LOCUS       NM_053143               5035 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus protocadherin beta 18 (Pcdhb18), mRNA.
ACCESSION   NM_053143
VERSION     NM_053143.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5035)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5035)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 5035)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 5035)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   5  (bases 1 to 5035)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   6  (bases 1 to 5035)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 5035)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020967.2.
            
            On Feb 17, 2023 this sequence version replaced NM_053143.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK140341.1, SRR9219382.159458.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5035              AC020967.2         98737-103771
FEATURES             Location/Qualifiers
     source          1..5035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.5 cM"
     gene            1..5035
                     /gene="Pcdhb18"
                     /gene_synonym="Pcdhb9; PcdhbR"
                     /note="protocadherin beta 18"
                     /db_xref="GeneID:93889"
                     /db_xref="MGI:MGI:2136756"
     exon            1..5035
                     /gene="Pcdhb18"
                     /gene_synonym="Pcdhb9; PcdhbR"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2527
                     /gene="Pcdhb18"
                     /gene_synonym="Pcdhb9; PcdhbR"
                     /note="PCDH-beta-18"
                     /codon_start=1
                     /product="protocadherin beta-18 precursor"
                     /protein_id="NP_444373.1"
                     /db_xref="CCDS:CCDS29184.1"
                     /db_xref="GeneID:93889"
                     /db_xref="MGI:MGI:2136756"
                     /translation="MAARGSCVSRQRQVLFLFLLGGLCLAGSELGRYSVTEETERGSF
                     VANLAKDLGLGVEALAAKRTRVVCDDNKQHLFLDSHTGDLLTNEKLDREKLCGPTEPC
                     MLYFQILMDNPFQIYRAELRILDINDHSPIFQDKKMILKILENTAVGTTFRLERAQDS
                     DGGRNGIQNYTISPNTFFHITVHNSDEGMIYPELVLDKALDWEGQPEFSLTLTALDGG
                     SPPRSGTATIHILVLDINDNAPQFPQELYEIQAPENSPIGLVVIKVTGEDVDSGVNAE
                     ISYSFFDASEDIRATFQINPFSGEITLKALLDYEFIKSYKLNVQAVDGGGLSARCTVL
                     VRVLDVNDNAPELIMSSLVNEVVENSPETVLAVFRINDRDSGENGKMVCHIQENLPFL
                     LKPSVDNFYILMTEGALDRESRAEYNITITVSDLGTPRLTTQHTIRVQVSDINDNAPA
                     FNQTSYTLFVRENNSPAMHIGTISATDSDAGSNAHITYSLLPTQDLQMTLTSLVSINA
                     DNGQLFAIKALDYEALQAFEFHVGATDRGSPELSSQALVRVVVLDDNDNAPFVLYPMQ
                     NASAPYTELLPRTAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEV
                     RTTRLLSERDVPKHRLLLLVKDNGDPPRSASVTLQVLLVDGFSQPYLPLPEVAHNPTQ
                     GEEDVLTLYLVIALASVSSLFLLSVLLFVGVRLCRRARAASLGGCSVPEGHFPGHLVD
                     VSGTGTLSQNYQYEVCLMGGSSGTSDFKFLKSIYPEVHAYSSQDNSDGNPTF"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb18"
                     /gene_synonym="Pcdhb9; PcdhbR"
                     /note="hexamer: AATAAA"
     polyA_site      3731
                     /gene="Pcdhb18"
                     /gene_synonym="Pcdhb9; PcdhbR"
                     /note="major polyA site"
