LOCUS       NM_033586               4763 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 3 (Pcdhga3), mRNA.
ACCESSION   NM_033586
VERSION     NM_033586.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4763)
  AUTHORS   Xu L, Zheng Y, Li X, Wang A, Huo D, Li Q, Wang S, Luo Z, Liu Y, Xu
            F, Wu X, Wu M and Zhou Y.
  TITLE     Abnormal neocortex arealization and Sotos-like syndrome-associated
            behavior in Setd2 mutant mice
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523829
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4763)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4763)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 4763)
  AUTHORS   Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M,
            Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T,
            Hirabayashi T and Yagi T.
  TITLE     Developmental epigenetic modification regulates stochastic
            expression of clustered protocadherin genes, generating single
            neuron diversity
  JOURNAL   Neuron 82 (1), 94-108 (2014)
   PUBMED   24698270
REFERENCE   5  (bases 1 to 4763)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   6  (bases 1 to 4763)
  AUTHORS   Frank M, Ebert M, Shan W, Phillips GR, Arndt K, Colman DR and
            Kemler R.
  TITLE     Differential expression of individual gamma-protocadherins during
            mouse brain development
  JOURNAL   Mol Cell Neurosci 29 (4), 603-616 (2005)
   PUBMED   15964765
REFERENCE   7  (bases 1 to 4763)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   8  (bases 1 to 4763)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4763)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4763)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC060691.1.
            
            On Dec 20, 2003 this sequence version replaced NM_033586.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060691.1, AY013797.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4763
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.55 cM"
     gene            1..4763
                     /gene="Pcdhga3"
                     /note="protocadherin gamma subfamily A, 3"
                     /db_xref="GeneID:93711"
                     /db_xref="MGI:MGI:1935215"
     exon            1..2573
                     /gene="Pcdhga3"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..2948
                     /gene="Pcdhga3"
                     /codon_start=1
                     /product="protocadherin gamma-A3 precursor"
                     /protein_id="NP_291064.1"
                     /db_xref="CCDS:CCDS37781.1"
                     /db_xref="GeneID:93711"
                     /db_xref="MGI:MGI:1935215"
                     /translation="MIRLGQGTAGALLCALLGTLCAAGFRQIRYSVPEELDKGSFVGN
                     ISKDLGLEPRELAERGVRIISRGKSQLFSLDPRSGSLVTRGRIDREELCAQSAPCLVS
                     FNILVEDKLKIFEVEVDISDINDNAPSFPTEELEIKIGELTVPGTRFPLKTAFDPDVG
                     MNALQNYKLNSNDYFSLAVNSVIDDAKYPELVLERALDREKKAVHQLDLIASDGGDPV
                     HTSKLCIQVIVSDANDNPPVFTKPEYHVSVLENVPVGTRLITVNATDPDEGFNAQVSY
                     ILDKMPGKIAQVFHLNSVTGDISILKSLDYEDAVFYEIKIEAQDGPGLFSRAKVLVTV
                     LDVNDNAPEVSVTSLTGSVPEEAPAGREIALINVHDRDSGQNGQVTVFVLGNLPFTLE
                     KSIDQYYRLVTARSLDHEEVSQYNISLRATDGGSPPLSTETHITLHVSDINDNPPTFT
                     HASYSAYIPENNARGASIFSVTAQDPDTDKNAQVTYSLAEDTLQGLPLSSYISINSNT
