LOCUS       NM_033577               4705 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily B, 5 (Pcdhgb5), mRNA.
ACCESSION   NM_033577
VERSION     NM_033577.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4705)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4705)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   3  (bases 1 to 4705)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   4  (bases 1 to 4705)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   5  (bases 1 to 4705)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   6  (bases 1 to 4705)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   7  (bases 1 to 4705)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   8  (bases 1 to 4705)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 22, 2019 this sequence version replaced NM_033577.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013807.1, BC057403.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2589              AC020971.3         161497-164085
            2590-2648           AC129315.3         25335-25393
            2649-2737           AC129315.3         33579-33667
            2738-4705           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4705
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.59 cM"
     gene            1..4705
                     /gene="Pcdhgb5"
                     /note="protocadherin gamma subfamily B, 5"
                     /db_xref="GeneID:93702"
                     /db_xref="MGI:MGI:1935196"
     exon            1..2589
                     /gene="Pcdhgb5"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2964
                     /gene="Pcdhgb5"
                     /codon_start=1
                     /product="protocadherin gamma-B5 precursor"
                     /protein_id="NP_291055.1"
                     /db_xref="CCDS:CCDS79631.1"
                     /db_xref="GeneID:93702"
                     /db_xref="MGI:MGI:1935196"
                     /translation="MWEGTAERGRGQRRPMLLPFLLPLFCPALSEQIRYKIPEEMPTG
                     SVVGNLAKDLGFSVQELPTRKLRISSEKPYFSVSSESGELLVSSRLDREQICGKKLVC
                     ALEFEAVAENPLNFYHVSVELEDINDHTPNFTHTFSELQISESAQPGTRFILEVAEDA
                     DIALNSLQNYKLSPSPGFSLVNKEKQDGRKYPELVLEKTLDREQQNYYRLVLTALDGG
                     DPPLSGTTELRIQVTDANDNPPVFNQEVYKVRLPENVPPGTTVLRVTATDKDEGVNSE
                     ISYSFHRAGQVFGLNSKSGEIITQKTLDFEEIKEYSIVVEARDGGGLVAQCTVEINIQ
                     DENDNRPEITVRSLLEMIPENAPPGTLIALIKIHDGDSGENGEVNCRLDDEVPFKIIS
                     SSKNSYKLVTDRALDRELTPEYNVTITATDRGKPPLSSSTKVTLHVGDVNDNAPLFHQ
                     ASYLVYIAENNPPGASIAQVSASDPDLGSNGHVSYSIIASDLEPKSLWSYVTVNAQSG
                     VVFAQRAFDHEQLRSFQLTLQARDHGSPTLSANVSMRVLVGDRNDNAPRVLYPALEPD
                     GSALFDMVPRAAQPGYLVTKVVAVDADSGHNAWLSYHVLQASDPGLFSLGLRTGEVRT
                     ARALGEKDAARQRLLVGVRDGGQPPLSATATLLLVFADSLQEALPDLSDHSLPPDPQA
                     ELQFYLVVALALVSVLFLLAVILAIALRLRHSSSPSVWNCFQPGFCSESKPVVFPNYS
                     EGTLPYSYNLYGAHAGKTECNFLKCSEPLSSGQGLLCPESSGALFPLCDSSEPTSHPE
                     PLTPQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADG
