LOCUS       NM_053147               6131 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus protocadherin beta 22 (Pcdhb22), mRNA.
ACCESSION   NM_053147
VERSION     NM_053147.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6131)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6131)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6131)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 6131)
  AUTHORS   Hasegawa,S., Kumagai,M., Hagihara,M., Nishimaru,H., Hirano,K.,
            Kaneko,R., Okayama,A., Hirayama,T., Sanbo,M., Hirabayashi,M.,
            Watanabe,M., Hirabayashi,T. and Yagi,T.
  TITLE     Distinct and Cooperative Functions for the Protocadherin-alpha,
            -beta and -gamma Clusters in Neuronal Survival and Axon Targeting
  JOURNAL   Front Mol Neurosci 9, 155 (2016)
   PUBMED   28066179
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6131)
  AUTHORS   You,L., Yan,K., Zou,J., Zhao,H., Bertos,N.R., Park,M., Wang,E. and
            Yang,X.J.
  TITLE     The chromatin regulator Brpf1 regulates embryo development and cell
            proliferation
  JOURNAL   J Biol Chem 290 (18), 11349-11364 (2015)
   PUBMED   25773539
REFERENCE   6  (bases 1 to 6131)
  AUTHORS   Wang,X., Weiner,J.A., Levi,S., Craig,A.M., Bradley,A. and
            Sanes,J.R.
  TITLE     Gamma protocadherins are required for survival of spinal
            interneurons
  JOURNAL   Neuron 36 (5), 843-854 (2002)
   PUBMED   12467588
REFERENCE   7  (bases 1 to 6131)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   8  (bases 1 to 6131)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 6131)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 6131)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020967.2.
            
            On Feb 17, 2023 this sequence version replaced NM_053147.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK043492.1, AF326315.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6131              AC020967.2         127615-133745
FEATURES             Location/Qualifiers
     source          1..6131
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.51 cM"
     gene            1..6131
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
                     /note="protocadherin beta 22"
                     /db_xref="GeneID:93893"
                     /db_xref="MGI:MGI:2136760"
     exon            1..6131
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2517
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
                     /codon_start=1
                     /product="protocadherin beta-15 precursor"
                     /protein_id="NP_444377.3"
                     /db_xref="CCDS:CCDS29187.1"
                     /db_xref="GeneID:93893"
                     /db_xref="MGI:MGI:2136760"
                     /translation="MKIGREHRKRQVLLIFLLLGVVGAGSEPRRYFVMEETPSGTVLA
                     DLVQDLGLGVAELAARGAQVVSEEKESRLQLDLQTGKLILNEKLDREELCGSTEPCVT
                     HFQVLLKKPLEIFQAELRVGDINDHSPEFPEREMAVKIIENSPVGTAFLLKTAQDLDV
                     GNNSVQNYKIGTNSHFHVSIRNRGDGRKYPELVLDKELDREVQAAFRLTLTALDGGSP
                     PRTGTSQIRIVVLDVNDNAPEFAQAFYRVQIPENSPSGSMVAKVSAKDLDTGTNGEVS
