LOCUS       NM_053146               3583 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus protocadherin beta 21 (Pcdhb21), mRNA.
ACCESSION   NM_053146
VERSION     NM_053146.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3583)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3583)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 3583)
  AUTHORS   Remeseiro S, Cuadrado A, Kawauchi S, Calof AL, Lander AD and Losada
            A.
  TITLE     Reduction of Nipbl impairs cohesin loading locally and affects
            transcription but not cohesion-dependent functions in a mouse model
            of Cornelia de Lange Syndrome
  JOURNAL   Biochim Biophys Acta 1832 (12), 2097-2102 (2013)
   PUBMED   23920377
REFERENCE   4  (bases 1 to 3583)
  AUTHORS   Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM,
            Heard E and Brockdorff N.
  TITLE     Epigenetic functions of smchd1 repress gene clusters on the
            inactive X chromosome and on autosomes
  JOURNAL   Mol Cell Biol 33 (16), 3150-3165 (2013)
   PUBMED   23754746
REFERENCE   5  (bases 1 to 3583)
  AUTHORS   Remeseiro S, Cuadrado A, Gomez-Lopez G, Pisano DG and Losada A.
  TITLE     A unique role of cohesin-SA1 in gene regulation and development
  JOURNAL   EMBO J 31 (9), 2090-2102 (2012)
   PUBMED   22415368
REFERENCE   6  (bases 1 to 3583)
  AUTHORS   Vanhalst K, Kools P, Vanden Eynde E and van Roy F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   7  (bases 1 to 3583)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   8  (bases 1 to 3583)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 3583)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020967.2.
            
            On Feb 17, 2023 this sequence version replaced NM_053146.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK134846.1, AF326314.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3583              AC020967.2         122891-126473
FEATURES             Location/Qualifiers
     source          1..3583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.51 cM"
     gene            1..3583
                     /gene="Pcdhb21"
                     /gene_synonym="Pcdhb18; PcdhbU"
                     /note="protocadherin beta 21"
                     /db_xref="GeneID:93892"
                     /db_xref="MGI:MGI:2136759"
     exon            1..3583
                     /gene="Pcdhb21"
                     /gene_synonym="Pcdhb18; PcdhbU"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2520
                     /gene="Pcdhb21"
                     /gene_synonym="Pcdhb18; PcdhbU"
                     /codon_start=1
                     /product="protocadherin beta 21 precursor"
                     /protein_id="NP_444376.1"
                     /db_xref="CCDS:CCDS29186.1"
                     /db_xref="GeneID:93892"
                     /db_xref="MGI:MGI:2136759"
                     /translation="MEPGVGAAQHIRQVLLFFVFLEGSSVLATTWRYSVPEEMETGSS
                     IANIIKDMDVGDLAARGARVIFDDYQPYLRLELETGNLLLNEKLDREALCSSSEPCIL
                     HFQVLLENPLQFFQAELLIEDINDHTPTFLEKLIFLNISESATPGTSFQMDDAQDLDI
                     GMNGIQNYSISPNPYFYLKLKDSGKGRRYPELVLVRSLDREKEASISLILTAMDGGSL
                     PRSGTVLVQVVVLDVNDNAPEFERTLYEVQVPENSSVDSLVIKVSATDLDSGINGEIS
                     YSFSHISRDVQKTFEIHPTSGEVRLKRLLDFEVIQSYTINIQAIDGGGLSGKSAIIVQ
                     VTDVNDNPPEIVITSLMSSIPENGLSEMVVAVFSLRDQDSGENGRMMCSIEDKLPFLL
                     KPTFKNFYTLVTEHPLDRESRAEYNITVMISDLGTPRLTTQHTITVHISDINDNAPAF
                     TQTTYTMFVRENNSPALHIGTISATDSDLGSNAHITYSLLPPQDQRLALTSLISINAD
                     NGQLFALRALDYETLQAFEFRVGATDRGSPALSSQALVRVVVLDDNDNAPFVLYPMQN
                     ASAPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVR
                     TTRLLSERDVPKHRLLLLVKDNGDPPRSASVTLHLLVVDGFSQPYLPLPEVAHDSTQV
                     DEEALTLYLVIALASVSSLFLLSVLLFVGVRLCRRARAASLSGYSEPDGHFSGHLVDV
                     SGAGTLSQSYQYEVCLTGMSDSNDIRFLKPVSQP"
ORIGIN      
        1 cttttaacca tcggaagcaa aggcactgga taaaacagca ctcgggcttt ctacaaaggt
       61 ggggcaccca caagaccctc cagaaaggat tgcaaatcta taaattccca aaggtccaga
      121 tgagcggaac cactctctga gctgccagag actgagtgga aacagcacaa cagaaagcat
      181 tttgtctaag gagtgatgga gcctggagtt ggagctgctc agcatataag gcaagtgctg
