LOCUS       NM_033584               4707 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protocadherin gamma subfamily A, 1 (Pcdhga1), mRNA.
ACCESSION   NM_033584
VERSION     NM_033584.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4707)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4707)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4707)
  AUTHORS   Ledderose,J., Dieter,S. and Schwarz,M.K.
  TITLE     Maturation of postnatally generated olfactory bulb granule cells
            depends on functional gamma-protocadherin expression
  JOURNAL   Sci Rep 3, 1514 (2013)
   PUBMED   23515096
REFERENCE   4  (bases 1 to 4707)
  AUTHORS   Chen,W.V., Alvarez,F.J., Lefebvre,J.L., Friedman,B., Nwakeze,C.,
            Geiman,E., Smith,C., Thu,C.A., Tapia,J.C., Tasic,B., Sanes,J.R. and
            Maniatis,T.
  TITLE     Functional significance of isoform diversification in the
            protocadherin gamma gene cluster
  JOURNAL   Neuron 75 (3), 402-409 (2012)
   PUBMED   22884324
  REMARK    Erratum:[Neuron. 2012 Sep 6;75(5):928-9]
REFERENCE   5  (bases 1 to 4707)
  AUTHORS   Prasad,T., Wang,X., Gray,P.A. and Weiner,J.A.
  TITLE     A differential developmental pattern of spinal interneuron
            apoptosis during synaptogenesis: insights from genetic analyses of
            the protocadherin-gamma gene cluster
  JOURNAL   Development 135 (24), 4153-4164 (2008)
   PUBMED   19029045
REFERENCE   6  (bases 1 to 4707)
  AUTHORS   Frank,M., Ebert,M., Shan,W., Phillips,G.R., Arndt,K., Colman,D.R.
            and Kemler,R.
  TITLE     Differential expression of individual gamma-protocadherins during
            mouse brain development
  JOURNAL   Mol Cell Neurosci 29 (4), 603-616 (2005)
   PUBMED   15964765
REFERENCE   7  (bases 1 to 4707)
  AUTHORS   Murata,Y., Hamada,S., Morishita,H., Mutoh,T. and Yagi,T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   8  (bases 1 to 4707)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 4707)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 4707)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020971.3 and AC129315.3.
            
            On Feb 22, 2019 this sequence version replaced NM_033584.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013792.1, ERR3363660.209191.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2591              AC020971.3         92301-94891
            2592-2650           AC129315.3         25335-25393
            2651-2739           AC129315.3         33579-33667
            2740-4707           AC129315.3         40217-42184
FEATURES             Location/Qualifiers
     source          1..4707
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.54 cM"
     gene            1..4707
                     /gene="Pcdhga1"
                     /note="protocadherin gamma subfamily A, 1"
                     /db_xref="GeneID:93709"
                     /db_xref="MGI:MGI:1935212"
     exon            1..2591
                     /gene="Pcdhga1"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..2966
                     /gene="Pcdhga1"
                     /codon_start=1
                     /product="protocadherin gamma-A1 precursor"
                     /protein_id="NP_291062.1"
                     /db_xref="CCDS:CCDS79622.1"
                     /db_xref="GeneID:93709"
                     /db_xref="MGI:MGI:1935212"
                     /translation="MAIPEKLTGWSLLVLVCLSLELLLEAGAGNIRYSVPEETDKGSF
                     VGSIAKDLGLETRELMERGIRIVSRGRSQLFSLNPRSGSLVTAGRIDREELCAQSTPC
                     VVSFNILMEDEMKLLPIEVEIIDINDNTPQFQLEELELKMSEITTPGTRIPLPLGQDL
                     DVGINSLQSYQLSANPHFSLDVQQGPEGPQQPEMVLQRPLDREKDAVHYLVLTASDGG
