LOCUS       NM_053131               3579 bp    mRNA    linear   ROD 05-APR-2024
DEFINITION  Mus musculus protocadherin beta 6 (Pcdhb6), mRNA.
ACCESSION   NM_053131 XM_909020
VERSION     NM_053131.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3579)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3579)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 3579)
  AUTHORS   Goodman,K.M., Rubinstein,R., Thu,C.A., Bahna,F., Mannepalli,S.,
            Ahlsen,G., Rittenhouse,C., Maniatis,T., Honig,B. and Shapiro,L.
  TITLE     Structural Basis of Diverse Homophilic Recognition by Clustered
            alpha- and beta-Protocadherins
  JOURNAL   Neuron 90 (4), 709-723 (2016)
   PUBMED   27161523
REFERENCE   4  (bases 1 to 3579)
  AUTHORS   Alvarez-Saavedra,M., De Repentigny,Y., Lagali,P.S., Raghu Ram,E.V.,
            Yan,K., Hashem,E., Ivanochko,D., Huh,M.S., Yang,D., Mears,A.J.,
            Todd,M.A., Corcoran,C.P., Bassett,E.A., Tokarew,N.J., Kokavec,J.,
            Majumder,R., Ioshikhes,I., Wallace,V.A., Kothary,R., Meshorer,E.,
            Stopka,T., Skoultchi,A.I. and Picketts,D.J.
  TITLE     Snf2h-mediated chromatin organization and histone H1 dynamics
            govern cerebellar morphogenesis and neural maturation
  JOURNAL   Nat Commun 5, 4181 (2014)
   PUBMED   24946904
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3579)
  AUTHORS   Dallosso,A.R., Hancock,A.L., Szemes,M., Moorwood,K.,
            Chilukamarri,L., Tsai,H.H., Sarkar,A., Barasch,J., Vuononvirta,R.,
            Jones,C., Pritchard-Jones,K., Royer-Pokora,B., Lee,S.B., Owen,C.,
            Malik,S., Feng,Y., Frank,M., Ward,A., Brown,K.W. and Malik,K.
  TITLE     Frequent long-range epigenetic silencing of protocadherin gene
            clusters on chromosome 5q31 in Wilms' tumor
  JOURNAL   PLoS Genet 5 (11), e1000745 (2009)
   PUBMED   19956686
  REMARK    Erratum:[PLoS Genet. 2009 Dec;5(12). doi:
            10.1371/annotation/012d5a44-8239-4057-8c3b-3dc159ea3a02]
REFERENCE   6  (bases 1 to 3579)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   7  (bases 1 to 3579)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   8  (bases 1 to 3579)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 3579)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020974.4.
            
            On Feb 22, 2019 this sequence version replaced NM_053131.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC150716.1, AY013788.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3579              AC020974.4         65962-69540
FEATURES             Location/Qualifiers
     source          1..3579
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.47 cM"
     gene            1..3579
                     /gene="Pcdhb6"
                     /gene_synonym="Pcdhb5B; PcdhbF"
                     /note="protocadherin beta 6"
                     /db_xref="GeneID:93877"
                     /db_xref="MGI:MGI:2136740"
     exon            1..3579
                     /gene="Pcdhb6"
                     /gene_synonym="Pcdhb5B; PcdhbF"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..2487
