LOCUS       NM_053144               7133 bp    mRNA    linear   ROD 08-AUG-2023
DEFINITION  Mus musculus protocadherin beta 19 (Pcdhb19), mRNA.
ACCESSION   NM_053144
VERSION     NM_053144.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7133)
  AUTHORS   Inoue YU, Morimoto Y, Yamada M, Kaneko R, Shimaoka K, Oki S, Hotta
            M, Asami J, Koike E, Hori K, Hoshino M, Imayoshi I and Inoue T.
  TITLE     An Optimized Preparation Method for Long ssDNA Donors to Facilitate
            Quick Knock-In Mouse Generation
  JOURNAL   Cells 10 (5), 1076 (2021)
   PUBMED   33946570
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7133)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7133)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 7133)
  AUTHORS   Gendrel AV, Tang YA, Suzuki M, Godwin J, Nesterova TB, Greally JM,
            Heard E and Brockdorff N.
  TITLE     Epigenetic functions of smchd1 repress gene clusters on the
            inactive X chromosome and on autosomes
  JOURNAL   Mol Cell Biol 33 (16), 3150-3165 (2013)
   PUBMED   23754746
REFERENCE   5  (bases 1 to 7133)
  AUTHORS   Hirano K, Kaneko R, Izawa T, Kawaguchi M, Kitsukawa T and Yagi T.
  TITLE     Single-neuron diversity generated by Protocadherin-beta cluster in
            mouse central and peripheral nervous systems
  JOURNAL   Front Mol Neurosci 5, 90 (2012)
   PUBMED   22969705
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7133)
  AUTHORS   Junghans D, Heidenreich M, Hack I, Taylor V, Frotscher M and Kemler
            R.
  TITLE     Postsynaptic and differential localization to neuronal subtypes of
            protocadherin beta16 in the mammalian central nervous system
  JOURNAL   Eur J Neurosci 27 (3), 559-571 (2008)
   PUBMED   18279309
REFERENCE   7  (bases 1 to 7133)
  AUTHORS   Vanhalst K, Kools P, Vanden Eynde E and van Roy F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   8  (bases 1 to 7133)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 7133)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 7133)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020967.2.
            
            On Feb 17, 2023 this sequence version replaced NM_053144.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK147520.1, AK046363.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7133              AC020967.2         106262-113394
FEATURES             Location/Qualifiers
     source          1..7133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.51 cM"
     gene            1..7133
                     /gene="Pcdhb19"
                     /gene_synonym="Pcdhb11; PcdhbS"
                     /note="protocadherin beta 19"
                     /db_xref="GeneID:93890"
                     /db_xref="MGI:MGI:2136757"
     exon            1..7133
                     /gene="Pcdhb19"
                     /gene_synonym="Pcdhb11; PcdhbS"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..2564
                     /gene="Pcdhb19"
                     /gene_synonym="Pcdhb11; PcdhbS"
                     /codon_start=1
                     /product="protocadherin beta 19 precursor"
                     /protein_id="NP_444374.2"
                     /db_xref="CCDS:CCDS29185.1"
                     /db_xref="GeneID:93890"
                     /db_xref="MGI:MGI:2136757"
                     /translation="MENQEGLYLQTRQVLLLFVFLGMSQAHSEAGRLSVVEEMLSGAL
