LOCUS       NM_053141               5278 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus protocadherin beta 16 (Pcdhb16), mRNA.
ACCESSION   NM_053141
VERSION     NM_053141.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5278)
  AUTHORS   Osipovich AB, Dudek KD, Greenfest-Allen E, Cartailler JP, Manduchi
            E, Potter Case L, Choi E, Chapman AG, Clayton HW, Gu G, Stoeckert
            CJ Jr and Magnuson MA.
  TITLE     A developmental lineage-based gene co-expression network for mouse
            pancreatic beta-cells reveals a role for Zfp800 in pancreas
            development
  JOURNAL   Development 148 (6) (2021)
   PUBMED   33653874
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5278)
  AUTHORS   Xu L, Zheng Y, Li X, Wang A, Huo D, Li Q, Wang S, Luo Z, Liu Y, Xu
            F, Wu X, Wu M and Zhou Y.
  TITLE     Abnormal neocortex arealization and Sotos-like syndrome-associated
            behavior in Setd2 mutant mice
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523829
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5278)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5278)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   5  (bases 1 to 5278)
  AUTHORS   Hasegawa S, Kumagai M, Hagihara M, Nishimaru H, Hirano K, Kaneko R,
            Okayama A, Hirayama T, Sanbo M, Hirabayashi M, Watanabe M,
            Hirabayashi T and Yagi T.
  TITLE     Distinct and Cooperative Functions for the Protocadherin-alpha,
            -beta and -gamma Clusters in Neuronal Survival and Axon Targeting
  JOURNAL   Front Mol Neurosci 9, 155 (2016)
   PUBMED   28066179
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5278)
  AUTHORS   Frank M and Kemler R.
  TITLE     Protocadherins
  JOURNAL   Curr Opin Cell Biol 14 (5), 557-562 (2002)
   PUBMED   12231349
  REMARK    Review article
REFERENCE   7  (bases 1 to 5278)
  AUTHORS   Vanhalst K, Kools P, Vanden Eynde E and van Roy F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   8  (bases 1 to 5278)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 5278)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 5278)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ182908.1, BC116625.1, AK036829.1 and BP762533.1.
            
            On Jun 8, 2007 this sequence version replaced NM_053141.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                CJ182908.1         2-97
            97-3423             BC116625.1         1-3327
            3424-4198           AK036829.1         3355-4129
            4199-5017           AK036829.1         4131-4949
            5018-5278           BP762533.1         47-307              c
FEATURES             Location/Qualifiers
     source          1..5278
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.5 cM"
     gene            1..5278
                     /gene="Pcdhb16"
                     /gene_synonym="Pcdhb8; PcdhbP"
                     /note="protocadherin beta 16"
                     /db_xref="GeneID:93887"
                     /db_xref="MGI:MGI:2136752"
