LOCUS       NM_033588               4666 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 5 (Pcdhga5), mRNA.
ACCESSION   NM_033588
VERSION     NM_033588.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4666)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4666)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 4666)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   4  (bases 1 to 4666)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   5  (bases 1 to 4666)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   6  (bases 1 to 4666)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   7  (bases 1 to 4666)
  AUTHORS   Wang X, Su H and Bradley A.
  TITLE     Molecular mechanisms governing Pcdh-gamma gene expression: evidence
            for a multiple promoter and cis-alternative splicing model
  JOURNAL   Genes Dev 16 (15), 1890-1905 (2002)
   PUBMED   12154121
REFERENCE   8  (bases 1 to 4666)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4666)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4666)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 24, 2019 this sequence version replaced NM_033588.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057404.1, AY013799.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2550              AC020971.3         124901-127450
            2551-2609           AC129315.3         25335-25393
            2610-2698           AC129315.3         33579-33667
            2699-4666           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.55 cM"
     gene            1..4666
                     /gene="Pcdhga5"
                     /note="protocadherin gamma subfamily A, 5"
                     /db_xref="GeneID:93713"
                     /db_xref="MGI:MGI:1935217"
     exon            1..2550
                     /gene="Pcdhga5"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2925
                     /gene="Pcdhga5"
                     /codon_start=1
                     /product="protocadherin gamma-A5 precursor"
                     /protein_id="NP_291066.1"
                     /db_xref="CCDS:CCDS79627.1"
                     /db_xref="GeneID:93713"
                     /db_xref="MGI:MGI:1935217"
                     /translation="MADPPRRWICNDLLTFFMLLGTLCAPGKGQIRYSVREELDKGSF
                     VGNISKDLGLEPRELAERGVRIISRGRSQLFSLNPRGGSLVTAGRIDREELCVQSSPC
                     LVSFNILVENKMKIYGVEVEILDINDNFPRFRDEELKVKVNENAAAGTRLVLPFARDG
                     DVGVNSLQGYKLSSNRHFSLDVKSGSDGQKHPELVLEQPLDREKESAHDLVLTALDGG
                     NPVLSSTVHISVTVLDANDNAPLFTQSEYRVSVPENTPVGTRLLTLTATDADEGINAK
                     LTFSFRNEEDKISETFQLDSNLGEISTIQSLDYEESRFYLMEVVAQDGGALLASAKVL
                     VTVQDVNDNAPEVILTSLTSSVSEDCLPGTIIALFSVHDADSGENGEISCSIPKNLPF
                     KLEKSVDNYYHLLTTRALDREETSDYNITVTVVDRGTPPLSTENHISLKVADINDNPP
                     TFSRPFYSTSISENNPRGVSIFSVYAYDADSGDNAQVTYSLAENTFQEVPVSSYVSIN
                     SDTGVLYALQSFDYEHLRDLQLLVTAKDSGTPPLSSNVSMSLFVLDQNDNIPEILYPT
                     IPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSIGLHTG
                     EVCTARALLDRDVLKQSLVVAVQDHGQPPLSATVTLTIAVGDSIPDVLTDLGNHNTLA
                     EPQDSDLTLYLVVSVAVVSCVFLGFVTVLLALRLRHWHMSRLLQTSTGRLADMPASHF
