LOCUS       NM_033591               4730 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 8 (Pcdhga8), mRNA.
ACCESSION   NM_033591
VERSION     NM_033591.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4730)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4730)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   3  (bases 1 to 4730)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   4  (bases 1 to 4730)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   5  (bases 1 to 4730)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   6  (bases 1 to 4730)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   7  (bases 1 to 4730)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   8  (bases 1 to 4730)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Nov 17, 2006 this sequence version replaced NM_033591.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054787.1, AK220461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2611              AC020971.3         156232-158842
            2612-2670           AC129315.3         25335-25393
            2671-2759           AC129315.3         33579-33667
            2760-4730           AC129315.3         40217-42187
FEATURES             Location/Qualifiers
     source          1..4730
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.59 cM"
     gene            1..4730
                     /gene="Pcdhga8"
                     /gene_synonym="mKIAA4054"
                     /note="protocadherin gamma subfamily A, 8"
                     /db_xref="GeneID:93716"
                     /db_xref="MGI:MGI:1935221"
     exon            1..2611
                     /gene="Pcdhga8"
                     /gene_synonym="mKIAA4054"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2986
                     /gene="Pcdhga8"
                     /gene_synonym="mKIAA4054"
                     /codon_start=1
                     /product="protocadherin gamma-A8 precursor"
                     /protein_id="NP_291069.1"
                     /db_xref="CCDS:CCDS37782.1"
                     /db_xref="GeneID:93716"
                     /db_xref="MGI:MGI:1935221"
                     /translation="MAASKNQHRHGRLVLLCTLMGTLCKISVGQIRYSVPEETDKGTV
                     VGNISKDLGLEPRELAERGVRIVSRGRSQLFSLNPRGGSLVTAGRIDREELCAQSTPC
                     LVNINILVEEKGKLFGVEIEITDINDNNPKFHVGDLEVKINEIAAPGARYPLPEAVDP
                     DVGINSLQSYQLSPNRHFSLHLQTGDDGTINPELVLERTLDREEEPTHHLVLTASDGG
                     EPRRSSTALIQITVLDTNDNAPVFDQPVYRVKVLENVAPGTLLLTVRASDPDEGVNGK
                     VTYKFRKINEKQSLLFHLHENTGEMTVAKNLDYEECSLYEMEIQAEDVGALLGRSKVI
                     IMVEDVNDNRPEVTITSLFNPVLENSLPGTVIAFLNVHDQDSGKNGQVVCYTHDNLPF
                     KLEKSIDNYYRLVTWKYLDREKVSTYNITVIASDLGAPPLSTETYIALTVADTNDNPP
                     RFSHTSYTAYLPENNLRGASIFSLTAHDPDSQENAQVTYSVSEDTIQGVPLSSYISIN
                     SDTGILYALQSFDFEKIQDLQLLVIATDSGSPPLSSNVSLSLFVLDQNDNAPEILYPS
                     FPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTG
                     EVRTARALLDRDALKQNLVMAVQDHGQPPLSATVTLTVAVANSIPEVLADLSSIMTPE
                     VPEDSDLTLHLVVAVAVVSCVFLVFVIVLLALRLQRWQKSRQLQGSRSGLAPAPPSHF
                     VGIDGVQAFLQTYSHEVSLTSGSQTSHIIFPQPNYADMLINQESCEKNDSLLTSIDFH
