LOCUS       NM_033585               4715 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 2 (Pcdhga2), mRNA.
ACCESSION   NM_033585
VERSION     NM_033585.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4715)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4715)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   3  (bases 1 to 4715)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   4  (bases 1 to 4715)
  AUTHORS   Dallosso AR, Hancock AL, Szemes M, Moorwood K, Chilukamarri L, Tsai
            HH, Sarkar A, Barasch J, Vuononvirta R, Jones C, Pritchard-Jones K,
            Royer-Pokora B, Lee SB, Owen C, Malik S, Feng Y, Frank M, Ward A,
            Brown KW and Malik K.
  TITLE     Frequent long-range epigenetic silencing of protocadherin gene
            clusters on chromosome 5q31 in Wilms' tumor
  JOURNAL   PLoS Genet 5 (11), e1000745 (2009)
   PUBMED   19956686
  REMARK    Erratum:[PLoS Genet. 2009 Dec;5(12). doi:
            10.1371/annotation/012d5a44-8239-4057-8c3b-3dc159ea3a02]
REFERENCE   5  (bases 1 to 4715)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   6  (bases 1 to 4715)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   7  (bases 1 to 4715)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Hara Y, Nagase T, Ohara O
            and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: I. The complete nucleotide sequences of 100 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 9 (5), 179-188 (2002)
   PUBMED   12465718
REFERENCE   8  (bases 1 to 4715)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4715)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4715)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 22, 2019 this sequence version replaced NM_033585.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013796.1, AB093250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2599              AC020971.3         99453-102051
            2600-2658           AC129315.3         25335-25393
            2659-2747           AC129315.3         33579-33667
            2748-4715           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4715
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.55 cM"
     gene            1..4715
                     /gene="Pcdhga2"
                     /gene_synonym="mKIAA0588"
                     /note="protocadherin gamma subfamily A, 2"
                     /db_xref="GeneID:93710"
                     /db_xref="MGI:MGI:1935214"
     exon            1..2599
                     /gene="Pcdhga2"
                     /gene_synonym="mKIAA0588"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..2974
                     /gene="Pcdhga2"
                     /gene_synonym="mKIAA0588"
                     /codon_start=1
                     /product="protocadherin gamma-A2 precursor"
                     /protein_id="NP_291063.1"
                     /db_xref="CCDS:CCDS79623.1"
                     /db_xref="GeneID:93710"
                     /db_xref="MGI:MGI:1935214"
                     /translation="MATLQKLPQSRMLVLLCALWAALWEAKAGQIRYSVPEEIDKGSF
                     VGSIAKDLGLEPQALEERGVRIVSRGKSQLFALNPRSGSLVTAGRIDREELCAQSTPC
                     LVNFNLLLEDKLTIYSVEVEVTDVNDNAPRFGVEDPELKISETTTPGFRIPLKSAHDA
                     DVGENTLQKYKLNSNDHFSLDVRTGADGNKYPELVLERALDREEEAVHHLVLVASDGG
                     NPVRSGTCRIRVKVLDANDNAPAFTQAEYRVRVPENTPVGTRILTVTATDADEGYNAQ
                     VTYFQEHDPGETTDAFELKSTSGDITITKSLDYEKAKFHEIDIEAQDGPGLLTRTKVI
                     VTVLDVNDNAPEFYMTSATASVPEDAPLGTVIALFNVHDRDSGQNAVVTCSLPEMLPF