                     VGNLVKDLGLQVDELSAREAQVASSDNKLPLQLNINTGDLLLSEPLDREELCGSTEPC
                     VLHFQVLLKNPLKILQAELQVTDVNDNSPVFLEKEMVLEIPENSPVGAVFLLESAIDL
                     DVGINAVKSYEISQNSHFHVTMRVNPDGRKYPELVLDKALDYEEQHELRLILTALDGG
                     TPPRSGTALVRVEVIDINDNSPEFDHMFYEVTVPENSMLGSLLITASAWDLDSGINGE
                     VSYAFSHASEDIRKTFAINEHSGEIRLKGYLDFETTESYSIIIKATDRGGLFGKSTVR
                     IQVMDVNDNFPEIIVSSFISPIPENTAETLVMIFSIRDKDSGENGKMVCTIPEGLPFV
                     LKSSIENYYHLETDGALDRESIAEYNITISVTDLGTPRLTTQHTIIVQVADINDNAPA
                     FTQTSYTMFFHENNSPALHIGTISATDSDAGSNAHITYSLMSAQDLQMALSSLISINA
                     DNGQLFALRALDYEVLQAFEFQVGATDRGSPALSSQALVRVVVLDDNDNAPFVLYPMQ
                     NASAPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEV
                     RTTRLLSERDAPKHRLLLLVKDNGDPPRSASVTLHVLVVDGFSQPYLPLPEVARNPAH
                     EEDALTLYLVTALASVSSLFLLSVMLFVGVRLCRRARAASLGGCTVPEGHFPDHLMGI
                     NSAGTLSQSYQYEVCLMGGSGTNEFRFLKPVSPNLQPQFPGKEIEESSTLRNSFGLFR
                     DCN"
ORIGIN      
        1 acagaaaact agaaagaaaa agaagccagg agggtgctac gtagaaacct tttgtccttc
       61 ggattctgag gattccgtgg acaaatcaag gggcacgttt tgcagaagtg tgtggtgaag
      121 cagaagtgat tctgccagaa gccttctgga aagcaactat ggagaatcaa gagggactct
      181 atctgcagac aaggcaagtc ctgcttctct ttgttttcct aggaatgtct caagcacact
      241 ctgaggctgg gagactttca gtggtggagg aaatgctgag tggggccttg gtagggaatt
      301 tggtaaagga cctggggctc caggtggatg agctgtctgc acgagaggct caagtggcct
      361 ctagtgataa taaactgcct ttgcaattga acataaatac aggagatttg ctccttagtg
      421 aaccgctgga cagggaggag ctgtgtggct ccactgagcc ctgtgtgctc catttccagg
      481 tgttactgaa aaacccctta aagattttgc aagctgagct tcaggtcacg gatgtaaatg
      541 acaactcccc cgtattcttg gaaaaggaga tggttttaga aatcccagag aacagccctg
      601 ttggtgctgt gttcttgttg gaaagtgcga tcgatttaga tgtaggaatc aatgctgtta
      661 aaagctacga gataagccag aactctcatt tccacgttac catgagagtt aatcccgatg
      721 gcaggaaata cccagagcta gttttggaca aggcgctgga ttacgaggag cagcatgagc
      781 ttcgtctcat cctcactgct ttggatggag ggacgccacc caggtctggg actgcattgg
      841 tccgagtgga ggtcatagat attaacgaca actcccccga gtttgaccac atgttctatg
      901 aagtgacggt tccagagaat agcatgcttg gctcactgct tatcactgcc tcggcttggg
      961 atttagactc aggaattaat ggtgaagtat cgtacgcctt ttcccatgca tcagaggata
     1021 ttcgaaaaac atttgcaatt aatgaacatt ctggagaaat acgtttaaaa ggctatttgg
     1081 actttgaaac aactgaatcc tactcgataa tcattaaagc tactgatcgg ggaggacttt
     1141 ttgggaaatc tacagtaaga attcaggtga tggatgtgaa cgacaatttt cctgaaatca
     1201 ttgtgtcatc gtttatcagt ccaatcccag aaaataccgc agagacttta gttatgattt
     1261 ttagcattcg agacaaggac tcgggtgaga atggcaagat ggtgtgtact attccggagg
     1321 gtctcccgtt tgtgctaaaa tcttctattg aaaattacta ccacttagaa acggatggag
     1381 cactggacag agagagcata gctgaataca acatcaccat ctctgttaca gacctgggca
     1441 cacccaggct cacaacccag cacaccataa tagtgcaggt ggccgacatc aatgacaatg
     1501 cccctgcctt cacccaaacc tcctatacca tgtttttcca tgagaacaac agccctgcat
     1561 tgcacatagg caccatcagc gccacagact ctgacgctgg ctccaatgcc cacatcacct
     1621 actcgctgat gtctgctcag gaccttcaaa tggccctctc ctcgctaatc tccattaacg
     1681 ctgacaacgg gcagctgttc gcgctcaggg cgctggacta tgaggtcctg caggccttcg
     1741 agttccaagt gggtgcgaca gaccgaggct cacctgcact cagcagccag gctctggtgc
