LOCUS       NM_033582               5047 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus protocadherin gamma subfamily C, 4 (Pcdhgc4), mRNA.
ACCESSION   NM_033582
VERSION     NM_033582.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5047)
  AUTHORS   Leon,W.R.M., Steffen,D.M., Dale-Huang,F.R., Rakela,B.,
            Breevoort,A., Romero-Rodriguez,R., Hasenstaub,A.R., Stryker,M.P.,
            Weiner,J.A. and Alvarez-Buylla,A.
  TITLE     The clustered gamma protocadherin PcdhgammaC4 isoform regulates
            cortical interneuron programmed cell death in the mouse cortex
  JOURNAL   Proc Natl Acad Sci U S A 121 (6), e2313596120 (2024)
   PUBMED   38285948
  REMARK    GeneRIF: The clustered gamma protocadherin PcdhgammaC4 isoform
            regulates cortical interneuron programmed cell death in the mouse
            cortex.
REFERENCE   2  (bases 1 to 5047)
  AUTHORS   Xu,L., Zheng,Y., Li,X., Wang,A., Huo,D., Li,Q., Wang,S., Luo,Z.,
            Liu,Y., Xu,F., Wu,X., Wu,M. and Zhou,Y.
  TITLE     Abnormal neocortex arealization and Sotos-like syndrome-associated
            behavior in Setd2 mutant mice
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523829
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5047)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5047)
  AUTHORS   Garrett,A.M., Bosch,P.J., Steffen,D.M., Fuller,L.C., Marcucci,C.G.,
            Koch,A.A., Bais,P., Weiner,J.A. and Burgess,R.W.
  TITLE     CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a
            crucial isoform-specific role for Pcdhgc4
  JOURNAL   PLoS Genet 15 (12), e1008554 (2019)
   PUBMED   31877124
  REMARK    GeneRIF: Results show that some gamma-Pcdh functions do not require
            molecular diversity, and confirm that at least some gamma-Pcdh
            isoforms have unique roles. These data suggest that the regulation
            of neuronal survival may require novel mechanisms of cPcdh
            interaction and/ or signaling involving gammaC4.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5047)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   6  (bases 1 to 5047)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 5047)
  AUTHORS   Wang,X., Weiner,J.A., Levi,S., Craig,A.M., Bradley,A. and
            Sanes,J.R.
  TITLE     Gamma protocadherins are required for survival of spinal
            interneurons
  JOURNAL   Neuron 36 (5), 843-854 (2002)
   PUBMED   12467588
REFERENCE   8  (bases 1 to 5047)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 5047)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 5047)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC064808.1.
            
            On Jan 11, 2004 this sequence version replaced NM_033582.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064808.1, SRR1660821.4840.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.68 cM"
     gene            1..5047
                     /gene="Pcdhgc4"
                     /note="protocadherin gamma subfamily C, 4"
