LOCUS       NM_033581               4687 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protocadherin gamma subfamily C, 3 (Pcdhgc3), mRNA.
ACCESSION   NM_033581
VERSION     NM_033581.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4687)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4687)
  AUTHORS   Steffen,D.M., Hanes,C.M., Mah,K.M., Valino Ramos,P., Bosch,P.J.,
            Hinz,D.C., Radley,J.J., Burgess,R.W., Garrett,A.M. and Weiner,J.A.
  TITLE     A Unique Role for Protocadherin gammaC3 in Promoting Dendrite
            Arborization through an Axin1-Dependent Mechanism
  JOURNAL   J Neurosci 43 (6), 918-935 (2023)
   PUBMED   36604170
  REMARK    GeneRIF: A Unique Role for Protocadherin gammaC3 in Promoting
            Dendrite Arborization through an Axin1-Dependent Mechanism.
REFERENCE   3  (bases 1 to 4687)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4687)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4687)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   6  (bases 1 to 4687)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   7  (bases 1 to 4687)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   8  (bases 1 to 4687)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   9  (bases 1 to 4687)
  AUTHORS   Obata,S., Sago,H., Mori,N., Rochelle,J.M., Seldin,M.F.,
            Davidson,M., St John,T., Taketani,S. and Suzuki,S.T.
  TITLE     Protocadherin Pcdh2 shows properties similar to, but distinct from,
            those of classical cadherins
  JOURNAL   J Cell Sci 108 (Pt 12), 3765-3773 (1995)
   PUBMED   8719883
REFERENCE   10 (bases 1 to 4687)
  AUTHORS   Sago,H., Kitagawa,M., Obata,S., Mori,N., Taketani,S.,
            Rochelle,J.M., Seldin,M.F., Davidson,M., St John,T. and Suzuki,S.T.
  TITLE     Cloning, expression, and chromosomal localization of a novel
            cadherin-related protein, protocadherin-3
  JOURNAL   Genomics 29 (3), 631-640 (1995)
   PUBMED   8575755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129315.3.
            
            On Nov 17, 2006 this sequence version replaced NM_033581.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059175.1, SRR1660817.144909.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2568              AC129315.3         6724-9291
            2569-2627           AC129315.3         25335-25393
            2628-2716           AC129315.3         33579-33667
            2717-4687           AC129315.3         40217-42187
FEATURES             Location/Qualifiers
     source          1..4687
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.67 cM"
     gene            1..4687
                     /gene="Pcdhgc3"
                     /gene_synonym="PC43; Pcdh2"
                     /note="protocadherin gamma subfamily C, 3"
                     /db_xref="GeneID:93706"
                     /db_xref="MGI:MGI:1935201"
     exon            1..2568
                     /gene="Pcdhgc3"
                     /gene_synonym="PC43; Pcdh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..2943
                     /gene="Pcdhgc3"
                     /gene_synonym="PC43; Pcdh2"
                     /note="protocadherin 2"
                     /codon_start=1
                     /product="protocadherin gamma-C3 precursor"
                     /protein_id="NP_291059.1"
                     /db_xref="CCDS:CCDS29192.1"
                     /db_xref="GeneID:93706"
                     /db_xref="MGI:MGI:1935201"
                     /translation="MVAEARSSGLVSPWRTVGVLLLLAALTEASTIIHYEILEERERG
                     FPVGNVVTDLGLDLGSLSARRLRVVSGASRRFFEVNWETGEMFVNDRLDREELCGTLP
                     SCTVTLELVVENPLELFSAEVVVQDINDNNPSFPTGEMKLEISEALAPGTRFPLESAH
                     DPDVGSNSLQTYELSHNEYFALRVQTREDGTKYAELVLERALDWEREPSVQLVLTALD
                     GGTPARSATLPIRITVLDANDNAPAFNQSLYRARVREDAPPGTRVAQVLATDLDEGLN