     exon            1..5271
                     /gene="Pcdhb16"
                     /gene_synonym="Pcdhb8; PcdhbP"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2630
                     /gene="Pcdhb16"
                     /gene_synonym="Pcdhb8; PcdhbP"
                     /note="Protocadherin-betaP; cell-cell adhesion molecule"
                     /codon_start=1
                     /product="protocadherin beta 16 precursor"
                     /protein_id="NP_444371.3"
                     /db_xref="CCDS:CCDS29182.1"
                     /db_xref="GeneID:93887"
                     /db_xref="MGI:MGI:2136752"
                     /translation="MEASRKLICRQRQVLFFFLLLGFPLTTAGELRRYSVVEEKEGRS
                     FVTNLVKDLGLGQLELSRRGAKVISKGNKLHLQLDQETGDLLLNEKVDREKLCGHTEP
                     CLLSFQVLLDNPLDIFQAELEVTDINDHSPEFLDKEIMLKISESSLPGATFPLKNAQD
                     MDVGQNGIDKYLISSNSYFRVLTRKRSDGKKYPELVLDRALDREEEAELRLTLTAQDG
                     GSLPRSGTTEVHIEVLDINDNAPQFEQLFYKAQIPEDSPIGFLIITVSATDKDIGVNG
                     QISYSLFQVSDDISKTFSIHPLTGEVRLKEHLDFEKTQSYEINIEARDAGTFSGKCTI
                     LAQVLDVNDHAPEIILSAFTNSILENLPETMVAVFSVSDLDSGENGKVSCSIQDDLPF
                     FLKPSGENFYTLLSQKPLDRESVAEYNITITVADMGSPILKTQVNLTVQVSDINDNAP
                     IFTQTSYTMFIRENNSPALHIGTISATDSDSGSNAHITYSLLPPHDHQLALASFISIN
                     ADNGQLFVLRALDYEALQAFEFHVGATDGGSPALSSQALVRMVVLDDNDNAPFVLYPM
                     QNASAPYTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGE
                     VHTSRLLSERDVHKHRLILLVKDNGDPPRSASVTLHVLLVDGFSQPYLPLPEVARDPD
                     HEDSELTLYLVIALASVSSLFLVSVLLFVGVRLCRRAREVSLGGCSVPEGHFPGHLVD
                     VSGTGTLSQSYQYEVCLTGDSGTGEFKYLKPILPNFQDHSFRPEMGENPNSRNDWSFG
                     IQLK"
     regulatory      5241..5246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb16"
                     /gene_synonym="Pcdhb8; PcdhbP"
     regulatory      5245..5250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb16"
                     /gene_synonym="Pcdhb8; PcdhbP"
     regulatory      5249..5254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb16"
                     /gene_synonym="Pcdhb8; PcdhbP"
     regulatory      5253..5258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb16"
                     /gene_synonym="Pcdhb8; PcdhbP"
     polyA_site      5271
                     /gene="Pcdhb16"
                     /gene_synonym="Pcdhb8; PcdhbP"
ORIGIN      
        1 ggcagttgtg gttccattaa taggggaaaa gaaaaaaaaa tcctgcagaa gcccggaagc
       61 ccagagaagc ccggactgga tgcttcagaa aggaggtctc agccctcgga aaaggactga
      121 aagaattctc aggtatctgg tgagataact acagtaccag atactagggg tgtttatagt
      181 tctgctgaaa catccttcag gactctgtac caccaagaac aatggaggcc agcaggaagc
      241 tcatttgcag acaaaggcaa gtcctttttt tctttctcct attaggcttc cctctaacga
      301 ctgcagggga actgaggcgc tattctgtgg tggaggaaaa ggagggtagg tcctttgtaa
      361 ccaatttagt aaaagacctg ggtcttgggc agctggaact ctcccggaga ggagctaagg
      421 tcatttctaa aggtaacaaa ctacatttgc agctggatca ggagacaggg gatttgctgt
