LOCUS       NM_033593               4706 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protocadherin gamma subfamily A, 10 (Pcdhga10), mRNA.
ACCESSION   NM_033593
VERSION     NM_033593.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4706)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4706)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 4706)
  AUTHORS   Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M,
            Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T,
            Hirabayashi T and Yagi T.
  TITLE     Developmental epigenetic modification regulates stochastic
            expression of clustered protocadherin genes, generating single
            neuron diversity
  JOURNAL   Neuron 82 (1), 94-108 (2014)
   PUBMED   24698270
REFERENCE   4  (bases 1 to 4706)
  AUTHORS   Ledderose J, Dieter S and Schwarz MK.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   5  (bases 1 to 4706)
  AUTHORS   Chen WV, Alvarez FJ, Lefebvre JL, Friedman B, Nwakeze C, Geiman E,
            Smith C, Thu CA, Tapia JC, Tasic B, Sanes JR and Maniatis T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   6  (bases 1 to 4706)
  AUTHORS   Prasad T, Wang X, Gray PA and Weiner JA.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   7  (bases 1 to 4706)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   8  (bases 1 to 4706)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4706)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4706)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 22, 2019 this sequence version replaced NM_033593.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013793.1, BC035540.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2590              AC020971.3         177542-180131
            2591-2649           AC129315.3         25335-25393
            2650-2738           AC129315.3         33579-33667
            2739-4706           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.61 cM"
     gene            1..4706
                     /gene="Pcdhga10"
                     /note="protocadherin gamma subfamily A, 10"
                     /db_xref="GeneID:93722"
                     /db_xref="MGI:MGI:1935227"
     exon            1..2590
                     /gene="Pcdhga10"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..2965
                     /gene="Pcdhga10"
                     /codon_start=1
                     /product="protocadherin gamma-A10 precursor"
                     /protein_id="NP_291071.1"
                     /db_xref="CCDS:CCDS79632.1"
                     /db_xref="GeneID:93722"
                     /db_xref="MGI:MGI:1935227"
                     /translation="MAAQRNLSERTKLVLLFLWMPWESAARQIRYSVPEELEKGSFVG
                     NIAKDLGLEPRQLAERGVRIISRGRSQLFSLNPRGGSLVTAGRIDREELCAQSAPCLV
                     SFNILVEDRVKLFGIEIEVTDVNDNAPKFQAETLDVKINENVAPGMRFPLPEATDPDV
                     GVNSLQSYQLSSNKHFSLVVQSGAKGVKYPELVLEQALDREEEAIHHLVLVASDGGNP
                     PRSGTVLITVTVFDANDNAPVFTSTEYRVNIPENLPVGTQLLKVTATDKDEGANGEVT
                     YAFRKSLDTQLSKFQLDKHTGEIKISENLDYEEMSFYEIEIQAEDGGAYLATAKVLIT
                     VEDVNDNSPEVTITSLFSPVTEDSPVGTVIALLNVHDLDSGQNGEVACSISGNLPFKL
                     EKSIDNYYRLVTQRALDREQVPAYNITVTATDGGNPPLSTKADFTLQVADINDNPPTF
                     SHPSYFTYIPENNPRGASIFSVTALDPDSKENAQIVYSLAEDTIEGAPLSSYISINSD
                     TGILYALWSFDYEQFRELQVQVTASDSGKPPLHSNVSLTLFVLDQNDNSPEILYPTMP
