LOCUS       NM_033589               4668 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 6 (Pcdhga6), mRNA.
ACCESSION   NM_033589
VERSION     NM_033589.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4668)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4668)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 4668)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   4  (bases 1 to 4668)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   5  (bases 1 to 4668)
  AUTHORS   Dallosso AR, Hancock AL, Szemes M, Moorwood K, Chilukamarri L, Tsai
            HH, Sarkar A, Barasch J, Vuononvirta R, Jones C, Pritchard-Jones K,
            Royer-Pokora B, Lee SB, Owen C, Malik S, Feng Y, Frank M, Ward A,
            Brown KW and Malik K.
  TITLE     Frequent long-range epigenetic silencing of protocadherin gene
            clusters on chromosome 5q31 in Wilms' tumor
  JOURNAL   PLoS Genet 5 (11), e1000745 (2009)
   PUBMED   19956686
  REMARK    Erratum:[PLoS Genet. 2009 Dec;5(12). doi:
            10.1371/annotation/012d5a44-8239-4057-8c3b-3dc159ea3a02]
REFERENCE   6  (bases 1 to 4668)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   7  (bases 1 to 4668)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   8  (bases 1 to 4668)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4668)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4668)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 22, 2019 this sequence version replaced NM_033589.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013800.1, BC059927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2552              AC020971.3         137627-140178
            2553-2611           AC129315.3         25335-25393
            2612-2700           AC129315.3         33579-33667
            2701-4668           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.57 cM"
     gene            1..4668
                     /gene="Pcdhga6"
                     /note="protocadherin gamma subfamily A, 6"
                     /db_xref="GeneID:93714"
                     /db_xref="MGI:MGI:1935218"
     exon            1..2552
                     /gene="Pcdhga6"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..2927
                     /gene="Pcdhga6"
                     /codon_start=1
                     /product="protocadherin gamma-A6 precursor"
                     /protein_id="NP_291067.1"
                     /db_xref="CCDS:CCDS79628.1"
                     /db_xref="GeneID:93714"
                     /db_xref="MGI:MGI:1935218"
                     /translation="MAALQRRPPCCELLLLLNLLWWLWGSEAGQLRYSIPEEVEKGSF
                     VGSIAKDLGLQPRELAERGIRIISRGRSQLFSLNQRSGSLVTAGRIDREELCAQSAPC
                     LVSFNILIEDKLNLYPVEVEIVDINDNAPRFLKEEMELKILENAALSSHFLLMGVYDP
                     DVGVNSIQGFKLSGSSHFSVHVQSQDHGPKYPELVLEHSLDREEEAVHHLVLVAMDGG
                     DPVRTGMARILVTVVDVNDNAPVFTQPIYRVSVPENLPVGTRVLTVNATDQDEGIHAE
                     ITYSFVRITEEISQIFCLNPLTGEISTSETLDYEDSRFYELDVEARDQSDLQDRAKVL
                     ITILDMNDNAPEVVVTSGSRAIAENSPSGTVIALFQVYDKDSERNGLVICSISESLPF
                     KLEESLDNYFRLVTNTELDREQVSSYNITVTATDRGTPPLSTKIFISLDVADINDNPP
                     VFSRSSYSVYVSENNPKGVSIFSLNAVDPDSEENAEIIYSLAKETLQGTPLSSFLSIN
                     SITGVLYALCSFDYEQFRELNLLVTASDRGKPPLSSNVSLNLFVLDQNDNVPEILYPV
