LOCUS       NM_033578               4684 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily B, 6 (Pcdhgb6), mRNA.
ACCESSION   NM_033578
VERSION     NM_033578.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4684)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4684)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 4684)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   4  (bases 1 to 4684)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   5  (bases 1 to 4684)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   6  (bases 1 to 4684)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   7  (bases 1 to 4684)
  AUTHORS   Wang X, Su H and Bradley A.
  TITLE     Molecular mechanisms governing Pcdh-gamma gene expression: evidence
            for a multiple promoter and cis-alternative splicing model
  JOURNAL   Genes Dev 16 (15), 1890-1905 (2002)
   PUBMED   12154121
REFERENCE   8  (bases 1 to 4684)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4684)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4684)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Nov 17, 2006 this sequence version replaced NM_033578.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054556.1, AY013808.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2565              AC020971.3         172620-175184
            2566-2624           AC129315.3         25335-25393
            2625-2713           AC129315.3         33579-33667
            2714-4684           AC129315.3         40217-42187
FEATURES             Location/Qualifiers
     source          1..4684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.61 cM"
     gene            1..4684
                     /gene="Pcdhgb6"
                     /note="protocadherin gamma subfamily B, 6"
                     /db_xref="GeneID:93703"
                     /db_xref="MGI:MGI:1935197"
     exon            1..2565
                     /gene="Pcdhgb6"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..2940
                     /gene="Pcdhgb6"
                     /codon_start=1
                     /product="protocadherin gamma-B6 precursor"
                     /protein_id="NP_291056.1"
                     /db_xref="CCDS:CCDS50259.1"
                     /db_xref="GeneID:93703"
                     /db_xref="MGI:MGI:1935197"
                     /translation="MGGSSARRKRPDRPQVLFTLLLPLFCPALGQPVRYSIPEELDRG
                     SVVGKLAKDLGLSVLEVSSRKLRVSAEKLHFSVDSESGDLLVKDRIDREQICKGRRKC
                     ELQLEAVLENPLNIFHVVVGIEDVNDNAPQFEKKETRLEILETVAVGTRIPLEPATDP
                     DINLNSVKDYQISSNPYFSLMVRVNPDGGKTPELSLEKLLDREEQRSHRLILTALDGG
                     DPPRSATTQIEISVKDNNDNPPVFSKEEYWVSVSENLSPGSSVLQVTATDEDEGVNAE
                     ILYYFRSTAQSTRHVFSLDEKTGVIKNNQSLDFEDIERYTMEVEAKDGGGLSTRCKII
                     IEVLDENDNSPEITITSLSDHILENSPPGVVVVLFKTRDRDFGGNGEVTCDIGKDLPF
                     KIQASSSNYYKLVTDGALDREQNPQYNVTITATDKGKPALSSSTTIVLHITDINDNAP
                     AFQKSSYIVHVAENNPPGASIAQVSASDPDLGANGHVSYSIIASDLEPKSLWSYVTVN
                     AQSGVVFAQRAFDHEQLRSFQLTLQARDQGKPSLSANVSMRVLVGDRNDNAPRVLYPA
                     LEPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASDPGLFSLGLRTG
                     EVRTARALGEKDAARQRLLVGVRDGGQPPLSATATLLLVFADSLQEALPDLSDRSLPP
