LOCUS       NM_001163308            2347 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus polycomb group ring finger 2 (Pcgf2), transcript
            variant 3, mRNA.
ACCESSION   NM_001163308
VERSION     NM_001163308.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2347)
  AUTHORS   Hoffmann,J., Schutze,T.M., Kolodziejczyk,A., Kuster,K., Krankel,A.,
            Reinhardt,S., Derihaci,R.P., Birdir,C., Wimberger,P., Koseki,H. and
            Albert,M.
  TITLE     Canonical and non-canonical PRC1 differentially contribute to
            regulation of neural stem cell fate
  JOURNAL   Life Sci Alliance 8 (4), e202403006 (2025)
   PUBMED   39933923
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2347)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2347)
  AUTHORS   Gao,M., Zhang,T., Chen,T., Chen,Z., Zhu,Z., Wen,Y., Qin,S., Bao,Y.,
            Zhao,T., Li,H., Liu,L., Hao,M., Wang,J., Wang,F., Wang,H., Zhou,B.,
            Zhang,H., Xia,G. and Wang,C.
  TITLE     Polycomb repressive complex 1 modulates granulosa cell
            proliferation in early folliculogenesis to support female
            reproduction
  JOURNAL   Theranostics 14 (4), 1371-1389 (2024)
   PUBMED   38389850
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2347)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   5  (bases 1 to 2347)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2347)
  AUTHORS   Asano,H., Ishida,A., Hasegawa,M., Ono,T., Yoshida,M.C.,
            Taniguchi,M. and Kanno,M.
  TITLE     The mouse Mel-18 'RING-finger' gene: genomic organization, promoter
            analysis and chromosomal assignment
  JOURNAL   DNA Seq 3 (6), 369-377 (1993)
   PUBMED   8219280
REFERENCE   7  (bases 1 to 2347)
  AUTHORS   Reddy,B.A., Etkin,L.D. and Freemont,P.S.
  TITLE     A novel zinc finger coiled-coil domain in a family of nuclear
            proteins
  JOURNAL   Trends Biochem Sci 17 (9), 344-345 (1992)
   PUBMED   1412709
  REMARK    Review article
REFERENCE   8  (bases 1 to 2347)
  AUTHORS   Freemont,P.S., Hanson,I.M. and Trowsdale,J.
  TITLE     A novel cysteine-rich sequence motif
  JOURNAL   Cell 64 (3), 483-484 (1991)
   PUBMED   1991318
REFERENCE   9  (bases 1 to 2347)
  AUTHORS   Tagawa,M., Sakamoto,T., Shigemoto,K., Matsubara,H., Tamura,Y.,
            Ito,T., Nakamura,I., Okitsu,A., Imai,K. and Taniguchi,M.
  TITLE     Expression of novel DNA-binding protein with zinc finger structure
            in various tumor cells
  JOURNAL   J Biol Chem 265 (32), 20021-20026 (1990)
   PUBMED   2246278
REFERENCE   10 (bases 1 to 2347)
  AUTHORS   Croyle,M.L., Bhattacharya,A., Gordon,D.F. and Maurer,R.A.
  TITLE     Analysis of the organization and nucleotide sequence of the
            chromosomal gene for the beta-subunit of rat thyrotropin
  JOURNAL   DNA 5 (4), 299-304 (1986)
   PUBMED   3017658
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            D90085.1, AK142837.1 and BB406926.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142837.1, SRR10662774.2509760.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                D90085.1           87-174
            89-941              AK142837.1         2-854
            942-2343            AK142837.1         856-2257
            2344-2347           BB406926.1         169-172
FEATURES             Location/Qualifiers
     source          1..2347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.06 cM"
     gene            1..2347
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /note="polycomb group ring finger 2"
                     /db_xref="GeneID:22658"
                     /db_xref="MGI:MGI:99161"
     exon            1..113
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
     exon            114..266
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1183
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /note="ring finger protein 110; zfp-144; DNA-binding
                     protein Mel-18; melanoma nuclear protein 18; zinc finger
                     protein 144"
                     /codon_start=1
                     /product="polycomb group RING finger protein 2"
                     /protein_id="NP_001156780.1"
                     /db_xref="CCDS:CCDS25327.1"
                     /db_xref="GeneID:22658"