                     LPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLIKASEPGLFSVGLHTG
                     EIRTARVLLDRDALKQSLVVAVQDHGQPPLSATVTLTVAVASSIPDILADLGSLDLPH
                     KSEDSSLTIYLVVAVATVSCIFFAFVMGLLVLRLWHWHKSRLLKATRKGVSNMSTSHF
                     VGIDGVQAFLQTYSHEVSLTADSRKSHLIFPQPNYAHTLISQEGCEKNEPLLIQEDSA
                     FCKEEDSLDQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASA
                     SEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK
                     APAGGNGNKKKSGKKEKK"
     exon            2553..2611
                     /gene="Pcdhga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2612..2700
                     /gene="Pcdhga6"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..4668
                     /gene="Pcdhga6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attctgaact ggctctcaac tggtctatgt tcgtttaagg accttgacct ctaattctgt
       61 ggattaccaa gtgggctggg gctgtttttc ccaccagcaa tcgctgggaa gtctttaaaa
      121 agccagtcat ggcggctctg cagaggcgcc cgccctgctg cgagttgctc ctgcttctca
      181 atctcctgtg gtggttgtgg ggctcagaag ctgggcagct ccgctactct attcccgagg
      241 aagtggagaa aggctccttc gtgggcagca tcgccaaaga cctggggctg cagccccgcg
      301 agctggcaga gcgcgggatt cgcatcatct ccagaggtag gtcgcagctt ttctccctaa
      361 accagcgaag cggcagcttg gtcaccgcgg gcaggataga ccgggaggag ctgtgcgccc
      421 agagcgcgcc ctgtcttgtg agctttaaca tccttataga agataaatta aatctttatc
      481 ctgtggaagt agaaatagtg gacattaatg acaatgcacc cagattctta aaggaagaaa
      541 tggaattgaa gattcttgaa aatgcagctc tatcctctca ttttctacta atgggtgtct
      601 atgaccccga tgtgggagtg aactccattc agggcttcaa gctcagcggt agtagtcact
      661 tctcagtaca tgtgcaaagc caagaccatg ggcccaaata cccggagctg gtgttggagc
      721 acagcctgga cagggaagag gaagccgttc accacttggt ccttgttgcc atggatggtg
      781 gtgaccctgt ccgaacaggc atggcgcgaa ttcttgtaac tgtcgtagat gtgaacgaca
      841 atgctccagt atttactcag cctatctatc gtgtgagtgt ccctgaaaac ctgcctgtgg
      901 gtacacgagt gttaacagtt aacgccaccg accaggatga aggaatccat gcagaaataa
      961 catattcctt tgtgaggatc acagaagaaa tctcgcagat tttctgcttg aatcctttaa
     1021 ctggggaaat ttccacttcc gaaactctag actatgagga ttcaagattt tatgagctgg
     1081 atgttgaagc ccgagatcaa tcagatcttc aagaccgagc aaaagtttta ataaccatct
     1141 tggacatgaa cgacaatgca ccggaagtag tggttacatc tggtagcaga gcaattgctg
     1201 aaaactcacc ttcagggacc gtaattgctc tttttcaagt ctatgataaa gactctgaac
     1261 ggaatggcct ggtaatatgc tccatatcag aaagtctccc atttaaattg gaagagtcat
     1321 tagacaatta ttttcggtta gtgacaaata cagaactgga tcgcgaacag gtatcttcgt
     1381 ataacatcac tgtgacagcc actgacagag gaacaccacc tctgtcaaca aaaatattca
     1441 tttccttaga tgtggcagac attaatgaca acccacctgt tttttcccgt tcatcctact
     1501 ctgtctatgt ctctgagaat aaccctaagg gcgtctccat cttctctttg aatgcagtgg
     1561 accctgacag tgaagaaaat gcagaaatta tttactctct ggccaaagaa acccttcagg
     1621 gaacacctct atcctccttc ctctccatca actccatcac tggtgtcctg tatgcactgt
     1681 gttcctttga ctatgagcag tttagagaac tgaatctact ggtgacagcc agtgacagag
     1741 ggaaaccccc acttagcagc aatgtgtcac ttaacctgtt tgtgctggac cagaatgaca
     1801 atgtacctga gattctgtac cctgttctcc ccacggatgg ttctactggt gtggagctgg
     1861 ccccccgctc tgcagaacct ggatatctag tgaccaaagt ggtggcagtg gacaaagact
     1921 caggtcagaa tgcctggctg tcctaccgcc tgatcaaggc cagtgagcca gggctcttct