                     DPQAELQFYLVVALALISVLFLLAVILAIALRLRHSSSPSVWGCFQSGLCSKARPGVS
                     LNYSEGTLPYSYNLCVGQTGKAELNFLKCSAPLPSSQEIVSGSSPGALIPLHLGDDLT
                     THPETLTPQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASE
                     AADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAP
                     AGGNGNKKKSGKKEKK"
     exon            2566..2624
                     /gene="Pcdhgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2625..2713
                     /gene="Pcdhgb6"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..4684
                     /gene="Pcdhgb6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaatacaca caccaagggg aactcataca gactaagata ctgattccca gcacaaaact
       61 ggggtcccgc tgtctcgggc caaacggacc tccaccctcg taccctgctg tgaagatctg
      121 aagatctact gggggcctga gccagcaatg ggagggagca gcgcgcggag gaagcgcccc
      181 gaccgcccgc aggtactgtt taccctgctg ctgcctttgt tctgtcccgc gctgggccag
      241 ccggtccgct actccatccc cgaggagctg gaccgcggat cggtggtggg gaagctcgcc
      301 aaggacctgg ggctcagtgt cctggaagtg tcgtctcgga agctgcgggt cagcgctgag
      361 aagctgcact tcagcgtgga ttcggagagc ggggacttac tggtgaagga ccgcatagat
      421 cgcgagcaga tatgcaaagg gaggagaaag tgtgagctgc agttggaagc tgtgctggaa
      481 aaccctttaa atatttttca tgtcgttgtg ggaattgagg atgttaatga taatgctcct
      541 caattcgaga agaaagaaac gcgtttagaa atcttagaaa ctgtggcggt tggtacacga
      601 ataccccttg agcctgccac tgaccccgac ataaatttga attcggttaa agattaccag
      661 ataagctcca acccttattt ctcattaatg gttagagtta atcctgatgg tggcaaaacc
      721 ccagagttgt ctctggagaa actcctagat agggaagaac agaggtctca tcgcttgata
      781 ctgactgcct tggatggagg ggacccaccc cggagtgcca ccactcagat agaaatatct
      841 gtaaaggaca acaatgacaa ccctccagtg tttagcaaag aggaatattg ggtcagtgtt
      901 agtgaaaatc tgtccccagg atcctctgtg ttgcaagtga cagccactga tgaggatgag
      961 ggcgtcaatg ctgagatact ttactacttt cggagcactg cgcagagcac aagacacgtg
     1021 ttctcactag atgagaaaac aggcgtgatc aagaataacc agtctctgga ttttgaagac
     1081 atagagaggt acaccatgga agtagaagcg aaggacggcg gtggtctctc tacacggtgt
     1141 aaaatcatca tagaagtcct agatgaaaat gacaacagtc cagaaatcac catcacctcc
     1201 ctttctgatc atatcttgga gaattctcct ccgggagtgg tggttgtcct cttcaaaacg
     1261 agagatcggg atttcggagg aaatggggaa gtcacgtgtg atataggcaa agacctgcct
     1321 ttcaagatcc aagcttcttc tagcaactac tacaagttag taacagatgg agccctagac
     1381 cgagagcaga acccacagta caatgtcacc atcaccgcca cggacaaagg caagccagca
     1441 ctctcttcca gtacaaccat cgttctgcac atcactgaca ttaacgacaa cgctccggct
     1501 ttccagaaat cttcatacat agtccatgtg gcagagaaca atccgcctgg agcctccatc
     1561 gctcaagtca gcgcctccga cccggatctg ggggccaatg gtcatgtctc ctactccatc
     1621 atagccagtg acctggagcc taaatcgctg tggtcctacg tgaccgtgaa tgcgcagagc
     1681 ggagtggtgt tcgcacagcg cgccttcgac cacgaacagc tgcgctcctt ccagctgaca
     1741 ctgcaggcgc gcgaccaggg aaagccctcg ctcagcgcca acgtgagcat gcgcgtgttg
     1801 gtgggtgacc gcaacgacaa cgcgccacgc gtgctgtatc ccgcgctcga gcccgacggc
     1861 tctgcgctct tcgacatggt gccacgcgct gccgagcctg gatacctggt aaccaaagtg
     1921 gtggcggtgg acgcagactc aggacacaat gcctggctgt cttaccacgt gctgcaggcc
     1981 agcgatcccg ggctcttcag cctgggactg cgcacaggcg aggtgcgcac agcgcgtgcc
     2041 ttgggcgaaa aggatgctgc gcggcagcgc ctgttggttg gtgttcgcga tggtggacag
