LOCUS       NM_033592               4717 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 9 (Pcdhga9), mRNA.
ACCESSION   NM_033592
VERSION     NM_033592.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4717)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4717)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   3  (bases 1 to 4717)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   4  (bases 1 to 4717)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   5  (bases 1 to 4717)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   6  (bases 1 to 4717)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   7  (bases 1 to 4717)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   8  (bases 1 to 4717)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Nov 17, 2006 this sequence version replaced NM_033592.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079567.1, AY013803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2608              AC020971.3         167462-170069
            2609-2667           AC129315.3         25335-25393
            2668-2756           AC129315.3         33579-33667
            2757-4717           AC129315.3         40217-42177
FEATURES             Location/Qualifiers
     source          1..4717
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.6 cM"
     gene            1..4717
                     /gene="Pcdhga9"
                     /note="protocadherin gamma subfamily A, 9"
                     /db_xref="GeneID:93717"
                     /db_xref="MGI:MGI:1935226"
     exon            1..2608
                     /gene="Pcdhga9"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2983
                     /gene="Pcdhga9"
                     /codon_start=1
                     /product="protocadherin gamma-A9 precursor"
                     /protein_id="NP_291070.1"
                     /db_xref="CCDS:CCDS37783.1"
                     /db_xref="GeneID:93717"
                     /db_xref="MGI:MGI:1935226"
                     /translation="MAAAPARRPHCRELVVLCALLGMLWEARAGQIRYSVPEETEKGY
                     IVGNISKDLGLEPRELAERGVRIISKGKTQLFSLSPRSGSLVTAGRIDREELCAQSAT
                     CLLNFKVLVEDRVKLYGVEVEVVDINDNAPKFEAENLFVKISEIAAPGARYPLPEAVD
                     PDVGINSLQSYQLSPNRHFSLHLQTGDDGTINPELVLERTLDREEEPTHHLVLTAYDG
                     GNPRRSSTALIQVTVLDTNDNAPVFDQPVYRVKVLENVAPGTLLLTVRASDPDEGANG
                     KVTYKFRKINEKHSLLFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDGGGLKGRTKV
                     VVMVEDVNDNRPEVTITSLFSPVREDAPPGTVILLFNAHDQDSGKNGQVVCSIQENPS
                     FKLENSVDDYYRLLTAQILDREKASEYNITVTATDRGTPSMSTEVHITLYVADINDNP
                     PAFSQTSYSVYLPENNPRGTSIFSVSAHDPDDEENAKVTYSLVENTIQGAPLSSYVSI
                     NSDTGVLYALQSFDYEQFQNLQMQVKASDNGHPPLSSNVSLSVFLLDQNDNAPKILYP
                     SLPTDGSTGVELAPRSAEAGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFTVGLRS
                     GEIRTARALLERDALKQSLVVAVQDHGQPPLSATITLTVAVADSIPDILADLGSINTP
                     ADPDSDITLYLVVAVAVVSCVFLLFVLVLLALRLRRWHASHLLQDAMGGSTGVPTSHI
                     VGVHGVQTFLQTYSQEFSLTPDSGKSHLIFPQPNYADTLISQESCGKSEPLCSSVEPK
                     FPIDDTPLVPQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASA
