LOCUS       NM_033575               4629 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protocadherin gamma subfamily B, 2 (Pcdhgb2), mRNA.
ACCESSION   NM_033575
VERSION     NM_033575.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4629)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4629)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4629)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 4629)
  AUTHORS   Toyoda,S., Kawaguchi,M., Kobayashi,T., Tarusawa,E., Toyama,T.,
            Okano,M., Oda,M., Nakauchi,H., Yoshimura,Y., Sanbo,M.,
            Hirabayashi,M., Hirayama,T., Hirabayashi,T. and Yagi,T.
  TITLE     Developmental epigenetic modification regulates stochastic
            expression of clustered protocadherin genes, generating single
            neuron diversity
  JOURNAL   Neuron 82 (1), 94-108 (2014)
   PUBMED   24698270
REFERENCE   5  (bases 1 to 4629)
  AUTHORS   Ledderose,J., Dieter,S. and Schwarz,M.K.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   6  (bases 1 to 4629)
  AUTHORS   Murata,Y., Hamada,S., Morishita,H., Mutoh,T. and Yagi,T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   7  (bases 1 to 4629)
  AUTHORS   Wang,X., Su,H. and Bradley,A.
  TITLE     Molecular mechanisms governing Pcdh-gamma gene expression: evidence
            for a multiple promoter and cis-alternative splicing model
  JOURNAL   Genes Dev 16 (15), 1890-1905 (2002)
   PUBMED   12154121
REFERENCE   8  (bases 1 to 4629)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4629)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4629)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Aug 29, 2018 this sequence version replaced NM_033575.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054557.1, AY013805.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2511              AC020971.3         120385-122895
            2512-2570           AC129315.3         25335-25393
            2571-2659           AC129315.3         33579-33667
            2660-4629           AC129315.3         40217-42186
FEATURES             Location/Qualifiers
     source          1..4629
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.55 cM"
     gene            1..4629
                     /gene="Pcdhgb2"
                     /note="protocadherin gamma subfamily B, 2"
                     /db_xref="GeneID:93700"
                     /db_xref="MGI:MGI:1935170"
     exon            1..2511
                     /gene="Pcdhgb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..2886
                     /gene="Pcdhgb2"
                     /note="3' RACE product; protocadherin gamma B2"
                     /codon_start=1
                     /product="protocadherin gamma-B2 precursor"
                     /protein_id="NP_291053.1"
                     /db_xref="CCDS:CCDS79626.1"
                     /db_xref="GeneID:93700"
                     /db_xref="MGI:MGI:1935170"
                     /translation="MRRGSGSGPAWWLQVLSPFLLLLFHGALADQIRYSIPEELAKNS
                     IVGNLARDLGLSVQNLPTRKLRVSAEKDYFTVNPESGDLLVGDRIDREQVCGKQPQCV
                     LEFDIVAEKPLNIFHVAVILQDVNDNAPLFKQSEVDLNIGESTRPGKAFPLDPALDLD
                     AGSNSLQKYYLTDNEYFEVTEKETPDGRKYPELILKRFLDREEHNFHQLVLTAVDGGD
                     PPRSGTTQIRIQVTDINDNPPMFSQDVFSVTLREDVPPGFSVLQVTATDQDEGVNAEI
                     TYAFHNVDEQVERIFNLDKRTGEITTKDNLDFETAKSYTLNVEAKDPGDLASHCSIQV
                     KILDENDCVPEVIVTSVFTPLPEDSPLGTVIALIKTRDRDSGENGDVYCHVLGNEGFV
