LOCUS       NM_178708               2408 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus PCI domain containing 2 (Pcid2), mRNA.
ACCESSION   NM_178708
VERSION     NM_178708.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2408)
  AUTHORS   Ye,B., Liu,B., Yang,L., Huang,G., Hao,L., Xia,P., Wang,S., Du,Y.,
            Qin,X., Zhu,P., Wu,J., Sakaguchi,N., Zhang,J. and Fan,Z.
  TITLE     Suppression of SRCAP chromatin remodelling complex and restriction
            of lymphoid lineage commitment by Pcid2
  JOURNAL   Nat Commun 8 (1), 1518 (2017)
   PUBMED   29138493
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2408)
  AUTHORS   Ye,B., Dai,Z., Liu,B., Wang,R., Li,C., Huang,G., Wang,S., Xia,P.,
            Yang,X., Kuwahara,K., Sakaguchi,N. and Fan,Z.
  TITLE     Pcid2 inactivates developmental genes in human and mouse embryonic
            stem cells to sustain their pluripotency by modulation of EID1
            stability
  JOURNAL   Stem Cells 32 (3), 623-635 (2014)
   PUBMED   24167073
  REMARK    GeneRIF: Pcid2 is present in the CBP/p300-EID1 complex to control
            the switch balance of mouse and human embryonic stem cells through
            modulation of EID1 degradation.
REFERENCE   3  (bases 1 to 2408)
  AUTHORS   Nakaya,T., Kuwahara,K., Ohta,K., Kitabatake,M., Toda,T., Takeda,N.,
            Tani,T., Kondo,E. and Sakaguchi,N.
  TITLE     Critical role of Pcid2 in B cell survival through the regulation of
            MAD2 expression
  JOURNAL   J Immunol 185 (9), 5180-5187 (2010)
   PUBMED   20870947
  REMARK    GeneRIF: Pcid2 is essential for B cell survival through the
            regulation of MAD2 expression during B cell differentiation
REFERENCE   4  (bases 1 to 2408)
  AUTHORS   Liu,L., Lee,S., Zhang,J., Peters,S.B., Hannah,J., Zhang,Y., Yin,Y.,
            Koff,A., Ma,L. and Zhou,P.
  TITLE     CUL4A abrogation augments DNA damage response and protection
            against skin carcinogenesis
  JOURNAL   Mol Cell 34 (4), 451-460 (2009)
   PUBMED   19481525
REFERENCE   5  (bases 1 to 2408)
  AUTHORS   Waning,D.L., Li,B., Jia,N., Naaldijk,Y., Goebel,W.S., HogenEsch,H.
            and Chun,K.T.
  TITLE     Cul4A is required for hematopoietic cell viability and its
            deficiency leads to apoptosis
  JOURNAL   Blood 112 (2), 320-329 (2008)
   PUBMED   18339895
REFERENCE   6  (bases 1 to 2408)
  AUTHORS   Li,B., Jia,N., Waning,D.L., Yang,F.C., Haneline,L.S. and Chun,K.T.
  TITLE     Cul4A is required for hematopoietic stem-cell engraftment and
            self-renewal
  JOURNAL   Blood 110 (7), 2704-2707 (2007)
   PUBMED   17616641
REFERENCE   7  (bases 1 to 2408)
  AUTHORS   Li,B., Jia,N., Kapur,R. and Chun,K.T.
  TITLE     Cul4A targets p27 for degradation and regulates proliferation, cell
            cycle exit, and differentiation during erythropoiesis
  JOURNAL   Blood 107 (11), 4291-4299 (2006)
   PUBMED   16467204
REFERENCE   8  (bases 1 to 2408)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (bases 1 to 2408)
  AUTHORS   Li,B., Yang,F.C., Clapp,D.W. and Chun,K.T.
  TITLE     Enforced expression of CUL-4A interferes with granulocytic
            differentiation and exit from the cell cycle
  JOURNAL   Blood 101 (5), 1769-1776 (2003)
   PUBMED   12393421
REFERENCE   10 (bases 1 to 2408)
  AUTHORS   Li,B., Ruiz,J.C. and Chun,K.T.
  TITLE     CUL-4A is critical for early embryonic development
  JOURNAL   Mol Cell Biol 22 (14), 4997-5005 (2002)
   PUBMED   12077329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC118533.1, BY281425.1, AK042945.1 and AK163697.1.
