LOCUS       NM_033576               4658 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily B, 4 (Pcdhgb4), mRNA.
ACCESSION   NM_033576
VERSION     NM_033576.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4658)
  AUTHORS   Xu L, Zheng Y, Li X, Wang A, Huo D, Li Q, Wang S, Luo Z, Liu Y, Xu
            F, Wu X, Wu M and Zhou Y.
  TITLE     Abnormal neocortex arealization and Sotos-like syndrome-associated
            behavior in Setd2 mutant mice
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523829
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4658)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4658)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 4658)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   5  (bases 1 to 4658)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   6  (bases 1 to 4658)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   7  (bases 1 to 4658)
  AUTHORS   Wang X, Su H and Bradley A.
  TITLE     Molecular mechanisms governing Pcdh-gamma gene expression: evidence
            for a multiple promoter and cis-alternative splicing model
  JOURNAL   Genes Dev 16 (15), 1890-1905 (2002)
   PUBMED   12154121
REFERENCE   8  (bases 1 to 4658)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4658)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4658)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 22, 2019 this sequence version replaced NM_033576.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013806.1, SRR1660811.162011.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2542              AC020971.3         150902-153443
            2543-2601           AC129315.3         25335-25393
            2602-2690           AC129315.3         33579-33667
            2691-4658           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4658
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.58 cM"
     gene            1..4658
                     /gene="Pcdhgb4"
                     /note="protocadherin gamma subfamily B, 4"
                     /db_xref="GeneID:93701"
                     /db_xref="MGI:MGI:1935173"
     exon            1..2542
                     /gene="Pcdhgb4"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2917
                     /gene="Pcdhgb4"
                     /note="protocadherin gamma C-VI"
                     /codon_start=1
                     /product="protocadherin gamma-B4 precursor"
                     /protein_id="NP_291054.1"
                     /db_xref="CCDS:CCDS79630.1"
                     /db_xref="GeneID:93701"
                     /db_xref="MGI:MGI:1935173"
                     /translation="MREGTAERGRGQRRPMLLPFLLPLFCPTLSEQIRYKIPEEMPTG
                     SVVGNLAKDLGFSVQELPTRKLRISSEKPYFSVSSESGELLVSSRLDREQICGKKLMC
                     ALEFEAVAENPLNFYHLSVELEDINDHTPKFAHTSFELQISESSKPGTRFILGSAHDA
                     DIGTNSLQNYQLSPNDHFSLVNKEKSDGSKYPEMILKTALDREKQKLYHLTLTALDFG
                     HPPLNSTAQIQVLVTDANDNPPVFSQDIYRVSLPENVYPGTTVLRVVATDQDEGVNSE
                     ITFSFSEAGQVTQFNLDSNTGEITTLHTLDFEEVKEYSLVLEAKDGGGMIAQCTVEIE
                     VLDENDNVPEVLFQSLPDLIMEDAEPGTYIALLKTRDKDSGRNGEVICKLEGGAPFKI
                     LTSSGNTYKLVTDGVLDREQNPEYNITIRATDKGDPPLSSSSSVTLHIGDVNDNAPVF
                     TKVSYLVHVAENNPPGASIAQVSASDPDLGANGQVTYYIIASDLEPESLWSYVTINAQ
