LOCUS       NM_033579               4691 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily B, 7 (Pcdhgb7), mRNA.
ACCESSION   NM_033579
VERSION     NM_033579.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4691)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4691)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 4691)
  AUTHORS   Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M,
            Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T,
            Hirabayashi T and Yagi T.
  TITLE     Developmental epigenetic modification regulates stochastic
            expression of clustered protocadherin genes, generating single
            neuron diversity
  JOURNAL   Neuron 82 (1), 94-108 (2014)
   PUBMED   24698270
REFERENCE   4  (bases 1 to 4691)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   5  (bases 1 to 4691)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   6  (bases 1 to 4691)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   7  (bases 1 to 4691)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   8  (bases 1 to 4691)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4691)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4691)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 22, 2019 this sequence version replaced NM_033579.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013809.1, BC066823.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2575              AC020971.3         182145-184719
            2576-2634           AC129315.3         25335-25393
            2635-2723           AC129315.3         33579-33667
            2724-4691           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4691
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.62 cM"
     gene            1..4691
                     /gene="Pcdhgb7"
                     /note="protocadherin gamma subfamily B, 7"
                     /db_xref="GeneID:93704"
                     /db_xref="MGI:MGI:1935199"
     exon            1..2575
                     /gene="Pcdhgb7"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..2950
                     /gene="Pcdhgb7"
                     /codon_start=1
                     /product="protocadherin gamma-B7 precursor"
                     /protein_id="NP_291057.1"
                     /db_xref="CCDS:CCDS79633.1"
                     /db_xref="GeneID:93704"
                     /db_xref="MGI:MGI:1935199"
                     /translation="MGGSSARRKRPGRPQVLFILLLPLFCPALGQPVRYSIPEELDRG
                     SVVGKLAKDLGLSVLEVSARKLRVSAEKLHFSVDSESGDLLVKDRIDREQICKGRRKC
                     ELQLEAVLENPLNIFHVVVEIEDVNDHAPQFPKDEINLEISESDSPGARTILESAKDL
                     DIGMNSLSKYQLSPNDYFLLLVKDNPDGSKYPELELQKMLDREAESTHHLMLTAVDGG
                     DPPRTGTTQLRIRVVDANDNRPVFSQDVYRVRLPEDLPPGTTVLRLKAMDQDEGINAE
                     FTYSFLGVANKAQFSLDPITGDIVTRQSLDFEEVEQYTIDVEAKDRGSLSSQCKVIIE
                     VLDENDNRPEIIITSLSDQISEDSPSGTVVALFKVRDRDSGENAEVMCSLSGNNPFKI
                     HSSSNNYYKLVTDSILDREQTPGYNVTITATDRGKPPLSSSTTITLNVADVNDNAPVF
                     QQQAYLINVAENNQPGTSITQVKAWDPDVGSNGLVSYSIIASDLEPKALSSFVSVNQD
                     SGVVYAQRAFDHEQIRSFQLTLQARDQGSPALSANVSMRVLVDDRNDNAPRVLYPTLE
                     PDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASDPGLFSLGLRTGEV
