LOCUS       NM_053130               3533 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin beta 5 (Pcdhb5), mRNA.
ACCESSION   NM_053130 XM_911651
VERSION     NM_053130.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3533)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3533)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 3533)
  AUTHORS   Hasegawa S, Kumagai M, Hagihara M, Nishimaru H, Hirano K, Kaneko R,
            Okayama A, Hirayama T, Sanbo M, Hirabayashi M, Watanabe M,
            Hirabayashi T and Yagi T.
  TITLE     Distinct and Cooperative Functions for the Protocadherin-alpha,
            -beta and -gamma Clusters in Neuronal Survival and Axon Targeting
  JOURNAL   Front Mol Neurosci 9, 155 (2016)
   PUBMED   28066179
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3533)
  AUTHORS   Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM,
            Heard E and Brockdorff N.
  TITLE     Epigenetic functions of smchd1 repress gene clusters on the
            inactive X chromosome and on autosomes
  JOURNAL   Mol Cell Biol 33 (16), 3150-3165 (2013)
   PUBMED   23754746
REFERENCE   5  (bases 1 to 3533)
  AUTHORS   Junghans D, Heidenreich M, Hack I, Taylor V, Frotscher M and Kemler
            R.
  TITLE     Postsynaptic and differential localization to neuronal subtypes of
            protocadherin beta16 in the mammalian central nervous system
  JOURNAL   Eur J Neurosci 27 (3), 559-571 (2008)
   PUBMED   18279309
REFERENCE   6  (bases 1 to 3533)
  AUTHORS   Vanhalst K, Kools P, Vanden Eynde E and van Roy F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   7  (bases 1 to 3533)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   8  (bases 1 to 3533)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 3533)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028661.1 and AK049825.1.
            
            On or before Aug 8, 2008 this sequence version replaced
            XM_911651.2, NM_053130.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK049825.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AK028661.1         3-12
            11-3533             AK049825.1         1-3523
FEATURES             Location/Qualifiers
     source          1..3533
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.47 cM"
     gene            1..3533
                     /gene="Pcdhb5"
                     /gene_synonym="Pcdhb4A; PcdhbE"
                     /note="protocadherin beta 5"
                     /db_xref="GeneID:93876"
                     /db_xref="MGI:MGI:2136739"
     exon            1..3533
                     /gene="Pcdhb5"
                     /gene_synonym="Pcdhb4A; PcdhbE"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2567
                     /gene="Pcdhb5"
                     /gene_synonym="Pcdhb4A; PcdhbE"
                     /note="Protocadherin-betaE; cell-cell adhesion molecule"
                     /codon_start=1
                     /product="protocadherin beta 5 precursor"
                     /protein_id="NP_444360.1"
