LOCUS       NM_146129               2752 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus phosphorylated CTD interacting factor 1 (Pcif1),
            transcript variant 4, mRNA.
ACCESSION   NM_146129 XM_488966
VERSION     NM_146129.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2752)
  AUTHORS   Song,W., Liu,L., Liang,H., Cheng,H., He,W., Yin,Q., Zhang,Z.,
            Lin,W., Li,H., Li,Q., Liu,W., Zhang,D., Chen,D. and Yuan,Q.
  TITLE     m6Am Methyltransferase PCIF1 Regulates Periodontal Inflammation
  JOURNAL   J Dent Res 103 (11), 1130-1140 (2024)
   PUBMED   39290151
  REMARK    GeneRIF: m[6]Am Methyltransferase PCIF1 Regulates Periodontal
            Inflammation.
REFERENCE   2  (bases 1 to 2752)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2752)
  AUTHORS   Wang,L., Wu,L., Zhu,Z., Zhang,Q., Li,W., Gonzalez,G.M., Wang,Y. and
            Rana,T.M.
  TITLE     Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation
            in colorectal cancer and anti-PD-1 immunotherapy
  JOURNAL   EMBO J 42 (2), e111673 (2023)
   PUBMED   36514940
  REMARK    GeneRIF: Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA
            methylation in colorectal cancer and anti-PD-1 immunotherapy.
REFERENCE   4  (bases 1 to 2752)
  AUTHORS   Pandey,R.R., Delfino,E., Homolka,D., Roithova,A., Chen,K.M., Li,L.,
            Franco,G., Vagbo,C.B., Taillebourg,E., Fauvarque,M.O. and
            Pillai,R.S.
  TITLE     The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1
            Regulates Transcript Levels in Mouse Tissues
  JOURNAL   Cell Rep 32 (7), 108038 (2020)
   PUBMED   32814042
  REMARK    GeneRIF: The Mammalian Cap-Specific m(6)Am RNA Methyltransferase
            PCIF1 Regulates Transcript Levels in Mouse Tissues.
REFERENCE   5  (bases 1 to 2752)
  AUTHORS   Sendinc,E., Valle-Garcia,D., Dhall,A., Chen,H., Henriques,T.,
            Navarrete-Perea,J., Sheng,W., Gygi,S.P., Adelman,K. and Shi,Y.
  TITLE     PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression
  JOURNAL   Mol Cell 75 (3), 620-630 (2019)
   PUBMED   31279659
REFERENCE   6  (bases 1 to 2752)
  AUTHORS   Boulias,K., Toczydlowska-Socha,D., Hawley,B.R., Liberman,N.,
            Takashima,K., Zaccara,S., Guez,T., Vasseur,J.J., Debart,F.,
            Aravind,L., Jaffrey,S.R. and Greer,E.L.
  TITLE     Identification of the m6Am Methyltransferase PCIF1 Reveals the
            Location and Functions of m6Am in the Transcriptome
  JOURNAL   Mol Cell 75 (3), 631-643 (2019)
   PUBMED   31279658
REFERENCE   7  (bases 1 to 2752)
  AUTHORS   Cowling,V.H.
  TITLE     CAPAM: The mRNA Cap Adenosine N6-Methyltransferase
  JOURNAL   Trends Biochem Sci 44 (3), 183-185 (2019)
   PUBMED   30679132
REFERENCE   8  (bases 1 to 2752)
  AUTHORS   Akichika,S., Hirano,S., Shichino,Y., Suzuki,T., Nishimasu,H.,
            Ishitani,R., Sugita,A., Hirose,Y., Iwasaki,S., Nureki,O. and
            Suzuki,T.
  TITLE     Cap-specific terminal N6-methylation of RNA by an RNA polymerase
            II-associated methyltransferase
  JOURNAL   Science 363 (6423) (2019)
   PUBMED   30467178
REFERENCE   9  (bases 1 to 2752)
  AUTHORS   Sun,H., Zhang,M., Li,K., Bai,D. and Yi,C.
  TITLE     Cap-specific, terminal N6-methylation by a mammalian m6Am
            methyltransferase
  JOURNAL   Cell Res 29 (1), 80-82 (2019)
   PUBMED   30487554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK089358.1.