     2101 ccacccctct cggccaccgc cacgctgctt ctagtattcg ctgatagctt gcaggaggcc
     2161 ctgccagacc tcagtgaccg ctcactgccc cctgatccgc aagccgagct gcagttctac
     2221 ttggtggtgg ccttggcctt gatttctgtg cttttcctcc tggctgtgat tctagccatt
     2281 gcacttcgac tgcgacactc ttccagcccc tcggtctggg gctgctttca gtctggtctt
     2341 tgttctaagg ctagaccagg ggtttctctc aactatagcg agggcactct accctattcc
     2401 tataatctgt gcgttgggca aacgggaaag gcggagttaa attttctgaa atgtagcgca
     2461 cctttgcctt cttctcaaga gatcgtttcc ggtagttctc ctggggcctt aattccgctt
     2521 caccttggag atgatttgac aacacatcct gagactctaa caccgcaagc cccgcccaac
     2581 actgactggc gtttctctca agcccagaga cccggcacga gcggatccca aaatggtgat
     2641 gaaactggca cctggcccaa caaccagttt gatacagaga tgctgcaagc catgatcttg
     2701 gcctctgcca gcgaagctgc tgatgggagc tctaccctgg gagggggcgc tggcaccatg
     2761 ggtctgagcg ctcgatacgg accccagttt accctgcagc acgtgcctga ctaccgccag
     2821 aacgtgtaca tccctggcag caatgccacg ctgaccaatg ccgctggcaa acgagatggc
     2881 aaggctccag caggtggtaa tggcaacaag aagaaatcgg gcaagaaaga gaagaagtaa
     2941 tatggaggcc aggccttgaa ccacaaggca gcctccctcc ccagccagtc cagctcgtcc
     3001 ttacttgtac ccaggcctca gaatttcagg gctcacccca ggatactggt aggagccagg
     3061 gccatgctcc ccgttgggaa acagaaacac gtgcccaagc caacaccccc tctctatacc
     3121 ctagggagtt gaatatgcaa agagagttct gctgggaccc ccctattcaa tcagtgattg
     3181 tacccacatg ggtagcaggg tttgtgtgtg tggacataca cacacacaca cacacacaca
     3241 cacacaaacc atgccacact cccttagtta cagctgaact cctccatctt ccaacccagg
     3301 caggcttatc catctcctgc cgccctctcc ccaccccacc cactccttca gtccctctct
     3361 ttgagcaagg tagctgggct gttggggtga ccggtgagct aagccggctc ctagttctga
     3421 acggtaggga gagtattaca atcttttggc ctctccttca gttcagcttt cccccaaagc
     3481 atggtttggt accagtcttc tcttttcctt ccagagcctg agaccaatgc ttaagttttg
     3541 ggggaacagg caccctccct ctggtactga tgatgcttgc tggattttgg gaaggcattt
     3601 tgctactaag cctcttttca atgcctgggg acaactagtc ttttgttttt cattgtttga
     3661 tgttcccact gcatgctgtg acttccctac acctcaaaga agagactcct ttgcatgtct
     3721 ggagacagta gggggtggta aactaaaggg aagttgagag tgtatactgc tgggagtggg
     3781 gcagtggaca aaacagcctg ttaatagggt cttgcaaggg gctctgtatg tacccagggg
     3841 actggctcaa tcctcacatt ctagccatag acaaacacca ggccagaccc ctccattctg
     3901 gttcagcctg ggcagcttgg gctgagccac caggaccaat ggatttaagc tgacatttca
     3961 gtccaagacg acgacttcta agtgagttta agaccagaga ggaaagaggg gcctctgtgg
     4021 gtgctgggta ctccagaggt gcccttggtg ggaggaccag tggtcttagc aggaaggggg
     4081 gcccagcaag gtcattcttg gaccctgggt ctagtccagt agctagaaaa agggaccaag
     4141 tggccataaa gtcccagcca atgatggggc ttttccagtg ggcccctgta gacctcaagc
     4201 ccctggcctc caccttacca ggtgccattt cttctcagaa ggccactgcc caggccccca
     4261 ggccgccccc ttgtggccag agaacggtta aagcccccca gtgcctcctt gtgcatagaa
     4321 cttcctctgc cctagccctt acagtagtgt agaagatccc cctcccccgc tggtgtagaa
     4381 tagccaatag tatagtgtgg tgtgctttta cgtgatggcg agtgggcagc gggcggtggg
     4441 ctgtacacag ccgtctgtcc tttgaatctc aatctgcctg cgcggcccgt gctgtgtttt
     4501 gtgctgtgtc cacacgctgc ggcgacccct ccctgtactg acttctctat aaaaagcttc
     4561 tcttcgcata gtcacgtagc tcctgcccat cccccttccg atatctctcg caagttttat
     4621 actctaatat ttatatggct tttttcttcg aaaattaaaa ataaaaaaat ggtttcttct
     4681 gaaa
//
