LOCUS       NM_033594               4764 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 11 (Pcdhga11), mRNA.
ACCESSION   NM_033594
VERSION     NM_033594.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4764)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4764)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   3  (bases 1 to 4764)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   4  (bases 1 to 4764)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   5  (bases 1 to 4764)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   6  (bases 1 to 4764)
  AUTHORS   Wang X, Su H and Bradley A.
  TITLE     Molecular mechanisms governing Pcdh-gamma gene expression: evidence
            for a multiple promoter and cis-alternative splicing model
  JOURNAL   Genes Dev 16 (15), 1890-1905 (2002)
   PUBMED   12154121
REFERENCE   7  (bases 1 to 4764)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   8  (bases 1 to 4764)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 4764)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC064675.1.
            
            On Jan 1, 2004 this sequence version replaced NM_033594.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064675.1, AY013794.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4764
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.62 cM"
     gene            1..4764
                     /gene="Pcdhga11"
                     /note="protocadherin gamma subfamily A, 11"
                     /db_xref="GeneID:93723"
                     /db_xref="MGI:MGI:1935228"
     exon            1..2595
                     /gene="Pcdhga11"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2970
                     /gene="Pcdhga11"
                     /codon_start=1
                     /product="protocadherin gamma-A11"
                     /protein_id="NP_291072.1"
                     /db_xref="CCDS:CCDS37784.1"
                     /db_xref="GeneID:93723"
                     /db_xref="MGI:MGI:1935228"
                     /translation="MANQSQRLDRRALIPLCIFLGTLLTFGTGQIRYSVPEETDKGFF
                     VGNISKDLGLEPWEVAERGVRIISRGQSQLFSLNPRGGSLVTAGRIDREELCDTMPSC
                     MLNLEILVEETLKIYGVEVEVLDINDNAPSFREEEVEIKVSEHTSPGSRFPLPSARDP
                     DAGMNSLQSYQLSPSSYFSLQVRGGTDGDKNPELVLEEGLDREKEASHHLLLTALDGG
                     DPVRKGTVPIRVVVLDVNDHIPKFTQPVYRVSIPENLSSGTRVLVVNASDPDEGINGE
                     VIYSFRKMKSKASEIFQLNSQTGEVLVGKPLDFEKYRFYEMEIQGQDGGGLLSTTTLL
                     ITVEDVNDNAPEITVTSASNSVPENSPSGTVIALLNVQDQDSGENGQVSCFIPSGLPF
                     KLEKTYGNYYKLITNSELDREQVESYNITLIAKDQGSPPLSTETHLLLKVADANDNPP
                     VFSSSSYLAYIPENNPRGSSIFSVTAIDRDSRENAQVTYSLAEYTIQGTPLSSYVSIN
                     SDTGVLYALQSFDYEQFQTLQLGVTASDNGDPPLSSNISLTLFVLDQNDNTPEILYPS
                     LPTDGSTGVELAPRSAEPGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFSVGLHTG
                     EVRTARAMMDKDALKQSLVVTVQDHGQPPLSATVKLTVAVADSIPEVLEDLVSLESPA
                     NPDESGLTLYLVVAITAVSCIFLIFVMVLLALKLRRWHSLRLLQAASGLAGVPPSHFV
                     GVDGMRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCGKSEPLLITEDSTT
                     VLGKCEPTDIQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILAS
