LOCUS       NM_197992                918 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus polycomb group ring finger 1 (Pcgf1), transcript
            variant 1, mRNA.
ACCESSION   NM_197992
VERSION     NM_197992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 918)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 918)
  AUTHORS   Putra,B.P., Ito,K., Cirillo,C., Sunardi,M., Koseki,H., Uesaka,T.
            and Enomoto,H.
  TITLE     Pcgf1 gene disruption reveals primary involvement of epigenetic
            mechanism in neuronal subtype specification in the enteric nervous
            system
  JOURNAL   Dev Growth Differ 65 (8), 461-469 (2023)
   PUBMED   37452641
  REMARK    GeneRIF: Pcgf1 gene disruption reveals primary involvement of
            epigenetic mechanism in neuronal subtype specification in the
            enteric nervous system.
REFERENCE   3  (bases 1 to 918)
  AUTHORS   Cho,K.W., Andrade,M., Bae,S., Kim,S., Eyun Kim,J., Jang,E.Y.,
            Lee,S., Husain,A., Sutliff,R.L., Calvert,J.W., Park,C. and
            Yoon,Y.S.
  TITLE     Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation
            Through Modulation of the TARDBP/RBM38 Axis
  JOURNAL   Circulation 147 (24), 1823-1842 (2023)
   PUBMED   37158107
REFERENCE   4  (bases 1 to 918)
  AUTHORS   Nakajima-Takagi,Y., Oshima,M., Takano,J., Koide,S., Itokawa,N.,
            Uemura,S., Yamashita,M., Andoh,S., Aoyama,K., Isshiki,Y.,
            Shinoda,D., Saraya,A., Arai,F., Yamaguchi,K., Furukawa,Y.,
            Koseki,H., Ikawa,T. and Iwama,A.
  TITLE     Polycomb repressive complex 1.1 coordinates homeostatic and
            emergency myelopoiesis
  JOURNAL   Elife 12, e83004 (2023)
   PUBMED   37266576
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 918)
  AUTHORS   Takano,J., Ito,S., Dong,Y., Sharif,J., Nakajima-Takagi,Y.,
            Umeyama,T., Han,Y.W., Isono,K., Kondo,T., Iizuka,Y., Miyai,T.,
            Koseki,Y., Ikegaya,M., Sakihara,M., Nakayama,M., Ohara,O.,
            Hasegawa,Y., Hashimoto,K., Arner,E., Klose,R.J., Iwama,A.,
            Koseki,H. and Ikawa,T.
  TITLE     PCGF1-PRC1 links chromatin repression with DNA replication during
            hematopoietic cell lineage commitment
  JOURNAL   Nat Commun 13 (1), 7159 (2022)
   PUBMED   36443290
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 918)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 918)
  AUTHORS   Ross,K., Sedello,A.K., Todd,G.P., Paszkowski-Rogacz,M., Bird,A.W.,
            Ding,L., Grinenko,T., Behrens,K., Hubner,N., Mann,M., Waskow,C.,
            Stocking,C. and Buchholz,F.
  TITLE     Polycomb group ring finger 1 cooperates with Runx1 in regulating
            differentiation and self-renewal of hematopoietic cells
  JOURNAL   Blood 119 (18), 4152-4161 (2012)
   PUBMED   22411870
  REMARK    GeneRIF: Pcgf1 is an epigenetic regulator of hematopoietic cell
            differentiation. Simultaneous depletion of Runx1 and Pcgf1 allows
            sustained self-renewal while blocking differentiation of lineage
            marker-negative cells in vitro.
REFERENCE   8  (bases 1 to 918)
  AUTHORS   Tavares,L., Dimitrova,E., Oxley,D., Webster,J., Poot,R.,
            Demmers,J., Bezstarosti,K., Taylor,S., Ura,H., Koide,H., Wutz,A.,
            Vidal,M., Elderkin,S. and Brockdorff,N.
  TITLE     RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target
            sites independently of PRC2 and H3K27me3
  JOURNAL   Cell 148 (4), 664-678 (2012)
   PUBMED   22325148
  REMARK    Erratum:[Cell. 2012 Jun 22;149(7):1647-8]
REFERENCE   9  (bases 1 to 918)
  AUTHORS   Taher,L., Collette,N.M., Murugesh,D., Maxwell,E., Ovcharenko,I. and
            Loots,G.G.