                     SEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK
                     APAGGNGNKKKSGKKEKK"
     exon            2609..2667
                     /gene="Pcdhga9"
                     /inference="alignment:Splign:2.1.0"
     exon            2668..2756
                     /gene="Pcdhga9"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..4717
                     /gene="Pcdhga9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaagccctg cacatcctac aaactggctc cgggactaca gcaaaattca accttctaac
       61 ttgggatgct ctggctttct cctgaggaat aagtatcatc tgacagtttg aggaagaaaa
      121 gaagagccta aggagttagc gagcagaaag agcattctga gaaaattccg tagcaaaagc
      181 aacaatggct gctgcccccg ccagacgccc gcactgcaga gaactggtcg tcttgtgtgc
      241 actgctaggg atgctgtggg aggccagggc cgggcaaatc cgctattccg tgccagaaga
      301 gacagaaaag ggctatatag tgggaaacat ctctaaggac ctgggactgg agccccgtga
      361 gctggcagag cgcggagtcc gcatcatctc caaaggtaag acccagcttt tctctctgag
      421 tccgcggagc ggcagcttgg tcaccgcagg caggatagac cgggaggagc tgtgcgctca
      481 gagcgcgact tgtctcctaa actttaaagt cctagttgag gacagagtga aactttatgg
      541 ggtggaagta gaagtggttg atatcaatga caatgcgcca aaatttgagg ccgaaaattt
      601 gtttgtaaaa atcagtgaaa tcgctgcccc cggagcaagg tatccactcc cagaagcggt
      661 tgacccagat gtgggcataa actccctcca gagttaccag ctcagcccca atcgccactt
      721 ctctctccac ctgcaaactg gagacgacgg aactataaac ccagagctgg tgctggagcg
      781 caccctggac cgagaggaag aacccactca ccacctggtc ctcaccgcct acgatggcgg
      841 caacccacgc cgctccagca cagcgctcat ccaggtcaca gtgttggata ctaacgataa
      901 tgcccctgtt ttcgaccaac cggtttaccg cgtgaaagtc cttgagaatg tggccccggg
      961 caccctgctg ctcacagtga gagctagcga cccggatgag ggtgccaatg ggaaggtgac
     1021 atacaaattc cggaaaatta atgaaaagca ttcgctgttg tttcatcttc atgaaaacac
     1081 tggggaaatg acagtagcga aaaatctgga ctatgaagaa tgttcgttgt atgaaatgga
     1141 aatacaggct gaagatggtg ggggactgaa agggcggacc aaagtggtag ttatggtaga
     1201 agatgtaaat gacaatcggc cggaagtgac cattacctct ctgtttagcc cagtaaggga
     1261 agatgcgccc ccagggacag taatcctcct tttcaatgct catgaccaag attctgggaa
     1321 gaatgggcaa gttgtctgtt ccatccagga gaacccatcc tttaaattag aaaactcagt
     1381 agacgattac tataggttgt tgacagccca gatccttgat cgagaaaagg cttctgagta
     1441 taacatcaca gtgacagcaa cagacagggg aaccccatcc atgtccacag aagttcacat
     1501 caccctgtat gtggctgaca tcaatgacaa tcctcctgcc ttctctcaaa cctcctactc
     1561 agtctatctc cccgaaaaca accccagagg cacctccatc ttctcagtta gcgcccatga
     1621 ccctgacgac gaggagaatg ctaaggttac ttactctttg gtggaaaaca ccatccaggg
     1681 ggcaccactc tcctcctacg tctccattaa ttctgacact ggcgtgctct atgctctgca
     1741 atcctttgac tatgagcagt ttcaaaacct tcaaatgcag gtgaaggcga gtgacaacgg
     1801 gcacccgcca ctcagcagca atgtgtccct gtctgtgttt ctattggatc agaatgacaa
     1861 tgctcccaag atcctgtatc cctccctccc gactgacggt tccactggtg tggaactggc
     1921 tccccgctca gcagaggctg ggtatctggt gaccaaggtg gtggcagtgg acaaagactc
     1981 tggacagaat gcttggttgt cttaccgtct gctcaaagct agtgagccag gacttttcac
     2041 agtggggcta cgctcaggcg aaatacgcac agctcgggcc ctgctagaga gagatgcact
     2101 caagcaaagc ctcgtggtag ctgtgcagga ccatggccag ccacctcttt cagctaccat