                     /db_xref="CCDS:CCDS29173.1"
                     /db_xref="GeneID:93876"
                     /db_xref="MGI:MGI:2136739"
                     /translation="MEKLERNHRNRQVIPFLFMLLWDQVLMVPTRYSVLEESESGSFV
                     AHLAKDLGLGAGELAARSARVVSDHDKQQFILDSETGDLLLREKLDREELCGSVDPCV
                     LHFQVFLEKPVQFFQGELLIQDINDNSPEFPDKELLLKILENSQPGTRFSLKLAQDLD
                     VGSNGLQQYTVNPNSHFHVLTRNNSEGKKYPELVQDRALDREEQAELSLILTALDGGS
                     PPRSGTALVRILIMDINDNAPEFVNNPYEVQVLESSPPDSPVLTVFAQDADAGNFGRV
                     SYGLFQASDEIQKTFSINEFTGEIRLKTKLDFEKTKSYHVEIEATDGGGLSGKGSVVI
                     EVLDVNDNAPELTISSLTSSVPENSPETVVAIIRIRDRDSGENGKMICSISDHVPFIL
                     KPSYKNFYTLVTESPLDRESRAEYNITITVSDLGTPRLTTQHTITVKVSDINDNAPAF
                     SQTSYTMFVRENNSPALHIGTISATDSDSGSNAHITYSLLPPHDQQLALHSLISINAD
                     NGQLFALSALDYEALQGFEFYVGATDRGSPELSSQALVRVVVLDDNDNAPFVLYPLQN
                     ASAPCTEVLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVR
                     TTRLLSERDAPKHRLLLLVKDNGEPQRSASVTLHVLLVDGFSQPYLPLPEVARDPAQD
                     DPDVLTLYLVIALASVSSLFLLSVLMFVGVRLCRRAREPSLGGCSVPEGHFPGHLVDV
                     SHAGTLSQSYQYDMCLTGESGTGEFKFLKPIVPNLMVQDTGNLHCRDSFVFS"
     regulatory      3514..3519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb5"
                     /gene_synonym="Pcdhb4A; PcdhbE"
                     /note="putative"
     polyA_site      3533
                     /gene="Pcdhb5"
                     /gene_synonym="Pcdhb4A; PcdhbE"
                     /note="putative"
ORIGIN      
        1 tttgtgttgc aagacagaat caaaaacaca caagtacagg aaacatctga aggaataccc
       61 gaccttgaat gggtttgggc cggggtatac tacgtgaaca aagtttctcc aaccaagaaa
      121 atagaattta gcattcaagg cattcagagg ctgttgaaca attggatgta atcactcgtg
      181 ttttcaccat ggagaagctg gagagaaatc atcgaaacag gcaagtgatt cctttccttt
      241 ttatgctgct ttgggatcag gtcctcatgg tgcctactcg gtactctgtc ttggaggaat
      301 cagaaagtgg ctcctttgta gcccatctgg ccaaggatct gggtctggga gctggggagc
      361 tggctgccag gtctgcacgg gtggtgtctg accatgacaa acagcaattc attctagatt
      421 ctgagactgg agatttgctt ctgagggaga aactagacag ggaagaactg tgtggctctg
      481 tggatccctg tgtgctgcat ttccaagtgt tcctagaaaa gccagtgcag ttttttcaag
      541 gagaattatt gatccaggat ataaatgaca actcgccaga attcccagat aaagaattgc
      601 tcttgaaaat actggaaaac agccagccag gcacacggtt ttcattaaaa ttagcccagg
      661 atttggatgt gggcagcaat gggcttcaac aatacacagt caaccccaac tctcattttc
      721 atgtcctcac tcgaaataat agcgagggca agaaataccc agagttggta caggacagag
      781 ccctggacag agaggagcag gcagagctga gcttaatcct cacagctctg gatggcgggt
      841 ctccaccgag gtcaggaaca gccctggttc gaatcctgat catggacatc aatgacaatg
      901 ctcctgagtt tgtgaacaac ccctatgagg tgcaggtcct agagagcagt cccccagact
      961 ccccagtcct gactgtcttc gcacaggatg cagatgctgg caactttggg agagtttcct
     1021 atggcttgtt ccaagcatca gatgaaatcc agaaaacttt ctcaataaac gaattcactg
     1081 gagaaatacg actgaaaacg aaattggatt ttgaaaaaac taaatcttac catgtagaaa