                     ENKDEDACAPQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASA
                     SEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK
                     APAGGNGNKKKSGKKEKK"
     exon            2612..2670
                     /gene="Pcdhga8"
                     /gene_synonym="mKIAA4054"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2759
                     /gene="Pcdhga8"
                     /gene_synonym="mKIAA4054"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..4730
                     /gene="Pcdhga8"
                     /gene_synonym="mKIAA4054"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcgaattct caaggctgat gaaatcagac cggcagattc cggagtccaa ctgcgtaact
       61 gcggagacat tctgtcccta aatgtgtgac tctccagctt tccgtaagat tatttccgtc
      121 gccacaagcg aaggtaatcc agccacctat gcccggtgaa gactgaggat tcttttgcaa
      181 atgaacaatg gctgcttcca agaatcaaca caggcatggc cggctggtgc tgctgtgtac
      241 gctgatgggg acgctgtgca agatcagcgt aggacagatt cgctactccg tgccagaaga
      301 gacagacaaa ggcactgtcg tgggcaacat ctccaaggac ctggggctgg agccccgcga
      361 gctggcggag cgcggggtcc gtatcgtctc cagaggtagg tcgcagcttt tctccctgaa
      421 tccgcggggc ggcagcttgg tcaccgcagg caggatagac cgggaggagc tgtgcgctca
      481 gagcacgcct tgtcttgtaa atatcaacat cctagttgag gagaaaggaa aactctttgg
      541 ggtagaaatt gaaataactg atattaacga taataatccg aagttccatg ttggagatct
      601 ggaggtgaaa attaatgaaa tcgctgcccc tggagcacgg tatccactcc cagaagcggt
      661 tgacccagat gtgggcataa actccctcca gagttaccag ctcagcccca atcgccactt
      721 ctctctccac ctgcaaactg gagacgacgg aactataaac ccagagctgg tgctagagcg
      781 cactctggac cgagaggaag aacccactca ccacctggtc ctcacggcct ccgatggcgg
      841 cgagccacgc cgctccagca cagcgcttat ccagatcaca gtgttggata ctaacgacaa
      901 tgcccctgtt tttgaccaac cggtttaccg cgtgaaagtc cttgagaatg tggccccagg
      961 caccctgctg ctcacagtaa gagctagcga cccggatgag ggcgtcaatg ggaaggtgac
     1021 atacaaattc cggaaaatta atgaaaagca gtcgctgttg ttccatcttc atgaaaacac
     1081 gggagaaatg acagtagcga aaaatctgga ctatgaagaa tgttcattgt atgaaatgga
     1141 aatacaggct gaagacgtag gggcgcttct ggggaggagc aaagtgataa ttatggtaga
     1201 agatgtaaat gacaatcggc cagaagtaac cattacatcc ttgtttaatc cggtattgga
     1261 aaattctctt cctggaacag taatcgcctt cttgaatgta catgaccaag actctggaaa
     1321 gaacggccaa gttgtctgtt acacgcatga taacttaccc tttaaactag aaaagtcaat
     1381 agataattat tatagattgg taacatggaa atacttggac cgagaaaaag tctctaccta
     1441 caatatcacg gtgatagctt cggacctagg agccccacct ctgtctactg aaacttatat
     1501 tgccctgact gtggcagaca ctaatgacaa ccctcctcgt ttttctcaca cttcctacac
     1561 agcctatctc ccagagaaca acctgagagg tgcctccatc ttctcattga ctgcacatga
     1621 ccctgacagc caggagaatg cccaggtcac ttactctgtg tctgaggaca ctatacaggg
     1681 agtgcctttg tcctcttaca tctccatcaa ctctgacact ggcatcctgt acgcactgca
     1741 atcttttgac tttgagaaga tacaagactt gcagctattg gttattgcca ctgacagtgg
     1801 aagcccacct ctcagcagca atgtgtccct gagcttgttt gtgttggacc agaatgacaa
     1861 tgcacctgag atcctatacc ccagcttccc cacagatggt tccactggcg tagaattagc
     1921 gccccgctct gcagagcctg gatacctggt gaccaaagtg gtggcagtgg acaaagactc
     1981 gggacagaat gcttggctgt cctaccgtct gctcaaggcc agcgaacctg ggctcttctc
     2041 tgtagggctt cacacgggtg aggtgcgtac agcgagggcc ctgctggaca gagatgctct