                     SGVLFAQRAFDHEQLRSFQLTLQARDHGSPTLSANVSMRLLVGDRNDNAPRVLYPTLE
                     PDGSALFDMVPRSAEPGYLVTKVVAVDADSGHNAWLSYHVLQASDPGLFSLGLRTGEV
                     RTARALGDRDSARQRLLVAVRDGGQPPLSATATLHLIFADSLQEVLPDLSDDPLPPDP
                     QSELQFYLVVALALISVLFLLAVILAIALRLRHSSSRKAWGCFQSEVVVPPNYSEGTL
                     PYSYNLCAAEFNSLTCNDQLKSGQDLQFADSAGALFPLCNSNESTSHQQAPPNTDWRF
                     SQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAADGSSTLGGGAGTMGLS
                     ARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAGGNGNKKKSGKKEKK"
     exon            2543..2601
                     /gene="Pcdhgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2690
                     /gene="Pcdhgb4"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..4658
                     /gene="Pcdhgb4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttccaag gcttcctttc tcagccttta caccgcttct ttctgagcaa aagaagaatc
       61 gtttcatgga ctagatctga taccaaagtt cgattggagc ccggaatatc cacaccacgc
      121 agcttcttcg taacccggcg tctccaggct ggtgagcaag gaaaggggag caagaaagat
      181 gcgggagggc actgctgaga ggggccgggg acagaggcgg ccaatgctcc ttcccttcct
      241 gctgcctttg ttctgcccca cgctctctga gcagatccgc tacaagatcc ccgaggaaat
      301 gcccaccggc tcggtagtgg ggaacctcgc caaggacctg ggtttcagtg tccaggagtt
      361 accgacgcga aagctacgca tcagttctga gaagccttac ttcagtgtga gctcagagag
      421 cggagagttg ctagtaagca gcaggctgga cagggagcag atatgcggga agaagctgat
      481 gtgtgctctg gaatttgagg ctgttgctga aaatccactg aacttttatc acttgagtgt
      541 ggagctggag gacattaatg accacacgcc aaaattcgcg cacacttcct ttgaattgca
      601 aataagtgag tcctcaaaac cagggacaag atttatctta ggatccgccc atgatgcaga
      661 tatcggaacc aattctctgc agaattacca gcttagtccc aatgatcatt tttcactggt
      721 gaataaagag aaatcagacg gtagtaagta ccctgaaatg atattaaaga cagctctaga
      781 ccgggaaaag cagaaactct accacttgac cctgactgct ttggactttg ggcatccacc
      841 cctcaacagc actgcacaga tacaggtcct agtgaccgat gccaatgata accctccagt
      901 gttcagccaa gacatataca gggtgagcct tcctgaaaac gtgtacccag gaaccaccgt
      961 gcttcgagtg gtggccacag accaagacga gggtgtcaac tccgagatca cgttttcttt
     1021 cagtgaagct ggccaggtta cccaatttaa cctggattct aataccggag aaattacaac
     1081 tctgcataca ttagatttcg aagaagtcaa agaatactcc cttgttttgg aagcaaagga
     1141 cggtgggggg atgattgcgc aatgtacggt ggaaatagaa gtcctagatg agaacgacaa
     1201 tgtccctgaa gtgttattcc aatctctacc tgatctcata atggaggatg ctgagccagg
     1261 gacatatatc gctctgctta aaacccgtga caaagattct ggacgcaatg gagaagttat
     1321 ctgtaaatta gaaggcggtg ctccgtttaa aatactcact tcttcaggaa acacgtataa
     1381 actagtgacg gatggagttc tagatcgtga gcagaacccg gaatacaaca ttactattag
     1441 agctactgac aagggtgacc cgcctctctc ttccagctca agtgtcacct tgcatatagg
     1501 cgatgtgaac gataacgccc cagttttcac gaaggtttca tacctggtcc atgttgcaga
     1561 aaacaatccg cctggagcct ccatcgctca agtcagcgcc tcagacccgg atttgggggc
     1621 caatggccag gttacctatt acatcatagc cagcgacctg gagcctgaat ctctgtggtc
     1681 ctacgtgacc ataaacgcgc aaagcggagt gctgttcgca cagcgcgcct tcgaccacga
     1741 acaactgcgc tccttccagc tgacactgca ggcgcgggac cacggatcgc ccacactcag
     1801 cgccaatgtg agcatgcgct tgttggtggg tgaccgcaac gacaacgcgc cccgagtgct
     1861 gtatcccacg ctcgagcccg acggctctgc gctcttcgac atggtgccgc gctctgccga
     1921 gcccggatac ctggtcacca aggtggtggc tgtggatgca gactcgggac acaatgcctg