                     VGMDGVQAYLQTYSHEISLTTDSKKSHLIFPQPNYADRLISEESCEKSEPLLIPHNIH
                     THKEEPGDAQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASA
                     SEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK
                     APAGGNGNKKKSGKKEKK"
     exon            2551..2609
                     /gene="Pcdhga5"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2698
                     /gene="Pcdhga5"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..4666
                     /gene="Pcdhga5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcaccagaga ccaaacaagc tcttggggaa agccaccatc cttagtcccg ctctccccgg
       61 ctttagagaa ataaggaaac agcaggttga accaggacta agaggaaaac aactaaagaa
      121 aagacaatgg cagacccacc gaggcgctgg atctgcaacg acttgctgac gttcttcatg
      181 ctgctgggga cgctgtgcgc gccaggaaag gggcagatcc gctactctgt gcgggaggag
      241 ctggacaaag gctccttcgt gggcaacatc tccaaggacc tggggctgga gccccgcgag
      301 ctggcggagc gcggggtccg cattatctcc agaggtaggt cgcagctttt ctctctgaac
      361 ccgcgaggcg gcagcctggt caccgcgggc aggatagaca gggaagagct gtgcgtccag
      421 agctctccct gtctcgtcag ctttaacatc ttggttgaaa ataaaatgaa aatttatgga
      481 gtagaagtgg aaatccttga tattaatgat aacttccccc ggttccgcga tgaggagtta
      541 aaagtaaaag ttaatgaaaa cgcagctgca ggaacacgtt tggtgctccc cttcgcgaga
      601 gatggggatg tgggtgtgaa ttccctccag ggttacaagc ttagctccaa ccggcacttc
      661 tctctggacg tgaagagcgg atctgacggg caaaaacacc cagagttggt gttggaacag
      721 cccctggacc gtgagaagga gtctgctcat gacctggtcc tcacagcttt ggatggcgga
      781 aacccagtac tttcgagcac cgtccatatc agcgtgaccg ttcttgatgc aaacgataac
      841 gcacccttgt ttacccaaag cgaatatagg gtgagtgttc cggagaacac acctgtgggc
      901 actagactcc tcacactcac cgccacggat gcagacgagg gaatcaacgc aaagttgacc
      961 ttctctttcc gcaacgaaga agacaaaatt tctgaaactt tccaactcga ttctaatctt
     1021 ggggaaatct caactattca atccctggac tatgaagaat ccagattcta tctcatggaa
     1081 gtggtagctc aggacggagg cgctcttctt gccagcgcta aggtgttggt cacagtccag
     1141 gatgtgaatg acaatgcccc agaagtgata ctcacctccc tcaccagctc cgtctctgaa
     1201 gactgtctac ccggaaccat aattgcgctt ttcagcgtac atgatgctga ttctggggag
     1261 aatggagaaa tttcatgttc tattcccaaa aacctgccct tcaaactgga aaagtcagtt
     1321 gataattact atcacctact aacaacaaga gcactggata gagaagagac ttcagattat
     1381 aacatcacag tgaccgttgt tgaccgtgga actcctcccc tgtctacaga aaaccacatc
     1441 tctctgaaag tagccgacat aaatgacaac ccacccacct tctctcgtcc cttctattcc
     1501 acttccatct cagaaaataa ccccagaggt gtctccattt tttcggttta cgcctatgac
     1561 gctgacagtg gtgataacgc ccaagtcact tactccctgg ctgaaaatac atttcaagaa
     1621 gtgcctgtgt catcctatgt ctccattaac tctgacactg gtgtcctgta tgcattgcaa
     1681 tcctttgact atgagcactt gagagacctg cagctactgg tgacagctaa ggacagtggg
     1741 actcctccac tcagcagcaa tgtgtccatg agcttgtttg tgctggacca gaatgacaac
     1801 attcctgaga tcctgtaccc aactattccc actgatggct ccacaggtgt ggaactggca
     1861 ccacgatctg cagagcctgg atacctggta accaaagtgg tggcagtgga caaagattcg
     1921 ggacagaatg cctggttgtc ctaccgcctg ctcaaggcca gtgaaccagg actcttctca
     1981 atagggcttc acacgggtga ggtgtgcaca gcaagggctc tgttggatag agatgttctc
     2041 aagcagagcc tggtggtggc tgtccaggac catggccagc cccctctctc agccactgtc