                     LKSSSKNYYKLVTDRTLDREAIPEYNVTIVAADRGKPPLSSNVIITLHISDVNDNAPV
                     FHQASYLVHVAENNPPGTSIAQVSASDPDLGSNGLISYSIIASDLEPRALSSFVSVNQ
                     DSGVVFAQRAFDHEQLRSFQLTLQARDHGSPTLSANVSMRVLVGDRNDNAPRVLYPTL
                     EPDGSALFDMVPRAAEPGYLVTKVVAVDADSGHNAWLSYHVLQASDPGLFSLGLRTGE
                     VRTARALGDRDSARQRLLVAVRDGGQPPLSATATLHLIFADSLQEVLPDLSDDPLPSD
                     PQSELQFYLVVALALISVLFLLSVILAIALRLRHSSRSAAWGCFQPGLSSNLATGVLP
                     NYNEGTLPYSYNVCIASQSAKTEFNFLNVTPEVAPQDLLCGDDSWVPGTLGDTDVPFV
                     SDSISKQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAA
                     DGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAG
                     GNGNKKKSGKKEKK"
     exon            2512..2570
                     /gene="Pcdhgb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2659
                     /gene="Pcdhgb2"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..4629
                     /gene="Pcdhgb2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcatctaga tacagcaaac atcagcaaga aaagtggccc taggaggatt tggccaccct
       61 caccaacaaa ggagcagagc ggcggcgcga gccaggagga tgaggagggg ctctgggagc
      121 ggtccggcct ggtggctgca ggtactgtcg cctttcctgt tgcttttgtt ccacggagct
      181 ctcgcggatc agatccgcta ctccattccc gaggagctgg ccaagaactc gatagtagga
      241 aacctcgcaa gggatctggg gctcagtgtc cagaatctgc ccacccggaa gctaagggtc
      301 agcgcagaga aggattattt tactgtaaat ccagagagtg gggacttact tgtgggtgac
      361 agaatagaca gagagcaggt ttgcgggaag cagcctcagt gtgttttgga gttcgatatt
      421 gtcgctgaga agcccttaaa tattttccac gtagctgtaa ttcttcagga tgtgaacgac
      481 aacgctcctc tattcaaaca gagtgaggtt gatttaaaca ttggagagtc caccagacca
      541 ggtaaagcat ttccattgga tccagccctc gatttagatg ctggttctaa ttctctgcaa
      601 aaatactatc tcactgacaa tgaatacttt gaagtcacgg agaaagagac cccagatgga
      661 cgtaaatatc ctgagttgat tctaaaacgt tttctggaca gagaagagca taattttcac
      721 caactggtcc tcacggctgt ggatggggga gatcctcccc gaagtggcac cacccagatc
      781 cgaatccaag tcacagacat caatgataac ccgccaatgt tcagccagga tgtgttcagt
      841 gtcacccttc gggaggatgt accaccaggc ttctccgtgc ttcaggtgac agccaccgac
      901 caggacgagg gtgtcaatgc agaaatcacc tacgcttttc acaatgtgga tgaacaagtg
      961 gaacggattt ttaacttaga caagagaaca ggagaaatca cgacaaagga taatttggat
     1021 ttcgagacag ctaagagtta caccctgaat gtagaagcaa aagatcccgg agacctagca
     1081 tcccattgta gtatccaagt gaaaattctg gatgagaatg attgtgtacc ggaagtaatt
     1141 gtgacgtcag tatttacccc cctaccagaa gattctccac taggaacagt catcgccttg
     1201 ataaaaacca gagacagaga ctctggagaa aatggagacg tctactgcca tgtgttggga
     1261 aatgaagggt ttgtattgaa atcttcttcg aagaattatt acaaactagt gacagacaga
     1321 actctagacc gggaggcgat accggaatac aacgtcacca ttgtagctgc cgataggggt
     1381 aagcccccgc tctcctctaa cgtaatcatc actctccata tctcagatgt caacgacaat
     1441 gcaccggttt ttcaccaggc ctcctacttg gtccatgtgg ctgagaacaa cccacctgga
     1501 acctccattg ctcaagtcag tgcttctgac ccggatttgg gatccaatgg cctcatttcc
     1561 tactccatca tagccagcga cctagagcca agggcactat cgtccttcgt gtccgtgaac
     1621 caggacagtg gagtggtgtt cgcgcagcgc gccttcgacc acgagcagct gcgctccttc
     1681 cagctgacac tacaggcgcg ggaccacgga tcgcccacac tcagtgccaa tgtgagcatg
     1741 cgtgtgctgg tgggcgaccg caacgacaac gcgccacgcg tgctgtatcc cacacttgag
     1801 cccgacggct ctgcgctctt cgacatggtg ccgcgcgctg ccgagcccgg atacctggtc
     1861 accaaggtgg tggctgtgga tgcagactcc ggacacaatg cctggctatc ttaccacgtg
