LOCUS       NM_033590               4660 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 7 (Pcdhga7), mRNA.
ACCESSION   NM_033590
VERSION     NM_033590.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4660)
  AUTHORS   Xu L, Zheng Y, Li X, Wang A, Huo D, Li Q, Wang S, Luo Z, Liu Y, Xu
            F, Wu X, Wu M and Zhou Y.
  TITLE     Abnormal neocortex arealization and Sotos-like syndrome-associated
            behavior in Setd2 mutant mice
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523829
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4660)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4660)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 4660)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   5  (bases 1 to 4660)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   6  (bases 1 to 4660)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   7  (bases 1 to 4660)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   8  (bases 1 to 4660)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4660)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4660)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Nov 17, 2006 this sequence version replaced NM_033590.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC077712.1, AY013801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2541              AC020971.3         145360-147900
            2542-2600           AC129315.3         25335-25393
            2601-2689           AC129315.3         33579-33667
            2690-4660           AC129315.3         40217-42187
FEATURES             Location/Qualifiers
     source          1..4660
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.58 cM"
     gene            1..4660
                     /gene="Pcdhga7"
                     /note="protocadherin gamma subfamily A, 7"
                     /db_xref="GeneID:93715"
                     /db_xref="MGI:MGI:1935219"
     exon            1..2541
                     /gene="Pcdhga7"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2916
                     /gene="Pcdhga7"
                     /codon_start=1
                     /product="protocadherin gamma-A7 precursor"
                     /protein_id="NP_291068.2"
                     /db_xref="CCDS:CCDS79629.1"
                     /db_xref="GeneID:93715"
                     /db_xref="MGI:MGI:1935219"
                     /translation="MAPGQRGWGSHYRGFVLLSILLGMRWEAWAGQILYSVSEETDKG
                     SFVGNITKDLGLQPRELAERGVRIITKGKTQLFSLNPRSGSLVTAGRIDREELCAQSP
                     RCLVSFNILIEDKMNLYPIEVEIMDVNDNAPRFLTEEINIKIMENAAPGVRFPLKEAT
                     DSDVGKNSLQRYQLSPNHHFSLVVQSGDDGTKYPELVLEKALDREEEGLHHLVLTAYD
                     GGDPLRSGTASIRVTVVDVNDHTPVFSLPLYQATVPENVPVGTRLLTVNAIDLDEGIY
                     GEVTYSFWKITPELLQIFHLSSLTGELSTLKGLDYEQSSFYELEVQAQDGAGSLTKAK
                     VLITVLDVNDNAPEVTVTSVSSPVPEDTPPGTVIALFYLQDKDSGKNGEVTCSLPENL
                     PFKLERSIDNYYRLVTARNLDREKMSVYNITLKATDGGIPPLSTETRMSIHVSDTNDN
                     PPTFSDSSYSIYVPENNPRGASIFSVTAQDPDSDKNAQVTYALAEDTIQGVPVSSYVS
                     INSDTGILYALGSFDYEQFRDLQLRVTARDSGDPPLSSNVSLKLFVLDKNDNAPEILY
                     PALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGPNAWLSYRLLKASEPGLFSVGLH