                     SSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGN
                     GNKKKSGKKEKK"
     exon            2590..2648
                     /gene="Pcdhgb5"
                     /inference="alignment:Splign:2.1.0"
     exon            2649..2737
                     /gene="Pcdhgb5"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..4705
                     /gene="Pcdhgb5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgtttt ctacggctcc ctttctcagc ctttacaccg cttctttccg agaaaaggaa
       61 gaatcgtttc gtgaactaga actggtatca aagaccgatt ggagcccgga atatccgcac
      121 cacggagcta cttcgtaacc cggcgtctcc aggctggtga gcaaggaaag gggagcaaga
      181 aggatgtggg agggcactgc tgagaggggc cggggacaga ggcggccaat gctccttccc
      241 ttcctgctgc ctttgttctg ccccgcgctc tctgagcaga tccgctacaa gatccccgag
      301 gaaatgccca ccggctcggt agtggggaac ctcgccaagg acctgggctt cagtgtccag
      361 gagttaccga ctcgaaagct acgcatcagt tctgagaagc cttacttcag tgtgagctca
      421 gagagcggag agttgctagt aagcagcagg ctggacaggg agcagatatg cgggaagaag
      481 ctggtgtgtg ctctggaatt tgaggctgtt gctgaaaatc cactgaactt ttatcatgtg
      541 agtgtggagc tggaggacat taatgaccac acgccaaact tcacgcacac tttctcggaa
      601 ctgcaaataa gtgagtctgc tcaaccgggc actcgcttca ttttagaagt agcagaagat
      661 gcagatattg ccttaaattc gctacagaat tataaactct ctcctagccc tggtttctcc
      721 ctggtgaata aagaaaaaca agatggtcgt aagtacccgg aattggtatt ggagaaaact
      781 ttagaccgcg agcaacagaa ttactaccga ctagtcctga cagccttaga cggcggggat
      841 cctcccctaa gtggcaccac tgagctgcga atccaagtca ctgatgccaa cgacaacccc
      901 cctgtgttca accaggaagt gtacaaagtc cgccttcctg agaacgtgcc cccaggtaca
      961 accgtgctac gagtgacagc tacagataaa gatgagggcg tgaattcaga gatttcttat
     1021 tcctttcaca gagctgggca agtgtttggt ctaaattcaa agagtggaga aattataaca
     1081 cagaaaacac tagatttcga agaaatcaaa gaatattcta tagtagtgga agcgcgggat
     1141 ggcggaggcc tggttgcaca atgtacagtt gaaattaaca ttcaagatga aaacgacaac
     1201 agaccagaaa ttactgtccg ttctctgcta gagatgattc cagagaacgc accgccggga
     1261 acactaattg ctttgatcaa aatacacgac ggagattctg gagaaaacgg ggaggttaat
     1321 tgtcgactag acgatgaagt gccctttaaa attatctctt cttccaaaaa ctcgtataaa
     1381 ttggttacgg atagagcctt agaccgagag ctgactccag aatacaatgt gaccattacg
     1441 gccactgaca gaggcaagcc acccctttcc tccagcacaa aagtcaccct acacgttggt
     1501 gacgtcaatg acaacgctcc gctttttcac caggcctcct acttggtgta catagctgag
     1561 aacaacccac ctggagcttc catcgctcaa gtcagcgcct ccgacccgga tctgggatcc
     1621 aatggtcatg tctcctactc catcatagct agtgacctgg agcctaaatc gctgtggtcc
     1681 tacgtgaccg tgaatgcgca gagcggagtg gtgttcgcgc agcgcgcctt cgaccacgag
     1741 cagctgcgct ccttccagct gacactgcag gcgcgggacc acggatcgcc cacactcagc
     1801 gccaacgtga gcatgcgcgt gctggtgggc gaccgcaacg acaacgcgcc acgcgttttg
     1861 tatcccgcgc tcgagcccga cggctctgcg ctcttcgaca tggtgccgcg cgctgcccag
     1921 cccggatacc tggtaaccaa agtggtggcg gtggacgcag actcgggaca caatgcctgg
     1981 ctgtcctacc acgtgctgca ggccagcgat cccgggctct tcagcctggg actgcgcacg
     2041 ggcgaggtgc gcacagcgcg tgccttgggc gaaaaggatg ctgcgcggca gcgcctgttg
     2101 gttggtgttc gcgatggtgg acagccaccc ctctcggcca ccgccacgct gcttctagta
     2161 ttcgctgata gcttgcagga ggccctgcca gacctcagtg accactcact gccccctgat