     1921 ctgcaggcca gcgatcccgg gctcttcagc ctgggactgc gcacaggcga ggtgcgcaca
     1981 gcgcgtgccc tgggagacag ggactcagcg cggcagcgcc ttctggtcgc tgtgcgtgat
     2041 ggtggacagc caccgctctc cgctacagcc acgctgcacc tcatcttcgc tgacagcctg
     2101 caggaggtcc tgccagacct cagcgatgac cctctaccat ctgaccctca gagtgagctt
     2161 cagttttacc tggtggtggc cttggccctg atctcagtac tcttcctcct gtcggtgatt
     2221 ctggctattg ccctgcgtct gagacactcc tccagatcag ctgcctgggg ctgctttcaa
     2281 cctggcctca gctctaacct tgcgactgga gttctcccca attacaatga ggggacttta
     2341 ccttattcct acaatgtgtg tattgcctca cagtcagcta agacagagtt taattttctc
     2401 aatgtgactc cggaagttgc tcctcaggac ctcctctgcg gcgacgactc ttgggtacca
     2461 ggtactcttg gagacactga cgttccgttt gtctcggatt ctatctcaaa gcaagccccg
     2521 cccaacactg actggcgttt ctctcaagcc cagagacccg gcacgagcgg atcccaaaat
     2581 ggtgatgaaa ctggcacctg gcccaacaac cagtttgata cagagatgct gcaagccatg
     2641 atcttggcct ctgccagcga agctgctgat gggagctcta ccctgggagg gggcgctggc
     2701 accatgggtc tgagcgctcg atacggaccc cagtttaccc tgcagcacgt gcctgactac
     2761 cgccagaacg tgtacatccc tggcagcaat gccacgctga ccaatgccgc tggcaaacga
     2821 gatggcaagg ctccagcagg tggtaatggc aacaagaaga aatcgggcaa gaaagagaag
     2881 aagtaatatg gaggccaggc cttgaaccac aaggcagcct ccctccccag ccagtccagc
     2941 tcgtccttac ttgtacccag gcctcagaat ttcagggctc accccaggat actggtagga
     3001 gccagggcca tgctccccgt tgggaaacag aaacacgtgc ccaagccaac accccctctc
     3061 tataccctag ggagttgaat atgcaaagag agttctgctg ggacccccct attcaatcag
     3121 tgattgtacc cacatgggta gcagggtttg tgtgtgtgga catacacaca cacacacaca
     3181 cacacacaca caaaccatgc cacactccct tagttacagc tgaactcctc catcttccaa
     3241 cccaggcagg cttatccatc tcctgccgcc ctctccccac cccacccact ccttcagtcc
     3301 ctctctttga gcaaggtagc tgggctgttg gggtgaccgg tgagctaagc cggctcctag
     3361 ttctgaacgg tagggagagt attacaatct tttggcctct ccttcagttc agctttcccc
     3421 caaagcatgg tttggtacca gtcttctctt ttccttccag agcctgagac caatgcttaa
     3481 gttttggggg aacaggcacc ctccctctgg tactgatgat gcttgctgga ttttgggaag
     3541 gcattttgct actaagcctc ttttcaatgc ctggggacaa ctagtctttt gtttttcatt
     3601 gtttgatgtt cccactgcat gctgtgactt ccctacacct caaagaagag actcctttgc
     3661 atgtctggag acagtagggg gtggtaaact aaagggaagt tgagagtgta tactgctggg
     3721 agtggggcag tggacaaaac agcctgttaa tagggtcttg caaggggctc tgtatgtacc
     3781 caggggactg gctcaatcct cacattctag ccatagacaa acaccaggcc agacccctcc
     3841 attctggttc agcctgggca gcttgggctg agccaccagg accaatggat ttaagctgac
     3901 atttcagtcc aagacgacga cttctaagtg agtttaagac cagagaggaa agaggggcct
     3961 ctgtgggtgc tgggtactcc agaggtgccc ttggtgggag gaccagtggt cttagcagga
     4021 aggggggccc agcaaggtca ttcttggacc ctgggtctag tccagtagct agaaaaaggg
     4081 accaagtggc cataaagtcc cagccaatga tggggctttt ccagtgggcc cctgtagacc
     4141 tcaagcccct ggcctccacc ttaccaggtg ccatttcttc tcagaaggcc actgcccagg
     4201 cccccaggcc gcccccttgt ggccagagaa cggttaaagc cccccagtgc ctccttgtgc
     4261 atagaacttc ctctgcccta gcccttacag tagtgtagaa gatccccctc ccccgctggt
     4321 gtagaatagc caatagtata gtgtggtgtg cttttacgtg atggcgagtg ggcagcgggc
     4381 ggtgggctgt acacagccgt ctgtcctttg aatctcaatc tgcctgcgcg gcccgtgctg
     4441 tgttttgtgc tgtgtccaca cgctgcggcg acccctccct gtactgactt ctctataaaa
     4501 agcttctctt cgcatagtca cgtagctcct gcccatcccc cttccgatat ctctcgcaag
     4561 ttttatactc taatatttat atggcttttt tcttcgaaaa ttaaaaataa aaaaatggtt
     4621 tcttctgaa
//
