LOCUS       NM_053129               3719 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protocadherin beta 4 (Pcdhb4), mRNA.
ACCESSION   NM_053129
VERSION     NM_053129.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3719)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3719)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3719)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 3719)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 3719)
  AUTHORS   Jensen,P., Magdaleno,S., Lehman,K.M., Rice,D.S., Lavallie,E.R.,
            Collins-Racie,L., McCoy,J.M. and Curran,T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
REFERENCE   6  (bases 1 to 3719)
  AUTHORS   McDougall,K., Kubu,C., Verdi,J.M. and Meakin,S.O.
  TITLE     Developmental expression patterns of the signaling adapters FRS-2
            and FRS-3 during early embryogenesis
  JOURNAL   Mech Dev 103 (1-2), 145-148 (2001)
   PUBMED   11335123
REFERENCE   7  (bases 1 to 3719)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   8  (bases 1 to 3719)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 3719)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 3719)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK036169.1, AK029277.1 and BB208858.1.
            
            On Sep 1, 2006 this sequence version replaced NM_053129.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK029277.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1544              AK036169.1         2-1545
            1545-3716           AK029277.1         1537-3708
            3717-3719           BB208858.1         320-322
FEATURES             Location/Qualifiers
     source          1..3719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..3719
                     /gene="Pcdhb4"
                     /gene_synonym="Pcdhb5A; PcdhbD"
                     /note="protocadherin beta 4"
                     /db_xref="GeneID:93875"
                     /db_xref="MGI:MGI:2136738"
     exon            1..3719
                     /gene="Pcdhb4"
                     /gene_synonym="Pcdhb5A; PcdhbD"
                     /inference="alignment:Splign:2.1.0"
     CDS             185..2539
                     /gene="Pcdhb4"
                     /gene_synonym="Pcdhb5A; PcdhbD"
                     /codon_start=1
                     /product="protocadherin beta 4 precursor"
                     /protein_id="NP_444359.3"
                     /db_xref="CCDS:CCDS29172.1"
                     /db_xref="GeneID:93875"
                     /db_xref="MGI:MGI:2136738"
                     /translation="METALAKMSQQRQVVFLTMLLLLWVSGSEAIKYSMPEETESGYL
                     VANLAQDLGIRVGELAAREARVHHRGNKDLLQLDAETGNLFLKEKLDREGLCGATEPC
                     VLHFQIILKNPVQFFQTELQLTDINDHSPEFPDTEMLLTIPESAQPGTVFPLKAAQDP
                     DMGSNAIQNYTVSPNLHFHVVTLSRSDGRKYPELVLDRALDREEQPELTLILTALDGG
                     APRRSGMTTVHIEIMDINDNAPQFVQSLYEVQVPENFPLDALLVTVSARDLDAGIYGN
                     IAYSLFQGDGDSQPFVIDEITGEIRLSKKLDFEVTPYYNVEIAATDGGGLSGKCTVAV
                     QVLDVNDNAPELTVSTLSSPIPENSPETVVAVFGVFDPDSGDNGRMVCSIQNELPFLL
                     KSTFENYYTLATERPLDRESIAEYNITITVSDMGTPRLTTQHTIKVQVSDINDNAPAF
                     TQTSYTLFVHENNSPALHIGTISATDSDSGSNAHITYSLLPPQDPQLALSSLISINAD
                     NGQLFALRALDYEALQAFEFHVGATDGGSPALSSQTLVRVVVLDDNDNAPFVLYPLQN
                     ASAPYTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVR
                     TTRLLSERDAPKHRLLLLVKDNGEPLRSASVTMHVLVVDGFSQPYLPLPEVALDPTRE
                     EDNLTLYLVISLASVSSLFLLSVLLFMGARLCRRAREASLGGYSVPEGHFPGHLVDVS
                     GAGTLSQSYQYEVCLSGDSGITDFKFLKPSNPNSLIPDNYMLNS"
     regulatory      3692..3697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb4"
                     /gene_synonym="Pcdhb5A; PcdhbD"
                     /note="putative"
ORIGIN      
        1 agaacttaca ccactcccta aaagaaggta gcattcactt tggatctaag gaagcgatct
       61 ccagagaagg cacagctcca acgggaagcc agcgagtaaa atttagttct gctatttcat
      121 taaagcacgt gtgtggattc taacacttta aagaccctgc acagatctgg atcccctgtg
      181 aacaatggag acagcgctag caaaaatgtc acagcaaagg caagttgttt ttcttactat
      241 gttgttgctt ttgtgggtgt ctggttcaga ggcaattaaa tattccatgc cagaagaaac
      301 agagagtggc tacttggtgg ctaacctggc acaagatctg gggatcaggg ttggggaact