                     KLERSVDSYYRLVTTRALDREQFSFYNITVSAKDGGSPSLSTDAHLLLQVADINDNPP
                     SFPRRVYSAYIPENNPRGTSIFSVLASDPDSNDNAHVTYSLAEDSFQGAPLSSYVSIN
                     SDTGVLYALRSFDYEQFQDLQLWVIAADSGNPPLSSNVSLSLFLVDQNDNTPEILYPA
                     LPTDGSTGVELAPRSADPGYLVTKVVAVDKDSGQNAWLSYRLLKASEPGLFSVGLHTG
                     EVRTARALLDRDALKQSLVVAVQDHGQPPLSATVTLTIAIADNIPEVLADLGSIRTPA
                     NPDDSELTLYLVVAVAVVSCVFLAFVIALLALRLRRWHLSRMLQASRDGLGGIPASHF
                     VGVDGVRAFLQTYSHEVSLTADSGKSHIIFPQPNYADTLISQESCEKTDFLSAPQSLL
                     DDKREETPQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASAS
                     EAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKA
                     PAGGNGNKKKSGKKEKK"
     exon            2600..2658
                     /gene="Pcdhga2"
                     /gene_synonym="mKIAA0588"
                     /inference="alignment:Splign:2.1.0"
     exon            2659..2747
                     /gene="Pcdhga2"
                     /gene_synonym="mKIAA0588"
                     /inference="alignment:Splign:2.1.0"
     exon            2748..4715
                     /gene="Pcdhga2"
                     /gene_synonym="mKIAA0588"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtttgtccg cagcttccgg tcagagaagg cgcaaagaaa ttcaacccaa ctgtctgata
       61 gttctctctc ctcggtgacc tgggtccggt gactgctggt gttctcagac cctgggagat
      121 acggactgga ctcccccact gtgctgaaag ctagttcaga ggaaactgca gaagggcaat
      181 ggcgacgctg cagaaactcc cccagagcag aatgctggtc ctcctgtgcg cactttgggc
      241 cgccctgtgg gaggccaaag ctggacagat ccgctactcc gtgccggagg agatcgacaa
      301 aggctccttc gtgggcagca tcgccaagga cctgggacta gagccccagg ctctggaaga
      361 acgaggggtc cgcatcgtct ccagaggtaa gtcgcagctc tttgctctga acccgcgaag
      421 cggcagcctg gtcaccgcag gcaggataga cagggaggag ctgtgcgccc agagcacgcc
      481 ctgtttggtg aactttaacc tactactgga agataaattg actatttatt ctgtggaggt
      541 ggaggtaaca gatgttaatg acaatgctcc tcgctttgga gtagaggatc cagaactaaa
      601 aatcagtgaa acaactacac caggattcag gattcctctt aagagtgcac atgatgcgga
      661 cgttggagag aacaccctcc agaagtataa actcaactca aatgaccact tctctctgga
      721 cgtgcgaact ggagcggatg ggaacaagta cccagagctg gtgctcgaac gtgccttgga
      781 ccgcgaggaa gaggctgttc atcatctggt tctagtcgcc tctgacgggg gcaatccagt
      841 gcgatctggc acctgccgca tccgtgtgaa ggtcttggat gcaaacgata acgctcctgc
      901 ttttacacag gctgagtatc gtgtgagagt tcctgaaaat acgcccgtag gcacccggat
      961 actcacagtg acagccactg acgcggatga gggatacaat gctcaagtga cttattttca
     1021 ggagcatgac cctggagaaa ctacagatgc atttgagcta aagtcaacat ctggagatat
     1081 aacaatcaca aaaagtctgg attatgagaa agctaaattc catgaaatcg atattgaggc
     1141 tcaggatggc ccaggccttc tgactaggac gaaagtaatt gtcaccgttc tagatgtcaa
     1201 cgacaatgcc ccggaatttt acatgacatc tgccactgct tctgtgcctg aagacgctcc
     1261 tctgggaacg gtaattgcac tcttcaatgt gcatgatagg gactctgggc agaatgctgt
     1321 cgtcacgtgt tcacttcccg aaatgcttcc tttcaagtta gaaaggtcgg tggacagtta
     1381 ctaccgactg gttacaacca gagcccttga cagggaacag ttctccttct ataacatcac
     1441 tgtaagcgcc aaagatggag ggagcccatc tctgtccaca gatgcacacc ttttgctgca
     1501 ggtggcagat atcaatgaca acccaccctc cttcccccgg agggtctact ctgcctacat
     1561 tcctgagaac aaccccagag gcacctccat cttttcagtg ctggcctctg accccgacag
     1621 taacgacaat gcccacgtaa cctactcttt agctgaagat agctttcaag gagcacccct
     1681 gtcctcctac gtctccatca actcagacac tggagtcctc tatgctctcc gctcctttga
     1741 ctatgagcag ttccaagact tgcagctgtg ggtgatagca gcagacagtg ggaaccctcc
     1801 actgagtagc aatgtgtcct tgagcctgtt tttagtggac cagaacgaca acacccctga
