LOCUS       NM_033595               5080 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 12 (Pcdhga12), mRNA.
ACCESSION   NM_033595 NM_015757
VERSION     NM_033595.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5080)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5080)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (bases 1 to 5080)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   4  (bases 1 to 5080)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   5  (bases 1 to 5080)
  AUTHORS   Lobas MA, Helsper L, Vernon CG, Schreiner D, Zhang Y, Holtzman MJ,
            Thedens DR and Weiner JA.
  TITLE     Molecular heterogeneity in the choroid plexus epithelium: the
            22-member gamma-protocadherin family is differentially expressed,
            apically localized, and implicated in CSF regulation
  JOURNAL   J Neurochem 120 (6), 913-927 (2012)
   PUBMED   22092001
  REMARK    GeneRIF: This study suggested an unsuspected role for the
            gamma-Pcdhs in CSF production and demonstrate a surprising
            molecular heterogeneity in the CP epithelium.
REFERENCE   6  (bases 1 to 5080)
  AUTHORS   Heymann R, Kallenbach S, Alonso S, Carroll P and Mitsiadis TA.
  TITLE     Dynamic expression patterns of the new protocadherin families CNRs
            and Pcdh-gamma during mouse odontogenesis: comparison with reelin
            expression
  JOURNAL   Mech Dev 106 (1-2), 181-184 (2001)
   PUBMED   11472853
REFERENCE   7  (bases 1 to 5080)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   8  (bases 1 to 5080)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 5080)
  AUTHORS   Hirano S, Ono T, Yan Q, Wang X, Sonta S and Suzuki ST.
  TITLE     Protocadherin 2C: a new member of the protocadherin 2 subfamily
            expressed in a redundant manner with OL-protocadherin in the
            developing brain
  JOURNAL   Biochem Biophys Res Commun 260 (3), 641-645 (1999)
   PUBMED   10403819
REFERENCE   10 (bases 1 to 5080)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Nov 17, 2006 this sequence version replaced NM_033595.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056998.1, AY013795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2961              AC020971.3         196106-199066
            2962-3020           AC129315.3         25335-25393
            3021-3109           AC129315.3         33579-33667
            3110-5080           AC129315.3         40217-42187
FEATURES             Location/Qualifiers
     source          1..5080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.63 cM"
     gene            1..5080
                     /gene="Pcdhga12"
                     /gene_synonym="pc2c; Pcdh13"
                     /note="protocadherin gamma subfamily A, 12"
                     /db_xref="GeneID:93724"
                     /db_xref="MGI:MGI:1935229"
     exon            1..2961
                     /gene="Pcdhga12"
                     /gene_synonym="pc2c; Pcdh13"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..3336
                     /gene="Pcdhga12"
                     /gene_synonym="pc2c; Pcdh13"
                     /note="protocadherin 13; protocadherin gamma B6;
                     protocadherin gamma A12"
                     /codon_start=1
                     /product="protocadherin gamma-A12"
                     /protein_id="NP_291073.1"
                     /db_xref="CCDS:CCDS29191.1"
                     /db_xref="GeneID:93724"
                     /db_xref="MGI:MGI:1935229"
                     /translation="MIPMQRREDCKGLVFLGVLLGMLWKAGSTQIRYSVPEELEKGSR
                     VGNISKDLGLEPRELEKRGVRIVSRGRAQLFALNPRSGSLVTAGRIDREELCMGSIKC
                     QLNLEILMEDIGKIYGVEIEVRDINDNAPYFRESELEIKMSENAAAGMRFPLPHAWDP
                     DIGKNSLQSYQLSPNAHFSLEVQNGADGNKYPELVLESSLDREEKAAHLLVLTASDAG
                     DPVRTGTARIRVMVVDANDNAPAFARSEYRVSVRENVAVGTQLLLVNATDPDEGANAE