                     RTARALSDKDAARQRLLVAVRDGGQPPLSATATLLLVFADSLQEALPDLVDHPIPSDP
                     QSELQFYLVVALALISVLFLLAVIFAIALRLRQSSSPSSTGCFGSVLGSKSRPVLPPN
                     YSEGTLPYAYNLCVPGDQLKPEFNYFSSVGDCPAAQDILNKDSSSALLASILTPGVEA
                     DEKTFNQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEA
                     ADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPA
                     GGNGNKKKSGKKEKK"
     exon            2576..2634
                     /gene="Pcdhgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            2635..2723
                     /gene="Pcdhgb7"
                     /inference="alignment:Splign:2.1.0"
     exon            2724..4691
                     /gene="Pcdhgb7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacacacca aggggaactc tcactcatac agactaagac accgattccc aggacaaaac
       61 tggggtcccg ctgtcccgag ccaaaaggac ctccaccctc gtaggctgaa ctctctccta
      121 ctgtgaagat ctgaagacct acaggggacc tgagccagca atgggaggga gcagcgcgcg
      181 gaggaagcgc cccggccgcc cgcaggtact gtttatcctg ctgctgcctt tgttctgtcc
      241 cgcgctgggc cagccggtcc gctactccat ccctgaggag ctggaccgcg ggtcggtggt
      301 ggggaagctc gccaaggacc tggggctcag tgtcctggaa gtgtcggctc ggaagctgcg
      361 ggtcagcgct gagaagctgc acttcagcgt ggattcggag agcggggact tactggtgaa
      421 ggaccgcata gatcgcgagc aaatatgcaa agggaggaga aagtgtgagc tgcagttgga
      481 agctgtgcta gaaaaccctt taaatatttt tcatgtcgtt gtggagattg aggatgttaa
      541 tgatcacgct cctcaatttc caaaagacga aataaaccta gagataagtg aatccgacag
      601 cccaggggcg agaacaattc tggagtcagc aaaagatctt gacattggta tgaattctct
      661 aagtaaatac cagttaagtc ctaacgacta ctttttattg ttggtgaaag acaatcctga
      721 tggtagtaaa tacccagaat tagaattgca aaagatgctg gaccgagaag cagagagcac
      781 acaccacctg atgctgactg ctgtagatgg tggggacccg ccccgtactg gtactactca
      841 gctccgaatc cgagtggtgg acgccaatga taaccgccca gtgttcagcc aagacgtgta
      901 cagagtccgc cttccagaag acttgcctcc aggaaccaca gtcctaaggc taaaggcaat
      961 ggatcaagac gagggcatca atgcagaatt tacatattcc ttcctaggtg tggctaacaa
     1021 agcccagttc tctctggatc ccataacagg agatattgta actcgccagt cgttggattt
     1081 tgaagaagta gagcaatata cgattgatgt ggaggcaaag gaccgaggat ctctttcttc
     1141 acagtgtaaa gtaattatag aggttctaga tgagaacgac aaccgcccag aaataatcat
     1201 cacttctctc tctgatcaga tttcggagga ttctccttcc ggaactgttg tggccctctt
     1261 caaggtacgg gatcgagatt ctggggaaaa cgcagaagtc atgtgcagtt taagcggaaa
     1321 caatccattt aagattcatt cttcttccaa caattactac aagttagtaa cagatagcat
     1381 cctagaccgg gaacagaccc cagggtacaa cgttactatc acagccactg ataggggcaa
     1441 gccgcccctt tcctccagca caaccatcac tctgaacgtc gctgatgtca acgacaatgc
     1501 acctgttttc caacagcagg cctacctgat aaacgtagca gaaaacaacc agcccggtac
     1561 ctccataacc caagtcaaag catgggatcc agatgtggga tccaatggcc tcgtctccta
     1621 ctccatcata gccagcgacc tagaaccaaa agcgctgtcg tccttcgtgt ccgtgaacca
     1681 ggacagtgga gtagtgtacg cgcagcgtgc ctttgaccat gagcagattc gctccttcca
     1741 gctgacttta caagcgcgag accaggggtc gcctgcgctc agcgccaacg tgagcatgcg
     1801 cgtgctggtg gacgaccgca acgacaacgc gccacgcgtg ctgtatccca cgctggagcc
     1861 cgatggctct gcactcttcg acatggtacc ccgtgccgct gagcctggat acctggtcac
     1921 caaagtggtg gctgtggatg cagactcagg acacaatgcc tggctgtctt accacgtgct
     1981 gcaggccagc gatcccggtc tcttcagcct ggggctgcgc acgggcgagg tgcgcacagc
