LOCUS       NM_033574               4684 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protocadherin gamma subfamily B, 1 (Pcdhgb1), mRNA.
ACCESSION   NM_033574
VERSION     NM_033574.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4684)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4684)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4684)
  AUTHORS   Ledderose,J., Dieter,S. and Schwarz,M.K.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   4  (bases 1 to 4684)
  AUTHORS   Chen,W.V., Alvarez,F.J., Lefebvre,J.L., Friedman,B., Nwakeze,C.,
            Geiman,E., Smith,C., Thu,C.A., Tapia,J.C., Tasic,B., Sanes,J.R. and
            Maniatis,T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   5  (bases 1 to 4684)
  AUTHORS   Schreiner,D. and Weiner,J.A.
  TITLE     Combinatorial homophilic interaction between gamma-protocadherin
            multimers greatly expands the molecular diversity of cell adhesion
  JOURNAL   Proc Natl Acad Sci U S A 107 (33), 14893-14898 (2010)
   PUBMED   20679223
  REMARK    GeneRIF: Data demonstrate role of the gamma-Pcdhs in synaptogenesis
            and implications for the molecular control of neuronal specificity.
REFERENCE   6  (bases 1 to 4684)
  AUTHORS   Gayet,O., Labella,V., Henderson,C.E. and Kallenbach,S.
  TITLE     The b1 isoform of protocadherin-gamma (Pcdhgamma) interacts with
            the microtubule-destabilizing protein SCG10
  JOURNAL   FEBS Lett 578 (1-2), 175-179 (2004)
   PUBMED   15581637
  REMARK    GeneRIF: Results identify SCG10 as a cytoplasmic interactor for
            protocadherin-gamma (Pcdhgamma)-b1 and other isoforms of the
            Pcdhgamma-b subfamily, and show that SCG10 and Pcdhgamma-b1 are
            found together in certain neuronal growth cones.
REFERENCE   7  (bases 1 to 4684)
  AUTHORS   Murata,Y., Hamada,S., Morishita,H., Mutoh,T. and Yagi,T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   8  (bases 1 to 4684)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4684)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4684)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 22, 2019 this sequence version replaced NM_033574.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013804.1, BC054741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2568              AC020971.3         110798-113365
            2569-2627           AC129315.3         25335-25393
            2628-2716           AC129315.3         33579-33667
            2717-4684           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4684
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.55 cM"
     gene            1..4684
                     /gene="Pcdhgb1"
                     /note="protocadherin gamma subfamily B, 1"
                     /db_xref="GeneID:93699"
                     /db_xref="MGI:MGI:1935169"
     exon            1..2568
                     /gene="Pcdhgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2627
                     /gene="Pcdhgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2716