     regulatory      5015..5020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb18"
                     /gene_synonym="Pcdhb9; PcdhbR"
                     /note="hexamer: AATAAA"
     polyA_site      5035
                     /gene="Pcdhb18"
                     /gene_synonym="Pcdhb9; PcdhbR"
                     /note="major polyA site"
ORIGIN      
        1 agcaaaattc tgaccgatga gggggaaagc tgaggctcct cacaactgaa ggaaaaatat
       61 atcctagatc cttccagcta ggtggaacat ctgaggtgta tgactgctag gagctgtgct
      121 gacacctgta gtaaagaaag aagaagcaat ggcagccaga ggatcatgtg tctccagaca
      181 aaggcaagtg ctatttctct tcctgctcgg gggtctgtgt ttggcaggtt ctgagcttgg
      241 acgttattca gtgactgagg aaacagaaag gggatcattt gtggcgaacc tagcaaagga
      301 tctagggcta ggggtggaag cactggctgc aaagagaact agggtggttt gtgatgataa
      361 caaacagcac ttgtttctgg attctcacac tggagatttg ctcacaaatg agaaactgga
      421 ccgtgagaag ctgtgcggcc ccacagagcc ctgcatgctt tatttccaaa ttttaatgga
      481 taaccccttt cagatttacc gggctgagct gagaattctg gatataaatg atcactcacc
      541 catattccag gacaaaaaga tgattttaaa aatactagaa aacacagctg tgggaacaac
      601 atttcgatta gaaagagcac aagactcaga tggcggacgg aatggcatcc aaaactacac
      661 catcagcccc aacacttttt ttcatattac cgttcataac agcgatgaag gaatgatata
      721 tcctgagctt gtgctagaca aagctctgga ttgggagggg cagccagagt tcagtctaac
      781 actcactgca cttgatggtg ggtctccacc caggtctggg acagccacta tacatattct
      841 ggttttggac atcaatgata atgccccaca gtttccccaa gaactgtatg aaatccaggc
      901 tccagaaaac agtccaatag gccttgttgt cattaaagtc accggagaag atgtagactc
      961 tggagtcaat gcagaaatat cctattcgtt ttttgatgct tctgaggata ttcgagcaac
     1021 ctttcaaatc aatcctttct ctggggaaat cactctcaaa gccttgcttg actatgagtt
     1081 cataaagtcc tataagttaa atgtacaagc agttgatggt gggggccttt cggcgagatg
     1141 tacggttcta gtgcgggttt tagacgttaa tgacaacgcc cctgaactga tcatgtcatc
     1201 acttgtcaac gaagttgttg agaactcacc tgaaaccgtg ctggcagttt ttaggattaa
     1261 tgacagagac tctggagaga atggaaaaat ggtttgccac attcaagaaa atctaccttt
     1321 ccttttaaaa ccttccgtgg acaattttta catcctaatg acagaaggag cactggacag
     1381 agagagcaga gctgaataca acatcaccat cactgtctct gacctgggca cacccaggct
     1441 cacaacccag cacaccataa gagtacaggt atctgatatc aatgacaacg cccccgcctt
     1501 caaccaaacc tcatacaccc tgttcgttcg cgagaacaac agccccgcca tgcacatagg
     1561 caccatcagc gccacagact ctgacgctgg ctccaatgcc cacatcacct actcgctgct
     1621 gccaacccaa gacctacaga tgaccctcac ctcgctggtc tctatcaatg ctgacaacgg
     1681 gcaactgttt gcaatcaagg ctctggacta tgaagcctta caggccttcg agttccacgt
     1741 gggtgccaca gaccgaggct cacctgagct cagcagccag gctctagtgc gcgtggtggt
     1801 gctggacgac aatgacaatg cgcccttcgt gctctacccg atgcagaacg cttctgcgcc
     1861 ctacaccgag ctgctgccca ggaccgcaga gcccggctac ctggtcacca aggtggtggc
     1921 tgtggaccgc gactctggac agaatgcctg gctgtcattc cagctactca aggccacgga
     1981 gcccgggctg ttcagtgtgt gggctcacaa tggcgaggtg cgcaccacca ggctgctgag
     2041 cgagcgcgat gtgcccaagc acaggctgct gctgctagtc aaggacaatg gcgatcctcc
     2101 gcgctctgcc agtgtcacac tgcaggtgct gctggtggat ggcttctctc agccctacct
     2161 gcctctgcca gaggtggcgc acaatcccac tcaaggggaa gaggatgtgc tcacgctgta
     2221 cctggtcata gccttggcat ctgtgtcttc tctcttcctc ttgtctgtgc tgctgtttgt
     2281 gggggtgaga ctgtgcagga gggccagggc ggcctctctt gggggctgct ccgtgccaga
     2341 gggacacttt cctggacacc ttgtggacgt cagcggtaca ggaacactgt cccagaacta