      241 cttttctttg ttttcctgga agggtcctcg gttcttgcca cgacctggag atattctgtg
      301 ccagaagaaa tggagactgg ctcctctata gccaatataa ttaaagatat ggatgtgggt
      361 gatctggctg cacggggggc cagagttata tttgatgact accagcctta tttgcggtta
      421 gaactggaga ctggcaactt gcttttgaat gaaaaactgg acagggaggc actttgttct
      481 agcagcgaac cctgtatatt gcatttccag gtgctattgg aaaatcctct gcaatttttt
      541 caggctgagc ttttgattga agacataaat gaccataccc ccacgttcct agaaaaactc
      601 atatttctaa atatctcaga aagtgctact ccaggaacct cattccaaat ggatgatgct
      661 caggacttag atatagggat gaatggtatc caaaactatt caataagccc caacccctat
      721 ttctacctta agttaaaaga cagtggtaaa ggaagaagat atccagagct ggtactggtt
      781 agatctctgg acagagaaaa ggaggcttca attagcttga tactaacagc tatggatggt
      841 gggtccctgc ccaggtcagg gactgtattg gttcaagttg tggttctgga tgtcaatgac
      901 aatgcccctg agtttgaaag gaccctgtat gaggtccaag taccagagaa cagttctgtg
      961 gactcactgg taatcaaggt gtctgcgaca gatttggatt cgggaataaa tggagaaata
     1021 tcttattcgt tttctcatat ctctagagat gtacaaaaaa cattcgaaat ccacccaacc
     1081 tctggtgaag tccgtttgaa aagactccta gattttgagg taattcagtc ttatacaata
     1141 aatattcaag ccattgatgg tggtggtctc tctggaaaat cagccattat tgtccaggtt
     1201 acagatgtga atgacaaccc accagaaata gtcattacat ctcttatgag ctctatccca
     1261 gagaacggtt tgtcagagat ggtggtcgct gttttcagtt tacgagacca agactctgga
     1321 gaaaatggga gaatgatgtg ttcaattgaa gacaaactcc cttttctctt gaaacctact
     1381 ttcaaaaatt tctacactct agtaacagag catccactgg acagagagag cagagctgag
     1441 tacaacatca ccgtcatgat ctccgacctg ggcacaccca ggctcacaac ccagcacacc
     1501 ataacagtgc acatctctga catcaacgac aacgcccctg ccttcaccca aaccacctac
     1561 accatgttcg tccgggagaa caacagccca gccctgcaca taggcaccat cagcgccaca
     1621 gactcagatt taggctccaa tgcccacatc acctactcac tgctgccacc ccaagaccag
     1681 cggctggccc tcacctcgct aatctccatc aacgctgaca acgggcagtt gtttgcgcta
     1741 agggcgctgg actatgaaac cctacaggcc ttcgagttcc gcgtgggtgc cacggaccga
     1801 ggctcacccg cgctcagcag ccaggcgctg gtgcgcgtgg tggtgctgga cgacaatgac
     1861 aatgcgccct tcgtgctcta cccgatgcag aacgcttctg cgccctgcac agagctgctg
     1921 cccagggcag cggagcccgg ctacctggtc accaaggtgg tggctgtgga tcgcgactct
     1981 ggccagaatg cctggctgtc gttccagcta ctcaaggcca cggagcctgg gctgttcagc
     2041 gtgtgggctc acaatggaga ggtgcgcact accagattgc tgagcgagcg cgatgtgccc
     2101 aagcacaggc tgctgctgct agtcaaggac aatggcgatc ctccgcgctc tgccagcgtc
     2161 acgctgcacc tgttggtggt ggatggcttc tctcagccct acctacctct gccagaggtt
     2221 gcgcacgact ctacccaagt ggatgaggaa gcgctcacac tctatttggt cattgccttg
     2281 gcgtctgtgt cttcgctctt cctcttgtct gtgctactgt tcgtgggggt gaggctgtgc
     2341 aggagggcca gggcggcctc tctgagtggc tactctgaac ctgatggaca cttctccggc
     2401 cacctggtgg atgtcagcgg tgcgggaacc ctgtcccaga gctatcagta tgaggtgtgt
     2461 ctgacaggaa tgtcagattc caatgatatt cggttcctaa agcctgtctc ccaaccttga
     2521 gcaggccgcg aaatgcgtga aagaaaacac ctcctctatg aatcagtttg gatacaatta
     2581 gcaatttgtt gactctcatc atggttcctg atgtacactg gttcttttta aacattcttg
     2641 ttttctatca ttttattttc atgagaaaca tctaaagttt tgcctttatt ttcctaattc
     2701 agtagataac tttcattttt atccttacag gttggtctca aaaaaaaaaa aatcatttcc
     2761 tgatgaagac agagaatact cattactgac aaatcccagt ttcttcaact tgttaaattc
     2821 tcaaaaatta atcattattg atttgaaaat cctcaccttc attctgttgt tttgaagcat
     2881 tgatgttttg aagataaagg agatacaaat gtaatgaatt atcagagtat cttctgtcta
     2941 atctaatatt atgctttcct atctagaata gttagagtgt ctgaaaaatg catggttttg
     3001 ttgtacagca gaattaatca gaaatttctc tgaaatgtca agacttttac tgatttaatg
     3061 aatgtccaac atgtaataca tataaatatt gtttaaatat ttttagatta tctcaaaggt
     3121 tgtaaaaaaa ttagattgct cctatgacat ctatctagcc cacctcacat tttctgaaaa
     3181 tgtctctctt cagcatagat atgggatcaa agctcagttt gttttgaaca actcaggtcc
     3241 ctctatggtt tcaaacaatt ggatcgagtg atgggcgttg ctaatctaaa ctgaaccagt
     3301 ctggtcctgg ttacctttaa attcacttta gaaaccagat gtattctagt ctctctgtta
     3361 ggaacgttac aagaaagtga tgtcatcttt cggtgtccta tcaaatgtca aacctccggg
     3421 agatgaaagg aaagacttag caagcaagta accttgtgga ggaccttcat tttgacacga
     3481 ctttcactat tgggttggga actggggaca gagaactaag acgtaataaa tgcccttgta
     3541 ataaatgctc ctcatacagc ttagtaaatg tttttttcta aaa
//