            
            On Dec 13, 2006 this sequence version replaced NM_178708.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC118533.1, AK163697.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               BC118533.1         1-373
            374-511             BY281425.1         215-352
            512-1213            AK042945.1         2-703
            1214-2408           AK163697.1         701-1895
FEATURES             Location/Qualifiers
     source          1..2408
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 5.73 cM"
     gene            1..2408
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /note="PCI domain containing 2"
                     /db_xref="GeneID:234069"
                     /db_xref="MGI:MGI:2443003"
     exon            1..569
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             534..1733
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /note="CSN12-like protein"
                     /codon_start=1
                     /product="PCI domain-containing protein 2"
                     /protein_id="NP_848823.2"
                     /db_xref="CCDS:CCDS52484.1"
                     /db_xref="GeneID:234069"
                     /db_xref="MGI:MGI:2443003"
                     /translation="MAHITINQYLQQVYEAIDTRDGASCAELVSFKHPHVANPRLQMA
                     SPEEKCQQVLEPPYDEMFAAHLRCTYAVGNHDFIEAYKCQTVIVQSFLRAFQAHKEEN
                     WALPVMYAVALDLRIFANNADQQLVKKGKSKVGDMLEKAAELLMSCFRVCASDTRAGI
                     EDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKDDYSTAQRITYKYYVGR
                     KAMFDSDFKQAEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHMPTIELLRKYHL
                     MQFSEVTKAVSEGNLLLLNEALAKHETFFIRCGIFLILEKLKIITYRNLFKKVYLLLK
                     THQLSLDAFLVALKFMHVEDVDIDEVQCILANLIYMGHIKGYISHQHQKLVVSKQNPF
                     PPLSTVC"
     exon            570..659
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            660..733
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            734..799
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            800..841
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            842..896
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1000
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1076
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1218
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1319
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1393
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1519
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1643
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..2408
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2157
                     /gene="Pcid2"
                     /gene_synonym="A730042J05Rik"
ORIGIN      
        1 ggatgctcag ggatgctgct ccgtgcgcta gcgcgccgag gggttgggga cgggatgctc
       61 tgcacccatt tatctggggt gccccagtgt gagatgtggg aggactcagg aacacatcct
      121 aggagtgcgc gggacgcctt cccagtgggc tctggacttt ggttccggga gagtcaggag
      181 cgcctctgca cacggagggt tggggatcgg gtcaccctca tgggagaggg gtgcgaggaa
      241 tcgggtcgct agcacaccga cgtgaccagg gacacgttcc caagtcggtt gggaactcct
      301 ccacgtcagt cctccgccct cgcgcgcgcc cccgccgcac ccgaggcgtc ccggcgaccg
      361 cgctgacagc tgcccccaaa gaagtgctct caccaccggc tcggctcggc tcggctcggc
      421 tcgctccacc ttcacccgct ccggaaccaa cgtgcagagg ttaccgtgtg gggacaagga
      481 gcggaaacgg acctgcgccg gaagtgaggc actcaacacc cgcggccgcc gctatggcgc
      541 acatcaccat taaccagtac ctacagcagg tatatgaagc catcgacacc agagatggag
      601 catcctgtgc agagctggta tcctttaagc accctcatgt tgcgaaccca cggctccaga
      661 tggcctctcc agaagagaaa tgccagcaag ttctggagcc cccatatgat gaaatgtttg
      721 cagctcattt aaggtgtacc tatgctgtgg ggaatcacga cttcatagaa gcgtacaagt
      781 gccagacggt gatagtccaa tcattcctcc gggcattcca ggctcacaaa gaggaaaact
      841 gggctctgcc tgtcatgtat gcagtagcac ttgaccttcg gatatttgcc aataatgcag
      901 accagcagtt ggtaaagaaa gggaagagca aagttggaga catgctggaa aaagctgccg
      961 agctgctgat gagctgcttc cgagtctgtg ccagtgacac ccgtgccggc atagaagact
     1021 ctaagaagtg ggggatgctg ttcctggtga accagctatt taaaatctac tttaagatca
     1081 acaaactcca tttgtgtaaa cctcttatca gagccatcga cagctcgaat ctgaaagatg
     1141 actatagcac agcgcagagg atcacgtaca agtactacgt ggggcgcaag gccatgtttg
     1201 acagtgactt caagcaagcg gaggagtacc tgtcgtttgc ctttgaacac tgccatcgct
     1261 ccagccagaa gaacaagagg atgattctga tctacctgct gccagtgaag atgctgctgg
     1321 gtcacatgcc gaccatcgag ctcctgagga aataccacct gatgcagttt tcagaagtga
     1381 ccaaagccgt cagtgagggc aacctgctgc tgctcaatga ggcgctggca aagcacgaga
     1441 cgttcttcat ccgctgtggc atcttcctca tcctggagaa gctgaagatc atcacgtaca
     1501 ggaacctctt caagaaagtg tatttgttac tcaagacaca tcagctgtcc ctagacgcct
     1561 ttctggtcgc tttgaagttc atgcacgtgg aagacgtgga cattgacgag gtccagtgca
     1621 ttctggccaa cttgatatac atgggtcaca ttaaaggcta catctcccat cagcatcaga
     1681 aactggtcgt cagcaagcag aaccctttcc ctccgctgtc cacagtgtgc tgatgcccag
     1741 gccttgccaa cagcgtgctc ctgctaccgc tgcccgctgg agctcacatc tcctggtgca
     1801 gtcgccagca cctgaggcac tcactgtggt ttccagtgtc ctaactcatg ccagccttgc
     1861 caagacctgg agttcttttt caagatggac caacaccctg ctgctggcct gtggtgctcc
     1921 tgagcgtccg ggaaggagac agctgggctt cggtttgttt atggaggcta cctttgtgac
     1981 atcttgtagg gtttcctccc tccctcctct ctctctctct ctctctctct ttctctctct
     2041 ctctctctct ttcttaaaaa ggtaacccaa gtttatacaa gtggcacgag ttctttactg
     2101 tctgttatgt aacacatctg ttttcatatg caaaatgtca gcattgtgag ctcggaatgc
     2161 tgggttaact tgaggcttct ttttaaaagt agaatttagg gggaggagag acggttcagg
     2221 cgagaacagc tactgctctg ccagaggatg tgtgtttgat tcctggcacc catatggcag
     2281 ctcacagcct ctaactccag ttctagggga cccattgcct tcgttggcct ccacgggctc
     2341 ctgcacacgt gtacaaaagc tcactcaggc aaacaggcat gcatacataa ataaatacac
     2401 cttttttt
//