                     VIYSFRYVDDKAAKVFKLDSNLGTISTIGELNHEESGFYEMEVQATDNAGYSARAKVL
                     VTVLDVNDNAPEVAITSLTNSVPENSPQGTLIALLNVNDQDSGENGQVICSIQENLPF
                     KLEKSYGNYYRLVTDAVLDREEVPSYNITMTATDRGSPPLTTETHLALDIADTNDNSP
                     VFLQASYWAYIPENNPRGASIASVTAHDPDSDKNAQVTYSLAEDTHQGVPLSSYVSIN
                     SDTGVLYALHSFDYEQFPDLQLQVIARDSGDPPLSSNVSLSLFVLDQNDNVPEILYPT
                     LPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTG
                     EISTARALMDRDALKQNLVVSVQDHGQPPLSATVTLTVAIADSIPDVLADLDNLESPS
                     TSETSGLTLYLVVAVAAVSTVFLVFVLVLLALRLRRWHSLRLLRAGGPGLADVAASHF
                     VGVDGVQAFLQTYSHEVSLTAGSRKSHLIFPQPNYADTLISQESCEKTEPLLPSGDSV
                     FSKDNHALNQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASA
                     SEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGK
                     APAGGNGNKKKSGKKEKK"
     exon            2962..3020
                     /gene="Pcdhga12"
                     /gene_synonym="pc2c; Pcdh13"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3109
                     /gene="Pcdhga12"
                     /gene_synonym="pc2c; Pcdh13"
                     /inference="alignment:Splign:2.1.0"
     exon            3110..5080
                     /gene="Pcdhga12"
                     /gene_synonym="pc2c; Pcdh13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tatgattgtg aatttttgtt ttttcagtaa taaattccaa cttgttacaa tagttcttcc
       61 ctttagaaat tttcaagaaa tctattgaaa tttttgtctt actggaaaat ataggaaaac
      121 aaacagctac tgaaaataat tcaaggaagt gaatttgtgg gggggggggg gttacggact
      181 gctcactgaa ctgcccagta ctgttgagtt ttctgtttcc atctccattt gaagaacagt
      241 aggtggagct atttaaggtt cacagaccaa aaatcctctc ccggagttca cgactgtgca
      301 gtaattggtt cggactctga gcgccgctgt tcaccacggg gaaggaaaag cagggaagcc
      361 ctgcttgctt tgcatgcgcc taaaacacaa tgcggacaga ttgagacaaa acccctctag
      421 gagcaaactg gcctggagga actcgtccca cctcctaact gtcttgctcc aaggcttcaa
      481 aagcagattc tggttcaggt gatcacaggc agaattggaa ataatcctca gttggtgatg
      541 atccccatgc aacggcggga ggactgcaaa gggctggtct tcctgggagt cctcctcggg
      601 atgctgtgga aagctggatc cacccagata cgctattcgg ttcccgagga gctggagaaa
      661 ggatctaggg tgggcaacat ctccaaggat ctggggctgg agccccgcga gctggagaag
      721 cgaggggtcc gcatcgtctc cagaggtagg gctcaacttt tcgctctaaa ccctcgaagc
      781 ggcagcctgg tcaccgcggg caggatagac cgggaggagc tgtgtatggg gtccatcaag
      841 tgtcagttaa atctagagat tctgatggaa gatataggga aaatatacgg agtagaaata
      901 gaagtgaggg acattaacga caacgctccc tacttccgtg aaagtgaatt agaaataaaa
      961 atgagcgaaa acgccgccgc tgggatgcgg ttccctcttc cccacgcttg ggatccagat
     1021 atcgggaaga actcgcttca gagctaccag ctcagcccga atgctcactt ctcactggag
     1081 gtgcagaacg gagctgatgg taacaagtac ccagaattgg tgctggagag ctcgctggat
     1141 cgggaggaaa aggccgctca tctcctagtc ctcaccgctt ccgacgcggg agacccggtt
     1201 cgcactggca cagcgcgcat ccgcgtgatg gttgtggatg cgaacgacaa cgcacctgcg
     1261 tttgctcggt ccgagtaccg cgtgagcgtg cgggagaacg tggctgtggg cactcagctg
     1321 ctgctggtca acgccaccga cccagacgaa ggcgccaatg cggaagtgat ctattccttc
     1381 cggtacgtgg acgacaaggc agcgaaagtt ttcaagctgg acagtaactt ggggacaata
     1441 tcaacaatag gggagctgaa tcatgaagaa tcggggttct acgagatgga ggtgcaagct
     1501 acagataacg cgggatattc tgcacgggcc aaggtcctgg tcacagttct ggacgtgaac
     1561 gacaatgccc ctgaagtagc catcacgtcc ctcaccaact ctgtcccaga aaactctccc
     1621 caagggacat taatagcact tttaaacgta aatgatcaag attctgggga aaatggacag
     1681 gtaatctgtt ccatccaaga gaatctgccc tttaagttag aaaagtctta cggaaactat
     1741 tatagattag tcacagatgc agtcctggac cgagaagagg ttcctagtta caacatcaca
     1801 atgaccgcca ctgacagggg aagtccgccc ctgacaacag aaactcacct cgcactggac
     1861 atagcagaca cgaacgataa ctcgcccgtt ttccttcagg cctcatactg ggcctacatc
     1921 ccagagaata accctagagg ggcctctatc gcatccgtga ccgcccacga ccccgacagt