                     SPIHSGTLQIHVQVVDVNDNPPAFTKAEYHVSVPENVPLGTRLLKVNATDPDEGANGR
                     VTYSFHKVDHSVVRKFQLDAYTGELSNKEPLDFEEYKVYPMEIQAQDGAGLMARAKVL
                     VTVLDVNDNAPEVGITSVTNTVPENFPPGTTIALISVHDQDADNNGHITCSIPGNLPF
                     KLEKLVDNYYRLVTERTLDREQSSRHNITITATDQGTPPLSTQAHISLLVTDINDNPP
                     VFEQDSYSVYIPENNPRGASIFSVKAQDADHNENALVTYALVEDTIQGVPLSSYFSIN
                     SDTGVVYALQSFDYEQFRDLQLRVMAHDSGNPQLSSNVSLSLFMIDQNDNAPEILYPV
                     LPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQNSWLSYRLLKASEPGLFSVGLHTG
                     EVRTARALLERDALKQSLVVAVQDHGQPPLSTTVTFTIAVADSIPDLLADLGSMGTPA
                     DPQDSDLTLYLVVAVAVVSCIFLAFVIVLLVLKLRHWYSSRLLQTEANGLTGLPASNF
                     VGVDGVHAFLQTYSREISLTADSRKSHLIFPQPNYADTLISHESCEKQEFLSAPQSLL
                     EDKEEIFSQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEMLQAMILASAS
                     EAADGSSTLGGGAGTMGLSARYGPQFTLQHVPDYRQNVYIPGSNATLTNAAGKRDGKA
                     PAGGNGNKKKSGKKEKK"
     exon            2592..2650
                     /gene="Pcdhga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2651..2739
                     /gene="Pcdhga1"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..4707
                     /gene="Pcdhga1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactctcct ttcatgccag actggaaacg tctgcctgaa actgcccagc gtatttctgg
       61 acagctctct gctataattg tctaaaataa ggcaaagaag accctggaaa ggcagagaag
      121 caataccctt gataccagat tgagaaaaaa aggcaggaag ccagagagca atggcgattc
      181 cagagaagtt aaccggctgg agcctgctgg tgctggtgtg tctttctctg gagctactgc
      241 tggaagctgg ggctggaaac atccgatact ctgtgccaga agaaaccgac aaaggctcct
      301 tcgtgggcag catcgccaag gacctgggac tggaaacccg ggagctgatg gagcgcggga
      361 tccgcatcgt ttccagaggt aggtcgcagc ttttctccct gaacccgcga agcggcagct
      421 tggtcaccgc aggcaggata gaccgggaag agctgtgcgc tcagagcacg ccatgtgtcg
      481 tcagctttaa catccttatg gaggatgaaa tgaagcttct ccctatcgaa gtagagataa
      541 ttgatattaa tgacaacact ccccaattcc agttagaaga gctagaatta aaaatgagtg
      601 aaataacgac tccaggtacc aggatccctc tgcctctcgg gcaagacctt gatgtgggga
      661 taaactcact tcagagctac cagctaagcg ccaaccctca cttctccctg gatgtgcaac
      721 agggacctga aggaccacaa cagccagaga tggtactgca gagacctcta gacagagaaa
      781 aagatgctgt ccactacctt gtcctcactg cctcggatgg cggcagccca atacattcag
      841 ggactctgca aattcatgtg caggtggtag atgtgaacga caacccacca gcatttacta
      901 aggcagagta tcacgtgagc gtccctgaga atgtcccttt aggcactcgg ctactcaaag
      961 tgaatgcaac tgacccggat gagggagcta atggcagagt aacctactcc tttcacaagg
     1021 tagaccacag tgtggtccgg aaatttcagt tggatgctta cacgggagaa ctatcaaata
     1081 aagaaccact agattttgaa gaatacaaag tttatccaat ggaaattcaa gctcaggatg
     1141 gtgctggact catggccaga gctaaggtgc tggtcactgt tttggatgtt aatgataatg
     1201 ccccggaagt tggaatcacg tctgtcacta acacagtacc agaaaacttt cctcctggga
     1261 ccacaattgc tcttatcagt gtgcatgatc aagacgctga taacaacggt cacatcacat
     1321 gttccatccc tggcaaccta ccctttaaac tggaaaagct agtcgacaat tattaccgct
     1381 tagtaacaga aagaacactg gacagagaac aaagttctag gcacaacatc acaataacag
     1441 caacagatca gggaactccg cccctatcta cccaagctca catctcactg ctagtgacag
     1501 atatcaatga caaccctcca gtttttgaac aggactccta ttctgtctac attcctgaaa
     1561 acaaccccag aggggcttcc atcttctcag taaaggccca ggatgctgac cacaatgaga
     1621 atgcactagt gacttacgcc ctggtggaag acactattca gggagtacct ttgtcttctt
     1681 acttctccat caattctgac actggagttg tctatgcatt gcaatccttt gactatgagc
     1741 agtttcgaga tttgcagcta agagtgatgg cccatgatag tgggaaccca caactcagca