                     TGEVRTARALLDRDALKQNLVVVVQDHGQPPLSATVTLTVAVANSIPDVLADLGSIRT
                     PSEPDDSDITLYLVVAVATVSCVFLVFVTVLLALRLWRWHKSHMLQASSGGGLEDVPA
                     SHFVGLDGVQAFLQTYSHEVSLTADSRKSHIIFPQPNYVDTLISQDSCEKSDSLLTSI
                     DFQECKGEAPSSQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMIL
                     ASASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKR
                     DGKAPAGGNGNKKKSGKKEKK"
     exon            2542..2600
                     /gene="Pcdhga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2689
                     /gene="Pcdhga7"
                     /inference="alignment:Splign:2.1.0"
     exon            2690..4660
                     /gene="Pcdhga7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggattccc ggcttccctt ccgcacactg gggtcctggc ggacacaact gggttctgag
       61 gcaccttcca agacctctca gggtgtgagc gagatcctca gggcagcaat ggcgcctgga
      121 cagagaggct ggggctcgca ctacagagga tttgtgctgc tctccattct cctggggatg
      181 cggtgggaag cctgggcagg acagattctc tactccgtgt ctgaagagac agacaaggga
      241 tcttttgtgg gaaatatcac caaggatctg ggactgcagc ctcgggagct ggcggagcgc
      301 ggggtccgca tcatcaccaa aggtaagacc cagcttttct ctctgaaccc gcggagcggc
      361 agcctggtca ccgcgggcag gatagatcgg gaggagctgt gcgctcagag cccgcgatgt
      421 ctcgtgagct ttaacatctt gatagaagac aagatgaatc tttaccctat agaggtggaa
      481 ataatggatg ttaatgacaa cgctcccaga ttcttaacag aagaaataaa cataaaaatt
      541 atggagaatg cagctcctgg ggtgcggttt ccactaaagg aagctacaga ttcagacgtg
      601 ggcaagaact ccctccagag ataccagctc agccccaatc accatttctc cctggttgtg
      661 caaagtggag atgatggcac caagtaccca gaactggtgc tggagaaggc tcttgatcgg
      721 gaagaagagg ggcttcacca tctggtcctc acagcctatg atggcgggga cccgctccga
      781 tctggcactg ccagcatccg cgtgacagtg gtggatgtga atgatcacac gccagtcttc
      841 tctctacccc tgtatcaagc gacagtccct gagaacgtgc cagtaggcac aagacttctc
      901 actgtaaatg ctatcgactt ggatgaggga atctatgggg aagtgactta ttctttctgg
      961 aaaataactc cagaacttct acaaatattc catctgagct ccctgacagg agagctgtcg
     1021 actttaaaag gtctagatta tgagcaatcc agcttctatg agctggaagt tcaagctcaa
     1081 gatggtgctg gcagtctgac caaggcaaaa gtactgatca cagttttgga tgtgaatgac
     1141 aatgccccag aagtgactgt cacatctgtg agcagcccag tccctgaaga cacgccacct
     1201 gggacagtga tcgctctctt ctacctccaa gacaaagatt cggggaagaa tggtgaggtg
     1261 acctgctctt tgccagaaaa cctgcctttt aagttagagc gatcaattga taattattac
     1321 aggttggtca cagcacgaaa cctggaccgg gaaaagatgt ctgtgtacaa catcacactg
     1381 aaggccacag atggtggaat ccctcccctg tccactgaaa ctcgcatgtc cattcatgtg
     1441 tcagacacca acgacaaccc acccaccttt tccgactctt cttactctat ctacgtcccg
     1501 gagaacaatc ccagaggagc ctccatcttc tcggtgactg cacaagaccc ggacagtgac
     1561 aagaatgccc aagtcactta cgctttagca gaagacacca tccagggggt accggtgtcg
     1621 tcctacgtct ccatcaactc tgacacgggt atcctatatg cacttggatc cttcgactat
     1681 gagcaatttc gggatctaca acttcgagtg actgctcgtg acagtgggga cccacctctc
     1741 agcagtaatg tgtcactgaa actctttgtg ctggacaaga atgataacgc ccctgagatc
     1801 ctgtaccctg ccctgcccac tgatggctcc acaggggtgg agctggctcc ccgctctgca
     1861 gaacctggat acctagtgac caaggtggta gctgtggaca aagactcagg cccaaatgct
     1921 tggctgtcct accgcctgct taaagccagt gagccagggc ttttctcagt agggctacac
     1981 actggtgagg tgcgcacagc aagagccctg ctggacagag atgcgctgaa acagaacctt