     2221 cctcaagccg agctgcagtt ctacttggtg gtggccttgg ccttagtttc tgtgcttttc
     2281 ctcctggctg tgattctagc catcgcactt cgactgcgac actcctccag cccctcggtc
     2341 tggaattgct ttcagcctgg attttgttct gaatctaagc ctgtggtttt ccccaactat
     2401 agtgaaggta ctttgccgta ttcctataat ctgtatggtg cacatgctgg aaagaccgag
     2461 tgtaatttcc taaaatgtag tgagccatta agttctggac aaggccttct ttgccctgag
     2521 tcatctgggg ccttgtttcc tctttgtgat tccagtgagc cgacttccca ccccgaacct
     2581 ctaacaccgc aagccccgcc caacactgac tggcgtttct ctcaagccca gagacccggc
     2641 acgagcggat cccaaaatgg tgatgaaact ggcacctggc ccaacaacca gtttgataca
     2701 gagatgctgc aagccatgat cttggcctct gccagcgaag ctgctgatgg gagctctacc
     2761 ctgggagggg gcgctggcac catgggtctg agcgctcgat acggacccca gtttaccctg
     2821 cagcacgtgc ctgactaccg ccagaacgtg tacatccctg gcagcaatgc cacgctgacc
     2881 aatgccgctg gcaaacgaga tggcaaggct ccagcaggtg gtaatggcaa caagaagaaa
     2941 tcgggcaaga aagagaagaa gtaatatgga ggccaggcct tgaaccacaa ggcagcctcc
     3001 ctccccagcc agtccagctc gtccttactt gtacccaggc ctcagaattt cagggctcac
     3061 cccaggatac tggtaggagc cagggccatg ctccccgttg ggaaacagaa acacgtgccc
     3121 aagccaacac cccctctcta taccctaggg agttgaatat gcaaagagag ttctgctggg
     3181 acccccctat tcaatcagtg attgtaccca catgggtagc agggtttgtg tgtgtggaca
     3241 tacacacaca cacacacaca cacacacaca aaccatgcca cactccctta gttacagctg
     3301 aactcctcca tcttccaacc caggcaggct tatccatctc ctgccgccct ctccccaccc
     3361 cacccactcc ttcagtccct ctctttgagc aaggtagctg ggctgttggg gtgaccggtg
     3421 agctaagccg gctcctagtt ctgaacggta gggagagtat tacaatcttt tggcctctcc
     3481 ttcagttcag ctttccccca aagcatggtt tggtaccagt cttctctttt ccttccagag
     3541 cctgagacca atgcttaagt tttgggggaa caggcaccct ccctctggta ctgatgatgc
     3601 ttgctggatt ttgggaaggc attttgctac taagcctctt ttcaatgcct ggggacaact
     3661 agtcttttgt ttttcattgt ttgatgttcc cactgcatgc tgtgacttcc ctacacctca
     3721 aagaagagac tcctttgcat gtctggagac agtagggggt ggtaaactaa agggaagttg
     3781 agagtgtata ctgctgggag tggggcagtg gacaaaacag cctgttaata gggtcttgca
     3841 aggggctctg tatgtaccca ggggactggc tcaatcctca cattctagcc atagacaaac
     3901 accaggccag acccctccat tctggttcag cctgggcagc ttgggctgag ccaccaggac
     3961 caatggattt aagctgacat ttcagtccaa gacgacgact tctaagtgag tttaagacca
     4021 gagaggaaag aggggcctct gtgggtgctg ggtactccag aggtgccctt ggtgggagga
     4081 ccagtggtct tagcaggaag gggggcccag caaggtcatt cttggaccct gggtctagtc
     4141 cagtagctag aaaaagggac caagtggcca taaagtccca gccaatgatg gggcttttcc
     4201 agtgggcccc tgtagacctc aagcccctgg cctccacctt accaggtgcc atttcttctc
     4261 agaaggccac tgcccaggcc cccaggccgc ccccttgtgg ccagagaacg gttaaagccc
     4321 cccagtgcct ccttgtgcat agaacttcct ctgccctagc ccttacagta gtgtagaaga
     4381 tccccctccc ccgctggtgt agaatagcca atagtatagt gtggtgtgct tttacgtgat
     4441 ggcgagtggg cagcgggcgg tgggctgtac acagccgtct gtcctttgaa tctcaatctg
     4501 cctgcgcggc ccgtgctgtg ttttgtgctg tgtccacacg ctgcggcgac ccctccctgt
     4561 actgacttct ctataaaaag cttctcttcg catagtcacg tagctcctgc ccatccccct
     4621 tccgatatct ctcgcaagtt ttatactcta atatttatat ggcttttttc ttcgaaaatt
     4681 aaaaataaaa aaatggtttc ttctg
//
