRVLEWMFGRIEGEDSAKLTPIGYIPKENALNL
                     KGLGGVNVEELFGISKEFWEKEVEEIDRYLEDQVNTDLPYEIERELRALKQRISQM"
     exon            365..546
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     exon            547..750
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     exon            751..938
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     exon            939..1101
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1326
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1458
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1554
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..2637
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2612..2617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /note="hexamer: AATAAA"
     polyA_site      2634
                     /gene="Pck1"
                     /gene_synonym="Pck-1; PEPCK; PEPCK-C"
                     /note="major polyA site"
ORIGIN      
        1 acagttggcc ttccctctgg gaacacaccc tcggtcaaca ggggaaatcc ggcaaggcgc
       61 tcagcgatct ctgatccaga ccttccaaaa ggaagaaagg tggcaccaga gttcctgcct
      121 ctctccacac cattgcaatt atgcctcctc agctgcataa cggtctggac ttctctgcca
      181 aggtcatcca gggcagcctc gacagcctgc cccaggcagt gaggaagttc gtggaaggca
      241 atgctcagct gtgccagccg gagtatatcc acatctgcga tggctccgag gaggagtacg
      301 ggcagttgct ggcccacatg caggaggagg gtgtcatccg caagctgaag aaatatgaca
      361 actgttggct ggctctcact gaccctcgag atgtggccag gatcgaaagc aagacagtca
      421 tcatcaccca agagcagaga gacacagtgc ccatccccaa aactggcctc agccagctgg
      481 gccgctggat gtcggaagag gactttgaga aagcattcaa cgccaggttc ccagggtgca
      541 tgaaaggccg caccatgtat gtcatcccat tcagcatggg gccactgggc tcgccgctgg
      601 ccaagattgg tattgaactg acagactcgc cctatgtggt ggccagcatg cggatcatga
      661 ctcggatggg catatctgtg ctggaggccc tgggagatgg ggagttcatc aagtgcctgc
      721 actctgtggg gtgccctctc cccttaaaaa agcctttggt caacaactgg gcctgcaacc
      781 ctgagctgac cctgatcgcc cacctcccgg accgcagaga gatcatctcc tttggaagcg
      841 gatatggtgg gaactcacta ctcgggaaga aatgctttgc gttgcggatc gccagccgtc
      901 tggctaagga ggaagggtgg ctggcggagc atatgctgat cctgggcata actaaccccg
      961 aaggcaagaa gaaatacctg gccgcagcct tccctagtgc ctgtgggaag actaacttgg
     1021 ccatgatgaa ccccagcctg cccgggtgga aggtcgaatg tgtgggcgat gacattgcct
     1081 ggatgaagtt tgatgcccaa ggcaacttaa gggctatcaa cccagaaaac gggttttttg
     1141 gagttgctcc tggcacctca gtgaagacaa atccaaatgc cattaaaacc atccagaaaa
     1201 acaccatctt caccaacgtg gccgagacta gcgatggggg tgtttactgg gaaggcatcg
     1261 atgagccgct ggccccggga gtcaccatca cctcctggaa gaacaaggag tggagaccgc
     1321 aggacgcgga accatgtgcc catcccaact cgagattctg cacccctgcc agccagtgcc
     1381 ccattattga ccctgcctgg gaatctccag aaggagtacc cattgagggt atcatctttg
     1441 gtggccgtag acctgaaggt gtcccccttg tctatgaagc cctcagctgg cagcatgggg
     1501 tgtttgtagg agcagccatg agatctgagg ccacagctgc tgcagaacac aagggcaaga
     1561 tcatcatgca cgaccccttt gccatgcgac ccttcttcgg ctacaacttc ggcaaatacc
     1621 tggcccactg gctgagcatg gcccaccgcc cagcagccaa gttgcccaag atcttccatg
     1681 tcaactggtt ccggaaggac aaagatggca agttcctctg gccaggcttt ggcgagaact
     1741 cccgggtgct ggagtggatg ttcgggcgga ttgaagggga agacagcgcc aagctcacgc
     1801 ccatcggcta catccctaag gaaaacgcct tgaacctgaa aggcctgggg ggcgtcaacg
     1861 tggaggagct gtttgggatc tctaaggagt tctgggagaa ggaggtggag gagatcgaca
     1921 ggtatctgga ggaccaggtc aacaccgacc tcccttacga aattgagagg gagctccgag
     1981 ccctgaaaca gagaatcagc cagatgtaaa tcccaatggg ggcgtctcga gagtcacccc
     2041 ttcccactca cagcatgcgc tgagatctag gagaaagcca gcctgctcca gctttgagat
     2101 agcggcacaa tgctgagtag atcagaaaag caccttttaa tagtcagttg agtagcacag
     2161 agaacaggct aggggcaaat aagattggga ggggaaatca ccgcatagtc tctgaagttt
     2221 gcatttgaca ccaatggggg ttttggttcc acttcaaggt cactcaggaa tccagttctt
     2281 cacgttagct gtagcagtta gctaaaatgc acagaaaaca tacttgagct gtatatatgt
     2341 gtgtgaacgt gtctctgtgt gagcatgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     2401 gtgtgtgtac atgcctgtct gtcccattgt ccacagtata tttaaaacct ttggggaaaa
     2461 atcttgggca aatttgtagc tgtaactaga gagtcatgtt gctttgttgc tagtatgtat
     2521 gtttaaatta tttttataca ccgcccttcc ttacctttct ttacataatt gaaattggta
     2581 tccggaccac ttcttgggaa aaaaattaca aaataaactt ttatagaaaa agtagat
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