                     ASEAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDG
                     KAPAGGNGNKKKSGKKEKK"
     exon            2596..2654
                     /gene="Pcdhga11"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2743
                     /gene="Pcdhga11"
                     /inference="alignment:Splign:2.1.0"
     exon            2744..4714
                     /gene="Pcdhga11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggatactca cgcatctcaa ctctggaagt aaaaacacct ccgttcgctt tggaatatgt
       61 tttggatgcg ggatacctgg aacctcgtag acacaaaagc tgactcggaa aaataaataa
      121 aaattaaacc ggcgcaagac ccttacggaa taacgctcac acccagccat ggcgaatcag
      181 tctcagcgcc tggaccgccg cgcgctgatc ccgctgtgca ttttcctggg gaccttgctg
      241 acctttggga caggacagat ccgatactcg gttccagaag aaacagataa aggcttcttc
      301 gtaggcaaca tctccaaaga cctggggctg gagccctggg aggtcgcgga acgcggagtc
      361 cgcatcatct ccaggggaca atcgcagctt ttctctctga atccgcgagg cggcagcttg
      421 gtcactgcag gtaggatcga ccgtgaagag ctatgtgata cgatgccctc ctgcatgctg
      481 aatttggaaa ttctcgtgga ggaaaccctg aagatttacg gagttgaggt ggaagtactg
      541 gacattaacg ataacgctcc cagcttccgg gaagaggaag tagagatcaa agtcagcgag
      601 cataccagtc ctgggtcgcg atttcctctt cctagcgcta gggatccaga cgcagggatg
      661 aactccctcc agagctacca gctcagccca agcagttatt tctccttgca ggtgagaggc
      721 gggactgatg gggacaagaa tccagagcta gtgctggagg aaggtctgga ccgggagaaa
      781 gaggcatctc accacctcct cctcacagcc ttagatgggg gagatcccgt ccgcaagggc
      841 acggttccca ttcgcgtggt ggtcctcgac gtcaatgatc acatcccaaa atttacacag
      901 cctgtgtata gagtgagtat tcctgaaaac ctcagctccg ggacgcgggt gctcgtggta
      961 aatgcctcag acccagatga ggggatcaac ggggaagtga tatactcttt ccggaaaatg
     1021 aaaagcaaag cttctgaaat atttcaactg aattctcaaa ctggggaggt tctagttgga
     1081 aagcctctgg attttgaaaa atacagattc tatgagatgg aaattcaagg ccaggatggt
     1141 ggagggctgc ttagcaccac tacgttgttg atcacggttg aagatgtgaa tgataacgct
     1201 ccagagataa ctgtcacctc tgccagtaac tcagtgccgg aaaattctcc ttcgggcaca
     1261 gtaattgctc ttctaaacgt tcaagatcaa gattctggag aaaatggtca ggtctcttgc
     1321 ttcattccta gtggtcttcc ttttaagtta gaaaagacgt atggaaatta ttataaattg
     1381 ataacaaata gtgaactgga ccgggagcag gtggagagct acaatattac attgatcgcc
     1441 aaagatcagg gcagtccacc gttgtctaca gaaactcacc tactgctcaa agtggcagat
     1501 gccaacgaca accctccagt tttctctagc tcctcttact tggcctacat tcctgaaaac
     1561 aaccccagag gctcttctat cttctcggtg accgccattg atagggatag cagagaaaat
     1621 gcccaggtca cttactctct ggctgagtac accatccagg gaacacctct gtcctcttac
     1681 gtttctatca attcagacac gggtgtgctg tatgccctgc aatccttcga ctatgagcaa
     1741 ttccagacct tacaactggg agtgaccgct agtgataatg gcgacccacc attaagcagc
     1801 aatatttcgc tgaccctttt cgtgctggac cagaatgaca acactccaga gattttatac
     1861 ccctctctcc ctaccgatgg ttccactggt gtggaattag cacctcgctc cgcagagccg
     1921 ggttatttag tgaccaaggt ggtggctgtg gacagagact ccgggcagaa cgcctggctg
     1981 tcctatcgcc tgctcaaagc cagcgagcca ggactcttct ccgtggggct gcacacgggg
     2041 gaggtacgca cggcccgagc catgatggac aaagatgctc tcaaacagag tctcgtggta
     2101 actgtgcaag accacggcca gcctcctctc tccgccactg tcaagctcac agtggcggtg
     2161 gctgacagca ttccagaggt tctggaggac ttggttagtc tggagtctcc cgccaacccg