      481 taaatgagaa agtggacagg gaaaaactgt gtgggcatac agagccatgc ttgctaagct
      541 tccaagtgtt gctagacaac cccttggata tttttcaagc tgagctagaa gtcacagaca
      601 taaatgacca ctcaccagaa ttcctggaca aagagatcat gctaaagata tcagaaagca
      661 gtcttcctgg agctacattt cctctgaaga atgctcagga catggatgta ggccaaaacg
      721 gtattgacaa gtatctgatc agttccaatt cctattttcg agtgctcact cggaaacgaa
      781 gcgatggcaa gaaataccct gaactggtac tagacagagc actggataga gaggaggaag
      841 ctgagctcag gctaaccctc acagcacagg atggtggctc tctgcctagg tctggaacca
      901 ctgaagtcca cattgaagtc ctggacatca atgataacgc tcctcaattt gagcagcttt
      961 tttacaaagc acagatccct gaggatagtc caataggctt tctgatcatc actgtctctg
     1021 ctacagacaa ggacattgga gtcaatggac agatctccta ttcacttttc caggtttcag
     1081 atgatattag caaaacattt tcaatccacc ccttgacagg ggaagtgcga ttgaaagaac
     1141 accttgattt tgaaaagact cagtcctatg aaatcaatat tgaagcaaga gacgctggga
     1201 ccttttctgg aaaatgcacg attctggccc aagtcttgga tgtgaatgac catgctccag
     1261 agattatcct gtctgcattt accaactcca ttcttgaaaa cttaccagaa accatggtgg
     1321 cagtttttag cgtttctgat ctagattccg gagaaaatgg gaaagtaagt tgttccattc
     1381 aggacgatct acccttcttc ctaaagcctt ctggggaaaa cttttatacg ctgttatcac
     1441 aaaaaccact ggacagagag agtgtagcag aatacaacat caccatcacc gttgcagaca
     1501 tggggagtcc catcctgaaa acacaagtca acttaacagt gcaggtatct gacatcaacg
     1561 acaacgcccc catcttcacc caaacctcct ataccatgtt catccgtgag aacaacagcc
     1621 ctgccctgca cataggcacc atcagtgcca cagactcaga ctcaggctcc aatgctcaca
     1681 tcacttactc gctgctgccg ccccatgacc accagctggc cctcgcctcg ttcatctcca
     1741 tcaacgcaga caatgggcag ctgttcgtgc tcagggcact ggactatgag gccctgcagg
     1801 cctttgaatt ccatgtgggt gccacagacg gaggttcgcc cgctctcagc agccaggcgc
     1861 tggtgcgcat ggtggtgctg gacgacaatg acaatgcgcc cttcgtgctc tacccgatgc
     1921 agaacgcctc tgcaccctac actgagctgc tgcccagggc ggcagagccc ggatacctgg
     1981 tcaccaaggt ggtggctgtg gaccgcgact ctggacagaa tgcctggctg tcgttccagc
     2041 tgctcaaagc tacggagccc gggctgttca gtgtgtgggc acacaatgga gaggtacata
     2101 cctccaggct gctgagcgag cgcgatgtgc acaagcacag gctgatactg ctagtcaagg
     2161 acaatggcga tcctccgcgc tctgccagtg tcacactgca tgtgctgctg gtggatggct
     2221 tctctcagcc ctacctgcct ctgccagagg tggcacgtga tcctgatcat gaggacagtg
     2281 agctcacatt gtacctggtc atagccttgg cttctgtgtc ttctctcttc ctggtgtctg
     2341 tgctgctgtt tgtgggggtg aggctgtgca ggagagccag ggaggtctct ctgggtggct
     2401 gctctgtgcc tgagggacac tttcctggcc atctggtgga tgtcagtggc acagggaccc
     2461 tgtctcagag ctaccaatat gaggtgtgtc ttactggaga ctctgggact ggtgagttca
     2521 aatatctgaa accaatttta cctaattttc aagaccattc ttttagacca gaaatgggtg
     2581 aaaatcccaa ctctaggaat gactggagtt ttggtattca gttaaaataa ctgcttttca
     2641 tcatgtgtac tggattttat catatactca actacttttc ttgctgtgcc cattttgaac
     2701 ttctaaaaca tacttaaaac ttgtttgcag gctattctct ccatggtttt agaaagtatc
     2761 tcagcttttc tccaaactgg aagatgaaat gttttaatct tgtttggttt tgtttgtttg
     2821 tttgtttgtt taatgtatca ctagttgcac aaatctttgt tctgggatgg tttggaaatg
