LOCUS       NM_027654               2182 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus polycomb group ring finger 6 (Pcgf6), transcript
            variant 1, mRNA.
ACCESSION   NM_027654
VERSION     NM_027654.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2182)
  AUTHORS   Del Vecchio,A., Mule,P., Fernandez-Perez,D., Amato,S., Lattanzi,G.,
            Zanotti,M., Rustichelli,S., Pivetti,S., Oldani,P., Mariani,A.,
            Iommazzo,F., Koseki,H., Facciotti,F., Tamburri,S., Ferrari,K.J. and
            Pasini,D.
  TITLE     PCGF6 controls murine Tuft cell differentiation via H3K9me2
            modification independently of Polycomb repression
  JOURNAL   Dev Cell 59 (3), 368-383 (2024)
   PUBMED   38228142
  REMARK    GeneRIF: PCGF6 controls murine Tuft cell differentiation via
            H3K9me2 modification independently of Polycomb repression.
REFERENCE   2  (bases 1 to 2182)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   3  (bases 1 to 2182)
  AUTHORS   Tanaskovic,N., Dalsass,M., Filipuzzi,M., Ceccotti,G.,
            Verrecchia,A., Nicoli,P., Doni,M., Olivero,D., Pasini,D.,
            Koseki,H., Sabo,A., Bisso,A. and Amati,B.
  TITLE     Polycomb group ring finger protein 6 suppresses Myc-induced
            lymphomagenesis
  JOURNAL   Life Sci Alliance 5 (8), e202101344 (2022)
   PUBMED   35422437
  REMARK    GeneRIF: Polycomb group ring finger protein 6 suppresses
            Myc-induced lymphomagenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2182)
  AUTHORS   Mei,H., Kozuka,C., Hayashi,R., Kumon,M., Koseki,H. and Inoue,A.
  TITLE     H2AK119ub1 guides maternal inheritance and zygotic deposition of
            H3K27me3 in mouse embryos
  JOURNAL   Nat Genet 53 (4), 539-550 (2021)
   PUBMED   33821003
  REMARK    GeneRIF: H2AK119ub1 guides maternal inheritance and zygotic
            deposition of H3K27me3 in mouse embryos.
REFERENCE   5  (bases 1 to 2182)
  AUTHORS   Liu,M., Zhu,Y., Xing,F., Liu,S., Xia,Y., Jiang,Q. and Qin,J.
  TITLE     The polycomb group protein PCGF6 mediates germline gene silencing
            by recruiting histone-modifying proteins to target gene promoters
  JOURNAL   J Biol Chem 295 (28), 9712-9724 (2020)
   PUBMED   32482889
  REMARK    GeneRIF: The polycomb group protein PCGF6 mediates germline gene
            silencing by recruiting histone-modifying proteins to target gene
            promoters.
REFERENCE   6  (bases 1 to 2182)
  AUTHORS   Tavares,L., Dimitrova,E., Oxley,D., Webster,J., Poot,R.,
            Demmers,J., Bezstarosti,K., Taylor,S., Ura,H., Koide,H., Wutz,A.,
            Vidal,M., Elderkin,S. and Brockdorff,N.
  TITLE     RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target
            sites independently of PRC2 and H3K27me3
  JOURNAL   Cell 148 (4), 664-678 (2012)
   PUBMED   22325148
  REMARK    Erratum:[Cell. 2012 Jun 22;149(7):1647-8]
REFERENCE   7  (bases 1 to 2182)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 2182)
  AUTHORS   Puschendorf,M., Terranova,R., Boutsma,E., Mao,X., Isono,K.,
            Brykczynska,U., Kolb,C., Otte,A.P., Koseki,H., Orkin,S.H., van
            Lohuizen,M. and Peters,A.H.
  TITLE     PRC1 and Suv39h specify parental asymmetry at constitutive
            heterochromatin in early mouse embryos
  JOURNAL   Nat Genet 40 (4), 411-420 (2008)
   PUBMED   18311137
REFERENCE   9  (bases 1 to 2182)
  AUTHORS   Akasaka,T., Takahashi,N., Suzuki,M., Koseki,H., Bodmer,R. and
            Koga,H.
  TITLE     MBLR, a new RING finger protein resembling mammalian Polycomb gene
            products, is regulated by cell cycle-dependent phosphorylation
  JOURNAL   Genes Cells 7 (8), 835-850 (2002)
   PUBMED   12167161
  REMARK    GeneRIF: regulation by cell cycle-dependent phosphorylation
REFERENCE   10 (bases 1 to 2182)
  AUTHORS   Kanno,M., Hasegawa,M., Ishida,A., Isono,K. and Taniguchi,M.
  TITLE     mel-18, a Polycomb group-related mammalian gene, encodes a
            transcriptional negative regulator with tumor suppressive activity
  JOURNAL   EMBO J 14 (22), 5672-5678 (1995)
   PUBMED   8521824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108814.22 and BC089460.1.