                     GVLYALCSFDYEQFRDLQLQITARDSGTPPLSSNTTLNLFVLDQNDNTPEILYPTLPV
                     DGSTGVELAPRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTGEVR
                     TARALLDRDALKQSLVVAVQDHGQPPLSATVTLTIAVADSIPDILGDLESIHTPANPQ
                     NSDLTLYLVVAVAVVSCIFLAFVIVLLALRLRRWYSSRLQASGNGLAGIPASHFVGLD
                     GVQAFLQTYSQEVSLTAGSRKSHLIFPQPNYADTLISQESCGKSEPLIIPQDLLETKE
                     DPTLPQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASEAA
                     DGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAPAG
                     GNGNKKKSGKKEKK"
     exon            2574..2632
                     /gene="Pcdhga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2721
                     /gene="Pcdhga3"
                     /inference="alignment:Splign:2.1.0"
     exon            2722..4692
                     /gene="Pcdhga3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctacacca agaacagtca gagaagacag aagcggcctc accacatcat cgggcaactc
       61 ggtggtgtgt gaattaagtc catgaaagat ttaactactt gagagggtaa ggctttaatc
      121 catcgtggga atcagagggg aggaaaaaaa cagaaaagga aatgatccgt ctgggacaag
      181 gaaccgcagg agctttgttg tgcgcgctcc tgggaacgct gtgcgcggct ggtttcaggc
      241 agatccgcta ctcggtgccg gaggaactgg acaaaggctc cttcgtgggc aacatctcca
      301 aggacctagg gctggagccc cgagagctgg cggagcgcgg ggtccgcatc atctccagag
      361 gtaaatctca gcttttctct ctggacccgc gaagcggcag cttggtcacc aggggcagga
      421 tagaccggga agagctgtgt gctcagagcg cgccctgtct cgtcagcttt aacatccttg
      481 tggaggataa gctgaaaata tttgaggtag aagttgacat tagcgatatt aatgataatg
      541 ctcctagttt tccaacggag gaattggaaa taaaaattgg tgaactaaca gttcctggaa
      601 cccgattccc acttaaaact gcatttgacc cggatgtggg catgaacgcc ctgcagaact
      661 ataagctcaa ttccaatgac tatttctcct tggctgtgaa cagcgtcatc gatgacgcca
      721 agtacccaga gctagtgctg gagcgagccc tggatcgtga gaaaaaggca gtccatcagc
      781 ttgatctcat tgcctctgat ggcggagacc ctgtgcacac cagcaagttg tgcatccagg
      841 tgatagtctc ggatgcaaat gacaacccac ctgtgtttac caagccagag taccatgtca
      901 gtgttttgga aaatgtgcca gtgggcaccc ggctgatcac agtgaacgcc actgatcctg
      961 atgagggatt caatgctcaa gtgtcctata ttctggataa aatgcctggg aaaattgctc
     1021 aggttttcca tctcaactca gtgaccggag atatatcaat attaaaaagt cttgattatg
     1081 aggacgctgt gttctatgaa atcaaaattg aagcacaaga cggaccaggt cttttttcaa
     1141 gagccaaggt tcttgtaacg gttctggatg tgaatgacaa cgccccggaa gtctcagtca
     1201 cttccctcac aggctcggtc ccagaggagg ctcccgctgg aagagaaatc gcacttatca
     1261 atgtacacga ccgagattct ggccagaacg ggcaagtcac agtttttgtc ctaggaaatc
     1321 tgccctttac tctagaaaaa tcaatagacc aatactaccg attagtgaca gccagatctt
     1381 tggatcatga ggaggtgtcc caatataata tcagtctaag agccacggat gggggaagtc
     1441 caccattgtc tacagaaact catatcactc tgcatgtgtc agacatcaac gacaaccctc
     1501 ctacattcac gcacgcctcc tattcagcct atatcccaga aaacaatgct aggggagcct
     1561 ccatcttctc tgttacagca caggacccag acactgacaa gaatgcacaa gtcacttact
     1621 cactggctga ggacacactt caggggctgc cactgtcatc ctacatctcc atcaactcca
     1681 acactggtgt cctgtatgct ctttgctcct ttgactatga gcagtttaga gacctgcaat
     1741 tacaaataac agctagagac agtgggaccc ctccactgag cagcaacaca acactgaacc
     1801 tatttgtgct ggaccagaat gacaacacac ctgagatcct gtatccgacc ctcccagtag
     1861 acggttccac aggggttgag ttggcacccc gctctgcaga tcctggatac ctggtgacca
     1921 aagtggtggc agtagacaaa gactcaggac agaacgcctg gctgtcctac cgcctgctca
     1981 aggccagtga gccagggctc ttctcagtag ggctgcacac aggagaggta cgcactgctc