            
            On Apr 6, 2007 this sequence version replaced NM_146129.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK089358.1, SRR1660813.167447.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2752              AK089358.1         2-2753
FEATURES             Location/Qualifiers
     source          1..2752
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.27 cM"
     gene            1..2752
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /note="phosphorylated CTD interacting factor 1"
                     /db_xref="GeneID:228866"
                     /db_xref="MGI:MGI:2443858"
     exon            1..122
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            123..292
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            293..435
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            436..560
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..698
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            699..826
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            827..981
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1129
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1213
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1313
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1476
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1649
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1736
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1737..1921
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2015
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2016..2191
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2752
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2673..2678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /note="hexamer: AATACA"
     polyA_site      2687
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
     polyA_site      2692
                     /gene="Pcif1"
                     /gene_synonym="2310022K11Rik; C20orf67; CAPAM;
                     F730014I05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggagtccc ggcccgggac acaagatggc ggcagcggcg ctggggaggg cgaggcggag
       61 gcggcaaaac gggcggtcga gcagaacgtg tggccgcatc ccctcgagtc cgcttcgggc
      121 agctgctgat tcacggagtc ccctgggtcc ctgtcaactg cagtgctgac cagcctaccc
      181 acctgtgcta cgccttcctg tgggcctccc ccctcttctg tgggaccccg tgacgtgggt
      241 tcagtccagc cagagaagaa aactctgatg ctagcgtcgc agcccccaga gggtcccgtg
      301 tgggtgctga gatggccaat gagaatcacg gcagcccccg ggaaggagcc tcccttctaa
      361 gtcactctcc aggcacctcc agtcagagcc agccctgttc tccaaagcca gttcgcctgg
      421 tacaggacct tccagaggag ctggtacatg caggctggga gaagtgctgg agccggaggg
      481 agagccgtcc ctactacttc aaccgattca ccaaccagtc tctgtgggag atgcccgtgc
      541 tgggtcagca cgacgtgctt tcggaccctc tggggctgaa tgcaacccca ctgccccaag
      601 actcaagctt ggtggaaacg cccccagtag agaacaagtc cagaaagcga cagctctcag
      661 aggagcagcc aagtggcaac ggagtgaaga agcccaagat tgaaatccct gtgacaccca
      721 caagccagtc agtgcccagt tcccctagca tcccaggaac cccaacactg aagatttggg
      781 gttcatccac tgaagataaa caggcagctc tcctccgacc cactgaggtg tactgggacc
      841 tggacatcca gaccaatgct gtcatcaagc acaggggtcc ttcagaggtc ctgcctccac
      901 accctgatgt tgagttgctc cgctcgcagc tcatcttgaa gctccgccag cactaccggg
      961 aactgtgcca gcagcgggag ggcattgagc cgccccggga atctttcaac cgctggatgc
     1021 tggagcgcaa agtggtggac aaaggatgtg atcctctgtt gccaagcaac tgtgaaccag
     1081 ttgtgtctcc atccatgttt cgtgaaatta tgaatgacat tcccatcagg ttatcccgaa
     1141 tcaagttccg ggaggaagcc aaacgcctgc tctttaaata cgcagaagct gccaggcggc
     1201 tcattgagtc caggagtgca tcccctgaca gcagaaaagt ggtcaaatgg aacgtggagg
     1261 acaccttcag ctggctgcgg aaagagcact cggcctccaa ggaggattac atggaccgcc
     1321 tggagcacct tcggaggcag tgtgggcccc atgtctctgc tgcagccaag gactctgtgg
     1381 aaggcatctg cagcaagatc taccacatct ccctggaata tgttaaacgg atccgagaaa
     1441 agcaccttgc tgtcctcaag gaaaacaaca tcccagagga agtggaggcc tcagagttgg
     1501 agccccgcct ggtgtactgc tacccagtgc gtctggccgt gtccgcaccc cccatgccta
     1561 gtgtggagat gcacgtggag aacagtgtgg tctgcatccg ctataagggg gagatggtca
     1621 aggtcagccg cagctacttc agcaaactgt ggctcctcta ccgctatagc tgtgtggatg
     1681 actctgcctt tgagaggttc ctgcctcgag tctggtgtct tctccgccga tatcagatga
     1741 tgtttggcgt gggcctctat gaggggactg gcctgcaggg gtcactgcca gtgcatgtct
     1801 ttgagaccct ccaccgactc tttggtgtca gtttcgagtg cttcgcctcc cccctcaact
     1861 gctacttccg ccagtactgt tctgccttcc ctgacacaga tggctacttt ggctcccgag
     1921 ggccctgcct ggacttcacc ccgctgagtg gttcctttga ggccaaccct ccgttctgcg
     1981 aggagctcat ggatgctatg gtctctcact tcgagaaact gctggagagc tcagcagaac
     2041 ccctgtcctt catcgtgttc atcccggagt ggcgggagcc ccccacacca gcgctcacca
     2101 ggatggagca gagccgcttc aaacgccacc agctggtctt gcctgccttt gagcacgagt
     2161 accgcagtgg ctcccagcac atctgcaaga aggaggaaat gcactacaag gccgtccaca
     2221 acacggcagt gctcttcctg cagaatggcc ccgggttcgc caagtggggg ccgacgccag
     2281 agcggctgca ggagctcacc gctgcctata agcagtcggg ccgcagccat ggctccagct
     2341 cttcttcctc ctcctcttcc tcctcctccg aggccaagga ccgggactca ggccgggaac
     2401 agggccctag tagagagcct caccccactt aacatatcct gcggggagga ggagctccag
     2461 gggtgctgtc acagactgct aggactcagc ctcagggctc tcccctgggg tggcagcagg
     2521 acttgagctg ccagggacat aggaatatta cggctctgcc agggatcccc ctccctgctc
     2581 tcaccctttc cgattcacca agtcccttgt aaataggccc gtgcctcccc agccccagac
     2641 cctgttgctg ccttgtttca tttgtaaaag gaaatacaga aactccccaa gagtgtgtga
     2701 gggtcttggg gcggttgcct cggtgaccac tccctaggtg ccccttatca ag
//