     1981 cagtgggact acacacaggt gagatccgca cagcaagggt cctgctggac agagatgctc
     2041 tcaagcagag cctggtggtg gctgtgcagg accatggcca gccgcctctc tcagctactg
     2101 ttacacttac tgtggctgtg gccagcagca ttcctgacat cctggctgac ttgggcagcc
     2161 ttgaccttcc acacaagtct gaagattcaa gccttacaat ctacctggtg gtggcggtgg
     2221 ccactgtttc gtgcatcttc tttgcttttg tcatggggct gctggtgctc aggctgtggc
     2281 actggcacaa gtcaagattg ctgaaggcca caaggaaagg tgtgtcaaat atgtccactt
     2341 cacatttcgt gggtattgat ggggtgcagg cttttctaca gacctattcc catgaggtct
     2401 ccctcacagc agactccagg aagagccatc tgatcttccc ccagcccaac tatgcccaca
     2461 cactcatcag tcaggagggc tgtgagaaaa atgagccttt attgatacag gaagactcgg
     2521 ctttttgcaa agaggaagac tctcttgatc agcaagcccc gcccaacact gactggcgtt
     2581 tctctcaagc ccagagaccc ggcacgagcg gatcccaaaa tggtgatgaa actggcacct
     2641 ggcccaacaa ccagtttgat acagagatgc tgcaagccat gatcttggcc tctgccagcg
     2701 aagctgctga tgggagctct accctgggag ggggcgctgg caccatgggt ctgagcgctc
     2761 gatacggacc ccagtttacc ctgcagcacg tgcctgacta ccgccagaac gtgtacatcc
     2821 ctggcagcaa tgccacgctg accaatgccg ctggcaaacg agatggcaag gctccagcag
     2881 gtggtaatgg caacaagaag aaatcgggca agaaagagaa gaagtaatat ggaggccagg
     2941 ccttgaacca caaggcagcc tccctcccca gccagtccag ctcgtcctta cttgtaccca
     3001 ggcctcagaa tttcagggct caccccagga tactggtagg agccagggcc atgctccccg
     3061 ttgggaaaca gaaacacgtg cccaagccaa caccccctct ctatacccta gggagttgaa
     3121 tatgcaaaga gagttctgct gggacccccc tattcaatca gtgattgtac ccacatgggt
     3181 agcagggttt gtgtgtgtgg acatacacac acacacacac acacacacac acaaaccatg
     3241 ccacactccc ttagttacag ctgaactcct ccatcttcca acccaggcag gcttatccat
     3301 ctcctgccgc cctctcccca ccccacccac tccttcagtc cctctctttg agcaaggtag
     3361 ctgggctgtt ggggtgaccg gtgagctaag ccggctccta gttctgaacg gtagggagag
     3421 tattacaatc ttttggcctc tccttcagtt cagctttccc ccaaagcatg gtttggtacc
     3481 agtcttctct tttccttcca gagcctgaga ccaatgctta agttttgggg gaacaggcac
     3541 cctccctctg gtactgatga tgcttgctgg attttgggaa ggcattttgc tactaagcct
     3601 cttttcaatg cctggggaca actagtcttt tgtttttcat tgtttgatgt tcccactgca
     3661 tgctgtgact tccctacacc tcaaagaaga gactcctttg catgtctgga gacagtaggg
     3721 ggtggtaaac taaagggaag ttgagagtgt atactgctgg gagtggggca gtggacaaaa
     3781 cagcctgtta atagggtctt gcaaggggct ctgtatgtac ccaggggact ggctcaatcc
     3841 tcacattcta gccatagaca aacaccaggc cagacccctc cattctggtt cagcctgggc
     3901 agcttgggct gagccaccag gaccaatgga tttaagctga catttcagtc caagacgacg
     3961 acttctaagt gagtttaaga ccagagagga aagaggggcc tctgtgggtg ctgggtactc
     4021 cagaggtgcc cttggtggga ggaccagtgg tcttagcagg aaggggggcc cagcaaggtc
     4081 attcttggac cctgggtcta gtccagtagc tagaaaaagg gaccaagtgg ccataaagtc
     4141 ccagccaatg atggggcttt tccagtgggc ccctgtagac ctcaagcccc tggcctccac
     4201 cttaccaggt gccatttctt ctcagaaggc cactgcccag gcccccaggc cgcccccttg
     4261 tggccagaga acggttaaag ccccccagtg cctccttgtg catagaactt cctctgccct
     4321 agcccttaca gtagtgtaga agatccccct cccccgctgg tgtagaatag ccaatagtat
     4381 agtgtggtgt gcttttacgt gatggcgagt gggcagcggg cggtgggctg tacacagccg
     4441 tctgtccttt gaatctcaat ctgcctgcgc ggcccgtgct gtgttttgtg ctgtgtccac
     4501 acgctgcggc gacccctccc tgtactgact tctctataaa aagcttctct tcgcatagtc
     4561 acgtagctcc tgcccatccc ccttccgata tctctcgcaa gttttatact ctaatattta
     4621 tatggctttt ttcttcgaaa attaaaaata aaaaaatggt ttcttctg
//