                     YSLFHSSQEMSKTFELNALSGEVRLIKTLDFETTPSYELDIEATDGGGLSGKCSVSIQ
                     VVDVNDNYPELIISSLTNPIPENSPETEVALFRIRDRDSGENGRTICSIQDGVPFTLE
                     PSVENFYRLVTDGALDREIRAEYNITISVTDLGIPKLTTQHTITVQVSDINDNAPAFT
                     QVSYTMLVHENNSPALHIGTISATDSDSGSNAHITYSLLPAQEPQLALNSLISINADN
                     GQLFALRALDYEALQAFEFHVSATDRGSPALSSQALVRIVVLDDNDNAPFVLYPMQNA
                     SAPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRT
                     TRLLSERDVPKHRLLLVVKDNGEPPRSASVTLQVLMVDGFSQPYLPLPEVVRDPSHQE
                     GDVLTLYLVIALASVSSLFLLSVLLFVGVRLCRRAREVSLGGCSVPEGHFPGHLVDVS
                     GAGTLSQSYQYEVCLTGDSQSNEFKFLKPVFSGIVDQNYGRQPDDQSFSSVLGM"
     regulatory      2777..2782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
                     /note="hexamer: AATAAA"
     polyA_site      2800
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
                     /note="major polyA site"
     regulatory      3049..3054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
                     /note="hexamer: AATAAT"
     polyA_site      3074
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
     regulatory      3255..3260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
                     /note="hexamer: TATAAA"
     polyA_site      3276
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
     regulatory      6105..6110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
                     /note="hexamer: AATAAA"
     polyA_site      6131
                     /gene="Pcdhb22"
                     /gene_synonym="Pcdhb15; PcdhbV"
ORIGIN      
        1 cttcagatcc caggcagagc tcagaccttt gagactccag agaatgctgc taatctacac
       61 ttgggagcag gctattaact gacaggtcga ccactgtctg gatacccttg taccctgggt
      121 gcagaagcaa agatgaagat tggaagggaa cacagaaaaa ggcaagttct gttgatcttt
      181 ctcttgctgg gagtggttgg ggcgggctcg gaaccccgcc gctactttgt gatggaggaa
      241 acacccagtg gcactgtttt ggcagatcta gtccaggacc tagggctggg agttgcggag
      301 ctagctgctc gaggagccca ggtagtctct gaggaaaagg aatcccgctt gcagctggat
      361 ctacagactg ggaagctaat cttaaatgaa aaactggacc gcgaggagct gtgcggctcc
      421 actgagccct gtgtcactca tttccaagtg ttactgaaaa aaccactgga aatatttcaa
      481 gctgagctac gagtaggaga cattaatgat cattctcctg agtttcctga aagagaaatg
      541 gccgtgaaaa tcatagagaa tagccctgtt ggcactgcgt ttctactcaa aacagctcag
      601 gatttggatg tgggaaataa cagcgttcag aactataaga ttggtaccaa ttctcatttc
      661 catgtttcca tccgcaaccg aggtgatgga agaaaatacc cagagctggt gctggacaag
      721 gagctcgatc gcgaggtgca ggcagcgttc agattaactc tgacagcgct agatggcggt
      781 tctccgccca ggactggcac ctcgcaaatc cgcattgttg tcttggatgt caatgacaat
      841 gcccctgagt ttgcacaggc tttctaccgg gtgcaaattc cagagaacag tccctcgggt
      901 tccatggttg ctaaggtctc tgctaaggat ttagacactg ggacaaatgg agaggtatca
      961 tactctcttt ttcacagttc tcaggaaatg agcaaaactt ttgagctaaa cgccctgtca
     1021 ggagaagttc gactaatcaa aacactggac tttgagacaa caccttcata tgaactagac
     1081 atagaggcaa ctgatggcgg gggtctttct ggaaaatgct ctgtttctat tcaggtggtg