                     /gene="Pcdhb6"
                     /gene_synonym="Pcdhb5B; PcdhbF"
                     /note="PCDH-beta-6"
                     /codon_start=1
                     /product="protocadherin beta-6 precursor"
                     /protein_id="NP_444361.1"
                     /db_xref="CCDS:CCDS29174.1"
                     /db_xref="GeneID:93877"
                     /db_xref="MGI:MGI:2136740"
                     /translation="METTLAKTPEKRQVVFLAILLLLWEAGSEAIRYSIPEETESGYL
                     VAHLAKDLGFRVGELATRRARIHHRGNKELLQLDVETGNLLLKEKPDREALCGATEPC
                     VLHFQIILENPVQFFQTELQLTDINDHSPEFPDTEMLLKIQESTQPATVFLLKAAQDS
                     DIGSNAVQNYTVSPNLHFHVVTLSRSDGRKYPELVLDRALDREEQPELTLILTALDGG
                     APPKSGTTTVRIEVVDINDNAPEFVQSLYSVEVPENSPLDALVVTVSARDLDAGIHGN
                     VAYSLFQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGGLSGKCTVAI
                     QVLDVNDNAPKLTISSLTSSIPENAPEAVVAVFSVSDPDSGDNGRMVCSIQNELPFLL
                     KPTFENYYTLAAEGPLDREIREEYNITIIVSDLGTPRLTTQHTITVQVVDINDNAPAF
                     TQTSYTMFVHENNNPALHIGTISATDSDSGSNAHITYSLLPPHDLQLSLASLVSINAD
                     NGQLFALRAMDYEALQAFEFHVVARDGGSPALSSQALVRVVVLDDNDNAPFILYPMQN
                     ASAPCTELLPRAAEPGYLVTKVVAVDSDSGQNAWLSFQLLKATEPGLFSVWAHNGEVR
                     TTRLLSERDVPKHRLLLLVKDNGEPPRSASVTLHVLLVDGFSQPYLPLPEVQHDSSQD
                     EDMLTLYLVIALASVSSLFLLSVLLFVGVRLCRRVREASLGACSVPEGHFSGHLVDVS
                     GMGTLSQSYQYEVCLSGDSGTTDFKFLNHYSQ"
ORIGIN      
        1 agaatgctga atgcttcccc gaaaaggggg gtatttacat aagatccggg gagaaaggac
       61 tcctgaaagc aattcagtaa ggtttattcg aggtcatttc accaaaacat ctgtgtgact
      121 gaaaccgaca agatttagaa gcactgctct ttggatcata gctcaacaat ggagacaacg
      181 ctagcaaaaa cgccagagaa aaggcaagtg gtttttcttg ctatattgtt gcttttgtgg
      241 gaggctggtt ctgaggcaat tagatattcc attccagaag aaacagagag tggctacttg
      301 gtggctcact tggcaaaaga tctgggtttc agggtagggg aactggccac tagaagggct
      361 cgaatccatc acagaggaaa caaagagctc ttgcagctag atgtggagac agggaatttg
      421 ctcctgaaag aaaaaccaga tcgcgaagca ctatgtgggg cgacagaacc ctgtgtgctg
      481 cacttccaga tcatactaga aaaccctgtg cagttctttc aaactgaact gcagctcaca
      541 gatataaacg accactctcc ggagttccct gacacagaaa tgctcctaaa aattcaagaa
      601 agcacacagc cagcaactgt gtttcttctg aaggcagctc aggactctga cattggaagc
      661 aacgctgttc agaactacac agtcagtccc aacctccatt tccatgtggt tactctcagt
      721 cgctcagatg gcaggaaata cccagagctg gtgctggaca gagccctgga cagggaggag
      781 cagcctgaac tcactttaat cctcactgct ctggatgggg gagctccgcc caagtctggg
      841 actaccactg ttcgaattga agtcgtggac atcaatgata atgcccccga atttgtacag
      901 tcactctatt cggtggaggt ccctgagaac agccccctcg atgccttagt tgtcacagtc
      961 tctgccagag atttagatgc tgggatacat ggcaatgtag cctactctct gtttcaaggt
     1021 gggggaggtc ctcagccatt tgtaatagat gaaatcacag gagaaattcg tcttaaaggg
     1081 gcactggatt ttgaagcaac ttcatactat accatggaaa ttgtagccac agacagtggt