                     /db_xref="GeneID:93707"
                     /db_xref="MGI:MGI:1935203"
     exon            1..2905
                     /gene="Pcdhgc4"
                     /inference="alignment:Splign:2.1.0"
     CDS             455..3280
                     /gene="Pcdhgc4"
                     /codon_start=1
                     /product="protocadherin gamma-C4 precursor"
                     /protein_id="NP_291060.1"
                     /db_xref="CCDS:CCDS29193.1"
                     /db_xref="GeneID:93707"
                     /db_xref="MGI:MGI:1935203"
                     /translation="MAAMPSTVRSWVEIWWGATLLFLFCHLGYVYGQIRYPVPEESQE
                     GTFVGNVAQDFLLDTESLSARRLQVAGEVNQRHFRVDLDSGALLIKNPIDREALCGLS
                     ASCIVPLEFVTEGPLEMYRAEVEIVDVNDHAPRFPRQQLDLEIGEAAPPGQRFPLEKA
                     QDADVGSNSISSYRLSSNEHFALDVKKRSDGSLVPELLLEKPLDREKQSDYRLVLTAV
                     DGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNASDPDLGP
                     SGNVTFSFSGHTPDRVRNLFSLHPTTGKLTLQGPLDFESENYYEFDVRARDGGSPAME
                     QHCSLRVDLLDVNDNAPHITVTSELGTLPESAEPGTVVALISVQDPDSGSNGDVSLRI
                     PDHLPFALKSAFRNQFSLVTAGPLDREARSSYDIMVTASDAGNPPLSTHRTIFLNISD
                     VNDNPPSFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLEPRNRDVSAS
                     SFISLNPQTGAVHATRSFDYEQTQTLQFEVQARDRGSPPLSSTVTVRLFVLDLNDNAP
                     AVLRPRARPGSLCPQALPPSVGAGHLVTKVTAVDLDSGYNAWVSYQLLEAPDPSLFAV
                     SRYAGEVRTAVPIPADLPPQKLVIVVKDSGSPPLSTSVTLLVSLEEDTHPVVPDLRES
                     SAPREGESRLTLYLAVSLVAICFVSFGSFVALLSKCLRGAACGVTCFPAGTCACLTRS
                     RRREGLPPSNGILRIQLGSEDPIKFVDVGGHSHGCTPLASAPTRSDSFMMVKSPSAPM
                     AGEPVRPSCPPSDLLYGLEQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEM
                     LQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLT
                     NAAGKRDGKAPAGGNGNKKKSGKKEKK"
     exon            2906..2964
                     /gene="Pcdhgc4"
                     /inference="alignment:Splign:2.1.0"
     exon            2965..3053
                     /gene="Pcdhgc4"
                     /inference="alignment:Splign:2.1.0"
     exon            3054..5024
                     /gene="Pcdhgc4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5000..5005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhgc4"
                     /note="hexamer: AATAAA"
     polyA_site      5024
                     /gene="Pcdhgc4"
                     /note="major polyA site"
ORIGIN      
        1 cgcgaaaagg ggcggggtga attgatgtgt tagaggggga atacatatat gatttctgcc
       61 tctccacgat gataacgagc cccggacaca aatgcgaact gaacagaagg aaggtcgaaa
      121 gaaacgttgg tatttattat gttggggggt ttgtttggcg ggggctgcat gtgtgtgttt
      181 cctcccaatg ctacgacgca ttaaccctgc tgctattggg acattctctt ctcagcctat
      241 tggctgagcc caggagttgc tgcctgccaa tcgggtaatg aaaggcagac aaatctaccc
      301 cgccaccagc aaaaaacggc gcgtaaccct tgcagcgccg gcggagccgc gccagacctg