     2041 gcgtgccttg agcgacaagg atgcagctcg tcagcgcctt ctggtcgctg tgcgtgatgg
     2101 tggacagcca cctctgtctg ccactgctac actgctccta gtttttgcag acagcctaca
     2161 agaagcgttg ccagacctcg tcgatcatcc catcccctcc gaccctcaga gtgagcttca
     2221 gttttacctg gtggtggctt tggccttgat ctcagtgctt ttccttctcg cagtaatttt
     2281 cgccattgct ttgcgcctgc gacagtcttc cagcccttca tccactggtt gctttgggtc
     2341 ggttcttggt tccaaatcta gaccagtact tccacccaac tacagcgagg gaacattgcc
     2401 ctatgcctat aatctgtgcg tgccgggaga tcaacttaaa ccagaattta attacttctc
     2461 atccgttgga gattgtccag ccgcacaaga tattctcaac aaagatagct cctcggcact
     2521 gttggctagt attttaactc ctggtgttga agcagacgag aagaccttta accagcaagc
     2581 cccgcccaac actgactggc gtttctctca agcccagaga cccggcacga gcggatccca
     2641 aaatggtgat gaaactggca cctggcccaa caaccagttt gatacagaga tgctgcaagc
     2701 catgatcttg gcctctgcca gcgaagctgc tgatgggagc tctaccctgg gagggggcgc
     2761 tggcaccatg ggtctgagcg ctcgatacgg accccagttt accctgcagc acgtgcctga
     2821 ctaccgccag aacgtgtaca tccctggcag caatgccacg ctgaccaatg ccgctggcaa
     2881 acgagatggc aaggctccag caggtggtaa tggcaacaag aagaaatcgg gcaagaaaga
     2941 gaagaagtaa tatggaggcc aggccttgaa ccacaaggca gcctccctcc ccagccagtc
     3001 cagctcgtcc ttacttgtac ccaggcctca gaatttcagg gctcacccca ggatactggt
     3061 aggagccagg gccatgctcc ccgttgggaa acagaaacac gtgcccaagc caacaccccc
     3121 tctctatacc ctagggagtt gaatatgcaa agagagttct gctgggaccc ccctattcaa
     3181 tcagtgattg tacccacatg ggtagcaggg tttgtgtgtg tggacataca cacacacaca
     3241 cacacacaca cacacaaacc atgccacact cccttagtta cagctgaact cctccatctt
     3301 ccaacccagg caggcttatc catctcctgc cgccctctcc ccaccccacc cactccttca
     3361 gtccctctct ttgagcaagg tagctgggct gttggggtga ccggtgagct aagccggctc
     3421 ctagttctga acggtaggga gagtattaca atcttttggc ctctccttca gttcagcttt
     3481 cccccaaagc atggtttggt accagtcttc tcttttcctt ccagagcctg agaccaatgc
     3541 ttaagttttg ggggaacagg caccctccct ctggtactga tgatgcttgc tggattttgg
     3601 gaaggcattt tgctactaag cctcttttca atgcctgggg acaactagtc ttttgttttt
     3661 cattgtttga tgttcccact gcatgctgtg acttccctac acctcaaaga agagactcct
     3721 ttgcatgtct ggagacagta gggggtggta aactaaaggg aagttgagag tgtatactgc
     3781 tgggagtggg gcagtggaca aaacagcctg ttaatagggt cttgcaaggg gctctgtatg
     3841 tacccagggg actggctcaa tcctcacatt ctagccatag acaaacacca ggccagaccc
     3901 ctccattctg gttcagcctg ggcagcttgg gctgagccac caggaccaat ggatttaagc
     3961 tgacatttca gtccaagacg acgacttcta agtgagttta agaccagaga ggaaagaggg
     4021 gcctctgtgg gtgctgggta ctccagaggt gcccttggtg ggaggaccag tggtcttagc
     4081 aggaaggggg gcccagcaag gtcattcttg gaccctgggt ctagtccagt agctagaaaa
     4141 agggaccaag tggccataaa gtcccagcca atgatggggc ttttccagtg ggcccctgta
     4201 gacctcaagc ccctggcctc caccttacca ggtgccattt cttctcagaa ggccactgcc
     4261 caggccccca ggccgccccc ttgtggccag agaacggtta aagcccccca gtgcctcctt
     4321 gtgcatagaa cttcctctgc cctagccctt acagtagtgt agaagatccc cctcccccgc
     4381 tggtgtagaa tagccaatag tatagtgtgg tgtgctttta cgtgatggcg agtgggcagc
     4441 gggcggtggg ctgtacacag ccgtctgtcc tttgaatctc aatctgcctg cgcggcccgt
     4501 gctgtgtttt gtgctgtgtc cacacgctgc ggcgacccct ccctgtactg acttctctat
     4561 aaaaagcttc tcttcgcata gtcacgtagc tcctgcccat cccccttccg atatctctcg
     4621 caagttttat actctaatat ttatatggct tttttcttcg aaaattaaaa ataaaaaaat
     4681 ggtttcttct g
//