     1801 gcgtggtggt gctggacgac aatgacaatg cgcccttcgt gctctacccg atgcagaacg
     1861 cctctgctcc ctgcacagag ctgctgccca gggcggcgga gcccggatac ctggtcacca
     1921 aggtggtggc tgtggatcgc gactctggcc agaatgcctg gctgtcgttc cagctgctca
     1981 aggctacaga gccagggctg ttcagcgtgt gggcacacaa tggcgaggtg cgcaccacca
     2041 ggctgctgag cgagcgcgat gcacccaagc acaggctgct gctgctggtc aaggacaatg
     2101 gcgatcctcc gcgctctgcc agcgtcacgc tgcacgtgct agtggtggat ggcttctctc
     2161 agccctacct gcctctgcca gaggtggcgc gcaatccagc gcacgaagag gacgccctaa
     2221 cactctacct agtcactgcc ttggcatctg tgtcttcgct cttcctcctc tctgtaatgc
     2281 tgtttgtggg agtaaggttg tgcaggaggg ccagggcagc ctctctgggt ggctgtactg
     2341 tgcctgaggg acactttcct gaccatctca tgggcattaa cagtgcggga actctgtccc
     2401 agagctacca gtatgaggtg tgtctgatgg gaggtagtgg gacaaatgag ttcagattct
     2461 tgaagccagt ttcccccaat ttacaacctc agttccctgg gaaagaaata gaggaaagct
     2521 ctactttgcg caatagtttt gggttattta gggactgtaa ttgatgctgt attttatttt
     2581 gtggctattc catgctaatg tgtatttctc cgaatttgca tgatctttaa atctaatgtt
     2641 tgcattttat tatgtccctc ccacttttca atttatgcca gcgcttgtaa taagatggta
     2701 atttattctg tagcccattc tctctgatga cctaactcgt aaaaaattta ccctgctccc
     2761 cttcccacct gtcttttcca acactttgac ttgcattttt gcttatgatg aaataaacag
     2821 accattttag gagtagttaa aaattttaag catatctttt gttaacttgt ggcttgttat
     2881 tatgggtgct attttcaaga aaactttttt aaagcaccct agtttaattt tttaatgttt
     2941 gttactattg aatatattga ttgcattgga aaatctattc tgtggtacaa ctattaggcc
     3001 tgttgagaag gagccaatag tgagtttggg gacagctcag tgatagatac ccaaatagat
     3061 aaaaacacat aataaacaag tggggacagg tggtggtaag ctccttacta acactatctt
     3121 atgtattctg gaaggtggct acaggggtac atgaatactg gggttactta taaaatcttg
     3181 aaatataagg ccttaatttt acaagtgtct cactaacttt atgaggacag aatgtaagcc
     3241 aggtggaaga aatggcacct aaacaatcct gtgaatagga gaaagcaagc ctgtgagata
     3301 atatacaatt ttgcttatgt tcccccatga aataaaggaa tgtgcactga gtactaattc
     3361 acaagtacac acatttgctg tgcatattat gcaacattca aatctaatgg aaagagtact
     3421 tagtctattg tgagtttgaa acttcctctc ttattctatt gcttgaattt cctgatatgg
     3481 tcataagcca ctgagtctgt ctcagattcc actgaagagc agcatccaaa agtatgatga
     3541 ccacattttt ttaacatatg aatgtgtcat gtcctaattg taaataataa taataataat
     3601 aataataata ataataattt caaccaccac aggggagagt tttatcttgg gtagagaatg
     3661 accagtctat aacagttctt gtccttgaag actgacaatt actgggaaat ataattgttt
     3721 tacatgaata gtacgtacgt aattacaggg aaaatgtaac ggttgagaga ggaagtctcc
     3781 tgtgaatttc ctaacaagtc taaagtctgt atttctagaa ggaggaaaat gagagatgat
     3841 gagcatcatg gagagagaaa gatggtaaag acgtgacaat aaaggatgtg agggcgaact
     3901 aagagaatgc tccccatccc atggactaga gacagcgtct gccagaaaca ttctttcaaa
     3961 gaaacttaac actgtgttac ttaacatttt aattagttag ttaaaacccc tcccacatcc
     4021 aagacaaccc agtgtttata ctttttgaaa gattccattg cattattagt ccctcaaact
     4081 atggaatctt tgcatccacg caaaatgtgc atatgggcta attaagttta atttcttact
     4141 ttggaaagta taagttggaa acagaaagtc ttttggcagt tatctaaggc tgggaaaatg
     4201 tgtaggaatg gagagtagtt gggtacaatt tatgtggggg ataaattgga aatgatttta
     4261 aattagaaat actactaata gttgtagagt tctacaacta taggaataag cactgagctg
     4321 tatagctcaa gtgtgtgaga tactatgatg actctatttc aacaaagacg tttaaagcaa
     4381 tagagaacaa ctctagaaga ctatgattcc acgtaagcta ggtcttcttt aaaccaccca