     1141 gatgtcaacg ataattaccc agaactaatt atatcatcgc tcaccaatcc aatcccagaa
     1201 aattcaccag agacagaggt ggctctgttt cggattcgag accgagactc tggagagaat
     1261 ggaaggacaa tttgttccat ccaggatggt gttcccttta cactggaacc ttccgttgag
     1321 aacttctata gactggtgac agatggagct ctggacagag agatcagagc tgagtacaac
     1381 attactatct ccgtcaccga cctgggcata cccaagctca caacccagca caccataaca
     1441 gtgcaggtgt ccgacatcaa cgacaatgcc cccgccttta cccaagtctc ctacaccatg
     1501 ctcgtccacg agaacaacag cccagccctg cacataggca ccatcagcgc cacagactca
     1561 gactcaggct ccaatgccca catcacctac tcgttgctgc cggcccagga gccacagctg
     1621 gccctcaact cactcatctc catcaacgct gacaacgggc agctgttcgc gctcagggcg
     1681 ctggactacg aggccctgca ggccttcgag ttccacgtga gtgccacaga ccgaggctca
     1741 ccagcgctca gcagccaggc tctggtgcgc atagtggtgc tggacgacaa tgacaatgcg
     1801 cccttcgtgc tctacccgat gcagaatgcc tctgcgccct gcacagagct gctgcccagg
     1861 gcggcagagc ccggctacct ggtcaccaag gtggtggctg tggatcgcga ctctggccag
     1921 aatgcctggc tgtcgttcca gctgctcaag gctacagagc ccgggttgtt cagcgtgtgg
     1981 gcgcacaatg gtgaggtgcg caccaccagg ctgttgagtg agcgagatgt acccaagcac
     2041 aggctgctgc tggtggtcaa ggacaatgga gagcctccgc gctctgctag cgtcacactg
     2101 caggtgctaa tggtggatgg cttctctcag ccctacctgc ctctgccaga ggtggtgcgc
     2161 gaccccagtc accaggaagg tgatgtgctc acgctgtacc tggtcatagc cttggcttct
     2221 gtgtcttctc tcttcctctt gtctgtgctg ctgtttgtgg gggtgaggct gtgcaggagg
     2281 gccagggagg tctctctggg tggctgctct gtgcctgagg gacactttcc tggccacctg
     2341 gtggatgtca gcggggcagg gaccctgtct cagagctacc agtatgaggt gtgtcttaca
     2401 ggagattctc agagtaatga gttcaaattc ttgaagcctg tgttttctgg tattgtagac
     2461 caaaactatg gtaggcaacc agatgatcag tccttctcaa gtgttttagg tatgtgaaac
     2521 gtcacatttc gctctctgta ttcttctgtc gcttttgctt ttgcattttt ttttcaaatc
     2581 tggtagtaat gtttacttgt gtttgttttt ccatttctct gctagtttac atagtattgc
     2641 tgttggttta ttagcttgtt aactgtttaa gtatttttcc aaatctattg ttgctgaaca
     2701 ttttacatca ggacacttca cgctcctgat tgaatttgcc atagtctgtc ctaaagaacg
     2761 tgtattttct gtaatgaata aaattctaat tacaaaagta tatttcctgt cctaggggaa
     2821 tagattagtt tatagagtgc ttgtgtgttt gttagaggcc ttaggttgga tccctccgta
     2881 aatccagcac ttggaggtgg aggcacgcta tcagaattca aggtcatctt ctacatagag
     2941 aatgcaagct aagcctgggc tatgtgatga acaaggtgga ttaagtctca aaaattaaaa
     3001 atataattct gttgtgtgtt cccatagaag aacatatgat ttcttttaaa taatacgtca
     3061 ttttaaaatc ggaagccctt agttttatta tttgcatggc tatgacttca gtagcctcat
     3121 ttgtcttttc tttggaagca gttcatattc gttaatgtca agtttcttcc agattcccta
     3181 attatgtttt ctattctcca acactgtaaa tatcatctca tggaaaccag acccacatca
     3241 ttcactctct ctcttataaa ttaatattga aaggggtaaa attatcttca ttgtctttag
     3301 ctgatgggag cccttggcat gatactgatg acattaagtc aatcagctcc aggaagactg
     3361 aaaagtgggg tgtgtgtacg tgtgcgtgtg tgcgcgtatg tgcatgtgtg tgcatgcgtg
     3421 tgtgtacgag tgtgtgtgtg cgtgtgtgta cgtgcgtgcg tgtgtgtgcg tgtgtgtacg
     3481 tgtgtgtgcg tgtgtgtgcg tgtgtgtacg tgcgtgcatg cgtgtgtgcg tgcgtgcgtg
     3541 cgtgcgtgtg tgtacgtgtg tgtgtacgtg cgtgcgtgtg tgtacgtgtg tgtgcgcgtg
     3601 cgtgcgtgcg tgcatgtgct tgcgtgcgtg tgtgtatgtg cgtgcgtgtg cgtgtgtgcg
