LOCUS       NM_033587               4697 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus protocadherin gamma subfamily A, 4 (Pcdhga4), mRNA.
ACCESSION   NM_033587
VERSION     NM_033587.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4697)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4697)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 4697)
  AUTHORS   Ledderose,J., Dieter,S. and Schwarz,M.K.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   4  (bases 1 to 4697)
  AUTHORS   Chen,W.V., Alvarez,F.J., Lefebvre,J.L., Friedman,B., Nwakeze,C.,
            Geiman,E., Smith,C., Thu,C.A., Tapia,J.C., Tasic,B., Sanes,J.R. and
            Maniatis,T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   5  (bases 1 to 4697)
  AUTHORS   Prasad,T., Wang,X., Gray,P.A. and Weiner,J.A.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   6  (bases 1 to 4697)
  AUTHORS   Frank,M., Ebert,M., Shan,W., Phillips,G.R., Arndt,K., Colman,D.R.
            and Kemler,R.
  TITLE     Differential expression of individual gamma-protocadherins during
            mouse brain development
  JOURNAL   Mol Cell Neurosci 29 (4), 603-616 (2005)
   PUBMED   15964765
REFERENCE   7  (bases 1 to 4697)
  AUTHORS   Murata,Y., Hamada,S., Morishita,H., Mutoh,T. and Yagi,T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   8  (bases 1 to 4697)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4697)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4697)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 22, 2019 this sequence version replaced NM_033587.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013798.1, BC049814.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2581              AC020971.3         115763-118343
            2582-2640           AC129315.3         25335-25393
            2641-2729           AC129315.3         33579-33667
            2730-4697           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4697
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.55 cM"
     gene            1..4697
                     /gene="Pcdhga4"
                     /note="protocadherin gamma subfamily A, 4"
                     /db_xref="GeneID:93712"
                     /db_xref="MGI:MGI:1935216"
     exon            1..2581
                     /gene="Pcdhga4"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..2956
                     /gene="Pcdhga4"
                     /note="PCDH-gamma-A4; protocadherin gamma-A4"
                     /codon_start=1
                     /product="protocadherin gamma-A4 precursor"
                     /protein_id="NP_291065.3"
                     /db_xref="CCDS:CCDS79625.1"
                     /db_xref="GeneID:93712"
                     /db_xref="MGI:MGI:1935216"
                     /translation="MAAPYKSDRRGLIWICIFLGSLCDIRAEQIRYSVPEELERGSVV
                     GNLAADLGLEPGKLAERGVRIVSRGKTQLFALNPRSGSLVTAGRVDREGLCDRSPKCT
                     ANLEILLEDKVRILAIEVEIIDVNDNAPSFGAQQREIKVAESENPGTRFPLPEAFDLD
                     IGVNALQGYQLSSNDHFSLDVQSGPDGIKYPELVLENALDREEEAVHHLVLTAFDGGD
                     PVRSGTATIQVTLVDTNDNAPVFTQPEYHISVKENLPVGTRLLTIKATDPDEGVNGEV
                     TYSFRNVREKISQLFQLNSLTGDITVLGELDYEDSGFYDVDVEAHDGPGLRARSKVLV
                     TVLDVNDNAPEVTVTSLTSSIQEASSPGTVIALFNVHDSDSGENGLVTCSIPDNLPFR
                     LEKTYGNYHRLLIHRTLDREEVSDYNITITATDQGTPPLSTETYISLQVVDINDNPPT
                     FTHASYSAYIPENNPRGASILSITAQDPDSGENAQVIYSLSEDTIQGAPMSSYVSINS
