LOCUS       NP_291070                932 aa            linear   ROD 04-AUG-2023
DEFINITION  protocadherin gamma-A9 precursor [Mus musculus].
ACCESSION   NP_291070
VERSION     NP_291070.1
DBSOURCE    REFSEQ: accession NM_033592.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 932)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 932)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   3  (residues 1 to 932)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   4  (residues 1 to 932)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   5  (residues 1 to 932)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   6  (residues 1 to 932)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   7  (residues 1 to 932)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   8  (residues 1 to 932)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079567.1, AY013803.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.6 cM"
     Protein         1..932
                     /product="protocadherin gamma-A9 precursor"
                     /calculated_mol_wt=98020
     sig_peptide     1..29
                     /inference="COORDINATES: ab initio prediction:SignalP:4.0"
                     /calculated_mol_wt=3206
     Region          31..113
                     /region_name="Cadherin_2"
                     /note="Cadherin-like; pfam08266"
                     /db_xref="CDD:462413"
     Region          140..239
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(145..146,202,204,235,237..238)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          247..344
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(254..255,309,311,340,342..343)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          357..449
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(359..360,412,414,445,447..448)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          457..559
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(464..465,522,524,555,557..558)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          580..667
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          688..772
                     /region_name="Cadherin_C_2"
                     /note="Cadherin cytoplasmic C-terminal; pfam16492"
                     /db_xref="CDD:465139"
     Region          811..>905
                     /region_name="Cadherin_tail"
                     /note="Cadherin C-terminal cytoplasmic tail,
                     catenin-binding region; pfam15974"
                     /db_xref="CDD:435046"
     CDS             1..932
                     /gene="Pcdhga9"
                     /coded_by="NM_033592.3:185..2983"
                     /db_xref="CCDS:CCDS37783.1"
                     /db_xref="GeneID:93717"
                     /db_xref="MGI:MGI:1935226"
ORIGIN      
        1 maaaparrph crelvvlcal lgmlwearag qirysvpeet ekgyivgnis kdlgleprel
       61 aergvriisk gktqlfslsp rsgslvtagr idreelcaqs atcllnfkvl vedrvklygv
      121 evevvdindn apkfeaenlf vkiseiaapg aryplpeavd pdvginslqs yqlspnrhfs
      181 lhlqtgddgt inpelvlert ldreeepthh lvltaydggn prrsstaliq vtvldtndna
      241 pvfdqpvyrv kvlenvapgt llltvrasdp degangkvty kfrkinekhs llfhlhentg
      301 emtvaknldy eecslyemei qaedggglkg rtkvvvmved vndnrpevti tslfspvred
      361 appgtvillf nahdqdsgkn gqvvcsiqen psfklensvd dyyrlltaqi ldrekaseyn
      421 itvtatdrgt psmstevhit lyvadindnp pafsqtsysv ylpennprgt sifsvsahdp
      481 ddeenakvty slventiqga plssyvsins dtgvlyalqs fdyeqfqnlq mqvkasdngh
      541 pplssnvsls vflldqndna pkilypslpt dgstgvelap rsaeagylvt kvvavdkdsg
      601 qnawlsyrll kasepglftv glrsgeirta rallerdalk qslvvavqdh gqpplsatit
      661 ltvavadsip diladlgsin tpadpdsdit lylvvavavv scvfllfvlv llalrlrrwh
      721 ashllqdamg gstgvptshi vgvhgvqtfl qtysqefslt pdsgkshlif pqpnyadtli
      781 sqescgksep lcssvepkfp iddtplvpqa ppntdwrfsq aqrpgtsgsq ngdetgtwpn
      841 nqfdtemlqa milasaseaa dgsstlggga gtmglsaryg pqftlqhvpd yrqnvyipgs
      901 natltnaagk rdgkapaggn gnkkksgkke kk
//