                     TDGSTGVELAPRSAELGYLVTKVVAVDRDSGQNAWLSYRLLKASEPGLFTVGLHTGEV
                     RTARALMERDALKQSLVVAVQDHGQPPLSATVTLTVAVADSIPDVLADLGNLEPPQDS
                     EASNLTLYLVVAVAAVSCVFLAFVIVLLALKLRRWHKSHVLQSSRDGLAGVPASHYVG
                     VDGVRAFLQTYSHEVSLTADSRKSHLIFPQPNYADTLISQESCEKKDPLSLLDDSKCP
                     VEDAPLVPQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASASE
                     AADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKAP
                     AGGNGNKKKSGKKEKK"
     exon            2591..2649
                     /gene="Pcdhga10"
                     /inference="alignment:Splign:2.1.0"
     exon            2650..2738
                     /gene="Pcdhga10"
                     /inference="alignment:Splign:2.1.0"
     exon            2739..4706
                     /gene="Pcdhga10"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagttccgg caaaccggct cctgggctgc aacgaaaatt actccgcact ttaaggtgct
       61 tccgctgcgg gagacccaag gggtcacaga aagaagaaaa gaaccgggtg aaacacactg
      121 ggcgcctggc ggatcgggaa aagctttgag agaattccgt agtcagaaga caatggccgc
      181 tcaaaggaat ctctcagagc gcaccaaact ggtcctcctt ttcttatgga tgccctggga
      241 atccgcagct cggcagatcc gctattcagt tcctgaggaa ctagagaaag gctcttttgt
      301 gggcaacatc gccaaggacc tggggctgga gccccgccag ctggcggaac gcggggtccg
      361 catcatctcc agaggtaggt ctcagctttt ctctctgaac ccgcgaggcg gcagcttagt
      421 caccgcgggc aggatagacc gggaggagct gtgcgcccag agcgcgccct gtctcgtcag
      481 ctttaacatc cttgttgaag atagagtgaa acttttcggg atagaaatag aggtaacgga
      541 tgtcaatgac aatgcgccaa aattccaagc agaaactcta gatgtaaaaa ttaatgaaaa
      601 tgtcgcccca ggaatgcgtt ttcctctccc ggaagctact gatccggatg tgggagtgaa
      661 ttctctgcag agctaccagc tcagctccaa taaacacttc tccctagtcg ttcagagcgg
      721 tgctaagggc gtcaagtacc cggagctagt gctggaacag gccctagatc gtgaggaaga
      781 ggcgattcac cacctggtcc tcgtggcctc tgacggagga aaccctccca gatcgggcac
      841 tgtcctcatc actgtgaccg tctttgatgc aaatgacaat gctccagtct tcacctccac
      901 tgaataccgc gtgaacattc cggagaacct gcctgtgggc acccaactgc taaaggtaac
      961 cgccaccgac aaagacgaag gtgccaatgg agaagtgaca tatgcattcc gaaaatcgct
     1021 ggacacacaa ttgtccaaat tccaactaga caaacatacc ggagaaataa aaatttctga
     1081 aaatctagat tatgaagaaa tgagtttcta tgaaatagaa atccaagctg aagatggagg
     1141 ggcctatctt gcaactgcga aggtgctgat tacagtagaa gatgtaaatg acaacagtcc
     1201 tgaggtgacc atcacatctc tcttcagtcc agtgacagaa gattcgccgg tgggaactgt
     1261 catagcccta ctaaacgtcc atgatttaga ctccgggcag aatggagagg tagcctgttc
     1321 catctcaggg aatcttccgt ttaagttaga aaagtccatt gacaattact ataggctagt
     1381 gacacaaaga gcccttgatc gggaacaggt acccgcttac aacatcacag taacagccac
     1441 tgatggggga aacccacctt tgtcaaccaa agctgacttc actctgcaag tggcagatat
     1501 caacgacaac ccacctacct tctctcatcc gtcctacttt acctacatcc cagagaacaa
     1561 tcccagaggc gcctccatct tctcagtgac tgccctcgat ccagacagca aagagaacgc
     1621 ccagatcgtt tactccctgg ctgaagacac cattgagggg gcgccacttt cttcctacat
     1681 atccatcaac tcagacactg gcatcctgta tgcgctctgg tcctttgact atgagcagtt
     1741 tcgtgaactg caggtacagg tgactgccag cgacagcgga aagccgcccc tccacagtaa
     1801 tgtgtcgttg actctgtttg tgctggatca aaatgacaac tctccagaaa tcttgtaccc
     1861 caccatgccc accgacggct ccactggggt agagcttgct ccccgctcag cagagctggg
     1921 ctatctggtg acgaaggtgg tggcagtgga cagagactcg ggacagaacg cctggctgtc