     2401 ccaatatgag gtgtgtctaa tgggaggttc ctctggtacc agtgatttca agttcttgaa
     2461 atcgatttac cctgaagttc atgcttatag ttcccaggac aatagtgatg ggaatcccac
     2521 attttgaagt ttctaattta attttgagta atgtttcatt ccatttaaca tataatacag
     2581 ccatatgaat attaatttgt atagtagttg ctacacagca aaactaactt cgttttcaac
     2641 ttccaagtag gtcacattta gatttttaca gtgtttttac tttagtactt tagtggttgt
     2701 ttcatgcttg tggtttttgt ttgtctattt atgtttttgt tttcttttct ttctagtaga
     2761 gtattgtcac tttaaatttg aggttttatc gtactcatac tgtacgatta tttggtttta
     2821 tttctcatta tagaaaactg aagcttgagg tttcgttgtt attgttctct tttcttttgt
     2881 tgctaagaat tgaccaagcc ttttgcatgg taagaaaatg ctccaccata gagctctatc
     2941 tccagccagg catgctttat actcactttt aaaagctgta tattctttta actttcactg
     3001 agtccgtttt tggcagtttc atgcatctat ctcctgcatt ctgtttatga taatctcttg
     3061 attaatctcc ttgcaacccc tattcctccc ttacaaatcc cttggcatgt tgctgatttt
     3121 gagtgttctg gtaattttat gcactatgtt aattaatgac ttctgcatgc atggagtcat
     3181 actttggact caatcattcc taactcttgt gtcccacttg tttccttcct tttccaagca
     3241 agtaccccat gctgctttct aaacatggct acttcattgc ccttatttcc catcttcctt
     3301 aagagttctt tcttttttat cttttctttg ttttcaaacc agagttgctt tatgtagatc
     3361 tggtatatct tgcatataat tttaatatgc aaattaattg tatcctaaaa ttagttctgc
     3421 agaccaggct gacctcaaac tcatagagat ccacccacct ctgctgcccg aatgctggga
     3481 ttaaacttat gtatcactac cacccagcaa gagctcagtt ttatgttcat tcttggtgac
     3541 atatatggca aattgtgtca tataatgcta atacaatgtg atagtctgca tgtaaatcag
     3601 cataaatttg agcacattta aattttattt gacaatattg atggactggt tggaaagata
     3661 actttcttgt tatattgaaa ctttaaaagt tgtcaaattt aaacattgaa ataaattaat
     3721 ggttacagaa agttttctct ccagtccctt tctatacagt tgttcttcga ctttgaccta
     3781 cttccagaca atgtttaact gccttatctt tataatcagc ttttatgtgt tacccacttt
     3841 ttgcagttct tatttcacat taatagacac acttacaaaa ggaactcatt tcccttatcc
     3901 tagggttttt gtagaataat cataaaatgt tatcagtttt gtttctgtgg gtttctatgc
     3961 tcaaacccaa ggcctcttaa atgaatacca tcctgaagta aaactaatat taatgtccac
     4021 ctgtataggt ttcctatgta cacatactta gtagtgcagt atgattacac tttgtttttt
     4081 ggaaaaaaca tcttttccaa agctaacagt tgctgtttta gatttggctt tatttccatt
     4141 cgtggttagt gatttttctg ctcctctctt tccatattaa gcgatcaatc aaagcagtga
     4201 gttaccttga gctgcactct ctgttctcac tactgttttt tacatcatat ccctcttgaa
     4261 tattatcttc ttgccttcaa atattcaaat atataagatg caaattattg tgtttatgta
     4321 ctaggagctt tcgttcatag gtcttctttt agatggttta ccttgtggct gtcatgcttt
     4381 aatacttttt ccacactgct ggccttttat aggacccagt atcatgtctg agtttacttt
     4441 cttacttggt tgacagacaa tttcattgaa atagatgcag aggcacttag gagaaataaa
     4501 acaacttttg atactttaca tagtgaagca atagtttcat ttgattgata gtttgactgg
     4561 gtataaaagt ataatttgaa aatttctccc tcaacgttaa aaagcacttc tccttttctt
     4621 aattgtgtag aactactttt cacagggaca attccattct aaagcctatc tctttttctg
     4681 aaattttccc ccatacattc tggaagcatt ggaaaactta ccctcagtag tctgagaata
     4741 ctgtagctgt ggctatttct ttgttaaccc attcatgagg ataaatcctg ttgatgttga
     4801 gattcacaat ttagaaaata actcatttta gcttgctata atttctcact tgtattttct
     4861 aaaaatcttg attaaatatt taattaactg gaagagttct atgagaccct aagctcattt
     4921 cattttgtat tttcactcta tttggtccat gttctacttt cttgcactgc tcatttaatc
     4981 attcaatctt gacttgtaag cttgcttttt ggtaaataaa tacttttaga agttt
//
