LOCUS       NM_053133               2340 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus protocadherin beta 8 (Pcdhb8), mRNA.
ACCESSION   NM_053133
VERSION     NM_053133.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2340)
  AUTHORS   Xu,L., Zheng,Y., Li,X., Wang,A., Huo,D., Li,Q., Wang,S., Luo,Z.,
            Liu,Y., Xu,F., Wu,X., Wu,M. and Zhou,Y.
  TITLE     Abnormal neocortex arealization and Sotos-like syndrome-associated
            behavior in Setd2 mutant mice
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523829
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2340)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2340)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 2340)
  AUTHORS   Goodman,K.M., Rubinstein,R., Thu,C.A., Bahna,F., Mannepalli,S.,
            Ahlsen,G., Rittenhouse,C., Maniatis,T., Honig,B. and Shapiro,L.
  TITLE     Structural Basis of Diverse Homophilic Recognition by Clustered
            alpha- and beta-Protocadherins
  JOURNAL   Neuron 90 (4), 709-723 (2016)
   PUBMED   27161523
REFERENCE   5  (bases 1 to 2340)
  AUTHORS   Toyoda,S., Kawaguchi,M., Kobayashi,T., Tarusawa,E., Toyama,T.,
            Okano,M., Oda,M., Nakauchi,H., Yoshimura,Y., Sanbo,M.,
            Hirabayashi,M., Hirayama,T., Hirabayashi,T. and Yagi,T.
  TITLE     Developmental epigenetic modification regulates stochastic
            expression of clustered protocadherin genes, generating single
            neuron diversity
  JOURNAL   Neuron 82 (1), 94-108 (2014)
   PUBMED   24698270
REFERENCE   6  (bases 1 to 2340)
  AUTHORS   Junghans,D., Heidenreich,M., Hack,I., Taylor,V., Frotscher,M. and
            Kemler,R.
  TITLE     Postsynaptic and differential localization to neuronal subtypes of
            protocadherin beta16 in the mammalian central nervous system
  JOURNAL   Eur J Neurosci 27 (3), 559-571 (2008)
   PUBMED   18279309
REFERENCE   7  (bases 1 to 2340)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   8  (bases 1 to 2340)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 2340)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 2340)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY013790.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC116268.1, AY013790.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2340
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.47 cM"
     gene            1..2340
                     /gene="Pcdhb8"
                     /gene_synonym="Pcdhb5C; PcdhbH"
                     /note="protocadherin beta 8"
                     /db_xref="GeneID:93879"
                     /db_xref="MGI:MGI:2136742"
     CDS             1..2340
                     /gene="Pcdhb8"
                     /gene_synonym="Pcdhb5C; PcdhbH"
                     /note="PCDH-beta-8"
                     /codon_start=1
                     /product="protocadherin beta-8 precursor"
                     /protein_id="NP_444363.1"
                     /db_xref="CCDS:CCDS29175.1"
                     /db_xref="GeneID:93879"
                     /db_xref="MGI:MGI:2136742"
                     /translation="METALTKTPEKRQVIFLAILLLLWEASSEAISYSMPEETESGYL
                     VANLAQDLGLRVGELTTRGARIHHNGNKELLQLDAERGNLLLKEKPDREALCGATEPC
                     VLHFQIILENPVQFFQTDLQFTDINDHFPEFPDTEMLLKIQEIAQPGTVFPLKAAQDP
                     DIGSNAVQNYTVSPNLHFHVVTLSRSDDRKYPELVLDRALDREEQPELTLILTALDGG
                     APPKSGTTTVRIEVVDINDNAPQFLQSLYAVEVPENSPLNALVVTVSARDLDAGIHGN
                     VAYSLFQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGGLSGKCTVAI
                     QVLDVNDNAPKLTISSLTSSIPENAPEAVVAVFSVSDPDSGDNGRMVCSIQNGLPFLL