      361 gcgcggggaa gggagatagg tgtctccagc tgctgtggct gttaggggcg ggtcagcttc
      421 tttggcgtct ccggaccaag tagagaatta gcggatggca gcaatgccca gcacggtgag
      481 aagctgggta gaaatttggt ggggggctac ccttttgttc ctcttttgcc acctgggcta
      541 cgtttatggg cagattcgct acccggtccc agaggagtca caggaaggga cttttgtagg
      601 gaatgtcgcc caagattttt tgctggatac agagagtcta tccgctcgca ggctgcaggt
      661 cgctggagag gtgaaccaaa gacacttccg tgtggatttg gacagcggag ccctgctcat
      721 caaaaatcca atcgatcgag aggcactgtg tgggctcagt gccagctgca tcgtgcccct
      781 ggagtttgta accgaagggc ctttggaaat gtaccgagcg gaggttgaga tcgtagatgt
      841 gaatgatcac gccccccgat ttccgcggca gcagttggac ttggaaatcg gggaagcagc
      901 tccgccagga cagcgtttcc ccttggaaaa ggctcaggat gcagatgttg ggagcaattc
      961 cattagcagc tacagactaa gctccaatga gcactttgcc ctggatgtca agaagcgcag
     1021 cgacggcagc ctggtcccag agcttcttct ggagaagccc ttggatcgtg agaagcaatc
     1081 cgactaccgc ctggtgctga ctgctgtaga tggagggaac ccccctagat ctggaaccgc
     1141 agagctccgg gtgtcagtgc tggatgtgaa tgacaacgcc ccagccttcc agcaatccag
     1201 ttacaggatc agcgtgttgg agagcgcgcc agcgggcatg gtgctcatcc agctcaatgc
     1261 ctctgaccca gacctgggac ctagtggtaa cgtcaccttt tcttttagtg gtcacacccc
     1321 tgaccgtgtg agaaacctct ttagccttca tcccactact ggaaagctta cccttcaggg
     1381 gcctctagac tttgagagtg agaattatta cgaatttgat gtaagggctc gtgatggggg
     1441 ttctccagct atggagcaac actgcagcct tagggtggat cttctagatg tgaacgacaa
     1501 cgccccccat atcacagtga cctctgagct tggaactcta ccagagagtg cagaacctgg
     1561 cactgtggta gcactaatca gtgtgcagga ccctgactcg gggtcaaatg gggatgtgag
     1621 cctacggatt cccgaccact taccatttgc cctcaagtct gccttcagga accagttctc
     1681 cctcgtgaca gcaggaccct tggaccgaga ggccagatcc agttacgaca tcatggttac
     1741 cgcttctgat gctgggaacc ctccgctgag cacccacagg acgattttcc tcaatatctc
     1801 agatgtgaat gataacccac cctcattctt tcagaggtcg catgaggtgt ttgttcctga
     1861 gaacaatcgc ccaggggacc tgctttgctc ccttgcagcc tctgacccag actctggctt
     1921 aaacgcgtta atctcatact ctctcttaga gcccagaaac cgagacgtat cggcttcttc
     1981 cttcatctct ctgaaccccc agacaggggc cgttcatgct actagatcat ttgactatga
     2041 acaaacacag acactgcagt ttgaggtgca ggccagggac aggggcagcc cacctctcag
     2101 cagcactgtg acagtgcgcc tgtttgttct agacctcaat gacaatgccc cagcagtgct
     2161 acgccccagg gccaggcctg gttccttatg tccccaggcg ttgcctccat cagttggcgc
     2221 tggtcacctc gtcacaaagg tgacggctgt ggacttagat tcaggttaca atgcttgggt
     2281 ttcctatcag ctcctggagg ccccagatcc cagcctgttt gcagtctccc gttatgcagg
     2341 ggaagtacgg actgctgttc ccatcccagc tgacctccca ccgcagaagc tggtcatagt
     2401 ggtgaaggac agtggtagcc caccactctc tacctctgtg actctcctag tgtccttaga
     2461 ggaagacact catccagttg tccccgatct tcgagaatct tcagctccca gggaaggaga
     2521 atcccgccta accctctact tggctgtgtc cttagtggcg atctgctttg tctcctttgg
     2581 ttcttttgtg gcactgctct ctaagtgtct tcgtggggct gcctgtggag taacgtgctt
     2641 tcctgctggc acctgcgcct gtctcaccag atctcggagg agggaggggc ttcctccttc