      361 ggcagctaga gaggcacgag tccatcacag aggaaacaaa gacctcttgc agctggatgc
      421 agagacagga aatctgttct tgaaggaaaa attagaccgt gaggggcttt gcggggcgac
      481 agaaccctgt gtgctgcact tccagatcat actgaaaaac cctgtgcagt tctttcaaac
      541 tgaactgcag ctcacagata taaatgacca ctctccggag ttccctgaca cggaaatgct
      601 cctaacaatc cctgagagcg cccagccagg aactgtgttt cctctgaagg cagctcagga
      661 ccctgacatg gggagcaacg ctattcagaa ctacacagtc agtcccaacc tccatttcca
      721 tgtcgttact ctcagtcgct cagatggcag gaaataccca gagctggtgc tggacagagc
      781 cctggacagg gaggagcagc ctgagctcac tttaatcctc accgctctgg atgggggagc
      841 tccacgaagg tctgggatga ccacagttca tattgaaatc atggacatca atgacaatgc
      901 tccccagttt gtacaatcgc tctatgaggt gcaggttccc gagaatttcc cccttgatgc
      961 cttacttgtc acggtctctg ctagggattt agatgctggg atatatggca atatagccta
     1021 ctctctgttt caaggtgatg gagactccca accatttgta atagatgaaa tcacaggaga
     1081 aatccgtcta agcaaaaagt tggactttga ggtaactcca tactataatg tggaaatcgc
     1141 agccacggat ggagggggac tttcaggaaa atgcactgta gctgttcagg tgttggatgt
     1201 gaatgataac gccccagagt tgacggtctc tacgctctca agccctatcc ccgaaaactc
     1261 cccagagact gtcgttgcag tttttggtgt ttttgaccca gattctgggg acaatggaag
     1321 gatggtgtgc tctattcaga acgaacttcc atttctttta aagtccacat ttgagaacta
     1381 ttatacttta gcgacagaga ggccactgga tagagagagt atcgctgagt acaacatcac
     1441 catcactgtc tcagacatgg gcacacccag gctcacaacc cagcatacta taaaagtgca
     1501 ggtgtctgac atcaacgaca acgcccccgc cttcacgcaa acctcctaca ccctgtttgt
     1561 ccatgagaac aacagccccg ccctgcacat aggcaccatc agtgccacag actcagactc
     1621 gggctccaat gcccacatca cctactcgct tctgccgccc caggacccgc agctggccct
     1681 ctcctcgctc atctccatca acgctgacaa cgggcagctg tttgcgctca gggcattgga
     1741 ttatgaggcc ctgcaggcct tcgagttcca cgtgggcgcc acagatggag gttcgcccgc
     1801 gctcagcagc cagactctgg tgcgcgtggt ggtgctagac gacaatgaca atgcgccctt
     1861 cgtgctctac ccactgcaga atgcttctgc gccctacacc gagctgctgc ccagggcagc
     1921 ggagcctggc tacctggtca ccaaggtggt ggcagtggac cgcgactctg gtcagaatgc
     1981 ctggctgtca ttccagctgc tcaaggctac ggagcccggg ttgttcagcg tgtgggcgca
     2041 caatggcgag gtgcgcacca ccaggctgct gagcgagcga gatgcaccca agcacaggtt
     2101 gctgttgctg gtcaaggaca atggagagcc tctgcgctct gccagtgtca caatgcacgt
     2161 gctagtggtg gatggtttct ctcagcccta cctgcccctg ccagaggtgg cgctggatcc
     2221 tacacgggaa gaagataatc tcacgctgta tcttgtcatc tccttggcat ctgtgtcttc
     2281 tctcttcctc ttgtctgtgc tgctgttcat gggggcgagg ctgtgcagga gggccaggga
     2341 ggcctctctg ggaggctact ctgtgcctga gggacacttt cctggccacc tggtggacgt
     2401 cagcggggca gggaccctgt cccagagcta tcagtatgag gtgtgtctga gcggagactc
     2461 tgggattaca gattttaagt tcctgaagcc cagcaatccc aatagtctga ttccagacaa
     2521 ttacatgttg aatagttaaa attacagaaa attcttagta atcaacaaga gaaggataag
     2581 tcatagttgc ttggatgtcg gtatttttct ggtaattagt aatacttctt tgagattatg
     2641 ttttatttct atgtgctttt actttttaca taatcaatta atgcttcaac tgcctgctgt
     2701 cttagtaatg cagtcttagc gtatattttc tgtcactagc aggaagtaga aatctttact
     2761 ctgctagtga taactcaaag ttttaaaatc tcatttaatg tagtgtattt gacaagcaat
     2821 gtagaatgcc aaacattttc aaaattttat ctgtaacagt ttttattttg attttcttag
     2881 aacgtacact cactgtacaa tgtggtggat ttgttgtggt gcttgcatac atgtagattg
     2941 tgtactttga tcatactcat ccctgatcat cagtctccgc ctataatttc acaatgtccc
     3001 taaatatcac ctggaagtga aaaatgttct tctattgtca ttgcgtgtgg ctattgttcc
     3061 attcattttc ctgcaaacaa tgtagtttca tttttcttaa tggattagta agattacatt
     3121 atgtggatta taggcgcagt tcaaatgtag agtatttgct tagcgtgcac agtatactgt
     3181 gtttgagtgc cagcaccata tagcatgttt aagatcatct gagttatatg agtctctgtc
     3241 tttcaaaaca aaaaaacaaa acaaaactgc actttacaaa taagtacttt actcatccat
     3301 tacaacaata ttaacctgtt ccctcaacag ttaagtaaaa tgttaactac agatgtttct
     3361 ttgagaagta taacagtttg aactccttta gaaacaatag ccttaaccca tctctttatt
     3421 gacacttgtt attaacattt tgagacaagg ggtctctact agccctggct gtcctggaat
     3481 cactatgtag accgagttgg cctcacagag acccacctgc ttctgcctcc tgagtatggg
     3541 gattaaagtc atgcaccaca gcacccagca gcaattaata ttcgagattt cattttaata
     3601 tagaccagag gttaaaaact ttgataaatc cattggatta cttttaagct tttagtcttc
     3661 agggttgttc aaagcacatt caaataacag gaataaatta aacatatgtt ttaaactac
//