     3661 tgcacgcttt tacttgttat agtgggaaaa tcctgatgta aacctcaaat tctgtcctca
     3721 gggtagtttc tggttgtaca gaatgccata tgtaaatgct ttgggtgatg atattgctga
     3781 ttgataagaa atttgcatta tataggatta acattagtta actaaacaaa ttttagtaag
     3841 gatgtgttga tgcagtattg gatgatttgg agaaaatatt cagaaagatt cccccaaaga
     3901 tgttcagtcc tgatcactag aacctgggaa tattacttta tattgtagag ataaaacatg
     3961 aacgataagg ttgttaataa ggtaaaccta aaacagggtg tatattctag atcatttggg
     4021 tgggtctgag agaaccagtg aaaagattta aaagcaaagc tgaatctacc cagcgatgta
     4081 gaagaatagg cagagatagt ggcacatgcc tttagtccca catttgggag gcagagacaa
     4141 gctgatctct gtgagttcaa ggcgagctgc tctacatagt aacttccagg acagctagag
     4201 ctacaaagtg agaccctgtc ttgaagaaaa acatgagaga gatgtggggg aggaaaaaga
     4261 aattccctaa ggactgtaag tgtatcttgt ggctcagtgt ttcgacctga catattctga
     4321 ctgtcatacc acaaggaagt gacttattcc actttgggag tttactaaaa agttcaatat
     4381 ctgtgtttcc tgatggctct ctttctccag ttgaagcctg aggatgcagc tgatgaagac
     4441 ctaaaagatg gaagtggagc caggcagtgg tggtgcaccc ctttaatccc agcactcagg
     4501 aggcagaggc aggcagatct ttaagcttga ggccagcctg gtctacagag ggacttccag
     4561 tacagccagg gctacacaga tacactccgt tttggagaga agtatggaca tgggttttta
     4621 attgggtgaa ggtgcagaga cagaaaaggt tcaggttgct ttgtatagac ttggtagaaa
     4681 tgtgatctta gcaagtctgc cagtaaagac acaagaggaa gtgaggcgtg tggtgctcat
     4741 aaaacacttt ggcttataga atttataatt taaaagaact atggggagaa atctggacat
     4801 taaatttatt actagtaaga gcccaggcaa ggaaaacact attaaaaact ggagaaattt
     4861 tgcagaaaac ttagctgaat catgacttac attttatgag aaagaaaaaa aaaactcatg
     4921 aatttgggca ttggcagagg aaatttcccg aaaaactgcc agaagtacaa cttgatttct
     4981 tctcactggt tatagtaaaa tatcagatga aaaaaatacg ctgtacccag gacctgatgc
     5041 ctggagggaa actctggatg tatcacaggg cccccagtgg agaagctaga gaaagtaccc
     5101 aaggagctaa agggatctgc aatcctatag gtggaacaac aatatgaact aaccagtacc
     5161 acaccaccac cacccccgga gctcgtgtct ctagctgaat atgaatcagg agatggccta
     5221 gtcggccatc agtggaaaga gaggcccatt ggtcgtgcaa actttatatg actcagtaca
     5281 ggggaatgcc aggaccaaga agtgggagtg ggtgggtggg ggagtggatt ttattagtgc
     5341 atttttaatg aatttttctg catgtatagg tataatgtga tgctaattgc agtaattgta
     5401 taacatactc tgtgactgaa agaactttca gaagttggtc ccatctttct gttctccact
     5461 gtgcctgcta atgggttaga aagtagcaag tattattttc tccaggctat tgttattaac
     5521 agccaatcag taggagtagt tcttgtcctt tggaagcaat gatgacaaat ttttaaataa
     5581 tgttgctttg aatagaaaac aagagaagta agtttattac tggtatattt agatttggac
     5641 tttctcttaa tttgtctaaa aaaaatcata ctcggatcaa tcctataagc cttctcatat
     5701 gttgagttgt tttgaagcag gcccagagat tcaaatttgt taggtcagtt catccaggtt
     5761 cccattgtct tataagttat ctggcagttg cttctccctc tattttataa aggtttgtat
     5821 gaggtatttg tgattgtttg aatgaaaatt gtctcccata agctaatgta tttgagtact
     5881 tagtccccag attctggata tgtttgggga ggcagtaaag gtcggctgga gaacgcacct
     5941 tactgctggt gggcttcaag agttcatagc actactccac atccagcttc ctctcttccc
     6001 ttggtgtttg ggactgaaga tgtgatctgt cagctgcttg ctctgctgcc tgctgctgta
     6061 cctcaccaac cattgtatat tctccctctg gaaatgtaag caaaaataaa ctctttcttc
     6121 cttcaggctc a
//