     2041 gtggtggttg tacaggacca tggccaaccc ccactctcag ccactgtgac actcactgtg
     2101 gctgtggcca acagcattcc tgatgtccta gcagacctag gcagcattag gacccccagt
     2161 gaacctgatg attcagatat caccctctac ctggtggtgg cagtggccac tgtttcctgt
     2221 gttttccttg tctttgtcac tgtgttattg gctctcaggc tgtggcgttg gcacaaatca
     2281 cacatgctac aggcttcttc aggtggtggc ctggaagatg tgcctgcctc acactttgta
     2341 ggtttggacg gtgtccaggc tttcctacaa acatattccc atgaggtttc actcactgca
     2401 gactctcgaa aaagccacat tatcttccct cagcccaatt acgtggatac acttatcagc
     2461 caagatagct gtgagaaaag tgattctttg ttaacatcca tagattttca agaatgtaag
     2521 ggtgaagccc caagttccca gcaagccccg cccaacactg actggcgttt ctctcaagcc
     2581 cagagacccg gcacgagcgg atcccaaaat ggtgatgaaa ctggcacctg gcccaacaac
     2641 cagtttgata cagagatgct gcaagccatg atcttggcct ctgccagcga agctgctgat
     2701 gggagctcta ccctgggagg gggcgctggc accatgggtc tgagcgctcg atacggaccc
     2761 cagtttaccc tgcagcacgt gcctgactac cgccagaacg tgtacatccc tggcagcaat
     2821 gccacgctga ccaatgccgc tggcaaacga gatggcaagg ctccagcagg tggtaatggc
     2881 aacaagaaga aatcgggcaa gaaagagaag aagtaatatg gaggccaggc cttgaaccac
     2941 aaggcagcct ccctccccag ccagtccagc tcgtccttac ttgtacccag gcctcagaat
     3001 ttcagggctc accccaggat actggtagga gccagggcca tgctccccgt tgggaaacag
     3061 aaacacgtgc ccaagccaac accccctctc tataccctag ggagttgaat atgcaaagag
     3121 agttctgctg ggacccccct attcaatcag tgattgtacc cacatgggta gcagggtttg
     3181 tgtgtgtgga catacacaca cacacacaca cacacacaca caaaccatgc cacactccct
     3241 tagttacagc tgaactcctc catcttccaa cccaggcagg cttatccatc tcctgccgcc
     3301 ctctccccac cccacccact ccttcagtcc ctctctttga gcaaggtagc tgggctgttg
     3361 gggtgaccgg tgagctaagc cggctcctag ttctgaacgg tagggagagt attacaatct
     3421 tttggcctct ccttcagttc agctttcccc caaagcatgg tttggtacca gtcttctctt
     3481 ttccttccag agcctgagac caatgcttaa gttttggggg aacaggcacc ctccctctgg
     3541 tactgatgat gcttgctgga ttttgggaag gcattttgct actaagcctc ttttcaatgc
     3601 ctggggacaa ctagtctttt gtttttcatt gtttgatgtt cccactgcat gctgtgactt
     3661 ccctacacct caaagaagag actcctttgc atgtctggag acagtagggg gtggtaaact
     3721 aaagggaagt tgagagtgta tactgctggg agtggggcag tggacaaaac agcctgttaa
     3781 tagggtcttg caaggggctc tgtatgtacc caggggactg gctcaatcct cacattctag
     3841 ccatagacaa acaccaggcc agacccctcc attctggttc agcctgggca gcttgggctg
     3901 agccaccagg accaatggat ttaagctgac atttcagtcc aagacgacga cttctaagtg
     3961 agtttaagac cagagaggaa agaggggcct ctgtgggtgc tgggtactcc agaggtgccc
     4021 ttggtgggag gaccagtggt cttagcagga aggggggccc agcaaggtca ttcttggacc
     4081 ctgggtctag tccagtagct agaaaaaggg accaagtggc cataaagtcc cagccaatga
     4141 tggggctttt ccagtgggcc cctgtagacc tcaagcccct ggcctccacc ttaccaggtg
     4201 ccatttcttc tcagaaggcc actgcccagg cccccaggcc gcccccttgt ggccagagaa
     4261 cggttaaagc cccccagtgc ctccttgtgc atagaacttc ctctgcccta gcccttacag
     4321 tagtgtagaa gatccccctc ccccgctggt gtagaatagc caatagtata gtgtggtgtg
     4381 cttttacgtg atggcgagtg ggcagcgggc ggtgggctgt acacagccgt ctgtcctttg
     4441 aatctcaatc tgcctgcgcg gcccgtgctg tgttttgtgc tgtgtccaca cgctgcggcg
     4501 acccctccct gtactgactt ctctataaaa agcttctctt cgcatagtca cgtagctcct
     4561 gcccatcccc cttccgatat ctctcgcaag ttttatactc taatatttat atggcttttt
     4621 tcttcgaaaa ttaaaaataa aaaaatggtt tcttctgaaa
//