     2101 caaacagaac ctggtgatgg ctgtgcagga ccatggccag cctcctctct cagccactgt
     2161 aactctcact gtggccgtgg ctaacagcat ccctgaagtg ttggctgact tgagcagcat
     2221 tatgacccct gaggtaccag aggattctga tctcacgctc cacctggtgg tggcagtggc
     2281 tgtggtctcc tgtgtcttcc ttgtctttgt cattgtcctc ctagctctca gacttcagcg
     2341 ctggcagaag tctcgccagc tccagggctc cagaagtgga ttggcccctg cacctccatc
     2401 acattttgtg ggcattgacg gggtacaagc ttttctacaa acctattctc atgaagtctc
     2461 actcacttca ggctcccaga caagccacat tatctttccg cagcccaact atgcagacat
     2521 gctcattaac caagaaagct gtgagaaaaa tgattcctta ttaacatcca tagatttcca
     2581 tgagaataag gatgaagatg cttgcgctcc gcaagccccg cccaacactg actggcgttt
     2641 ctctcaagcc cagagacccg gcacgagcgg atcccaaaat ggtgatgaaa ctggcacctg
     2701 gcccaacaac cagtttgata cagagatgct gcaagccatg atcttggcct ctgccagcga
     2761 agctgctgat gggagctcta ccctgggagg gggcgctggc accatgggtc tgagcgctcg
     2821 atacggaccc cagtttaccc tgcagcacgt gcctgactac cgccagaacg tgtacatccc
     2881 tggcagcaat gccacgctga ccaatgccgc tggcaaacga gatggcaagg ctccagcagg
     2941 tggtaatggc aacaagaaga aatcgggcaa gaaagagaag aagtaatatg gaggccaggc
     3001 cttgaaccac aaggcagcct ccctccccag ccagtccagc tcgtccttac ttgtacccag
     3061 gcctcagaat ttcagggctc accccaggat actggtagga gccagggcca tgctccccgt
     3121 tgggaaacag aaacacgtgc ccaagccaac accccctctc tataccctag ggagttgaat
     3181 atgcaaagag agttctgctg ggacccccct attcaatcag tgattgtacc cacatgggta
     3241 gcagggtttg tgtgtgtgga catacacaca cacacacaca cacacacaca caaaccatgc
     3301 cacactccct tagttacagc tgaactcctc catcttccaa cccaggcagg cttatccatc
     3361 tcctgccgcc ctctccccac cccacccact ccttcagtcc ctctctttga gcaaggtagc
     3421 tgggctgttg gggtgaccgg tgagctaagc cggctcctag ttctgaacgg tagggagagt
     3481 attacaatct tttggcctct ccttcagttc agctttcccc caaagcatgg tttggtacca
     3541 gtcttctctt ttccttccag agcctgagac caatgcttaa gttttggggg aacaggcacc
     3601 ctccctctgg tactgatgat gcttgctgga ttttgggaag gcattttgct actaagcctc
     3661 ttttcaatgc ctggggacaa ctagtctttt gtttttcatt gtttgatgtt cccactgcat
     3721 gctgtgactt ccctacacct caaagaagag actcctttgc atgtctggag acagtagggg
     3781 gtggtaaact aaagggaagt tgagagtgta tactgctggg agtggggcag tggacaaaac
     3841 agcctgttaa tagggtcttg caaggggctc tgtatgtacc caggggactg gctcaatcct
     3901 cacattctag ccatagacaa acaccaggcc agacccctcc attctggttc agcctgggca
     3961 gcttgggctg agccaccagg accaatggat ttaagctgac atttcagtcc aagacgacga
     4021 cttctaagtg agtttaagac cagagaggaa agaggggcct ctgtgggtgc tgggtactcc
     4081 agaggtgccc ttggtgggag gaccagtggt cttagcagga aggggggccc agcaaggtca
     4141 ttcttggacc ctgggtctag tccagtagct agaaaaaggg accaagtggc cataaagtcc
     4201 cagccaatga tggggctttt ccagtgggcc cctgtagacc tcaagcccct ggcctccacc
     4261 ttaccaggtg ccatttcttc tcagaaggcc actgcccagg cccccaggcc gcccccttgt
     4321 ggccagagaa cggttaaagc cccccagtgc ctccttgtgc atagaacttc ctctgcccta
     4381 gcccttacag tagtgtagaa gatccccctc ccccgctggt gtagaatagc caatagtata
     4441 gtgtggtgtg cttttacgtg atggcgagtg ggcagcgggc ggtgggctgt acacagccgt
     4501 ctgtcctttg aatctcaatc tgcctgcgcg gcccgtgctg tgttttgtgc tgtgtccaca
     4561 cgctgcggcg acccctccct gtactgactt ctctataaaa agcttctctt cgcatagtca
     4621 cgtagctcct gcccatcccc cttccgatat ctctcgcaag ttttatactc taatatttat
     4681 atggcttttt tcttcgaaaa ttaaaaataa aaaaatggtt tcttctgaaa
//