     2101 acactcacta tcgctgtagg agatagcatc ccagatgtac tgactgactt aggcaaccac
     2161 aacacactgg cagagcccca ggattcagac ctcacactct acctagtggt ttcggtggca
     2221 gtggtgtcct gtgtctttct gggatttgtt accgtgctgt tggccctcag gctgaggcac
     2281 tggcacatgt cacgcctgct tcagacttcc acaggcagat tggccgacat gcccgcctcc
     2341 cattttgtgg gcatggatgg ggtgcaggct tacctgcaga cctattccca cgaaatctcc
     2401 ctcactacag actccaaaaa gagccacctg atcttccccc agcccaatta tgctgacagg
     2461 ctcattagtg aagagagctg tgagaagagt gagcctcttc tgatacctca taatatacac
     2521 acacacaaag aagagcccgg agatgctcag caagccccgc ccaacactga ctggcgtttc
     2581 tctcaagccc agagacccgg cacgagcgga tcccaaaatg gtgatgaaac tggcacctgg
     2641 cccaacaacc agtttgatac agagatgctg caagccatga tcttggcctc tgccagcgaa
     2701 gctgctgatg ggagctctac cctgggaggg ggcgctggca ccatgggtct gagcgctcga
     2761 tacggacccc agtttaccct gcagcacgtg cctgactacc gccagaacgt gtacatccct
     2821 ggcagcaatg ccacgctgac caatgccgct ggcaaacgag atggcaaggc tccagcaggt
     2881 ggtaatggca acaagaagaa atcgggcaag aaagagaaga agtaatatgg aggccaggcc
     2941 ttgaaccaca aggcagcctc cctccccagc cagtccagct cgtccttact tgtacccagg
     3001 cctcagaatt tcagggctca ccccaggata ctggtaggag ccagggccat gctccccgtt
     3061 gggaaacaga aacacgtgcc caagccaaca ccccctctct ataccctagg gagttgaata
     3121 tgcaaagaga gttctgctgg gaccccccta ttcaatcagt gattgtaccc acatgggtag
     3181 cagggtttgt gtgtgtggac atacacacac acacacacac acacacacac aaaccatgcc
     3241 acactccctt agttacagct gaactcctcc atcttccaac ccaggcaggc ttatccatct
     3301 cctgccgccc tctccccacc ccacccactc cttcagtccc tctctttgag caaggtagct
     3361 gggctgttgg ggtgaccggt gagctaagcc ggctcctagt tctgaacggt agggagagta
     3421 ttacaatctt ttggcctctc cttcagttca gctttccccc aaagcatggt ttggtaccag
     3481 tcttctcttt tccttccaga gcctgagacc aatgcttaag ttttggggga acaggcaccc
     3541 tccctctggt actgatgatg cttgctggat tttgggaagg cattttgcta ctaagcctct
     3601 tttcaatgcc tggggacaac tagtcttttg tttttcattg tttgatgttc ccactgcatg
     3661 ctgtgacttc cctacacctc aaagaagaga ctcctttgca tgtctggaga cagtaggggg
     3721 tggtaaacta aagggaagtt gagagtgtat actgctggga gtggggcagt ggacaaaaca
     3781 gcctgttaat agggtcttgc aaggggctct gtatgtaccc aggggactgg ctcaatcctc
     3841 acattctagc catagacaaa caccaggcca gacccctcca ttctggttca gcctgggcag
     3901 cttgggctga gccaccagga ccaatggatt taagctgaca tttcagtcca agacgacgac
     3961 ttctaagtga gtttaagacc agagaggaaa gaggggcctc tgtgggtgct gggtactcca
     4021 gaggtgccct tggtgggagg accagtggtc ttagcaggaa ggggggccca gcaaggtcat
     4081 tcttggaccc tgggtctagt ccagtagcta gaaaaaggga ccaagtggcc ataaagtccc
     4141 agccaatgat ggggcttttc cagtgggccc ctgtagacct caagcccctg gcctccacct
     4201 taccaggtgc catttcttct cagaaggcca ctgcccaggc ccccaggccg cccccttgtg
     4261 gccagagaac ggttaaagcc ccccagtgcc tccttgtgca tagaacttcc tctgccctag
     4321 cccttacagt agtgtagaag atccccctcc cccgctggtg tagaatagcc aatagtatag
     4381 tgtggtgtgc ttttacgtga tggcgagtgg gcagcgggcg gtgggctgta cacagccgtc
     4441 tgtcctttga atctcaatct gcctgcgcgg cccgtgctgt gttttgtgct gtgtccacac
     4501 gctgcggcga cccctccctg tactgacttc tctataaaaa gcttctcttc gcatagtcac
     4561 gtagctcctg cccatccccc ttccgatatc tctcgcaagt tttatactct aatatttata
     4621 tggctttttt cttcgaaaat taaaaataaa aaaatggttt cttctg
//