     2881 tacaagaggg taaaaagggg aaatcaattc aaccgaatca gatggaattc agggtgtgtt
     2941 ctctcactga atacacccga catagcaatg ctcaaacaca acgaggtcta atcagatagg
     3001 agaacgaggg gctcactggg acctctgcct tttgctttat ttggcctcta ctggactgtc
     3061 tttgttgatg ttttctctta aaaatcttac ttagccacat ggttcctcat tagcttgcta
     3121 ttagttttca tatcactact ttaagctgct ttctactttg ttcgtttgct tgcttgcttg
     3181 cttgcttgct tgcttgtttt ttggttggtg ttgaggtttc agaatggtgt cccttattta
     3241 cctggtaggt tgaaagagca tagcagtagc attgagtttt cacttctgtt aaatacttgc
     3301 cagtcagaga aactgcatca gccagtattg attttttttc ctttctttgt tgccattcca
     3361 catttctttc ttgccagtca tgtgcttagt taaaagaata cattttcact gtcttttttt
     3421 ttttctctag caaatagatt agggcatatg gttagcttat agtgagatgt aagatgtggt
     3481 gccttccaca gctcttcagt tgaagagaaa ctgggggggg gacctatgca taccaagtaa
     3541 ggtctgtctc tctgatctac cactttcaat acccaagaac acttgtaaag ggagatgtct
     3601 cacctggaaa gggatttcac cctttgttca tgttatgttc ttcctaggat gttcgtggta
     3661 taatgagcgc acaaatactc atgttggctc tgtgataggt gtgacgggct aaagtagcat
     3721 gaaatggact tagctgtgat gatccctggc aactcaggag ttctcatatt attccccgcg
     3781 ttgccaattt cttagccttt ttaaacattc agaaataaag gaagtcccat gtcattattc
     3841 tagcttttat gctatggtca gttcttatgc tatggaatct atttgtgtgt ttgtgtgttt
     3901 gtgtgcctgt tggtgcatga gtgcttgcag atgtccttgc gcctctgcat gttgaggtcg
     3961 gaagttgatg tctaccttcg ttgctcagtt atctagacta gccagggagc tctgtggaaa
     4021 cactgactaa ctggtcatga ttctgggcaa taaaaggaaa agtctgagat ccaatcctag
     4081 ttacctgatt ctaatgaccc agttcttagt aatatgcttt actgataagc atatactggt
     4141 agcattattt tcctatgaag agaaatccat ttgtcccact ccatgaataa aatgaccctg
     4201 tgtaaatgta atctttagct catagtttgt atttctttct atagcagtga ccacactgct
     4261 tagaaaataa cccaaagggc tcacaaaaat caatgaccta agtaaattgg atcacactac
     4321 aactgctctc ttcatgacga agaaatcagc ctgattatat tcttgtgggc actcaatgag
     4381 tcacatgctt tattgtggaa gtgagttgtc ctatatgggc agcagaatca ctctatggtt
     4441 gtgtttattg gaccttatct gtctcttcag tcatcttcta taaactctaa aatattatac
     4501 acttcatatt cagtgggccc attattaaaa ttaaatatct tatgctcact tcagcattgt
     4561 gtatgtgttt gaaagcaatt gctttctaga agtttagctg aaaactaatt ttaagaaaac
     4621 tacaagcaat attatggatg aattttcaca cttaaataac tgagagattc ttgaaattct
     4681 gtaaaaaaaa tgatgtttct aattactttc tggtgcagtt aaccttttat ctttggcaaa
     4741 ataatgcccg ttgatgcctt cttttaaata atactataaa acatcagagg accatacatg
     4801 actttttaag aagaatgatt tggcacaact gaataagaaa ttctttagca cttaattatg
     4861 ctattcatat agaagctatc agtttttggt gttttcaaac aataatccat atttatgtcc
     4921 tgttctgttt ctctgttgct gtcagaaaat tcacaagaag ttgcttaaaa caataaaatg
     4981 tattatccca tagttttgta aataaaaaaa aaaaaccaat aagtgtctaa ttgaactaac
     5041 aagagaagtc catgggaaca cattgtgctc tggagacttt atagaacctt ttttgtcttt
     5101 tccatccaga tgttgcccac attacatggt gcatggtccc ttcaacttca cagcatgtaa
     5161 cgtttcttgt atagccattt tctctgaccc actctgaaaa tattctttga ataaaagttc
     5221 tttatcaaaa taaataaata aataaataaa taaataaatt ctttatccaa aaaaaaaa
//