     1141 ttgaggccac agatggagga ggcctttctg ggaagggctc tgtggtgata gaggtgttgg
     1201 atgtgaacga caatgcccca gagctgacca tatcttcact gaccagctca gtcccagaaa
     1261 attctccaga aactgtggtc gctatcatcc gaatacggga tagagattct ggagagaatg
     1321 ggaagatgat ttgttcaatt tcagatcatg tgccattcat tttaaaaccc tcttacaaga
     1381 acttttacac cctggtgaca gagagccctc tggatagaga gagcagagct gagtacaaca
     1441 tcaccatcac agtctccgac ctgggcacac ccaggctcac aacccagcac accataacag
     1501 tgaaggtgtc cgacattaac gacaacgccc ctgccttcag ccaaacctcc tacaccatgt
     1561 ttgtccgcga gaacaacagc cctgccctgc acattggcac catcagtgcc acagactcag
     1621 actcaggctc caatgctcac atcacctact cgctgctgcc accccacgac caacagctgg
     1681 ccctccactc gctcatctcc atcaatgctg acaatgggca gctatttgcg ctcagtgcgc
     1741 tggactatga ggccctgcag ggcttcgaat tctacgtggg tgccacagac cgaggctctc
     1801 ctgagctcag cagccaggct ctggtgcgcg tggtggtgct agacgacaat gacaatgcgc
     1861 ccttcgtgct ctacccactg cagaatgctt ctgcgccctg cactgaggtg ctgcccaggg
     1921 ctgcggagcc tggatacctg gtcaccaagg tggtggctgt ggaccgcgac tctggccaga
     1981 atgcctggtt gtcattccag ctgctcaagg ccacggagcc cggactgttc agcgtgtggg
     2041 ctcacaatgg cgaggtgcgc accaccaggc tgctgagtga gcgagatgca cccaagcaca
     2101 ggctgctgct gctggtcaag gacaatggag agcctcagcg ctctgccagc gtcacgctgc
     2161 acgtgttgct ggtggatggc ttctctcaac cttacctgcc cctgcctgaa gtggcgcgcg
     2221 accccgcaca ggatgatccg gatgtgctca cgctctacct tgtcattgcc ttggcctctg
     2281 tgtcttctct ctttcttttg tctgtgctga tgttcgtggg agtgaggctg tgcaggaggg
     2341 ccagggaacc ctctctgggt ggctgctctg tgcctgaggg ccactttcct ggccacctgg
     2401 tggatgtgag ccatgcaggg accctgtccc agagctacca gtatgacatg tgtctaacag
     2461 gagaatctgg gactggtgag ttcaaattcc tcaagcccat agtccccaac ctaatggttc
     2521 aggatacggg aaatcttcac tgcagggata gctttgtatt cagctaagta tatatttccc
     2581 caagtgatgt acaaatgttt tcttttaaga aatgatcttg ttcttatgaa gttttccact
     2641 agtttaacct acttatatct cttacagtgc tgatagtttc tttcttattg atatgaacat
     2701 attaggcttt tagttggact aaaatatttc atatttttca ccacatatga ctatctctta
     2761 gtgattaaca tttccacaag catatataat ccaaataata taagattttt gaatatgaaa
     2821 ctatctcaga aaactctttt gtttttgtat ggttttgtga cttctgctct ttcattgaag
     2881 tttcatcttt tcaaaggtag attgtttaaa atcacttatg ttgcctggat ttttctgtgt
     2941 ggctagaatg taacatagga acaacaatgt gaaccaacga gtaccggcag agctcccagg
     3001 gactaaacca ccaaccaaag agtacacatg gtgggacaca tggccccagc cgcatatgta
     3061 accagaggat tgcctagtcg ctcatcaatg ggaggagagg cccttggtcc tgtgaaggct
     3121 cgatgtccca gtgtagggga atgccgtggc cagaaagtgg gagtgggtgg gttggtgaga
     3181 gggggagagg gagaggagag aggaaaggag gagggtgttt ttcagagggg aaatcaggaa
     3241 cagggataac atttgaaatg taaataaaga aaatgtccaa taaaaaaata aggaagtagc
     3301 attatgtcgt attcattgcc agtttaagcc ccctggatag ccaagcctta acatttaaag
     3361 tgtatatcaa tttacacaaa ggttgtgaca gtttttgttt gtgagcatca tgcatgctag
     3421 tagctttatt tacttggttg tgcatgttct ggaattttga agttatattt ggcaaaaatt
     3481 aaagagaatg tgtagtttct catgcgttta ttaaataaaa ctgttaaatc act
//