     2701 caatgggatc ctccgaatcc agctagggtc agaagatcct atcaagtttg ttgacgtggg
     2761 aggccactct catggctgta caccattggc ttctgcgcct actcggagtg atagcttcat
     2821 gatggtgaag tcacccagtg cacctatggc tggggagccc gtgcggccaa gctgtccacc
     2881 ctctgatctt ctctatgggc tagagcaagc cccgcccaac actgactggc gtttctctca
     2941 agcccagaga cccggcacga gcggatccca aaatggtgat gaaactggca cctggcccaa
     3001 caaccagttt gatacagaga tgctgcaagc catgatcttg gcctctgcca gcgaagctgc
     3061 tgatgggagc tctaccctgg gagggggcgc tggcaccatg ggtctgagcg ctcgatacgg
     3121 accccagttt accctgcagc acgtgcctga ctaccgccag aacgtgtaca tccctggcag
     3181 caatgccacg ctgaccaatg ccgctggcaa acgagatggc aaggctccag caggtggtaa
     3241 tggcaacaag aagaaatcgg gcaagaaaga gaagaagtaa tatggaggcc aggccttgaa
     3301 ccacaaggca gcctccctcc ccagccagtc cagctcgtcc ttacttgtac ccaggcctca
     3361 gaatttcagg gctcacccca ggatactggt aggagccagg gccatgctcc ccgttgggaa
     3421 acagaaacac gtgcccaagc caacaccccc tctctatacc ctagggagtt gaatatgcaa
     3481 agagagttct gctgggaccc ccctattcaa tcagtgattg tacccacatg ggtagcaggg
     3541 tttgtgtgtg tggacataca cacacacaca cacacacaca cacacaaacc atgccacact
     3601 cccttagtta cagctgaact cctccatctt ccaacccagg caggcttatc catctcctgc
     3661 cgccctctcc ccaccccacc cactccttca gtccctctct ttgagcaagg tagctgggct
     3721 gttggggtga ccggtgagct aagccggctc ctagttctga acggtaggga gagtattaca
     3781 atcttttggc ctctccttca gttcagcttt cccccaaagc atggtttggt accagtcttc
     3841 tcttttcctt ccagagcctg agaccaatgc ttaagttttg ggggaacagg caccctccct
     3901 ctggtactga tgatgcttgc tggattttgg gaaggcattt tgctactaag cctcttttca
     3961 atgcctgggg acaactagtc ttttgttttt cattgtttga tgttcccact gcatgctgtg
     4021 acttccctac acctcaaaga agagactcct ttgcatgtct ggagacagta gggggtggta
     4081 aactaaaggg aagttgagag tgtatactgc tgggagtggg gcagtggaca aaacagcctg
     4141 ttaatagggt cttgcaaggg gctctgtatg tacccagggg actggctcaa tcctcacatt
     4201 ctagccatag acaaacacca ggccagaccc ctccattctg gttcagcctg ggcagcttgg
     4261 gctgagccac caggaccaat ggatttaagc tgacatttca gtccaagacg acgacttcta
     4321 agtgagttta agaccagaga ggaaagaggg gcctctgtgg gtgctgggta ctccagaggt
     4381 gcccttggtg ggaggaccag tggtcttagc aggaaggggg gcccagcaag gtcattcttg
     4441 gaccctgggt ctagtccagt agctagaaaa agggaccaag tggccataaa gtcccagcca
     4501 atgatggggc ttttccagtg ggcccctgta gacctcaagc ccctggcctc caccttacca
     4561 ggtgccattt cttctcagaa ggccactgcc caggccccca ggccgccccc ttgtggccag
     4621 agaacggtta aagcccccca gtgcctcctt gtgcatagaa cttcctctgc cctagccctt
     4681 acagtagtgt agaagatccc cctcccccgc tggtgtagaa tagccaatag tatagtgtgg
     4741 tgtgctttta cgtgatggcg agtgggcagc gggcggtggg ctgtacacag ccgtctgtcc
     4801 tttgaatctc aatctgcctg cgcggcccgt gctgtgtttt gtgctgtgtc cacacgctgc
     4861 ggcgacccct ccctgtactg acttctctat aaaaagcttc tcttcgcata gtcacgtagc
     4921 tcctgcccat cccccttccg atatctctcg caagttttat actctaatat ttatatggct
     4981 tttttcttcg aaaattaaaa ataaaaaaat ggtttcttct gaaaaaaaaa aaaaaaaaaa
     5041 aaaaaaa
//