     1861 gatcctgtac cctgccctcc ccactgatgg gtccactggt gtggaactag cgcctcgatc
     1921 tgcagaccct ggatacctgg tgaccaaagt ggtggcagta gacaaagact caggacagaa
     1981 cgcttggctg tcctaccgcc tgctcaaggc cagtgagcca gggctcttct cagtgggact
     2041 acacacaggc gaggtacgaa ctgctcgggc cctgctggac agagacgctc tgaaacaaag
     2101 cctggtggtg gctgtgcagg accatggcca accccctctc tccgccactg tcacactcac
     2161 catagcaata gctgacaaca tccccgaagt cctggctgat ctgggcagca tcaggacccc
     2221 tgccaaccct gacgattcag aactcactct ctacctggtg gtggcagtgg ctgtggtctc
     2281 ctgtgtcttc ctggcctttg tcattgctct gctggcactc aggctgaggc gctggcatct
     2341 gtctcggatg cttcaggctt caagagatgg cttagggggc atccctgcct cacactttgt
     2401 gggagtggac ggagtacgtg ctttcctgca gacctattcc catgaagtct cgctcaccgc
     2461 agactcaggg aaaagccaca ttatcttccc tcaaccaaac tatgcagata ctctcatcag
     2521 ccaggagagc tgtgaaaaaa ctgatttcct ctcagcacct cagtctttac ttgatgataa
     2581 aagagaagaa acccctcagc aagccccgcc caacactgac tggcgtttct ctcaagccca
     2641 gagacccggc acgagcggat cccaaaatgg tgatgaaact ggcacctggc ccaacaacca
     2701 gtttgataca gagatgctgc aagccatgat cttggcctct gccagcgaag ctgctgatgg
     2761 gagctctacc ctgggagggg gcgctggcac catgggtctg agcgctcgat acggacccca
     2821 gtttaccctg cagcacgtgc ctgactaccg ccagaacgtg tacatccctg gcagcaatgc
     2881 cacgctgacc aatgccgctg gcaaacgaga tggcaaggct ccagcaggtg gtaatggcaa
     2941 caagaagaaa tcgggcaaga aagagaagaa gtaatatgga ggccaggcct tgaaccacaa
     3001 ggcagcctcc ctccccagcc agtccagctc gtccttactt gtacccaggc ctcagaattt
     3061 cagggctcac cccaggatac tggtaggagc cagggccatg ctccccgttg ggaaacagaa
     3121 acacgtgccc aagccaacac cccctctcta taccctaggg agttgaatat gcaaagagag
     3181 ttctgctggg acccccctat tcaatcagtg attgtaccca catgggtagc agggtttgtg
     3241 tgtgtggaca tacacacaca cacacacaca cacacacaca aaccatgcca cactccctta
     3301 gttacagctg aactcctcca tcttccaacc caggcaggct tatccatctc ctgccgccct
     3361 ctccccaccc cacccactcc ttcagtccct ctctttgagc aaggtagctg ggctgttggg
     3421 gtgaccggtg agctaagccg gctcctagtt ctgaacggta gggagagtat tacaatcttt
     3481 tggcctctcc ttcagttcag ctttccccca aagcatggtt tggtaccagt cttctctttt
     3541 ccttccagag cctgagacca atgcttaagt tttgggggaa caggcaccct ccctctggta
     3601 ctgatgatgc ttgctggatt ttgggaaggc attttgctac taagcctctt ttcaatgcct
     3661 ggggacaact agtcttttgt ttttcattgt ttgatgttcc cactgcatgc tgtgacttcc
     3721 ctacacctca aagaagagac tcctttgcat gtctggagac agtagggggt ggtaaactaa
     3781 agggaagttg agagtgtata ctgctgggag tggggcagtg gacaaaacag cctgttaata
     3841 gggtcttgca aggggctctg tatgtaccca ggggactggc tcaatcctca cattctagcc
     3901 atagacaaac accaggccag acccctccat tctggttcag cctgggcagc ttgggctgag
     3961 ccaccaggac caatggattt aagctgacat ttcagtccaa gacgacgact tctaagtgag
     4021 tttaagacca gagaggaaag aggggcctct gtgggtgctg ggtactccag aggtgccctt
     4081 ggtgggagga ccagtggtct tagcaggaag gggggcccag caaggtcatt cttggaccct
     4141 gggtctagtc cagtagctag aaaaagggac caagtggcca taaagtccca gccaatgatg
     4201 gggcttttcc agtgggcccc tgtagacctc aagcccctgg cctccacctt accaggtgcc
     4261 atttcttctc agaaggccac tgcccaggcc cccaggccgc ccccttgtgg ccagagaacg
     4321 gttaaagccc cccagtgcct ccttgtgcat agaacttcct ctgccctagc ccttacagta
     4381 gtgtagaaga tccccctccc ccgctggtgt agaatagcca atagtatagt gtggtgtgct
     4441 tttacgtgat ggcgagtggg cagcgggcgg tgggctgtac acagccgtct gtcctttgaa
     4501 tctcaatctg cctgcgcggc ccgtgctgtg ttttgtgctg tgtccacacg ctgcggcgac
     4561 ccctccctgt actgacttct ctataaaaag cttctcttcg catagtcacg tagctcctgc
     4621 ccatccccct tccgatatct ctcgcaagtt ttatactcta atatttatat ggcttttttc
     4681 ttcgaaaatt aaaaataaaa aaatggtttc ttctg
//