                     NTGVLYALRSFDYEQFQDLKLLVTARDSGTPPLSSNVSLSLSVLDQNDNTPEILYPTI
                     PTDGSTGVELTPRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGE
                     VRTARALLDRDALKQSLVVTVQDHGQPPLSATVTLTIAVSDNIPDILADLVNINAPID
                     QEDSDITLYLVVAVAAVSCVFLAFVIVLLIHRLRRWHSTRLLQAAGNGLSSLPASHFV
                     GVDGVHAFLQTYSHEVSLTADSGKSHLIFPQPNYADTLISQESCGKSDPLLVSQDLLE
                     IKGDSSLQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASE
                     AADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAP
                     AGGNGNKKKSGKKEKK"
     exon            2582..2640
                     /gene="Pcdhga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2729
                     /gene="Pcdhga4"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..4697
                     /gene="Pcdhga4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaaaggact ggtgatgatc ttaaacaagg cagcaatctg gactccagga gcaccagcgt
       61 ccaacagtac aagaacagta tcttgaaacc caaagattgt ggggttcatc aggcctgcac
      121 agactgaacg cccaagctca ggaccctctg cggcaggact gcaatggcgg ctccttacaa
      181 atcagaccgc aggggactaa tctggatctg cattttcctt ggatccctat gcgacatccg
      241 cgcggaacag atccggtact ctgtgccgga ggagctggaa aggggctctg tggtgggtaa
      301 tctcgccgcg gacctggggc tggagcctgg aaaactggca gaacgcggag tccgcatcgt
      361 ctccagaggt aagacccagc tctttgctct gaacccgcga agcggcagtt tggtgacagc
      421 agggagggtc gacagagaag ggctctgtga cagatcccca aagtgtaccg caaatctgga
      481 gattctccta gaggataaag tgaggattct agccatagaa gtggagatta tcgatgttaa
      541 tgataatgcc cccagctttg gagcacagca gagagaaata aaagtcgctg aaagtgaaaa
      601 tcctgggaca agatttcctc ttcctgaagc ctttgatctg gacatagggg tgaacgcctt
      661 gcagggttac cagctcagct ccaatgatca cttctccctg gatgtgcaaa gtggaccgga
      721 tgggattaag tatccagagc tagtgctgga aaatgcctta gaccgcgagg aagaagccgt
      781 tcatcacctg gttctcaccg ccttcgacgg aggcgacccg gttcgctctg gtactgccac
      841 aattcaagta acactcgtgg acaccaacga caatgctcct gtattcactc agccagagta
      901 ccacattagt gtgaaagaga atttgcctgt aggcacccgg ctgcttacca taaaagccac
      961 tgacccggat gaaggagtca acggagaagt gacgtattct ttccggaacg taagagagaa
     1021 aatctcccag ctcttccagc tgaattctct gactggggac attacagtgt tgggggaact
     1081 ggattatgaa gactctggat tctacgatgt tgacgtagaa gcccatgatg ggcctggtct
     1141 tcgagccaga agtaaggtac tggtgacagt tctggatgta aatgacaatg ccccggaagt
     1201 cacagtcacc tctctcacca gctctatcca ggaagcttct tccccaggca cagtgattgc
     1261 actcttcaac gtgcacgaca gcgactctgg agagaacggc cttgtcactt gttctattcc
     1321 agataatctt ccattcagac tggaaaagac ctatggaaat tatcatcggt tgttgataca
     1381 caggactctg gacagggaag aagtctctga ctataacatt acaataactg ccaccgacca
     1441 gggaactcca cctctgtcta cagagactta tatctcattg caggtggtag atattaatga
     1501 caacccgccg accttcaccc atgcctccta ttctgcttac attccagaaa acaaccctag
     1561 aggagcttcc atcttatcca taacagccca ggacccagac agtggtgaga atgcccaggt
     1621 tatctattct ctgtcagagg acactatcca gggggcacct atgtcctcct acgtctccat
     1681 aaactccaat accggtgtcc tttatgcact gcgttccttt gattatgagc agtttcaaga
     1741 cttgaagtta ctggtgacag ccagggacag tgggactcct ccactcagca gcaacgtgtc
     1801 cctgagcttg tctgtgctgg accagaacga taacacccct gagatcctgt atcccaccat
     1861 ccccactgat ggttctactg gtgtggagct gacacctcgt tctgcagatc ctggatacct
     1921 ggtgaccaag gtggtggccg tagacaaaga ctcaggacag aacgcctggc tgtcctaccg
