LOCUS       NM_053127               2789 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin beta 2 (Pcdhb2), mRNA.
ACCESSION   NM_053127
VERSION     NM_053127.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2789)
  AUTHORS   Xu L, Zheng Y, Li X, Wang A, Huo D, Li Q, Wang S, Luo Z, Liu Y, Xu
            F, Wu X, Wu M and Zhou Y.
  TITLE     Abnormal neocortex arealization and Sotos-like syndrome-associated
            behavior in Setd2 mutant mice
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523829
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2789)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2789)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 2789)
  AUTHORS   Hasegawa S, Kumagai M, Hagihara M, Nishimaru H, Hirano K, Kaneko R,
            Okayama A, Hirayama T, Sanbo M, Hirabayashi M, Watanabe M,
            Hirabayashi T and Yagi T.
  TITLE     Distinct and Cooperative Functions for the Protocadherin-alpha,
            -beta and -gamma Clusters in Neuronal Survival and Axon Targeting
  JOURNAL   Front Mol Neurosci 9, 155 (2016)
   PUBMED   28066179
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2789)
  AUTHORS   Vanhalst K, Kools P, Vanden Eynde E and van Roy F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   6  (bases 1 to 2789)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   7  (bases 1 to 2789)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   8  (bases 1 to 2789)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB617745.1, AY013781.1 and BC021789.1.
            
            On Sep 1, 2006 this sequence version replaced NM_053127.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC021789.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               BB617745.1         31-166
            137-2536            AY013781.1         1-2400
            2537-2789           BC021789.1         2527-2779
FEATURES             Location/Qualifiers
     source          1..2789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..2789
                     /gene="Pcdhb2"
                     /gene_synonym="PcdhbB"
                     /note="protocadherin beta 2"
                     /db_xref="GeneID:93873"
                     /db_xref="MGI:MGI:2136735"
     exon            1..2775
                     /gene="Pcdhb2"
                     /gene_synonym="PcdhbB"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2536
                     /gene="Pcdhb2"
                     /gene_synonym="PcdhbB"
                     /codon_start=1
                     /product="protocadherin beta-2"
                     /protein_id="NP_444357.1"
                     /db_xref="CCDS:CCDS29170.1"
                     /db_xref="GeneID:93873"
                     /db_xref="MGI:MGI:2136735"
                     /translation="MEAGEEMEQILKKRQVLLFFVLLGIAQAGSTIRRYSVEEEAENG
                     VFVANLLKDLGLEVEELAARGPRVISKGKKLNLEFNRQTGDLLLREKLDREELCGPAE
                     PCVVPFQVLLGNPLQIFQAELQIRDINDHSPVFLDKEITLKISESTASGTTFLIERAQ
                     DLDVGSNGLQTYTINPNFYFHLNLQNSPDGTVLPQLVLDKVLDREERSEIRLILTALD
                     GGNPPRSGTVQILIEVLDINDNAPVFSKLRYEVQIPENSPVGSQVATVSARDLDIGDH
                     GNIAYAFSQASEDIRKTFRMNATSGEILLVKTLDFESIQAYTICVQATDGGGLSGSSV
                     VIVQVMDLNDNPPELTMSTFTNHIPENAPETVIAVFSVADSDSGDNGKMVCSIQEDLP
                     FILKPSFENFYTLMTNTALDRETRSQYNITIMVSDLGTPRLTAQHTIIVQVSDINDNA
                     PAFTQTSYTIFVRENNSPALHIGTISATDSDSGSNAHITYSLLPPQDPQLALHSLVSI
                     NADNGQLFALRALDYEDQQTFKFHVGATDGGSPALSSQTLVRVVVLDDNDNAPFVLYP
                     LQNSSVPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNG
                     EVRTTRLLSERDAPKHRLLLLVKDNGDPPHSASVTLQVLVVDGFSQPYLPLPEVARDP