            
            On Oct 24, 2015 this sequence version replaced NM_027654.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089460.1, AB047007.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC108814.22        7961-7982
            23-2182             BC089460.1         1-2160
FEATURES             Location/Qualifiers
     source          1..2182
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 39.11 cM"
     gene            1..2182
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /note="polycomb group ring finger 6"
                     /db_xref="GeneID:71041"
                     /db_xref="MGI:MGI:1918291"
     exon            1..456
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1149
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 134; polycomb group RING finger protein 6;
                     Mel18- and Bmi1-like RING finger protein"
                     /codon_start=1
                     /product="polycomb group RING finger protein 6 isoform 1"
                     /protein_id="NP_081930.1"
                     /db_xref="CCDS:CCDS29885.1"
                     /db_xref="GeneID:71041"
                     /db_xref="MGI:MGI:1918291"
                     /translation="MDEAETDATENKRASEAKRASAMPPPPPPPPPISPPALIPAPAA
                     GEEGPASLGQAGAAGCSRSRPPALEPERSLGRLRGRFEDYDEELEEEEEMEEEEEEEE
                     EMSHFSLRLESGRADSEDEEERLINLVELTPYILCSICKGYLIDATTITECLHTFCKS
                     CIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYK
                     ERGLEVPKPAAPQPVPSSKGKTKKVLESVFRIPPELDMSLLLEFIGANEDTGHFKPLE
                     KKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLERYQTLREIRRAIGDTAM
                     QDGLLVLHYGLVVSPLKIT"
     exon            457..556
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     exon            557..653
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     exon            654..709
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     exon            710..769
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     exon            770..878
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     exon            879..906
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1005
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1092
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..2161
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2140..2145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /note="hexamer: AATAAA"
     polyA_site      2161
                     /gene="Pcgf6"
                     /gene_synonym="4933407A11Rik; MBLR; Rnf134"
                     /note="major polyA site"
ORIGIN      
        1 acgaaagggg gctcgtgctc aactcgcgcg ctagccgtcc gactcgcctt gcctcgctct
       61 caactcgcca gatttctgat ccccgccatg gacgaggctg agacggacgc cacggaaaac
      121 aagcgcgcct ctgaggccaa gcgagcctca gccatgccgc caccgccacc gcctccgcct
      181 cccatctctc cgcccgccct catcccggca cccgcggccg gcgaggaggg cccggcgtcc
      241 ctgggccagg cgggcgctgc cggctgctct cgctctcggc ccccggcgtt ggagcccgag
      301 cgcagcctgg gccgcttgag aggccgcttc gaggactacg atgaagagtt ggaagaggag
      361 gaggagatgg aggaggaaga agaggaggag gaagagatga gccacttctc tctgcgtctg
      421 gagtccggac gggcagactc cgaggacgag gaggagcgcc tgataaacct tgtcgagctg
      481 accccctaca tcctgtgttc gatttgcaaa ggttacctga tagatgcaac caccattaca
      541 gagtgtcttc ataccttttg taaaagctgc attgtgagac atttttacta tagtaacaga
      601 tgcccaaaat gcaacatagt tgtccaccag actcagcctc tttataatat aaggttggac
      661 cggcagttac aagacatagt atacaaatta gtgatcaatc tagaggaaag agaaaaaaag
      721 caaatgcatg acttctataa agaaagaggt ctagaagtcc ccaagcctgc tgctccacag
      781 ccagtccctt caagcaaagg aaaaaccaag aaggtcctag agtcagtgtt tcgtattcca
      841 cctgaacttg atatgtcttt attacttgag ttcattggtg ctaatgaaga caccggacat
      901 tttaagccat tggaaaagaa gtttgtgcgt gtttcaggag aagcaactat cgggcatgta
      961 gaaaaatttc ttagaagaaa aatgggtctt gatccagctt gtcaggtaga tatcatctgt
     1021 ggggatcact tactggagcg gtaccaaact ctacgggaaa tccgacgtgc aataggtgat
     1081 acagcaatgc aggacggtct gcttgttctt cattatggtc ttgtggtttc tcctttgaaa
     1141 ataacttgaa gatgcaaagg tatatgagga gagaaaccca gtcggaggca tctgcatatc
     1201 tgcattgcac caaagattct cacaaagcac gtaactacga ctactttccg ctgttaagag
     1261 ctggcttctg ttgtcaccag aaccctagca ttgtgtgtgt acaacttgaa acaatagaat
     1321 gtatttgcta cactaaagac tatggaaaca gcactcataa ctcaggggaa aaaactgaaa
     1381 acactgaatt ttaaaattcc ttgtgattcc aaatatgagg aagttgctgg ttgcttccca
     1441 tctttgaggt gggtgggtca gtttcccaga gctgggactc tgccctccag ctgcatgggc
     1501 tgggtggttt ccttcagaac agctttgctt tgagttcaga gccagtctgt taaacctcgg
     1561 gtgcgctccg caccgaaact actggccact tacaagttcc tgtcctattc tgaacttcaa
     1621 acaaaattcc actgatacca ctaaagccct gttcctcagc tctgaggctg agactgtctc
     1681 ctgttagaaa tggctcttct taactaacat cccttaaaca aatatgaggt gcttctttct
     1741 gatgggacac tgggtcaggt gtcacaaaat tccctcagtg tggctgtgaa tgatggcact
     1801 gcttctaaca gtagcaacaa atttcaggtg aatgaccaga agtttacaga acccttattg
     1861 ttcctcagtc acttaaatga tctggttcca tgttaatgtt tctgttttct tgccatttgg
     1921 ataaagaatg agagtctttg agaaccttgc tttcacagag acttcattgt aaacattact
     1981 ttgcctaaaa ttagcatcct gatgctttct aaaatacata ttttatagac ttcatagcaa
     2041 aatttccaaa tctgtacaga aatttaaaaa attagactta aattggcgat tgtttttgta
     2101 aagaatttat gaactgtaca taaatctctt ctgacattta ataaaaattt attttagcca
     2161 aaaaaaaaaa aaaaaaaaaa aa
//
