LOCUS       NM_033583               4708 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily C, 5 (Pcdhgc5), mRNA.
ACCESSION   NM_033583
VERSION     NM_033583.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4708)
  AUTHORS   Osipovich AB, Dudek KD, Greenfest-Allen E, Cartailler JP, Manduchi
            E, Potter Case L, Choi E, Chapman AG, Clayton HW, Gu G, Stoeckert
            CJ Jr and Magnuson MA.
  TITLE     A developmental lineage-based gene co-expression network for mouse
            pancreatic beta-cells reveals a role for Zfp800 in pancreas
            development
  JOURNAL   Development 148 (6) (2021)
   PUBMED   33653874
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4708)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4708)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 4708)
  AUTHORS   Onouchi T, Kishino-Kaneko Y, Kameshita I, Ishida A and Sueyoshi N.
  TITLE     Regulation of Ca(2+)/calmodulin-dependent protein kinase
            phosphatase (CaMKP/PPM1F) by protocadherin-gammaC5 (Pcdh-gammaC5)
  JOURNAL   Arch Biochem Biophys 585, 109-120 (2015)
   PUBMED   26386307
  REMARK    GeneRIF: C-terminal cytoplasmic fragment of PcdhgC5 acts as a
            scaffold for CaMKP and CaMKI to regulate CaMKP activity.
REFERENCE   5  (bases 1 to 4708)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   6  (bases 1 to 4708)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   7  (bases 1 to 4708)
  AUTHORS   Wang X, Su H and Bradley A.
  TITLE     Molecular mechanisms governing Pcdh-gamma gene expression: evidence
            for a multiple promoter and cis-alternative splicing model
  JOURNAL   Genes Dev 16 (15), 1890-1905 (2002)
   PUBMED   12154121
REFERENCE   8  (bases 1 to 4708)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4708)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4708)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129315.3.
            
            On Nov 17, 2006 this sequence version replaced NM_033583.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF464163.1, SRR1660821.199763.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2589              AC129315.3         19860-22448
            2590-2648           AC129315.3         25335-25393
            2649-2737           AC129315.3         33579-33667
            2738-4708           AC129315.3         40217-42187
FEATURES             Location/Qualifiers
     source          1..4708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.69 cM"
     gene            1..4708
                     /gene="Pcdhgc5"
                     /note="protocadherin gamma subfamily C, 5"
                     /db_xref="GeneID:93708"
                     /db_xref="MGI:MGI:1935205"
     exon            1..2589
                     /gene="Pcdhgc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..2964
                     /gene="Pcdhgc5"
                     /codon_start=1
                     /product="protocadherin gamma-C5 precursor"
                     /protein_id="NP_291061.1"
                     /db_xref="CCDS:CCDS29194.1"
                     /db_xref="GeneID:93708"
                     /db_xref="MGI:MGI:1935205"
                     /translation="MRPMASPQVAGKWQVLCMLSLCCCGWVSGQLRYSVVEESEPGTL
                     VGNVAQDLGLKGTDLLSRRLRLGSEENGRYFSLSLVSGALAVSQKIDRESLCGASTSC
                     LLPVQVVTEHPLELTRVEVEILDLNDNSPSFATPDREMRISESAAPGARFPLDSAQDP
                     DVGTNTVSFYTLSPNSHFSLHVKTLKDGKLFPELVLEQQLDRETQARHQLVLTAVDGG
                     TPARSGTSLISVIVLDVNDNAPTFQSSVLRVGLPENTPPGTLLLRLNATDPDEGTNGQ