     2221 gatgagtcag gcctcaccct ctacctagtg gtggccatca ctgcagtctc ctgcatcttc
     2281 ctcatctttg tcatggtact gctggctctc aagcttaggc gctggcactc attacgtctg
     2341 ctccaggctg ccagcggatt ggctggtgtg cctccttcgc actttgtggg cgtggacggg
     2401 atgcgcgctt tcctccagac gtattcccac gaagtttcgc tcactgcaga ctcaaggaag
     2461 agtcacctca tcttcccgca gcccaactat gcagacacac tcatcagcca ggagagctgt
     2521 gggaaaagcg agcctctcct gataactgaa gactcaacta cagttttagg caaatgtgaa
     2581 ccgacagata ttcagcaagc cccgcccaac actgactggc gtttctctca agcccagaga
     2641 cccggcacga gcggatccca aaatggtgat gaaactggca cctggcccaa caaccagttt
     2701 gatacagaga tgctgcaagc catgatcttg gcctctgcca gcgaagctgc tgatgggagc
     2761 tctaccctgg gagggggcgc tggcaccatg ggtctgagcg ctcgatacgg accccagttt
     2821 accctgcagc acgtgcctga ctaccgccag aacgtgtaca tccctggcag caatgccacg
     2881 ctgaccaatg ccgctggcaa acgagatggc aaggctccag caggtggtaa tggcaacaag
     2941 aagaaatcgg gcaagaaaga gaagaagtaa tatggaggcc aggccttgaa ccacaaggca
     3001 gcctccctcc ccagccagtc cagctcgtcc ttacttgtac ccaggcctca gaatttcagg
     3061 gctcacccca ggatactggt aggagccagg gccatgctcc ccgttgggaa acagaaacac
     3121 gtgcccaagc caacaccccc tctctatacc ctagggagtt gaatatgcaa agagagttct
     3181 gctgggaccc ccctattcaa tcagtgattg tacccacatg ggtagcaggg tttgtgtgtg
     3241 tggacataca cacacacaca cacacacaca cacacaaacc atgccacact cccttagtta
     3301 cagctgaact cctccatctt ccaacccagg caggcttatc catctcctgc cgccctctcc
     3361 ccaccccacc cactccttca gtccctctct ttgagcaagg tagctgggct gttggggtga
     3421 ccggtgagct aagccggctc ctagttctga acggtaggga gagtattaca atcttttggc
     3481 ctctccttca gttcagcttt cccccaaagc atggtttggt accagtcttc tcttttcctt
     3541 ccagagcctg agaccaatgc ttaagttttg ggggaacagg caccctccct ctggtactga
     3601 tgatgcttgc tggattttgg gaaggcattt tgctactaag cctcttttca atgcctgggg
     3661 acaactagtc ttttgttttt cattgtttga tgttcccact gcatgctgtg acttccctac
     3721 acctcaaaga agagactcct ttgcatgtct ggagacagta gggggtggta aactaaaggg
     3781 aagttgagag tgtatactgc tgggagtggg gcagtggaca aaacagcctg ttaatagggt
     3841 cttgcaaggg gctctgtatg tacccagggg actggctcaa tcctcacatt ctagccatag
     3901 acaaacacca ggccagaccc ctccattctg gttcagcctg ggcagcttgg gctgagccac
     3961 caggaccaat ggatttaagc tgacatttca gtccaagacg acgacttcta agtgagttta
     4021 agaccagaga ggaaagaggg gcctctgtgg gtgctgggta ctccagaggt gcccttggtg
     4081 ggaggaccag tggtcttagc aggaaggggg gcccagcaag gtcattcttg gaccctgggt
     4141 ctagtccagt agctagaaaa agggaccaag tggccataaa gtcccagcca atgatggggc
     4201 ttttccagtg ggcccctgta gacctcaagc ccctggcctc caccttacca ggtgccattt
     4261 cttctcagaa ggccactgcc caggccccca ggccgccccc ttgtggccag agaacggtta
     4321 aagcccccca gtgcctcctt gtgcatagaa cttcctctgc cctagccctt acagtagtgt
     4381 agaagatccc cctcccccgc tggtgtagaa tagccaatag tatagtgtgg tgtgctttta
     4441 cgtgatggcg agtgggcagc gggcggtggg ctgtacacag ccgtctgtcc tttgaatctc
     4501 aatctgcctg cgcggcccgt gctgtgtttt gtgctgtgtc cacacgctgc ggcgacccct
     4561 ccctgtactg acttctctat aaaaagcttc tcttcgcata gtcacgtagc tcctgcccat
     4621 cccccttccg atatctctcg caagttttat actctaatat ttatatggct tttttcttcg
     4681 aaaattaaaa ataaaaaaat ggtttcttct gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     4741 aaaaaaaaaa aaaaaaaaaa aaaa
//