     1141 ggtctttcag gaaaatgcac tgtagctatc caggtgttgg atgtgaacga caatgcccct
     1201 aaactcacca tctcttcgct cactagttcc atcccagaaa atgctcctga ggctgtagtt
     1261 gctgttttca gtgtctctga cccagattcg ggggataatg gaaggatggt gtgttctatt
     1321 caaaacgaac ttccatttct tttgaagcct acatttgaaa attactacac tttagcggca
     1381 gaagggccac tggacagaga gatcagagaa gagtacaaca tcaccatcat agtctccgat
     1441 ttgggcacac ccaggctcac aacccagcac accataacag tgcaggtggt ggacatcaat
     1501 gacaatgccc ctgccttcac ccaaacctcc tacaccatgt ttgtccatga gaacaacaac
     1561 cccgccctgc acataggcac catcagtgcc acagactcag actcaggctc caatgcccac
     1621 atcacatact cgctgctgcc gccccatgac ctacagctgt cccttgcctc gctggtctcc
     1681 atcaatgcag acaacggaca gctgttcgct ctcagggcaa tggactatga ggccctacag
     1741 gcctttgaat tccatgtggt tgccagagat ggaggctcac ctgcgctcag cagccaggct
     1801 ctggtgcgcg tggtggtgct ggatgacaat gacaatgcgc ccttcattct ctacccgatg
     1861 cagaacgcct ctgcgccctg cactgagctg ctgcccaggg ctgcggagcc tggctacctg
     1921 gtaaccaaag tggtggcagt ggactctgac tcgggccaga atgcttggct gtcattccag
     1981 ttgctcaagg ccacggaacc tgggttgttc agcgtgtggg ctcacaatgg cgaggtgcgc
     2041 accaccaggc tgctgagtga acgagatgta cccaagcaca ggctgctgtt gctggtcaag
     2101 gacaatggag aacctccgcg gtctgccagc gtcactcttc atgtgctgct agtggatggc
     2161 ttctctcagc cctacctgcc tctgcctgag gtgcagcacg actcttcaca ggatgaagac
     2221 atgctcacac tctacctggt cattgccttg gcctctgtgt cttctctctt cctcctgtct
     2281 gtgctgctgt tcgtgggggt gaggctttgc aggagggtca gggaggcctc tctgggtgcc
     2341 tgctctgtgc ccgagggaca cttttctggc cacttagtgg atgtcagcgg tatggggaca
     2401 ttgtcccaga gctaccagta tgaggtgtgt ctgagcggag actctgggac aacagatttc
     2461 aaattcctga accattattc acaatagagt ccttcaggaa tccaactaaa tttcagtgtt
     2521 aggatcaccc aggttttggt aactgagtaa gaatgagttt cttggctatt aatatttccc
     2581 tttgcattta acaatttttc cttgaaatat atgtctatgt tgattttacc catgatttct
     2641 aattgtgtag ggttttttaa aaataatttt tctttccttt cctttccttt tttttttttt
     2701 tgttgtttgc ttcgtatttt atcaatccaa tcttaatgca tgtttgtctt cactaatttg
     2761 atagggaaat aagtaacttc gctgtgtttc gatggccatt tcaattactg ttcttaggaa
     2821 tcatttcttc ctttgcattt atgactgtat ttggaaatat atccacttca aattgtacct
     2881 tgttgaagct gtgcatgtaa cttgctgagt attgtttgtt ttacttttaa ctttcactgc
     2941 tgtgcattaa ctgtgctaag tacaatgttc actggggcgt tttcagagat gcacatacca
     3001 caccatgata acattctcct aattaccatc ttctatattc ccactgcttc ctccccatca
     3061 gtctcctaaa agcccctctt tgctttcatg ggcttcttgt gttacagtgc gataattgag
     3121 cctcaatgat ctgtagtttc atttattcct gaaaatgccc gtttcatttt tcgtgatgcc
     3181 tgtgcatcaa gaactccatt gtgcatgtgt gtgttttcct cccccacacg cctactgtat
     3241 ataatgataa agcagctttg tctacagctg atgaagtgtg accataagat acagctatct
     3301 gtcatatttt acatgctttg tacacaaaca gaagtagagc aatttatttc ttatctttac
     3361 tgaccgccac aattagtatt tcaagatttt atttgcttat atacaaccct atattgctac
     3421 taaaatatac cagagatggc catttgtgac ttaagtcatt gtacatgatg tagtgtgctt
     3481 tcattttgta tgagccgaca tttggtgagg catgtgttcg gatgataagt tgaattgtaa
     3541 atcatggttg taaatgaggg cacattaaac tttcaacag
//