     1981 cctgctcaag gccagcgagc cagggctctt ctcagtgggg ctgcacacag gtgaggtacg
     2041 cactgctcgg gccctgctgg acagagatgc tctcaagcag agcctggtgg tgaccgtgca
     2101 ggaccatggc cagccccctc tctccgccac tgtcacactc accatagctg tgtcagacaa
     2161 cattccagac atcctggctg atctggtcaa cattaacgcc cccattgacc aggaggattc
     2221 agacatcaca ttgtacctgg tggtagctgt ggctgcggtc tcttgtgtct tcttagcctt
     2281 tgtcattgtg ctgctgatac acaggctccg tcgctggcac tcaactcgcc tgcttcaggc
     2341 tgcaggtaat gggttgtcat ccttgcctgc ctcacatttt gtgggtgtgg atggtgtaca
     2401 cgctttccta cagacctatt ctcatgaggt ctcactcaca gcagactctg ggaagagtca
     2461 cctgatcttc ccacagccca actacgcaga cacactcatc agccaggaga gctgtgggaa
     2521 gagtgatcct ctcctggtat ctcaagactt gcttgaaata aaaggagact ccagtctgca
     2581 gcaagccccg cccaacactg actggcgttt ctctcaagcc cagagacccg gcacgagcgg
     2641 atcccaaaat ggtgatgaaa ctggcacctg gcccaacaac cagtttgata cagagatgct
     2701 gcaagccatg atcttggcct ctgccagcga agctgctgat gggagctcta ccctgggagg
     2761 gggcgctggc accatgggtc tgagcgctcg atacggaccc cagtttaccc tgcagcacgt
     2821 gcctgactac cgccagaacg tgtacatccc tggcagcaat gccacgctga ccaatgccgc
     2881 tggcaaacga gatggcaagg ctccagcagg tggtaatggc aacaagaaga aatcgggcaa
     2941 gaaagagaag aagtaatatg gaggccaggc cttgaaccac aaggcagcct ccctccccag
     3001 ccagtccagc tcgtccttac ttgtacccag gcctcagaat ttcagggctc accccaggat
     3061 actggtagga gccagggcca tgctccccgt tgggaaacag aaacacgtgc ccaagccaac
     3121 accccctctc tataccctag ggagttgaat atgcaaagag agttctgctg ggacccccct
     3181 attcaatcag tgattgtacc cacatgggta gcagggtttg tgtgtgtgga catacacaca
     3241 cacacacaca cacacacaca caaaccatgc cacactccct tagttacagc tgaactcctc
     3301 catcttccaa cccaggcagg cttatccatc tcctgccgcc ctctccccac cccacccact
     3361 ccttcagtcc ctctctttga gcaaggtagc tgggctgttg gggtgaccgg tgagctaagc
     3421 cggctcctag ttctgaacgg tagggagagt attacaatct tttggcctct ccttcagttc
     3481 agctttcccc caaagcatgg tttggtacca gtcttctctt ttccttccag agcctgagac
     3541 caatgcttaa gttttggggg aacaggcacc ctccctctgg tactgatgat gcttgctgga
     3601 ttttgggaag gcattttgct actaagcctc ttttcaatgc ctggggacaa ctagtctttt
     3661 gtttttcatt gtttgatgtt cccactgcat gctgtgactt ccctacacct caaagaagag
     3721 actcctttgc atgtctggag acagtagggg gtggtaaact aaagggaagt tgagagtgta
     3781 tactgctggg agtggggcag tggacaaaac agcctgttaa tagggtcttg caaggggctc
     3841 tgtatgtacc caggggactg gctcaatcct cacattctag ccatagacaa acaccaggcc
     3901 agacccctcc attctggttc agcctgggca gcttgggctg agccaccagg accaatggat
     3961 ttaagctgac atttcagtcc aagacgacga cttctaagtg agtttaagac cagagaggaa
     4021 agaggggcct ctgtgggtgc tgggtactcc agaggtgccc ttggtgggag gaccagtggt
     4081 cttagcagga aggggggccc agcaaggtca ttcttggacc ctgggtctag tccagtagct
     4141 agaaaaaggg accaagtggc cataaagtcc cagccaatga tggggctttt ccagtgggcc
     4201 cctgtagacc tcaagcccct ggcctccacc ttaccaggtg ccatttcttc tcagaaggcc
     4261 actgcccagg cccccaggcc gcccccttgt ggccagagaa cggttaaagc cccccagtgc
     4321 ctccttgtgc atagaacttc ctctgcccta gcccttacag tagtgtagaa gatccccctc
     4381 ccccgctggt gtagaatagc caatagtata gtgtggtgtg cttttacgtg atggcgagtg
     4441 ggcagcgggc ggtgggctgt acacagccgt ctgtcctttg aatctcaatc tgcctgcgcg
     4501 gcccgtgctg tgttttgtgc tgtgtccaca cgctgcggcg acccctccct gtactgactt
     4561 ctctataaaa agcttctctt cgcatagtca cgtagctcct gcccatcccc cttccgatat
     4621 ctctcgcaag ttttatactc taatatttat atggcttttt tcttcgaaaa ttaaaaataa
     4681 aaaaatggtt tcttctg
//