                     /gene="Pcdhgb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2717..4684
                     /gene="Pcdhgb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctttttcca gcacccatga gaacatccgt ccggttcctg tgccctcttc aagcgccggg
       61 caaatcctgc cctcaaatca caaacatcta gggcactagc tgtctttttg aaatcccaga
      121 gaaacctcga aaagaagcta cctggcaagc tcagaacggc agagcaaccc cagcggcttt
      181 ggaacgatgg aaaatcaggt attgcttcac ttcctggtgc ctttgttctg cggcgccctc
      241 tcccagccca tccactactc cattccggag gagctagcca agggctctct agtggggagt
      301 ctcgccaagg atctgggact cagtatccaa gaattgccag ctcgaaaact gagagttagt
      361 gcagaggatt atttcagcgt tagtgcagag agtggggatt tgttagtgag cggcaggata
      421 gacagagaaa agatttgtgg gaggaaatct gagtgtgcac tggaatttga atctgttact
      481 gaaaacccga tgaacatttt ccacgtaacg gttgccatcc aagacattaa cgataatgca
      541 ccacatttct ttgggaaaag cattgaattg gagatctgtg agtcagcctt agcaggggca
      601 aaattccctc tggactctgc gcgagatgca gatgtgggaa gcaactccct gaagatgtac
      661 actgtcagcc ccaatccaca cttctccttg tcaacgaagg aaagtcctga tggaagtaaa
      721 tacccagaac tgctgctgga aacccctctg gacagggagc atcagagctc ccatcactta
      781 atactgaccg ccatggatgg tggagacccg cccctaagca gcaccaccca ggtctggatc
      841 aaagtcaccg acgccaatga caatgctcca gtgttcagcc aggacactta caaagttagc
      901 cttcgtgaaa acataccccc aggaacgtta gtgctgcaag tgacagcttc tgatcaggat
      961 gagagtattc acggagagat cacctatgcc ttccttaatg ccccagcaag tactaacctt
     1021 gtcttcaatc tcaatccaaa tactggagct atcacaacta atggtacatt ggattttgaa
     1081 gaaaagaata gatacacatt gggtgtagaa gccaaggacg gaggggtgca cacggctcac
     1141 tgtaatgttc agatcgaaat tcttgatgac aacgacaatg ccccagaggt gacattcatg
     1201 tccttttcta accaagttcc agaggattca gtccttggaa cagtaatcgc cctcattaaa
     1261 gttcgagaca aagattctgg acaaaatggt ttggtggcat gccatattca ggaagaactt
     1321 cccttcaaat tacaacccac ctccaagaat tattacaagt tagtgattga caaggcccta
     1381 aaccgagaac agaccccaga gtacaacgtc actatcacag ctactgacag tggcaagccc
     1441 tcgctttcct ccaagacatg tgttactgta cacatcacag atatcaacga caatgcaccg
     1501 gtttttcacc aggcctccta cttggtccac gtggctgaga acaacccacc tggagcctct
     1561 attgctcaag tcagcgcctc agatccggat ttgggatcca atggcctcat ttcctactcc
     1621 atcatagcca gcgacctaga gccaagggca ctatcgtcct tcgtgtccgt gaaccaggac
     1681 agtggagtgg tgttcgcgca gcgcgccttc gaccacgagc agctgcgttc cttccagctg
     1741 acactgcagg cgcgggacca cggatcgccc acactcagtg ccaatgtgag catgcgcgtg
     1801 ttggtgggtg accgcaacga caacgcacca cgcgtgctgt atcccacact tgagcccgac
     1861 ggctctgcgc tcttcgacat ggtgccgcgc gctgccgagc ccggatacct ggtcaccaag
     1921 gtggtggctg tggacgcaga ctccggacac aatgcctggc tgtcttacca cgtgctgcag
     1981 gccagcgatc ccgggctctt cagcctggga ctgcgcacag gcgaggtgcg cacagcgcgt
     2041 gccctgggag acagggactc agcgcggcag cgccttctgg tcgctgtgcg tgatggtgga
     2101 cagccaccgc tctccgctac agccacgctg cacctcatct tcgctgacag cctgcaggag
     2161 gtcctgccag acctcagcga tgaccctcta ccatctgacc ctcagagtga gcttcagttt
     2221 tacctggtgg tggccttggc cctgatctca gtgctcttcc tcctggcggt gattctggct