                     /db_xref="MGI:MGI:99161"
                     /translation="MHRTTRIKITELNPHLMCALCGGYFIDATTIVECLHSFCKTCIV
                     RYLETNKYCPMCDVQVHKTRPLLSIRSDKTLQDIVYKLVPGLFKDEMKRRRDFYAAYP
                     LTEVPNGSNEDRGEVLEQEKGALGDDEIVSLSIEFYEGVRDREEKKNLTENGDGDKEK
                     TGVRFLRCPAAMTVMHLAKFLRNKMDVPSKYKVEILYEDEPLKEYYTLMDIAYIYPWR
                     RNGPLPLKYRVQPACKRLTLPTVPTPSEGTNTSGASECESVSDKAPSPATLPATSSSL
                     PSPATPSHGSPSSHGPPATHPTSPTPPSTAAGTTTATNGGTSNCLQTPSSTSRGRKMT
                     VNGAPCPP"
     exon            267..363
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
     exon            364..419
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
     exon            420..470
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
     exon            471..579
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
     exon            580..634
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
     exon            635..730
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
     exon            731..811
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
     exon            812..2347
                     /gene="Pcgf2"
                     /gene_synonym="mel-18; Mel18; Rnf110; Zfp144"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtttctcccc tcccgccgac cgagcgagcg acagggctgt ggtccccctc ccctcccttc
       61 cctccctccc tcccatcccc ccctccccga gacccaccgg accccgaagc cagggtgaca
      121 cttcccaaat ctcctcagtc ctgaccccgg catcatgcat cggaccacac ggattaaaat
      181 cacggagctg aaccctcacc tcatgtgtgc cctctgtggg ggctatttta ttgatgccac
      241 caccattgtg gaatgcttac attccttctg caaaacctgc atcgtacgct acttggagac
      301 caacaaatac tgccccatgt gtgacgtcca ggtccataaa actcgaccac tgctgagcat
      361 cagatcagac aaaaccctcc aggacattgt ctacaagttg gtgcctgggc tttttaaaga
      421 tgaaatgaaa cggcgacggg acttctatgc agcatacccc ctgacagagg tccccaacgg
      481 ctccaacgag gaccgaggcg aggtcctgga acaggagaag ggggctctgg gtgacgacga
      541 gattgtcagt ctttccattg agttctacga aggcgtcagg gaccgagagg agaagaagaa
      601 cctcacggag aatggagatg gggacaagga gaagacagga gtgcgattcc tgcggtgccc
      661 agcagccatg accgtcatgc acctggcaaa gttcctccgc aacaaaatgg atgtgcccag
      721 caagtacaag gtggagatcc tctatgaaga tgagcccctg aaggaatact acaccttaat
      781 ggacattgcg tacatctacc cctggcgaag gaatgggcct ctccccctca agtaccgtgt
      841 ccagccagcc tgcaagcggc tcaccctgcc cacggtgcca accccctcag aaggcaccaa
      901 caccagcggg gcatcagagt gtgagtcagt cagcgacaag gctcccagcc ctgccaccct
      961 tccggccacc tcctcctcct tgcccagccc tgcgacccca tcccatggct ctcccagctc
     1021 ccacggcccc ccagctaccc atcctacttc ccccactcca ccttcaactg ccgctgggac
     1081 caccacagct accaatgggg gcacttcgaa ctgcctgcaa acgccatcct ccaccagcag
     1141 ggggcgcaag atgactgtta atggcgctcc ttgcccccct tgaggaaagg gaccctctcc
     1201 ttccgcagcc atcttttccc tcctttttac tttttctggg cccccttttc cacttttgac
     1261 tttccctggt tcctcccatt ttcagagtgg gaggtgggtt ttataaataa atctatatat
     1321 atataaatat atatatgtac ataggaaaaa ccaaatatac atacttattt tctatggacc
     1381 aaccagatta atttaaatgc cacaggaaac tcgtgtgtgt gtgtgtgtgt gtgtgtatgt
     1441 gtgtgtatgg gtgggggtgt ctaggtctag ggggtctttg tagttcactc tgctcttctt
     1501 ggggggtgta tctggtggtc ttaaggggcc attggaagta ttaatgtcct tccctatgtc
     1561 ccttctgctt tccagggcag agggcgtgtt gggtccccta gccctagctg actagtgggt
     1621 ccatcttggc tgttccccat acctgtccaa acccccaccc ccaccccccc gttgttgaat
     1681 gttcagagtt gctgagacag tcagtgcctt tcacaaatgc agtctgtgtc ctctggcagt
     1741 gaggaccaag tggctgtgaa gaaggcattt ccctcacctc ctcagacagt ggaagccccc
     1801 cccccaaccc tccatcccta ccctcctgtg ggagacctgg ccctataaag tctatatgtg
     1861 actttggcat ggtgaacact tcattttctc ctgtcctacc ccaacccaag aacgcaatct
     1921 agcaagactg gaggtgacac tcactggggg cctagagtag agggtggccc cagacaagca
     1981 cagactccag ttctgccaaa agccaacagc cctccagtcc actgcctcac cccccagctg
     2041 aggccaggca gggataggac agaggcatct agaagcacaa gaaaataaaa gaatgagctg
     2101 accccaactc tacctggtgg accacctatt aggggcagac cttgctctcg cctgctcttc
     2161 ctcaagtgta catagatttg gggggagggt gggggggaaa gaggacaggg tgttggctta
     2221 gtgtgtgagg ttctgagccc atgggtctgt ttgcaccacg tcctgagtct gaggtcctgt
     2281 gactgtaccc tcctgtccta ggtcatttat atctcttggc tttgtaataa atgctgtgta
     2341 cactctc
//
