LOCUS       NM_178762               3496 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus PC-esterase domain containing 1A (Pced1a), transcript
            variant 1, mRNA.
ACCESSION   NM_178762
VERSION     NM_178762.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3496)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3496)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3496)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX890605.4.
            
            On Jan 5, 2022 this sequence version replaced NM_178762.4.
            
            Transcript Variant: This variant (1) encodes the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032354.1, AK032762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-867               BX890605.4         117293-118159       c
            868-947             BX890605.4         116694-116773       c
            948-1186            BX890605.4         116347-116585       c
            1187-1337           BX890605.4         116106-116256       c
            1338-1584           BX890605.4         115771-116017       c
            1585-1845           BX890605.4         113511-113771       c
            1846-3496           BX890605.4         111564-113214       c
FEATURES             Location/Qualifiers
     source          1..3496
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.22 cM"
     gene            1..3496
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /note="PC-esterase domain containing 1A"
                     /db_xref="GeneID:319513"
                     /db_xref="MGI:MGI:2442177"
     exon            1..867
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /inference="alignment:Splign:2.1.0"
     CDS             744..2093
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /note="protein FAM113A; family with sequence similarity
                     113, member A"
                     /codon_start=1
                     /product="PC-esterase domain-containing protein 1A"
                     /protein_id="NP_848877.2"
                     /db_xref="CCDS:CCDS50711.1"
                     /db_xref="GeneID:319513"
                     /db_xref="MGI:MGI:2442177"
                     /translation="MVFCLENEMPHRLLGSAMVHFHASEVQQLLHNKFVVILGDSIQR
                     AVYKDLVLLLQKDTLLTASQLKAKGELSFEQDQLVAGGQLGELHNGTQYREVRQFCSG
                     SGHHLVRFYFLTRVYSEYLEDILEELSYGPAPDLVIINSCLWDLSRYGRCSMESYREN
                     LERVFVRMDQVLPDSCLLVWNLAMPLGERVTGGFLLPELQPLAVSLRQDVVEGNFYSA
                     TLAGKHCFDVLDLHFHFRHAVRHRHRDGVHWDQHAHRHLSHLLLAHVADAWGVELPKH
                     DRLPDPWIEDWSEMDHSFQGSHKQPPDFREKLALPLLPPFHLPPPMSFPYPLEPSPPP
                     LFPPLPQDTPFFQGQPFPPYEFKYNAMEDFSMPGCGPGMNFVPGPLPPSVSGPVSHGQ
                     HRGPVVHRGKPRCVLNNPYHVPRIGGPCRHRLRHSDRLIHTYKQDRRGHAHSGTWPG"
     exon            868..947
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1186
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1337
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1584
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1845
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..3496
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2193..2198
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /note="hexamer: AATAAA"
     polyA_site      2218
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /note="major polyA site"
     regulatory      2936..2941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /note="hexamer: ATTAAA"
     regulatory      2953..2958
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /note="hexamer: ATTAAA"
     polyA_site      2959
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /note="major polyA site"
     polyA_site      2983
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
     regulatory      3470..3475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
                     /note="hexamer: AATAAA"
     polyA_site      3496
                     /gene="Pced1a"
                     /gene_synonym="A930025D01Rik; Fam113a"
ORIGIN      
        1 agaactgtgg gcaagctacg ctgagctatc gtcctgccct cggcgcggcg gcccgagtgg
       61 acctagccct ggtttctgtc ctccacagcg gccaacctcg ctgcctttct gactcctccg
      121 gcgttgggga tcgcataggg cgggacacgg gtgaccgaaa gtgggagcca tgagcatctg