     2281 attgccctgc gtctgagaca ctcctccaga tcagctgcct ggggctgctt tcagcctggc
     2341 ctcagcctga agtctcaacc tgtggttcct cccaactaca atgaggggac attaccctat
     2401 tcctataatc tctgcgttgc ttcacattct acgactatgg cagggtttaa ttttcaccac
     2461 gtggcaccag aggttgctcc ccctcaggat ctcctgtgcg atgatccttc tgtggttgta
     2521 tgtggcaata atgaagatcc ccaagtctcg gacgactctg ctttccagca agccccgccc
     2581 aacactgact ggcgtttctc tcaagcccag agacccggca cgagcggatc ccaaaatggt
     2641 gatgaaactg gcacctggcc caacaaccag tttgatacag agatgctgca agccatgatc
     2701 ttggcctctg ccagcgaagc tgctgatggg agctctaccc tgggaggggg cgctggcacc
     2761 atgggtctga gcgctcgata cggaccccag tttaccctgc agcacgtgcc tgactaccgc
     2821 cagaacgtgt acatccctgg cagcaatgcc acgctgacca atgccgctgg caaacgagat
     2881 ggcaaggctc cagcaggtgg taatggcaac aagaagaaat cgggcaagaa agagaagaag
     2941 taatatggag gccaggcctt gaaccacaag gcagcctccc tccccagcca gtccagctcg
     3001 tccttacttg tacccaggcc tcagaatttc agggctcacc ccaggatact ggtaggagcc
     3061 agggccatgc tccccgttgg gaaacagaaa cacgtgccca agccaacacc ccctctctat
     3121 accctaggga gttgaatatg caaagagagt tctgctggga cccccctatt caatcagtga
     3181 ttgtacccac atgggtagca gggtttgtgt gtgtggacat acacacacac acacacacac
     3241 acacacacaa accatgccac actcccttag ttacagctga actcctccat cttccaaccc
     3301 aggcaggctt atccatctcc tgccgccctc tccccacccc acccactcct tcagtccctc
     3361 tctttgagca aggtagctgg gctgttgggg tgaccggtga gctaagccgg ctcctagttc
     3421 tgaacggtag ggagagtatt acaatctttt ggcctctcct tcagttcagc tttcccccaa
     3481 agcatggttt ggtaccagtc ttctcttttc cttccagagc ctgagaccaa tgcttaagtt
     3541 ttgggggaac aggcaccctc cctctggtac tgatgatgct tgctggattt tgggaaggca
     3601 ttttgctact aagcctcttt tcaatgcctg gggacaacta gtcttttgtt tttcattgtt
     3661 tgatgttccc actgcatgct gtgacttccc tacacctcaa agaagagact cctttgcatg
     3721 tctggagaca gtagggggtg gtaaactaaa gggaagttga gagtgtatac tgctgggagt
     3781 ggggcagtgg acaaaacagc ctgttaatag ggtcttgcaa ggggctctgt atgtacccag
     3841 gggactggct caatcctcac attctagcca tagacaaaca ccaggccaga cccctccatt
     3901 ctggttcagc ctgggcagct tgggctgagc caccaggacc aatggattta agctgacatt
     3961 tcagtccaag acgacgactt ctaagtgagt ttaagaccag agaggaaaga ggggcctctg
     4021 tgggtgctgg gtactccaga ggtgcccttg gtgggaggac cagtggtctt agcaggaagg
     4081 ggggcccagc aaggtcattc ttggaccctg ggtctagtcc agtagctaga aaaagggacc
     4141 aagtggccat aaagtcccag ccaatgatgg ggcttttcca gtgggcccct gtagacctca
     4201 agcccctggc ctccacctta ccaggtgcca tttcttctca gaaggccact gcccaggccc
     4261 ccaggccgcc cccttgtggc cagagaacgg ttaaagcccc ccagtgcctc cttgtgcata
     4321 gaacttcctc tgccctagcc cttacagtag tgtagaagat ccccctcccc cgctggtgta
     4381 gaatagccaa tagtatagtg tggtgtgctt ttacgtgatg gcgagtgggc agcgggcggt
     4441 gggctgtaca cagccgtctg tcctttgaat ctcaatctgc ctgcgcggcc cgtgctgtgt
     4501 tttgtgctgt gtccacacgc tgcggcgacc cctccctgta ctgacttctc tataaaaagc
     4561 ttctcttcgc atagtcacgt agctcctgcc catccccctt ccgatatctc tcgcaagttt
     4621 tatactctaa tatttatatg gcttttttct tcgaaaatta aaaataaaaa aatggtttct
     4681 tctg
//