     1801 gcaatgtatc tctgagtctg ttcatgatag atcagaatga caatgcccca gagatcctgt
     1861 accctgtcct ccctactgat ggctccactg gtgtggagct agcacctcga tctgctgagc
     1921 ccggttacct agtgaccaaa gtggtagcag tggacaaaga ctcaggacaa aactcttggc
     1981 tgtcctaccg tctgctcaag gccagtgaac cagggctctt ctcggtagga ctacacactg
     2041 gtgaggtacg cactgctcgg gccctgctgg agagagatgc tctcaagcag agcctggtgg
     2101 tggctgtgca ggaccacggc cagcctcctc tgtccaccac agtcacattt accatagcag
     2161 tagctgacag catccctgac ctcctggctg acctgggcag catggggacc cctgccgatc
     2221 cccaggattc agacctgaca ctctacctgg tggtggcagt ggctgtagtc tcctgcatct
     2281 tcctagcctt tgtaatagtg ctcttggtgc tcaagctgcg acattggtac tcctcacgct
     2341 tgctccagac tgaagcaaat ggactgactg gcctgcctgc ctccaacttt gtaggtgttg
     2401 atggggtgca tgcatttcta cagacctatt cccgtgagat ctcactcact gctgactctc
     2461 gaaagagcca cttgatcttc ccgcaaccca actatgcaga cacactcatc agccacgaga
     2521 gctgtgagaa acaggaattt ttgtcagcac cccagtctct gcttgaagat aaagaggaaa
     2581 tattttctca gcaagccccg cccaacactg actggcgttt ctctcaagcc cagagacccg
     2641 gcacgagcgg atcccaaaat ggtgatgaaa ctggcacctg gcccaacaac cagtttgata
     2701 cagagatgct gcaagccatg atcttggcct ctgccagcga agctgctgat gggagctcta
     2761 ccctgggagg gggcgctggc accatgggtc tgagcgctcg atacggaccc cagtttaccc
     2821 tgcagcacgt gcctgactac cgccagaacg tgtacatccc tggcagcaat gccacgctga
     2881 ccaatgccgc tggcaaacga gatggcaagg ctccagcagg tggtaatggc aacaagaaga
     2941 aatcgggcaa gaaagagaag aagtaatatg gaggccaggc cttgaaccac aaggcagcct
     3001 ccctccccag ccagtccagc tcgtccttac ttgtacccag gcctcagaat ttcagggctc
     3061 accccaggat actggtagga gccagggcca tgctccccgt tgggaaacag aaacacgtgc
     3121 ccaagccaac accccctctc tataccctag ggagttgaat atgcaaagag agttctgctg
     3181 ggacccccct attcaatcag tgattgtacc cacatgggta gcagggtttg tgtgtgtgga
     3241 catacacaca cacacacaca cacacacaca caaaccatgc cacactccct tagttacagc
     3301 tgaactcctc catcttccaa cccaggcagg cttatccatc tcctgccgcc ctctccccac
     3361 cccacccact ccttcagtcc ctctctttga gcaaggtagc tgggctgttg gggtgaccgg
     3421 tgagctaagc cggctcctag ttctgaacgg tagggagagt attacaatct tttggcctct
     3481 ccttcagttc agctttcccc caaagcatgg tttggtacca gtcttctctt ttccttccag
     3541 agcctgagac caatgcttaa gttttggggg aacaggcacc ctccctctgg tactgatgat
     3601 gcttgctgga ttttgggaag gcattttgct actaagcctc ttttcaatgc ctggggacaa
     3661 ctagtctttt gtttttcatt gtttgatgtt cccactgcat gctgtgactt ccctacacct
     3721 caaagaagag actcctttgc atgtctggag acagtagggg gtggtaaact aaagggaagt
     3781 tgagagtgta tactgctggg agtggggcag tggacaaaac agcctgttaa tagggtcttg
     3841 caaggggctc tgtatgtacc caggggactg gctcaatcct cacattctag ccatagacaa
     3901 acaccaggcc agacccctcc attctggttc agcctgggca gcttgggctg agccaccagg
     3961 accaatggat ttaagctgac atttcagtcc aagacgacga cttctaagtg agtttaagac
     4021 cagagaggaa agaggggcct ctgtgggtgc tgggtactcc agaggtgccc ttggtgggag
     4081 gaccagtggt cttagcagga aggggggccc agcaaggtca ttcttggacc ctgggtctag
     4141 tccagtagct agaaaaaggg accaagtggc cataaagtcc cagccaatga tggggctttt
     4201 ccagtgggcc cctgtagacc tcaagcccct ggcctccacc ttaccaggtg ccatttcttc
     4261 tcagaaggcc actgcccagg cccccaggcc gcccccttgt ggccagagaa cggttaaagc
     4321 cccccagtgc ctccttgtgc atagaacttc ctctgcccta gcccttacag tagtgtagaa
     4381 gatccccctc ccccgctggt gtagaatagc caatagtata gtgtggtgtg cttttacgtg
     4441 atggcgagtg ggcagcgggc ggtgggctgt acacagccgt ctgtcctttg aatctcaatc
     4501 tgcctgcgcg gcccgtgctg tgttttgtgc tgtgtccaca cgctgcggcg acccctccct
     4561 gtactgactt ctctataaaa agcttctctt cgcatagtca cgtagctcct gcccatcccc
     4621 cttccgatat ctctcgcaag ttttatactc taatatttat atggcttttt tcttcgaaaa
     4681 ttaaaaataa aaaaatggtt tcttctg
//