                     GEIVYSFGSHNRAGVRELFALDLVTGVLTIKGRLDFEDTKLHEIYIQAKDKGANPEGA
                     HCKVLVEVVDVNDNAPEITVTSVYSPVPEDAPLGTVIALLSVTDLDAGENGLVTCEVP
                     PGLPFSLTSSLKNYFTLKTSAALDRETMPEYNLSITARDSGIPSLSALTTVKVQVSDI
                     NDNPPQSSQSSYDVYVEENNLPGVPILNLSVWDPDAPPNARLSFFLLEPGAETGLVSR
                     YFTINRDNGVLTTLVPLDYEDQREFQLTAHINDGGTPVLATNISVNVFVTDRNDNAPQ
                     VLYPRPGQSSVEMLPRGTAAGHVVSRVVGWDADAGHNAWLSYSLLGAPNQSLFAVGLH
                     TGQISTARPIQDTDSPRQILTVLISDSGEPLLSTTATLTVSVTEESPEARAEFPSGSA
                     PREQNKNLTFYLLLSLILVSVGFAVTVLGVIIFKVYKWKRSRDLYRAPVSSLYRTPGP
                     SLHADAVRGGLMPPHLYHQVYLTTDSRRSDPLLKKPGAASPLASRQNTLRSCDPVFYR
                     QVLGAESAPPGQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILA
                     SASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRD
                     GKAPAGGNGNKKKSGKKEKK"
     exon            2569..2627
                     /gene="Pcdhgc3"
                     /gene_synonym="PC43; Pcdh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2716
                     /gene="Pcdhgc3"
                     /gene_synonym="PC43; Pcdh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..4687
                     /gene="Pcdhgc3"
                     /gene_synonym="PC43; Pcdh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4663..4668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhgc3"
                     /gene_synonym="PC43; Pcdh2"
                     /note="hexamer: AATAAA"
     polyA_site      4687
                     /gene="Pcdhgc3"
                     /gene_synonym="PC43; Pcdh2"
                     /note="major polyA site"
ORIGIN      
        1 cgggcgaaca aatcagcggc gcccagaaag ccatgtcgga ctcggcgccc agcgcccaag
       61 cgctaacccg ctgaaagttt ctctgccaga cctccgggac cacctggacc ccggcaagag
      121 gagctgcttt tgagtgagat ggtcgcagag gcccggagca gcggactggt aagcccctgg
      181 agaacggtgg gagttttgct tctgctagct gccttaaccg aggcttccac catcattcac
      241 tatgagatcc tggaggagag agagaggggg ttccccgtgg gtaacgtggt cacggatctt
      301 ggtttggatc tcggcagtct gtcggcccgc cggctccggg tggtgtccgg agctagccgt
      361 aggttctttg aggtgaactg ggagactgga gagatgttcg tcaacgatcg actggaccga
      421 gaggagctgt gcgggacgct gccctcctgc actgtaactc tggagttggt ggtagagaac
      481 ccgctggagc tgttcagcgc ggaagtggtg gtccaggaca tcaacgacaa caatccctct
      541 ttccccaccg gggaaatgaa attggagatt agcgaggcct tggcgccggg gacgcgcttt
      601 ccgctcgaga gcgcgcacga tcccgatgtg gggagcaact ctttacaaac ctatgagctg
      661 agccacaatg agtactttgc gctccgcgtg cagactcgag aagacggcac gaaatatgcg
      721 gagctggtcc tggagcgcgc cctagattgg gaacgggagc caagtgtcca gttggtactg
      781 accgcgctgg atggaggaac cccagctcgc tccgccaccc ttccaattcg tatcacagtg
      841 ctggacgcga atgacaatgc gcctgccttc aatcagtctt tgtatcgggc gcgcgtccgg
      901 gaggatgcac ccccaggcac gcgcgtcgcc caggttcttg caactgacct ggatgagggc
      961 ctcaacggag aaatcgttta ctccttcggc agccacaatc gtgctggggt gcgggaacta
     1021 ttcgctttag acctcgtaac cggggtgctg acaatcaagg gtcgcctgga cttcgaagac
     1081 accaaactcc atgagattta catccaggcc aaagacaaag gtgccaatcc cgaaggagcg
     1141 cattgcaaag tacttgtaga ggttgtagac gtaaatgaca atgccccgga aatcacagtc
     1201 acctctgtat acagccctgt ccctgaggat gctcctctgg ggactgtcat tgctttgctc
     1261 agtgtgactg atctggatgc tggagagaac gggttggtga cctgcgaggt tccacccggt
     1321 ctccccttta gcctgacttc ttccctcaag aattacttca ctttgaaaac cagtgcagcc
     1381 ctggatcgtg agaccatgcc agaatacaat ctcagcatca cagctcgaga ctcgggaatc
     1441 ccctctctct cagctcttac aacagtgaag gtccaagtgt ccgacatcaa cgacaatcct
     1501 cctcagtcgt cccaatcctc ctacgacgtt tatgttgagg aaaataacct acccggcgtt
     1561 cctatattaa acctaagtgt ctgggacccc gacgccccgc ccaatgcccg cctttccttc
     1621 tttctcttgg aaccaggagc ggaaactggg ctcgtgagtc gctatttcac aataaatcgt