                     KPTFKNFYTLVTERPLDRESNAEYNITITVSDLGTPRLTTQHTITVQVSDINDNAPAF
                     TQTSYTLFVHENNSPALHIGTISATDSDSGSNGLIIYSLLPPHDQQLGLASLISINSD
                     NGQLFALRALDYEALQAFEFHVGATDRGSPALSSEALVRVVVLDDNDNAPFVLYPLQN
                     ASAPCTELLPRAAEPGYLITKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVR
                     TTRLLSERDAPKHRLLLLVKDNGEPLRSASVMLQVLVVDGFSQPYLPLPEVALNPTQE
                     EDMLTLYLVIALASVSSLFLLSVLLFVGVKLCKKAREASLADCSIPEGHFPSHLVDVS
                     GAGTLSQSYHYEVCLTEDSGTSDFKFMNPIIPSSLLQDS"
     exon            1..2340
                     /gene="Pcdhb8"
                     /gene_synonym="Pcdhb5C; PcdhbH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggagacag cgctaacaaa aacgccagag aaaaggcaag tcattttcct tgctatattg
       61 ttgcttttgt gggaggctag ttctgaggca attagctatt ccatgccaga agaaacggag
      121 agtggctact tggtggctaa cctggcacaa gatctggggc tcagggttgg ggaactgacc
      181 actagagggg cacgaatcca tcacaatggt aacaaagagc tcttgcagct tgatgcagag
      241 agagggaatt tgctcctgaa ggaaaaacca gatcgcgaag cactgtgtgg ggcgacagaa
      301 ccctgtgtgc tgcacttcca gatcatacta gaaaaccctg tgcagttctt tcaaacagac
      361 ttgcagttca cagatataaa cgaccatttc ccagagttcc ctgacacaga aatgctccta
      421 aaaattcaag aaattgccca gccagggact gtgtttcctc tgaaggcagc tcaggaccct
      481 gacataggga gcaacgctgt tcagaactac acagtcagtc ccaacctcca tttccatgtc
      541 gttactctca gtcgctcaga tgacaggaaa tacccagagc tggtgctgga cagagccctg
      601 gacagggagg agcagcctga actcacttta atcctcactg ctctggatgg cggagctcca
      661 cccaagtctg ggacaaccac tgttcggatt gaagtcgtgg acatcaatga taatgccccc
      721 cagttcttac agtcactcta tgcggtggag gtccctgaga acagtcccct caatgcctta
      781 gttgtcactg tctctgccag ggatttagat gctgggatac atggcaatgt agcctactct
      841 ctgtttcaag gcgggggagg tcctcagcca tttgtaatag atgaaatcac aggagaaatt
      901 cgacttaaag gggcattgga ttttgaagca acttcatact ataccatgga aattgtagcc
      961 acagacagtg gtggtctttc aggaaaatgc actgtagcta tccaggtgtt ggatgtgaac
     1021 gacaatgccc ctaaactcac catatcttcg ctcactagtt ccatcccaga aaatgctccg
     1081 gaggctgtag ttgctgtttt cagtgtctct gacccagatt cgggggacaa tggaaggatg
     1141 gtgtgttcaa ttcagaacgg acttccattt cttttaaaac ccacattcaa gaacttttac
     1201 accttagtca cggagagacc cctggataga gagagcaacg ctgagtacaa catcacaatc
     1261 acggtctctg acctgggcac acccaggctc acaacccagc acaccataac agtgcaagtg
     1321 tccgacatca acgataatgc tcctgccttc actcaaacct cttacacctt gtttgttcac
     1381 gagaacaaca gccctgccct gcacataggc accatcagcg ccacagactc agactctggc
     1441 tccaatggcc ttattatcta ctcgttgctg ccgccccatg accagcagct gggccttgcc
     1501 tcgctgatct ccatcaactc agacaacggg cagctgtttg cgctcagggc gctggactac
     1561 gaggccctgc aggccttcga gttccacgtg ggcgccacag acagaggctc gcccgcgctc
     1621 agctcagagg ctctggtgcg cgtagtggtg ctggatgaca atgacaatgc gcccttcgtg
     1681 ctctacccac tgcaaaacgc ttctgcgccc tgcactgagc tgctgcccag ggctgcggag
     1741 cctggctacc tgatcaccaa ggtggtggca gtggaccgcg actctggcca gaatgcctgg
     1801 ctgtcattcc agctgctcaa ggccacagag cccgggctgt tcagcgtgtg ggcgcacaat
     1861 ggcgaagtgc gcaccaccag gctgctgagc gagcgagatg cacccaagca caggctgctg
     1921 ctgctggtca aggacaatgg agagcctctg cgctctgcta gtgtcatgct gcaggtgcta
     1981 gtggtggatg gcttctctca gccctacctg cctctgccag aggtggcgct caaccccaca
     2041 caggaagaag acatgctcac tctctatctg gttattgcct tggcttctgt gtcttcactt
     2101 ttcctcttgt ctgtgctgct gtttgtgggg gtgaagttgt gcaagaaggc cagggaggct
     2161 tctctggctg actgctctat tcctgaggga cactttccta gccacttggt ggatgtcagt
     2221 ggtgcgggga ccttatccca gagttaccat tatgaggtct gtctgactga ggactctggg
     2281 acctcagatt tcaagttcat gaaccccatt attcctagta gtctccttca ggactcttag
//