  TITLE     Global gene expression analysis of murine limb development
  JOURNAL   PLoS One 6 (12), e28358 (2011)
   PUBMED   22174793
REFERENCE   10 (bases 1 to 918)
  AUTHORS   Nunes,M., Blanc,I., Maes,J., Fellous,M., Robert,B. and
            McElreavey,K.
  TITLE     NSPc1, a novel mammalian Polycomb gene, is expressed in neural
            crest-derived structures of the peripheral nervous system
  JOURNAL   Mech Dev 102 (1-2), 219-222 (2001)
   PUBMED   11287196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104324.21.
            
            On Mar 31, 2022 this sequence version replaced NM_197992.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028560.1, DV064595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AC104324.21        114887-115019
            134-239             AC104324.21        115436-115541
            240-392             AC104324.21        115657-115809
            393-464             AC104324.21        115975-116046
            465-570             AC104324.21        116181-116286
            571-604             AC104324.21        116463-116496
            605-691             AC104324.21        116595-116681
            692-772             AC104324.21        117091-117171
            773-918             AC104324.21        117251-117396
FEATURES             Location/Qualifiers
     source          1..918
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..918
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /note="polycomb group ring finger 1"
                     /db_xref="GeneID:69837"
                     /db_xref="MGI:MGI:1917087"
     exon            1..133
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..820
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nervous system polycomb 1; polycomb group RING finger
                     protein 1; RING finger protein 68; nervous system
                     Polycomb-1"
                     /codon_start=1
                     /product="polycomb group RING finger protein 1 isoform 1"
                     /protein_id="NP_932109.2"
                     /db_xref="CCDS:CCDS20270.1"
                     /db_xref="GeneID:69837"
                     /db_xref="MGI:MGI:1917087"
                     /translation="MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEH
                     IVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDR
                     VMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVSQPSGEEPALSNLGLPFSSFDHSKA
                     HYYRYDEQLSLCLERLSSGKDKNKNVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHV
                     QLLFDNEVLPDHMTMKQLWLSRWFGKPSPLLLQYSVKEKRR"
     exon            134..239
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..392
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /inference="alignment:Splign:2.1.0"
     exon            393..464
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /inference="alignment:Splign:2.1.0"
     exon            465..570
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /inference="alignment:Splign:2.1.0"
     exon            571..604
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..691
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /inference="alignment:Splign:2.1.0"
     exon            692..772
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..918
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      898..903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /note="hexamer: AATAAA"
     polyA_site      918
                     /gene="Pcgf1"
                     /gene_synonym="2010002K04Rik; Nspc1"
                     /note="major polyA site"
ORIGIN      
        1 aggcggtacc ggaagtggcg ggctgggatc agcctttaag atggcgtctc ctcagggggg
       61 ccagattgcg atcgcgatga ggcttcggaa ccagctccag tcagtgtaca agatggaccc
      121 actacggaac gaggaggagg tccgggtgaa gatcaaagac ctgaatgaac acatcgtttg
      181 ctgcctgtgc gcgggctact tcgtggatgc caccaccatc acagagtgtc tccacacctt
      241 ctgcaaaagt tgtatcgtga agtacctgca aaccagcaag tactgcccca tgtgcaacat
      301 caagatccac gagacgcagc cgttgctcaa tctcaaactg gatcgggtca tgcaggacat
      361 agtgtataag ctagtgccag gcttgcaaga cagtgaagag aaacggattc gggaattcta
      421 tcagtcccga ggcttagaca gagtctccca gcccagtggt gaagagccag ccctgagcaa
      481 ccttggcctc cccttcagca gttttgacca ctctaaagcc cactattatc gatatgatga
      541 acagctgagc ctatgcctgg agcggctgag ttctggcaaa gacaagaata aaaatgtcct
      601 tcagaacaag tatgttcggt gttctgtgag agctgaggtc cgccatctcc gaagggttct
      661 gtgtcaccga ctaatgctaa atccacagca tgtacagctc ctttttgaca atgaggttct
      721 cccagatcac atgacaatga aacagctatg gctgtcccgc tggttcggca agccatctcc
      781 tttgcttctc caatacagtg tgaaagagaa gaggaggtag gggccaggct tgcttccacc
      841 cccttcccac ccctccccag atatttatgt gaaattaact gtggctttat tttttgaaat
      901 aaatgctttt aaaaagca
//