     1681 gacaatggag tcttgactac cttagtaccc ctggactatg aggatcagag agagttccaa
     1741 ctaacagctc atataaacga cggaggtacc ccagtcttag ccaccaacat cagcgtgaac
     1801 gtatttgtta ctgaccgcaa tgacaacgcc ccccaggtcc tgtatccccg gcctggccag
     1861 agttcggtgg agatgctgcc tcgaggtaca gctgcgggcc acgtggtctc acgggtggta
     1921 ggctgggacg cagatgcagg gcacaatgct tggctctcct acagcctctt gggagccccc
     1981 aaccagagcc tttttgccgt ggggcttcac acgggtcaga tcagcactgc ccgcccaatc
     2041 caggacacag attcaccaag gcagattctc acagtcttga tctcagacag tggagaacct
     2101 ttgctctcca ccaccgccac cctgactgtg tcagtaactg aggagtctcc ggaagcccgg
     2161 gccgagttcc cttctggctc agctccccga gaacagaaca aaaatctcac cttttatcta
     2221 cttctttctc taatcttggt ctctgtggga ttcgcagtca cagtgttggg agtgatcata
     2281 ttcaaagttt acaagtggaa gcggtctagg gacctctacc gagctccagt gagctccctg
     2341 taccgaaccc cagggccctc cttgcacgca gacgcggtgc gaggaggcct aatgccaccg
     2401 cacctgtacc atcaggtgta cctcaccacg gactctcgcc gcagcgaccc actgctgaag
     2461 aagcctggtg ctgccagccc actggccagc cgccagaaca cgctgcgaag ttgtgatcct
     2521 gtgttctata gacaggtgtt gggtgcagag agcgcccccc ctggacagca agccccgccc
     2581 aacactgact ggcgtttctc tcaagcccag agacccggca cgagcggatc ccaaaatggt
     2641 gatgaaactg gcacctggcc caacaaccag tttgatacag agatgctgca agccatgatc
     2701 ttggcctctg ccagcgaagc tgctgatggg agctctaccc tgggaggggg cgctggcacc
     2761 atgggtctga gcgctcgata cggaccccag tttaccctgc agcacgtgcc tgactaccgc
     2821 cagaacgtgt acatccctgg cagcaatgcc acgctgacca atgccgctgg caaacgagat
     2881 ggcaaggctc cagcaggtgg taatggcaac aagaagaaat cgggcaagaa agagaagaag
     2941 taatatggag gccaggcctt gaaccacaag gcagcctccc tccccagcca gtccagctcg
     3001 tccttacttg tacccaggcc tcagaatttc agggctcacc ccaggatact ggtaggagcc
     3061 agggccatgc tccccgttgg gaaacagaaa cacgtgccca agccaacacc ccctctctat
     3121 accctaggga gttgaatatg caaagagagt tctgctggga cccccctatt caatcagtga
     3181 ttgtacccac atgggtagca gggtttgtgt gtgtggacat acacacacac acacacacac
     3241 acacacacaa accatgccac actcccttag ttacagctga actcctccat cttccaaccc
     3301 aggcaggctt atccatctcc tgccgccctc tccccacccc acccactcct tcagtccctc
     3361 tctttgagca aggtagctgg gctgttgggg tgaccggtga gctaagccgg ctcctagttc
     3421 tgaacggtag ggagagtatt acaatctttt ggcctctcct tcagttcagc tttcccccaa
     3481 agcatggttt ggtaccagtc ttctcttttc cttccagagc ctgagaccaa tgcttaagtt
     3541 ttgggggaac aggcaccctc cctctggtac tgatgatgct tgctggattt tgggaaggca
     3601 ttttgctact aagcctcttt tcaatgcctg gggacaacta gtcttttgtt tttcattgtt
     3661 tgatgttccc actgcatgct gtgacttccc tacacctcaa agaagagact cctttgcatg
     3721 tctggagaca gtagggggtg gtaaactaaa gggaagttga gagtgtatac tgctgggagt
     3781 ggggcagtgg acaaaacagc ctgttaatag ggtcttgcaa ggggctctgt atgtacccag
     3841 gggactggct caatcctcac attctagcca tagacaaaca ccaggccaga cccctccatt
     3901 ctggttcagc ctgggcagct tgggctgagc caccaggacc aatggattta agctgacatt
     3961 tcagtccaag acgacgactt ctaagtgagt ttaagaccag agaggaaaga ggggcctctg
     4021 tgggtgctgg gtactccaga ggtgcccttg gtgggaggac cagtggtctt agcaggaagg
     4081 ggggcccagc aaggtcattc ttggaccctg ggtctagtcc agtagctaga aaaagggacc
     4141 aagtggccat aaagtcccag ccaatgatgg ggcttttcca gtgggcccct gtagacctca
     4201 agcccctggc ctccacctta ccaggtgcca tttcttctca gaaggccact gcccaggccc
     4261 ccaggccgcc cccttgtggc cagagaacgg ttaaagcccc ccagtgcctc cttgtgcata
     4321 gaacttcctc tgccctagcc cttacagtag tgtagaagat ccccctcccc cgctggtgta
     4381 gaatagccaa tagtatagtg tggtgtgctt ttacgtgatg gcgagtgggc agcgggcggt
     4441 gggctgtaca cagccgtctg tcctttgaat ctcaatctgc ctgcgcggcc cgtgctgtgt
     4501 tttgtgctgt gtccacacgc tgcggcgacc cctccctgta ctgacttctc tataaaaagc
     4561 ttctcttcgc atagtcacgt agctcctgcc catccccctt ccgatatctc tcgcaagttt
     4621 tatactctaa tatttatatg gcttttttct tcgaaaatta aaaataaaaa aatggtttct
     4681 tctgaaa
//