                     LDYSFGDHTSETVKNLFGLDPSSGAIHVLGPVDFEESNFYEIHARARDQGQPAMEGHC
                     VIQVDVGDANDNPPEVLLASLVNPVLESTPVGTVVGLFNVRDRDSGRNGEVSLKTSPN
                     LPFQIKPSENHYSLLTSQPLDREATSHYTIELLASDAGSPPLHTHLTLRLNISDVNDN
                     APHFTQQLYTAYIPENRPPGSLLCTVAASDPDEGDNARLTYSIVGSQIQGAPASSFVY
                     VNPEDGRIFAQRTFDYELLQMLQIVVGVRDSGSPRLHANTSLHVFVLDQNDNAPAVLH
                     PRPGREFSAPQRLPRSAPPGSLVTKVTAVDADAGHNAWLSYSLLPQSTAPGLFLVSAH
                     TGEVRTARALLEDDSDTQQVVVLVRDNGDPSLSSTATVLLVLEDEDAEEMPKSSDFLT
                     HPPERSDLTLYLIVALAAVSLLSLVTFTFMSAKCLRRHEDGDRGGGHCCRGQDSPSRE
                     FYKQSSPNLQVSSDGTLKYMEVTLRPTDSQSHCYRTCFSPASDGSDFTFLRPLSVQQP
                     SALALEPEALRSRSSTLRERSQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFD
                     TEMLQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNA
                     TLTNAAGKRDGKAPAGGNGNKKKSGKKEKK"
     exon            2590..2648
                     /gene="Pcdhgc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2737
                     /gene="Pcdhgc5"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..4708
                     /gene="Pcdhgc5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acctcagagc agttttttaa agaggctgga aggagacata ggagacttca gcttctgcac
       61 tccaggctct gggtttttac cttggagaca ggacagcaca gttactctcc aagaagggac
      121 ttctgggtca tgaggcctat ggcatcacca caggtcgctg ggaaatggca agtgctgtgt
      181 atgttgtcct tgtgctgctg tggctgggtg tctgggcagc ttcggtattc agtggtggag
      241 gagtctgagc cggggacttt ggtggggaac gttgctcaag atctgggctt aaaggggaca
      301 gatctattga gccgcaggct gagattgggc tctgaggaga atgggcgcta tttttccctg
      361 agtttggtga gcggagcttt ggcagtgagt cagaaaattg accgagagag cctgtgcgga
      421 gccagcacta gctgcctgct gcctgtacag gtggtaactg aacacccact ggagctcacc
      481 cgggtagagg tagagatcct ggacctcaat gacaactctc ccagctttgc cactcctgat
      541 cgagagatgc gcatctcgga atcagctgca cctggagcca ggttcccact ggatagtgcc
      601 caagacccag atgtgggcac caatactgtg agcttttata ctctcagccc caacagccac
      661 ttctctctgc atgtgaagac cctaaaagat ggaaagctct tcccagagct agtgctagag
      721 caacagctag accgtgagac ccaggcaaga catcagctag tactcactgc cgtggatggg
      781 ggaaccccag cccgctcagg gaccagcctt atctcggtca ttgtgctgga cgtcaatgat
      841 aatgccccaa ccttccagtc ctcggttcta cgtgtgggac tcccagagaa cacacccccg
      901 ggtacactgc tgctccgtct caatgccact gatccagacg agggcaccaa tggccaacta
      961 gactactctt ttggagacca tacatctgaa acagtgaaga atctctttgg cctggatcct
     1021 agcagtggag caatccatgt gttgggtcca gtagattttg aggaatcaaa tttctatgaa
     1081 attcatgcaa gagctcgaga ccagggacag ccagccatgg agggccactg tgtaattcaa
     1141 gtagatgtag gggatgctaa cgacaacccc cctgaagtgc tgctggcatc tttggtcaac
     1201 cctgtgctag agagcacacc cgtaggcacg gttgtggggt tgtttaatgt gcgggaccga
     1261 gactcaggta gaaatggtga ggtgagcctg aagacatctc caaacctgcc atttcagatc
     1321 aagccttctg agaaccacta ctcactgctc accagccagc ctctggaccg agaggccaca
     1381 tcccattata ccatcgagct gctggccagt gatgctggat caccccccct acatacccat
     1441 ctcaccctca ggctgaacat ttcagacgtt aatgataacg caccccattt cacccaacag
     1501 ctctacactg cttatatccc agaaaaccgc ccaccaggct ctctcctctg tactgtggct
     1561 gcctctgatc cagacgaggg ggataatgcc cgcctcacct attctattgt ggggagtcaa
     1621 atccagggag ccccagcctc ctcctttgtg tatgtcaacc ccgaggatgg acgaatcttt
     1681 gcccagcgga cctttgacta tgagttactg cagatgctgc aaatcgtggt gggggtccgt
     1741 gattccggct ctccccgact gcatgctaac acatctctcc atgtgtttgt cctcgatcag
     1801 aatgataatg ccccagctgt gctgcaccca cgacctggca gggagttctc agcccctcag