     4441 ggcacaggag ttgtacagac aggagagcag actcaacaga aggtccaggt aactgtcttg
     4501 ttgcttcaag cttttccaga catatgagca ccaagacctc tctatttttg aaggaactgt
     4561 gtttcctaac tctagtggag agtaaccaag acttcacttt tgggagcttc tgtgttcaca
     4621 tacaagtcac taaccaattt tctaaaatgt gagcttttca gcagtcagtc tctgagccaa
     4681 caattacatc tgatgaataa aagttaccct tacattaacg aagggtagtt tcattttctt
     4741 tgcaaccatt ctactgaaaa ttctatttta aaggtcataa ataatgtcta taaacactaa
     4801 ataacactct gtcaccaaaa gaaagagatg caactacaca ttgctttgta atgtctttct
     4861 ctttcttgtg acggtgtcaa tgaaaatggt tgtataaagg gagcaacttt gccctcgtgg
     4921 ttcttctaga atcagatttc actccaaatg actgctccag cattgtctat ggcaaactaa
     4981 tagtctgtat ggctgcaact tctagctgtc gtacctgtgt tctagatggc ttggggaaag
     5041 gatggtcatt tagaactctt ctgtcccaga caaaatagaa gtaaagacag ttgtcaatcc
     5101 atctgtaaaa ttgccaaggt caaacaaaac cacaaagagg caggtcagct aagttgtcgt
     5161 gtgtcttagt tacctttcta tttctgtgat aaaacatatg atcatggcaa cttattctaa
     5221 aaaaaaaaaa tgcttaactc tggacttaca gtttcagagg gttagaatcc aggatggcac
     5281 agcaaatgtt tgctggcagg aacagctgag agctcacatc ttgatctgca cattggaagc
     5341 agagagaaaa ctctaggaat ggtgtgagtg ttttgaaatc tcaaagctcc aatgacacac
     5401 ttcctccaac caggccatac ctcctaatcc tttccaagta gttctaccag gtagggatcg
     5461 agtattcaaa catagaagcc catggcaagc attctcattc atacttcaac attgtgtgtt
     5521 tgggtacgtg tagaagcatg gtacatattt tagcagtcat ctatcagggt caaccacaaa
     5581 tactgcttta aatacaatag acaatgttaa catttacttt attcttgact ttgaggtatt
     5641 tgctgctggt tttcttggtc tttttaaagt ctgattgtct ttcaaagaat gattttgaag
     5701 ccgtagtctt tttttgtttt aagaaagata ctcgtttttc tttttccttt tttcttttaa
     5761 ataagtgaag gttggctcta ctgccctgtg tacaaggaaa ttcacagaca ctatttaaaa
     5821 aaagtaagac tagcacttgt ccgtgaacta catactcata tattttaaat tattcctgga
     5881 ttaggtataa tacccaatac ctagtaacaa gagagtatca tacatactca atataaatga
     5941 aatttggtgg ctatgttgta attgttatat ttaattttat tttggagata aggattgaac
     6001 caggacttca atgagcatat catacactca catcactact gaggtaatgc cacataaatt
     6061 acttgttttc tcttaaaaga cttttagtta attttcttct ggttgctctg caaatgtcag
     6121 cttacaaatt tcagtgacta aaacctttgg aggcaacact atagataagg agacaaaggt
     6181 acatactttc tccaggtcta tagagcgtga gtgacagaac catgattcag tgttcctaaa
     6241 tattatccat ttcctagggt gcagttacat gtctcttcaa gatgtttctg ttattcttta
     6301 cctctgcagt gttatatctt tagttactag ctaatcgatt ttttattccc ttcaagttcc
     6361 atagaaagat catcttactg tgtcatatcc tcccatatgc acatgagcac atgtttgtat
     6421 gcatgtgtgt atatgtgtct tcagacaccg tgtccctaca tactctcagt gatgcatatg
     6481 tgtatatgtg tcttcagaca cggtgtcctt acatactctc agtgacatgg agctcactgt
     6541 gtagaccata ctcaccttaa actctatagg tccccctact tctgcctttc aagtgttggc
     6601 attgaaggtt tgagccactg caccttactg tgtttttaat gtaaaagcaa ggaatccaat
     6661 attaccttgt cttaagttca ctactaacaa agaagtagtg tgttgtgtag ttttcatgac
     6721 tcatgagtgt atgtttgtgt gtaagtgtaa atggtaatgt aattggataa tgaactcacc
     6781 ccaacaaata tttaccaaag cggtggtaaa tatttgtaac tactaaagaa ttgtcatgaa
     6841 ataaatattt tttattaatt tggggacact ttattgtatc tttttgagct gaacattcaa
     6901 agcactaatg atttcataca gagtatggtc tgtgtttgga ttccaattca aacaaaccaa
     6961 caacacaaga cattttgtag aaaaacggga aagctcaaac agactgagtt ataagctata
     7021 tgcaaaaagt atttctacac atctattgtg gtaatgattt gtaattatat tttaaaggct
     7081 ttgataatta taaataacag atgaatattt agaaataaat gcaatctatg tga
//