     2041 gggccctgct ggacagagat gctctcaagc agagcctggt ggtggccgtg caggaccacg
     2101 gccagcctcc tctctccgcc actgtcacgc tcaccatagc agtggctgac agcattcctg
     2161 acatcctggg ggacctggaa agcatccata cccctgctaa cccccaaaat tcagacctga
     2221 cactctacct ggtggtggca gtggctgtgg tctcctgcat cttcctggcc tttgtcattg
     2281 tgctgctggc ccttaggctt cgacgttggt actcatcacg cctacaggct tcaggaaatg
     2341 gattggctgg cataccagcc tctcactttg tgggtctaga tggggtgcaa gctttcctgc
     2401 agacctactc ccaggaagtt tcacttaccg caggctctcg gaagagtcac ctgatcttcc
     2461 cacaacccaa ctacgcagac acgctcatca gccaggagag ctgtgggaaa agcgagcctc
     2521 ttataatacc tcaagattta cttgaaacga aagaagaccc cacgctgcct cagcaagccc
     2581 cgcccaacac tgactggcgt ttctctcaag cccagagacc cggcacgagc ggatcccaaa
     2641 atggtgatga aactggcacc tggcccaaca accagtttga tacagagatg ctgcaagcca
     2701 tgatcttggc ctctgccagc gaagctgctg atgggagctc taccctggga gggggcgctg
     2761 gcaccatggg tctgagcgct cgatacggac cccagtttac cctgcagcac gtgcctgact
     2821 accgccagaa cgtgtacatc cctggcagca atgccacgct gaccaatgcc gctggcaaac
     2881 gagatggcaa ggctccagca ggtggtaatg gcaacaagaa gaaatcgggc aagaaagaga
     2941 agaagtaata tggaggccag gccttgaacc acaaggcagc ctccctcccc agccagtcca
     3001 gctcgtcctt acttgtaccc aggcctcaga atttcagggc tcaccccagg atactggtag
     3061 gagccagggc catgctcccc gttgggaaac agaaacacgt gcccaagcca acaccccctc
     3121 tctataccct agggagttga atatgcaaag agagttctgc tgggaccccc ctattcaatc
     3181 agtgattgta cccacatggg tagcagggtt tgtgtgtgtg gacatacaca cacacacaca
     3241 cacacacaca cacaaaccat gccacactcc cttagttaca gctgaactcc tccatcttcc
     3301 aacccaggca ggcttatcca tctcctgccg ccctctcccc accccaccca ctccttcagt
     3361 ccctctcttt gagcaaggta gctgggctgt tggggtgacc ggtgagctaa gccggctcct
     3421 agttctgaac ggtagggaga gtattacaat cttttggcct ctccttcagt tcagctttcc
     3481 cccaaagcat ggtttggtac cagtcttctc ttttccttcc agagcctgag accaatgctt
     3541 aagttttggg ggaacaggca ccctccctct ggtactgatg atgcttgctg gattttggga
     3601 aggcattttg ctactaagcc tcttttcaat gcctggggac aactagtctt ttgtttttca
     3661 ttgtttgatg ttcccactgc atgctgtgac ttccctacac ctcaaagaag agactccttt
     3721 gcatgtctgg agacagtagg gggtggtaaa ctaaagggaa gttgagagtg tatactgctg
     3781 ggagtggggc agtggacaaa acagcctgtt aatagggtct tgcaaggggc tctgtatgta
     3841 cccaggggac tggctcaatc ctcacattct agccatagac aaacaccagg ccagacccct
     3901 ccattctggt tcagcctggg cagcttgggc tgagccacca ggaccaatgg atttaagctg
     3961 acatttcagt ccaagacgac gacttctaag tgagtttaag accagagagg aaagaggggc
     4021 ctctgtgggt gctgggtact ccagaggtgc ccttggtggg aggaccagtg gtcttagcag
     4081 gaaggggggc ccagcaaggt cattcttgga ccctgggtct agtccagtag ctagaaaaag
     4141 ggaccaagtg gccataaagt cccagccaat gatggggctt ttccagtggg cccctgtaga
     4201 cctcaagccc ctggcctcca ccttaccagg tgccatttct tctcagaagg ccactgccca
     4261 ggcccccagg ccgccccctt gtggccagag aacggttaaa gccccccagt gcctccttgt
     4321 gcatagaact tcctctgccc tagcccttac agtagtgtag aagatccccc tcccccgctg
     4381 gtgtagaata gccaatagta tagtgtggtg tgcttttacg tgatggcgag tgggcagcgg
     4441 gcggtgggct gtacacagcc gtctgtcctt tgaatctcaa tctgcctgcg cggcccgtgc
     4501 tgtgttttgt gctgtgtcca cacgctgcgg cgacccctcc ctgtactgac ttctctataa
     4561 aaagcttctc ttcgcatagt cacgtagctc ctgcccatcc cccttccgat atctctcgca
     4621 agttttatac tctaatattt atatggcttt tttcttcgaa aattaaaaat aaaaaaatgg
     4681 tttcttctga aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4741 aaaaaaaaaa aaaaaaaaaa aaa
//