     2161 cactctcaca gtggctgtgg cagacagcat ccctgacatc ctagctgact tgggcagtat
     2221 caacactcct gcagaccccg attctgacat tactctctac ctggtggtag cagttgctgt
     2281 ggtctcctgt gtcttcctac tctttgtgct agtgctgctg gcccttaggc tacggcgctg
     2341 gcatgcttcg cacctgctgc aggatgcaat gggcggatcc actggggtac caacatcaca
     2401 tattgtgggt gtgcatgggg ttcagacttt cctacaaacc tattctcaag agttttccct
     2461 cacacctgac tctgggaaga gccacctgat cttcccccag cccaactacg cagacacact
     2521 catcagccag gagagctgtg ggaagagtga acctctgtgc agttcagttg agcccaagtt
     2581 tcctattgat gacactcctt tggttcctca agccccgccc aacactgact ggcgtttctc
     2641 tcaagcccag agacccggca cgagcggatc ccaaaatggt gatgaaactg gcacctggcc
     2701 caacaaccag tttgatacag agatgctgca agccatgatc ttggcctctg ccagcgaagc
     2761 tgctgatggg agctctaccc tgggaggggg cgctggcacc atgggtctga gcgctcgata
     2821 cggaccccag tttaccctgc agcacgtgcc tgactaccgc cagaacgtgt acatccctgg
     2881 cagcaatgcc acgctgacca atgccgctgg caaacgagat ggcaaggctc cagcaggtgg
     2941 taatggcaac aagaagaaat cgggcaagaa agagaagaag taatatggag gccaggcctt
     3001 gaaccacaag gcagcctccc tccccagcca gtccagctcg tccttacttg tacccaggcc
     3061 tcagaatttc agggctcacc ccaggatact ggtaggagcc agggccatgc tccccgttgg
     3121 gaaacagaaa cacgtgccca agccaacacc ccctctctat accctaggga gttgaatatg
     3181 caaagagagt tctgctggga cccccctatt caatcagtga ttgtacccac atgggtagca
     3241 gggtttgtgt gtgtggacat acacacacac acacacacac acacacacaa accatgccac
     3301 actcccttag ttacagctga actcctccat cttccaaccc aggcaggctt atccatctcc
     3361 tgccgccctc tccccacccc acccactcct tcagtccctc tctttgagca aggtagctgg
     3421 gctgttgggg tgaccggtga gctaagccgg ctcctagttc tgaacggtag ggagagtatt
     3481 acaatctttt ggcctctcct tcagttcagc tttcccccaa agcatggttt ggtaccagtc
     3541 ttctcttttc cttccagagc ctgagaccaa tgcttaagtt ttgggggaac aggcaccctc
     3601 cctctggtac tgatgatgct tgctggattt tgggaaggca ttttgctact aagcctcttt
     3661 tcaatgcctg gggacaacta gtcttttgtt tttcattgtt tgatgttccc actgcatgct
     3721 gtgacttccc tacacctcaa agaagagact cctttgcatg tctggagaca gtagggggtg
     3781 gtaaactaaa gggaagttga gagtgtatac tgctgggagt ggggcagtgg acaaaacagc
     3841 ctgttaatag ggtcttgcaa ggggctctgt atgtacccag gggactggct caatcctcac
     3901 attctagcca tagacaaaca ccaggccaga cccctccatt ctggttcagc ctgggcagct
     3961 tgggctgagc caccaggacc aatggattta agctgacatt tcagtccaag acgacgactt
     4021 ctaagtgagt ttaagaccag agaggaaaga ggggcctctg tgggtgctgg gtactccaga
     4081 ggtgcccttg gtgggaggac cagtggtctt agcaggaagg ggggcccagc aaggtcattc
     4141 ttggaccctg ggtctagtcc agtagctaga aaaagggacc aagtggccat aaagtcccag
     4201 ccaatgatgg ggcttttcca gtgggcccct gtagacctca agcccctggc ctccacctta
     4261 ccaggtgcca tttcttctca gaaggccact gcccaggccc ccaggccgcc cccttgtggc
     4321 cagagaacgg ttaaagcccc ccagtgcctc cttgtgcata gaacttcctc tgccctagcc
     4381 cttacagtag tgtagaagat ccccctcccc cgctggtgta gaatagccaa tagtatagtg
     4441 tggtgtgctt ttacgtgatg gcgagtgggc agcgggcggt gggctgtaca cagccgtctg
     4501 tcctttgaat ctcaatctgc ctgcgcggcc cgtgctgtgt tttgtgctgt gtccacacgc
     4561 tgcggcgacc cctccctgta ctgacttctc tataaaaagc ttctcttcgc atagtcacgt
     4621 agctcctgcc catccccctt ccgatatctc tcgcaagttt tatactctaa tatttatatg
     4681 gcttttttct tcgaaaatta aaaataaaaa aatggtt
//