     1861 cgtctccccc gatctgctcc tcctggttct ttggtcacca aggtgacagc cgtggatgct
     1921 gacgctggtc acaatgcatg gctctcttac tctctcttac cacagtccac agcccccgga
     1981 ctgttccttg tatctgcaca cactggtgag gtgcgcacag cccgggcctt attggaggat
     2041 gactctgata cccaacaggt ggtggtcctg gtgagggata atggtgaccc ttcactatcc
     2101 tccacagcaa cagtactgct ggttctggag gacgaggatg cagaggaaat gcccaaatcc
     2161 agtgacttcc tcacacaccc tcctgagcgg tcagacctca ccctttacct tattgtggca
     2221 ctagcagctg tcagtctctt atccttagtt accttcactt tcatgtcagc taagtgtctg
     2281 cggaggcatg aagatgggga ccggggtggg ggccactgct gcaggggcca ggactcaccc
     2341 tccagggagt tctataagca gtccagcccc aacctccagg tgagctcaga tggcacacta
     2401 aagtacatgg aggtgaccct gcggcccacg gactctcaga gccattgcta caggacctgc
     2461 ttttctccgg cctcggatgg cagtgacttc actttcctca ggcccctcag cgttcagcag
     2521 ccctcagcct tggcgctgga acccgaggcc ttgcgttccc gctctagtac gctgcgggag
     2581 cggagccagc aagccccgcc caacactgac tggcgtttct ctcaagccca gagacccggc
     2641 acgagcggat cccaaaatgg tgatgaaact ggcacctggc ccaacaacca gtttgataca
     2701 gagatgctgc aagccatgat cttggcctct gccagcgaag ctgctgatgg gagctctacc
     2761 ctgggagggg gcgctggcac catgggtctg agcgctcgat acggacccca gtttaccctg
     2821 cagcacgtgc ctgactaccg ccagaacgtg tacatccctg gcagcaatgc cacgctgacc
     2881 aatgccgctg gcaaacgaga tggcaaggct ccagcaggtg gtaatggcaa caagaagaaa
     2941 tcgggcaaga aagagaagaa gtaatatgga ggccaggcct tgaaccacaa ggcagcctcc
     3001 ctccccagcc agtccagctc gtccttactt gtacccaggc ctcagaattt cagggctcac
     3061 cccaggatac tggtaggagc cagggccatg ctccccgttg ggaaacagaa acacgtgccc
     3121 aagccaacac cccctctcta taccctaggg agttgaatat gcaaagagag ttctgctggg
     3181 acccccctat tcaatcagtg attgtaccca catgggtagc agggtttgtg tgtgtggaca
     3241 tacacacaca cacacacaca cacacacaca aaccatgcca cactccctta gttacagctg
     3301 aactcctcca tcttccaacc caggcaggct tatccatctc ctgccgccct ctccccaccc
     3361 cacccactcc ttcagtccct ctctttgagc aaggtagctg ggctgttggg gtgaccggtg
     3421 agctaagccg gctcctagtt ctgaacggta gggagagtat tacaatcttt tggcctctcc
     3481 ttcagttcag ctttccccca aagcatggtt tggtaccagt cttctctttt ccttccagag
     3541 cctgagacca atgcttaagt tttgggggaa caggcaccct ccctctggta ctgatgatgc
     3601 ttgctggatt ttgggaaggc attttgctac taagcctctt ttcaatgcct ggggacaact
     3661 agtcttttgt ttttcattgt ttgatgttcc cactgcatgc tgtgacttcc ctacacctca
     3721 aagaagagac tcctttgcat gtctggagac agtagggggt ggtaaactaa agggaagttg
     3781 agagtgtata ctgctgggag tggggcagtg gacaaaacag cctgttaata gggtcttgca
     3841 aggggctctg tatgtaccca ggggactggc tcaatcctca cattctagcc atagacaaac
     3901 accaggccag acccctccat tctggttcag cctgggcagc ttgggctgag ccaccaggac
     3961 caatggattt aagctgacat ttcagtccaa gacgacgact tctaagtgag tttaagacca
     4021 gagaggaaag aggggcctct gtgggtgctg ggtactccag aggtgccctt ggtgggagga
     4081 ccagtggtct tagcaggaag gggggcccag caaggtcatt cttggaccct gggtctagtc
     4141 cagtagctag aaaaagggac caagtggcca taaagtccca gccaatgatg gggcttttcc
     4201 agtgggcccc tgtagacctc aagcccctgg cctccacctt accaggtgcc atttcttctc
     4261 agaaggccac tgcccaggcc cccaggccgc ccccttgtgg ccagagaacg gttaaagccc
     4321 cccagtgcct ccttgtgcat agaacttcct ctgccctagc ccttacagta gtgtagaaga
     4381 tccccctccc ccgctggtgt agaatagcca atagtatagt gtggtgtgct tttacgtgat
     4441 ggcgagtggg cagcgggcgg tgggctgtac acagccgtct gtcctttgaa tctcaatctg
     4501 cctgcgcggc ccgtgctgtg ttttgtgctg tgtccacacg ctgcggcgac ccctccctgt
     4561 actgacttct ctataaaaag cttctcttcg catagtcacg tagctcctgc ccatccccct
     4621 tccgatatct ctcgcaagtt ttatactcta atatttatat ggcttttttc ttcgaaaatt
     4681 aaaaataaaa aaatggtttc ttctgaaa
//