     1981 gacaaaaatg cccaagtcac ttactcccta gctgaggaca cccaccaggg cgtgcccctt
     2041 tcctcttacg tttccatcaa ctcggacact ggtgtcctgt acgcactgca ttcctttgac
     2101 tacgagcagt tcccagacct acaactgcaa gtgatagcgc gtgacagcgg ggacccgcca
     2161 ctcagcagca acgtgtcact gagcttgttc gtgctggatc agaatgacaa cgtccccgaa
     2221 atcttgtacc ccactctccc taccgacggt tctactggag tggagctagc accccgctca
     2281 gcagagcctg gctatctggt gacaaaggtg gtggcagtgg acagagactc aggacagaac
     2341 gcctggctgt cctaccgtct gctaaaggcc agcgagccag ggctcttctc cgtggggctg
     2401 cacacgggcg agataagcac ggctcgggcc ctgatggaca gagatgctct caaacagaac
     2461 ctcgtagtgt ctgtgcagga ccacggccag cctcctctct ctgccactgt cacgctcact
     2521 gtggcgatcg ccgacagcat ccccgacgtc ctggcagatc tagacaatct agaatctcct
     2581 tccacctccg aaacttcagg gctcactctc tatctggtgg tggccgtggc ggcggtctcc
     2641 accgtcttcc tggtctttgt tctggtgctg ctggcgctca ggctgcggcg ctggcactca
     2701 ctgcgcctgc tccgggctgg gggacccgga ttggctgacg ttgcagcctc tcactttgtg
     2761 ggcgtagacg gagtgcaagc tttcttgcag acttattcgc acgaggtctc gctcactgcg
     2821 ggctcccgaa agagtcactt gattttcccg cagcccaact atgcagacac gctcatcagc
     2881 caggagagct gcgagaaaac cgagcctctt ttaccatcgg gtgattcggt tttttctaaa
     2941 gacaatcatg cattaaatca gcaagccccg cccaacactg actggcgttt ctctcaagcc
     3001 cagagacccg gcacgagcgg atcccaaaat ggtgatgaaa ctggcacctg gcccaacaac
     3061 cagtttgata cagagatgct gcaagccatg atcttggcct ctgccagcga agctgctgat
     3121 gggagctcta ccctgggagg gggcgctggc accatgggtc tgagcgctcg atacggaccc
     3181 cagtttaccc tgcagcacgt gcctgactac cgccagaacg tgtacatccc tggcagcaat
     3241 gccacgctga ccaatgccgc tggcaaacga gatggcaagg ctccagcagg tggtaatggc
     3301 aacaagaaga aatcgggcaa gaaagagaag aagtaatatg gaggccaggc cttgaaccac
     3361 aaggcagcct ccctccccag ccagtccagc tcgtccttac ttgtacccag gcctcagaat
     3421 ttcagggctc accccaggat actggtagga gccagggcca tgctccccgt tgggaaacag
     3481 aaacacgtgc ccaagccaac accccctctc tataccctag ggagttgaat atgcaaagag
     3541 agttctgctg ggacccccct attcaatcag tgattgtacc cacatgggta gcagggtttg
     3601 tgtgtgtgga catacacaca cacacacaca cacacacaca caaaccatgc cacactccct
     3661 tagttacagc tgaactcctc catcttccaa cccaggcagg cttatccatc tcctgccgcc
     3721 ctctccccac cccacccact ccttcagtcc ctctctttga gcaaggtagc tgggctgttg
     3781 gggtgaccgg tgagctaagc cggctcctag ttctgaacgg tagggagagt attacaatct
     3841 tttggcctct ccttcagttc agctttcccc caaagcatgg tttggtacca gtcttctctt
     3901 ttccttccag agcctgagac caatgcttaa gttttggggg aacaggcacc ctccctctgg
     3961 tactgatgat gcttgctgga ttttgggaag gcattttgct actaagcctc ttttcaatgc
     4021 ctggggacaa ctagtctttt gtttttcatt gtttgatgtt cccactgcat gctgtgactt
     4081 ccctacacct caaagaagag actcctttgc atgtctggag acagtagggg gtggtaaact
     4141 aaagggaagt tgagagtgta tactgctggg agtggggcag tggacaaaac agcctgttaa
     4201 tagggtcttg caaggggctc tgtatgtacc caggggactg gctcaatcct cacattctag
     4261 ccatagacaa acaccaggcc agacccctcc attctggttc agcctgggca gcttgggctg
     4321 agccaccagg accaatggat ttaagctgac atttcagtcc aagacgacga cttctaagtg
     4381 agtttaagac cagagaggaa agaggggcct ctgtgggtgc tgggtactcc agaggtgccc
     4441 ttggtgggag gaccagtggt cttagcagga aggggggccc agcaaggtca ttcttggacc
     4501 ctgggtctag tccagtagct agaaaaaggg accaagtggc cataaagtcc cagccaatga
     4561 tggggctttt ccagtgggcc cctgtagacc tcaagcccct ggcctccacc ttaccaggtg
     4621 ccatttcttc tcagaaggcc actgcccagg cccccaggcc gcccccttgt ggccagagaa
     4681 cggttaaagc cccccagtgc ctccttgtgc atagaacttc ctctgcccta gcccttacag
     4741 tagtgtagaa gatccccctc ccccgctggt gtagaatagc caatagtata gtgtggtgtg
     4801 cttttacgtg atggcgagtg ggcagcgggc ggtgggctgt acacagccgt ctgtcctttg
     4861 aatctcaatc tgcctgcgcg gcccgtgctg tgttttgtgc tgtgtccaca cgctgcggcg
     4921 acccctccct gtactgactt ctctataaaa agcttctctt cgcatagtca cgtagctcct
     4981 gcccatcccc cttccgatat ctctcgcaag ttttatactc taatatttat atggcttttt
     5041 tcttcgaaaa ttaaaaataa aaaaatggtt tcttctgaaa
//