     1981 ctatcgccta ctcaaggcca gcgaaccagg gctcttcact gtagggctgc acacgggtga
     2041 ggtgcgcaca gcccgagccc tgatggaaag agatgctctc aagcagagtc tagtggtggc
     2101 tgtgcaggac catggccagc ctcctctctc cgcaacggtc actttgactg ttgcagtagc
     2161 tgacagcatc cctgatgtcc tggcagactt gggcaacctg gagccaccac aggactctga
     2221 ggcctcaaac ctcacactct acctagtagt ggcagtggca gctgtttctt gcgtctttct
     2281 cgcctttgtc attgtgttgt tggcactcaa actccggcgc tggcacaagt ctcacgtgct
     2341 gcagtcttcg agagatggat tggctggcgt gcctgcctct cactatgtgg gcgtggacgg
     2401 ggtgcgcgct ttcctgcaga cctattcgca cgaggtttcc ctcactgctg attcgcggaa
     2461 gagtcatctg atcttcccgc agcctaacta cgcagacaca ctcatcagcc aggagagctg
     2521 tgagaaaaaa gatcctttgt ctttgttaga tgattccaag tgtcctgtag aagacgctcc
     2581 tttggtgcca caagccccgc ccaacactga ctggcgtttc tctcaagccc agagacccgg
     2641 cacgagcgga tcccaaaatg gtgatgaaac tggcacctgg cccaacaacc agtttgatac
     2701 agagatgctg caagccatga tcttggcctc tgccagcgaa gctgctgatg ggagctctac
     2761 cctgggaggg ggcgctggca ccatgggtct gagcgctcga tacggacccc agtttaccct
     2821 gcagcacgtg cctgactacc gccagaacgt gtacatccct ggcagcaatg ccacgctgac
     2881 caatgccgct ggcaaacgag atggcaaggc tccagcaggt ggtaatggca acaagaagaa
     2941 atcgggcaag aaagagaaga agtaatatgg aggccaggcc ttgaaccaca aggcagcctc
     3001 cctccccagc cagtccagct cgtccttact tgtacccagg cctcagaatt tcagggctca
     3061 ccccaggata ctggtaggag ccagggccat gctccccgtt gggaaacaga aacacgtgcc
     3121 caagccaaca ccccctctct ataccctagg gagttgaata tgcaaagaga gttctgctgg
     3181 gaccccccta ttcaatcagt gattgtaccc acatgggtag cagggtttgt gtgtgtggac
     3241 atacacacac acacacacac acacacacac aaaccatgcc acactccctt agttacagct
     3301 gaactcctcc atcttccaac ccaggcaggc ttatccatct cctgccgccc tctccccacc
     3361 ccacccactc cttcagtccc tctctttgag caaggtagct gggctgttgg ggtgaccggt
     3421 gagctaagcc ggctcctagt tctgaacggt agggagagta ttacaatctt ttggcctctc
     3481 cttcagttca gctttccccc aaagcatggt ttggtaccag tcttctcttt tccttccaga
     3541 gcctgagacc aatgcttaag ttttggggga acaggcaccc tccctctggt actgatgatg
     3601 cttgctggat tttgggaagg cattttgcta ctaagcctct tttcaatgcc tggggacaac
     3661 tagtcttttg tttttcattg tttgatgttc ccactgcatg ctgtgacttc cctacacctc
     3721 aaagaagaga ctcctttgca tgtctggaga cagtaggggg tggtaaacta aagggaagtt
     3781 gagagtgtat actgctggga gtggggcagt ggacaaaaca gcctgttaat agggtcttgc
     3841 aaggggctct gtatgtaccc aggggactgg ctcaatcctc acattctagc catagacaaa
     3901 caccaggcca gacccctcca ttctggttca gcctgggcag cttgggctga gccaccagga
     3961 ccaatggatt taagctgaca tttcagtcca agacgacgac ttctaagtga gtttaagacc
     4021 agagaggaaa gaggggcctc tgtgggtgct gggtactcca gaggtgccct tggtgggagg
     4081 accagtggtc ttagcaggaa ggggggccca gcaaggtcat tcttggaccc tgggtctagt
     4141 ccagtagcta gaaaaaggga ccaagtggcc ataaagtccc agccaatgat ggggcttttc
     4201 cagtgggccc ctgtagacct caagcccctg gcctccacct taccaggtgc catttcttct
     4261 cagaaggcca ctgcccaggc ccccaggccg cccccttgtg gccagagaac ggttaaagcc
     4321 ccccagtgcc tccttgtgca tagaacttcc tctgccctag cccttacagt agtgtagaag
     4381 atccccctcc cccgctggtg tagaatagcc aatagtatag tgtggtgtgc ttttacgtga
     4441 tggcgagtgg gcagcgggcg gtgggctgta cacagccgtc tgtcctttga atctcaatct
     4501 gcctgcgcgg cccgtgctgt gttttgtgct gtgtccacac gctgcggcga cccctccctg
     4561 tactgacttc tctataaaaa gcttctcttc gcatagtcac gtagctcctg cccatccccc
     4621 ttccgatatc tctcgcaagt tttatactct aatatttata tggctttttt cttcgaaaat
     4681 taaaaataaa aaaatggttt cttctg
//