     1981 gctgtcttac catgtgctgc aggccagtga ccctgggctc ttcagcctgg gactgcgcac
     2041 aggcgaggtg cgcacagcgc gtgccctggg agacagggac tcagcgcggc agcgccttct
     2101 ggtcgctgtg cgtgatggtg gacaaccacc gctctcggct acagccacgc tgcacctcat
     2161 cttcgctgac agcctgcaag aggtcctgcc agacctcagc gatgaccctt tgcccccgga
     2221 ccctcaatct gagctgcagt tctacttggt ggtggccttg gccttgattt ctgtcctttt
     2281 cctcctggct gtgattctag ccattgcact tcgactgcga cactcctcca gcaggaaggc
     2341 atggggctgc tttcagtcgg aagtggtggt tccccccaac tacagtgagg ggactttgcc
     2401 gtattcctac aatctgtgtg ctgcagagtt taactcccta acatgtaatg atcagttgaa
     2461 atcaggacaa gatctacaat ttgcagattc agcgggggcc ttgtttccac tttgtaattc
     2521 caatgagtca acctcccatc agcaagcccc gcccaacact gactggcgtt tctctcaagc
     2581 ccagagaccc ggcacgagcg gatcccaaaa tggtgatgaa actggcacct ggcccaacaa
     2641 ccagtttgat acagagatgc tgcaagccat gatcttggcc tctgccagcg aagctgctga
     2701 tgggagctct accctgggag ggggcgctgg caccatgggt ctgagcgctc gatacggacc
     2761 ccagtttacc ctgcagcacg tgcctgacta ccgccagaac gtgtacatcc ctggcagcaa
     2821 tgccacgctg accaatgccg ctggcaaacg agatggcaag gctccagcag gtggtaatgg
     2881 caacaagaag aaatcgggca agaaagagaa gaagtaatat ggaggccagg ccttgaacca
     2941 caaggcagcc tccctcccca gccagtccag ctcgtcctta cttgtaccca ggcctcagaa
     3001 tttcagggct caccccagga tactggtagg agccagggcc atgctccccg ttgggaaaca
     3061 gaaacacgtg cccaagccaa caccccctct ctatacccta gggagttgaa tatgcaaaga
     3121 gagttctgct gggacccccc tattcaatca gtgattgtac ccacatgggt agcagggttt
     3181 gtgtgtgtgg acatacacac acacacacac acacacacac acaaaccatg ccacactccc
     3241 ttagttacag ctgaactcct ccatcttcca acccaggcag gcttatccat ctcctgccgc
     3301 cctctcccca ccccacccac tccttcagtc cctctctttg agcaaggtag ctgggctgtt
     3361 ggggtgaccg gtgagctaag ccggctccta gttctgaacg gtagggagag tattacaatc
     3421 ttttggcctc tccttcagtt cagctttccc ccaaagcatg gtttggtacc agtcttctct
     3481 tttccttcca gagcctgaga ccaatgctta agttttgggg gaacaggcac cctccctctg
     3541 gtactgatga tgcttgctgg attttgggaa ggcattttgc tactaagcct cttttcaatg
     3601 cctggggaca actagtcttt tgtttttcat tgtttgatgt tcccactgca tgctgtgact
     3661 tccctacacc tcaaagaaga gactcctttg catgtctgga gacagtaggg ggtggtaaac
     3721 taaagggaag ttgagagtgt atactgctgg gagtggggca gtggacaaaa cagcctgtta
     3781 atagggtctt gcaaggggct ctgtatgtac ccaggggact ggctcaatcc tcacattcta
     3841 gccatagaca aacaccaggc cagacccctc cattctggtt cagcctgggc agcttgggct
     3901 gagccaccag gaccaatgga tttaagctga catttcagtc caagacgacg acttctaagt
     3961 gagtttaaga ccagagagga aagaggggcc tctgtgggtg ctgggtactc cagaggtgcc
     4021 cttggtggga ggaccagtgg tcttagcagg aaggggggcc cagcaaggtc attcttggac
     4081 cctgggtcta gtccagtagc tagaaaaagg gaccaagtgg ccataaagtc ccagccaatg
     4141 atggggcttt tccagtgggc ccctgtagac ctcaagcccc tggcctccac cttaccaggt
     4201 gccatttctt ctcagaaggc cactgcccag gcccccaggc cgcccccttg tggccagaga
     4261 acggttaaag ccccccagtg cctccttgtg catagaactt cctctgccct agcccttaca
     4321 gtagtgtaga agatccccct cccccgctgg tgtagaatag ccaatagtat agtgtggtgt
     4381 gcttttacgt gatggcgagt gggcagcggg cggtgggctg tacacagccg tctgtccttt
     4441 gaatctcaat ctgcctgcgc ggcccgtgct gtgttttgtg ctgtgtccac acgctgcggc
     4501 gacccctccc tgtactgact tctctataaa aagcttctct tcgcatagtc acgtagctcc
     4561 tgcccatccc ccttccgata tctctcgcaa gttttatact ctaatattta tatggctttt
     4621 ttcttcgaaa attaaaaata aaaaaatggt ttcttctg
//
