LOCUS       NP_291073                932 aa            linear   ROD 04-AUG-2023
DEFINITION  protocadherin gamma-A12 [Mus musculus].
ACCESSION   NP_291073 NP_056572
VERSION     NP_291073.1
DBSOURCE    REFSEQ: accession NM_033595.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 932)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 932)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   3  (residues 1 to 932)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   4  (residues 1 to 932)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   5  (residues 1 to 932)
  AUTHORS   Lobas MA, Helsper L, Vernon CG, Schreiner D, Zhang Y, Holtzman MJ,
            Thedens DR and Weiner JA.
  TITLE     Molecular heterogeneity in the choroid plexus epithelium: the
            22-member gamma-protocadherin family is differentially expressed,
            apically localized, and implicated in CSF regulation
  JOURNAL   J Neurochem 120 (6), 913-927 (2012)
   PUBMED   22092001
  REMARK    GeneRIF: This study suggested an unsuspected role for the
            gamma-Pcdhs in CSF production and demonstrate a surprising
            molecular heterogeneity in the CP epithelium.
REFERENCE   6  (residues 1 to 932)
  AUTHORS   Heymann R, Kallenbach S, Alonso S, Carroll P and Mitsiadis TA.
  TITLE     Dynamic expression patterns of the new protocadherin families CNRs
            and Pcdh-gamma during mouse odontogenesis: comparison with reelin
            expression
  JOURNAL   Mech Dev 106 (1-2), 181-184 (2001)
   PUBMED   11472853
REFERENCE   7  (residues 1 to 932)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   8  (residues 1 to 932)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (residues 1 to 932)
  AUTHORS   Hirano S, Ono T, Yan Q, Wang X, Sonta S and Suzuki ST.
  TITLE     Protocadherin 2C: a new member of the protocadherin 2 subfamily
            expressed in a redundant manner with OL-protocadherin in the
            developing brain
  JOURNAL   Biochem Biophys Res Commun 260 (3), 641-645 (1999)
   PUBMED   10403819
REFERENCE   10 (residues 1 to 932)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Oct 29, 2003 this sequence version replaced NP_056572.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056998.1, AY013795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..932
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.63 cM"
     Protein         1..932
                     /product="protocadherin gamma-A12"
                     /note="protocadherin 13; protocadherin gamma B6;
                     protocadherin gamma A12"
                     /calculated_mol_wt=100703
     Region          30..112
                     /region_name="Cadherin_2"
                     /note="Cadherin-like; pfam08266"
                     /db_xref="CDD:462413"
     Region          137..238
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(144..145,201,203,234,236..237)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          246..343
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(253..254,308,310,339,341..342)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          355..448
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(358..359,411,413,444,446..447)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          456..558
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Site            order(463..464,521,523,554,556..557)
                     /site_type="other"
                     /note="Ca2+ binding site [ion binding]"
                     /db_xref="CDD:206637"
     Region          579..666
                     /region_name="Cadherin_repeat"
                     /note="Cadherin tandem repeat domain; cd11304"
                     /db_xref="CDD:206637"
     Region          689..772
                     /region_name="Cadherin_C_2"
                     /note="Cadherin cytoplasmic C-terminal; pfam16492"
                     /db_xref="CDD:465139"
     Region          811..>905
                     /region_name="Cadherin_tail"
                     /note="Cadherin C-terminal cytoplasmic tail,
                     catenin-binding region; pfam15974"
                     /db_xref="CDD:435046"
     CDS             1..932
                     /gene="Pcdhga12"
                     /gene_synonym="pc2c; Pcdh13"
                     /coded_by="NM_033595.4:538..3336"
                     /db_xref="CCDS:CCDS29191.1"
                     /db_xref="GeneID:93724"
                     /db_xref="MGI:MGI:1935229"
ORIGIN      
        1 mipmqrredc kglvflgvll gmlwkagstq irysvpeele kgsrvgnisk dlgleprele
       61 krgvrivsrg raqlfalnpr sgslvtagri dreelcmgsi kcqlnleilm edigkiygve
      121 ievrdindna pyfreselei kmsenaaagm rfplphawdp digknslqsy qlspnahfsl
      181 evqngadgnk ypelvlessl dreekaahll vltasdagdp vrtgtarirv mvvdandnap
      241 afarseyrvs vrenvavgtq lllvnatdpd eganaeviys fryvddkaak vfkldsnlgt
      301 istigelnhe esgfyemevq atdnagysar akvlvtvldv ndnapevait sltnsvpens
      361 pqgtlialln vndqdsgeng qvicsiqenl pfkleksygn yyrlvtdavl dreevpsyni
      421 tmtatdrgsp plttethlal diadtndnsp vflqasyway ipennprgas iasvtahdpd
      481 sdknaqvtys laedthqgvp lssyvsinsd tgvlyalhsf dyeqfpdlql qviardsgdp
      541 plssnvslsl fvldqndnvp eilyptlptd gstgvelapr saepgylvtk vvavdrdsgq
      601 nawlsyrllk asepglfsvg lhtgeistar almdrdalkq nlvvsvqdhg qpplsatvtl
      661 tvaiadsipd vladldnles pstsetsglt lylvvavaav stvflvfvlv llalrlrrwh
      721 slrllraggp gladvaashf vgvdgvqafl qtyshevslt agsrkshlif pqpnyadtli
      781 sqescektep llpsgdsvfs kdnhalnqqa ppntdwrfsq aqrpgtsgsq ngdetgtwpn
      841 nqfdtemlqa milasaseaa dgsstlggga gtmglsaryg pqftlqhvpd yrqnvyipgs
      901 natltnaagk rdgkapaggn gnkkksgkke kk
//