                     AQDEDILTLYLVIALASVSSLFLLSVLLFVGVRLCRRARATSLGGCSMPEGHFPAHLV
                     DVGGAGTLSQSYQYEVCLTGDTGTPDFKFLKPIIPNFLLQSSETENDTNPSYRNSFEF
                     S"
ORIGIN      
        1 ggggagagga aaccttctaa ggcattcgtt ccggaaagtc ttgggcctgg ggattttgga
       61 cttgtcccag tgtctacaag atatttgcag agcgagtcag taactacgtg aaccacgact
      121 gggagagcag aaagtgatgg aggctggaga ggaaatggag caaatcctga aaaaaaggca
      181 agtcctgctg ttctttgttt tgctgggcat agctcaggct gggtccacaa ttaggcgcta
      241 ttccgtggag gaggaagcag agaacggtgt ttttgtggca aatttgttaa aggacctggg
      301 gctggaggta gaggaactcg ctgcacgggg accgcgagtc atttccaaag ggaaaaaatt
      361 gaacttagaa ttcaataggc aaacaggaga tttgttgtta agggagaaac tggaccggga
      421 ggagctgtgt ggacctgctg aaccctgtgt ggtacctttc caggtgttac tgggaaatcc
      481 tttgcagatt tttcaggctg agctacagat tagggacata aatgatcatt ctcccgtttt
      541 tctggacaaa gaaattactt tgaaaatttc agaaagtact gcttccggta ccactttcct
      601 aatagaacgt gctcaagact tagatgtagg aagcaacggt ctccaaactt acacaatcaa
      661 ccccaatttc tattttcatc ttaatctaca aaacagtcct gatggcacag tattgccaca
      721 gctggttctg gacaaagtgc tggatcggga ggagcgatca gaaatcagat taatactcac
      781 agctctagat ggtgggaatc cacccaggtc tggcaccgtc caaatcctta ttgaagtctt
      841 agacatcaat gacaatgccc cggtgttttc aaagcttcgc tatgaggttc agatcccaga
      901 gaacagtcct gttggatccc aggttgctac tgtctctgct agggatttag acattgggga
      961 ccatggaaat atagcttacg ccttttccca agcctctgaa gacattcgga aaacgtttcg
     1021 aatgaatgca acatccggag aaatcctttt agtaaagaca ctggattttg aatccatcca
     1081 ggcatataca atatgtgttc aggctacaga tggtggggga ctttctggaa gcagtgtggt
     1141 gattgttcaa gtaatggatt tgaatgacaa ccctccagaa ctgactatgt ccacatttac
     1201 caatcacatc ccagaaaacg ccccggaaac cgtaattgct gtgtttagtg ttgcagattc
     1261 tgactctgga gacaatggaa aaatggtttg ctccatccaa gaagatcttc cttttattct
     1321 aaaaccctca tttgagaact tttacactct tatgacaaac acagccctgg atcgagagac
     1381 cagatcacag tacaacatca ctatcatggt ctcagacctg ggcacaccca ggctaacagc
     1441 tcagcacacc ataatagtac aggtgtctga catcaacgac aacgcccccg ccttcaccca
     1501 aacctcctat accatatttg tccgagaaaa caacagccct gccctgcaca taggcaccat
     1561 cagtgccaca gattcagact caggctctaa tgcccacatc acctactcgc tgctgccgcc
     1621 ccaagaccca cagttggccc tccattccct ggtctccatc aatgcagaca acgggcagct
     1681 gttcgcgctc agggcgctgg actacgagga ccagcagacc ttcaagttcc atgtgggcgc
     1741 cacagatgga ggatcaccgg cactcagcag ccagactctg gtgcgtgtgg tggtgctgga
     1801 tgacaatgat aatgcgccct tcgtgctcta cccactacag aactcttctg tgccctgcac
     1861 tgagctgctg cccagggcgg cagagcccgg atacctagtc accaaggtgg tggcagtgga
     1921 ccgcgactct ggccagaatg cctggttgtc attccagctg ctcaaggcca cggagcccgg
     1981 gctgttcagc gtgtgggcgc acaatggcga ggtgcgcacc accaggctgc tgagtgagcg
     2041 agatgcaccc aaacacaggc tgctgctgct ggtcaaggac aatggagacc ctccgcattc
     2101 tgccagcgtc acattgcagg tgctagtggt ggatggcttc tctcaaccct acttgcctct
     2161 gccagaggtg gcccgcgacc ctgcccaaga tgaggacata ctaacactct acctggtcat
     2221 tgccttggcc tctgtgtctt ctctcttcct cctgtctgta ctgctgttcg tgggggtaag
     2281 gctgtgcagg agggccagag ccacctcgct gggtggctgc tctatgcccg aaggccactt
     2341 tccagcccac ctggtagatg ttggcggcgc ggggaccctg tcccagagtt atcaatatga
     2401 agtgtgcctg actggagata ctgggacccc agatttcaag ttcttgaaac caatcatccc
     2461 caatttcctc cttcagagtt cagagacaga gaatgataca aaccctagtt acaggaatag
     2521 ttttgaattc agttaaatat tggtgaggat ataccgagtc tagtctcagc taaaacctgg
     2581 cccgattgta ctgctttgtt aacagaagtt gtctcttctt tgaaagtagc tatcttactc
     2641 taatcctttg catgttcctg gtatttctat aaaagaaagg tatgtggaag aaggaatcta
     2701 aattttgctt gcattccaat tttagtcttg taattttatt tggcttacaa tgtgaaagtg
     2761 aaaattgtat tttcaaaaaa aaaaaaaaa
//