      181 aggcacagat gctggaggcg ttggctggac caccgtagcg cacgcatggc gagcgctggg
      241 cgtcgagctg cgtacctaca gctaacctgg gcacccgggc tctgtggggc gggatctttg
      301 cagaacccac cgctctccag gggcatggga tcattgactc tagatcagga catcgctgcc
      361 gagacgctgt cgcacggcac ctgggcctgc cctactggcc cgtgaatccc tggagccccc
      421 gagagacttg gtaactggcg cgagcggacg aatgcgcacg cgcggggccg ccgttgacac
      481 gtggcagggc aaaggcgtct ctgcgcgcgc gaagcgctgt agtctaagac tacggcccaa
      541 gtgacccttc ttccctccga gtgtgataaa ggctgctgcc gtgttgggat tcgccttgcc
      601 gctcccactt tcctccccat tacacagagc agccagggag gggccagcgc gcatgggtca
      661 tcttggaaca gaccggacct acctagagtc cctgccctct gtcagcttat tggcctctcc
      721 ctgcagctgg tgtcagtggc agcatggtct tctgtttgga aaacgagatg ccacaccgcc
      781 tgctgggaag cgccatggtc cacttccatg cctcagaagt ccagcagctg ctacacaaca
      841 agttcgtggt cattttgggg gactccatcc aaagagctgt gtataaggac ctggtgcttc
      901 tgctccagaa agacacactg ctcacagctt cccagttaaa agccaagggg gagctgagct
      961 ttgaacagga ccagctggtg gctgggggcc agctgggaga gctgcacaac gggacacagt
     1021 accgcgaggt ccgccagttc tgctctggct ctggccacca ccttgtgcgc ttctacttcc
     1081 tcacccgagt ttactccgag taccttgagg acatcctgga ggagctgtca tatggacctg
     1141 cccctgacct agtgatcatc aactcctgcc tctgggatct ctccagatat ggccgctgct
     1201 caatggagag ctacagggag aacctggaac gagtctttgt acgaatggac caggttttac
     1261 cagactcttg tctgctggtg tggaacttgg caatgcctct gggggaacgt gtcactgggg
     1321 gtttcctcct gccagagctc cagcccctgg cagtgtctct gcgacaggat gtggttgagg
     1381 ggaacttcta cagcgctaca ctagccggga aacactgttt cgacgtccta gatctccact
     1441 tccatttccg gcatgctgtc cgtcaccgtc atcgagatgg tgtccattgg gaccagcatg
     1501 cacaccgcca cctctcgcac ttacttctgg cccacgtggc cgatgcctgg ggtgtggagc
     1561 tgcccaaaca tgaccggctg ccagacccat ggattgagga ctggtcagag atggatcatt
     1621 cattccaggg aagccataag cagcccccag acttcaggga gaagctggcc ttgcccctgc
     1681 tcccaccttt ccacttgcct cctcccatgt cttttcctta cccacttgag ccctcaccac
     1741 ctcccttgtt cccacccctg ccccaggata cccccttttt ccaaggccag ccctttccac
     1801 cctatgaatt caaatacaat gcaatggagg acttctcaat gccaggatgt ggccctggaa
     1861 tgaactttgt gcctggcccc ctgccaccat cagtctctgg ccctgtctcc cacggtcaac
     1921 accggggccc agtggtccac cggggcaagc cacgttgtgt tctgaacaac ccctaccatg
     1981 taccaagaat tgggggtcca tgcaggcatc gactcagaca ctcagacaga ctgatccaca
     2041 catacaaaca ggacaggcgg ggacatgccc attcgggaac atggcctgga taggcaggat
     2101 cttaggttgg agctagagat accagtggcc ctggagaggc tgtctggtag cctagctgtt
     2161 gggccggggt gttcttgtcc attgctgata tcaataaaag catggaagga cagagtgaca
     2221 ttcctgtgtc ggggagcagg tctcccaaac catgacctta aggcatgggg aagctgccct
     2281 tggcctctgt gcaaactatt tagaaatctg tgaagaattt ctagcacagg ttcatcttca
     2341 caagaacaca tacacactaa ataaagatcc ccagagggtc ccttgttatc aacagttctt
     2401 tgggactttg tcattagcag gcattcagta agttgttaga acctaagtga gaagcttcca
     2461 agtgctgggg aaagtccagc taggatccca ttggttcctt ggcttgatgt gcaaacagag
     2521 catacgctgg atgctggatg gggtgaggga cgggatgctt gcctcagctt agaaataggg
     2581 gaggaggggc tggagtatga cagggacaat ggacagagag tagggtctta gggacccatt
     2641 acatttgaat tagaatggag ggaacagaat tcttgggttc atttttgttc ctactaatga
     2701 aacctttcaa aaggaccaca tcccactgaa aagaaaacaa aaactgatca gatcagatcg
     2761 atggattttg gttaataacc tggcaaatta gtgaagggca tggttaacag gcgggtgcta
     2821 aggaagtggt gacagacaat gtgagttaat aaaacctttg ggggagacaa gagacttgca
     2881 gaggcactgg cacagtacct aagacaaatg tatgaattcc tttcttctga acaagattaa
     2941 agggggacag aaattaaaag cttttttggt ttgtttttac agagctaaga attttgataa
     3001 ttttccttgc agaaatggaa tttttttttc ttttcatcat caaaaaactc actgttagag
     3061 cagtcttctc cagctgcagt ttgtccaggc cttgtcactt tctgcatttc cttccagaga
     3121 cttttgtgtc attggttttc cagtgttgga gaaaactgca catatattga tttccaggaa
     3181 aaacttgagt tttttagcct catgggccag cgctgttggt ttcttggcct tttctacttg
     3241 tttcttgaat tctgcccttg aaaattctat aactcacact ctataagcaa cctggagatg
     3301 ggtatactta attaatactg tttacacact tcctctgtgt tcttaattcc taccccattt
     3361 tactttgact tcccatgccc caaccctttt taaaaatatt ttctaatagt cccttaaagt
     3421 tttttggaat aagatagaaa ctcctacact taaaatctgt cctaaaaaga ataaagagat
     3481 tttattttgg ctgtca
//
