LOCUS       NM_053139               3438 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus protocadherin beta 14 (Pcdhb14), mRNA.
ACCESSION   NM_053139
VERSION     NM_053139.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3438)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3438)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 3438)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 3438)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   5  (bases 1 to 3438)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   6  (bases 1 to 3438)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 3438)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB622429.1, AY013775.1 and AK083065.1.
            
            On Jun 6, 2007 this sequence version replaced NM_053139.2.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               BB622429.1         4-189
            187-2577            AY013775.1         1-2391
            2578-3438           AK083065.1         2527-3387
FEATURES             Location/Qualifiers
     source          1..3438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.5 cM"
     gene            1..3438
                     /gene="Pcdhb14"
                     /gene_synonym="2210006M07Rik; PcdhbN"
                     /note="protocadherin beta 14"
                     /db_xref="GeneID:93885"
                     /db_xref="MGI:MGI:2136749"
     exon            1..3438
                     /gene="Pcdhb14"
                     /gene_synonym="2210006M07Rik; PcdhbN"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..2577
                     /gene="Pcdhb14"
                     /gene_synonym="2210006M07Rik; PcdhbN"
                     /note="Protocadherin-betaN; cell-cell adhesion molecule;
                     PCDH-beta-14"
                     /codon_start=1
                     /product="protocadherin beta-14 precursor"
                     /protein_id="NP_444369.3"
                     /db_xref="CCDS:CCDS29180.1"
                     /db_xref="GeneID:93885"
                     /db_xref="MGI:MGI:2136749"
                     /translation="METSLHKAPQKRQVTAIIFLLLLWEAGSATITYSVLEETDRGSL
                     VGNLAKDLGLSLRELITRGAQILSKGNKQLLQLEQKSGNLLLKEKLDREELCGSTNPC
                     ILHFQVLLKSPVQFIQGEIQLQDVNDHAPEFMEDEILLKILESSLPGAVFPLKIAQDL
                     DVGSNTVQNYTISTNAHFHLLTRNHSDGRKYPELVLDKALDREEQAQIRLTLTAMDSG
                     SPPKTGTTQVVIVVLDINDNAPEFAQGLYEVQVQENSPVGSLVLTVSARDLDAGTHGE
                     LSYSLFQSSNQVLQAFEVNTDTGEIRVRKLLDFEEIQSYRMEIEASDGGGLSGKCTVV
                     IHVMDVNDNAPELTMSVLISEIPENSPETIVAIFGISDPDSGDNGKMVCSVQDRLPFL
                     LKPNEENFYTLVTERALDRESRAEYNITITVSDMGTPRLTTQHTITVQVSDINDNAPA
                     FTHTSYTMFVRENNSPALHIGTISATDSDSGSNAHITYSLLPPHDPQLALNSLISINA
                     DNGQLFALRALDYEALQAFEFHVGATDGGSPALSSQALVRVVVLDDNDNAPFVLYPMQ
                     NASAPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKTTEPGLFSVWAHNGEV
                     RTTRLLSERDVPKHRLLLLVKDNGEPPHSASVTLHVLLVDGFSQPYLPLPEVARDPAQ
                     EDVLTLYLVIALASVSSLFLVSVLLFVGVRLCRKAGETSLGGCSVPEGHFPGHLVDVS
                     GTGTLSQSYQYEVCLTGGTGTNEFKFLKPVLPNFLNEGGYRNTEENSNFRDSLGFS"
     regulatory      3119..3124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb14"
                     /gene_synonym="2210006M07Rik; PcdhbN"
                     /note="hexamer: ATTAAA"
     polyA_site      3146
                     /gene="Pcdhb14"
                     /gene_synonym="2210006M07Rik; PcdhbN"
                     /note="major polyA site"
ORIGIN      
        1 tttcttgctg ctgagaaggg aagcttttca cagctctgcc gatcgatcct ttcagagagg
       61 tggataagct gcgtccagca acattaaaaa gagaagaatc ttaaatttat gtagccagga
      121 ttcctgagct gttcacaaag caattcttgg atgattatct gctgcatctt ttggagcaga
      181 ggaacgatgg agacatcact ccacaaggca ccacagaaaa ggcaagtgac cgccattatc
      241 tttctgttac tgctgtggga ggcaggtagt gcaaccatca cgtattccgt tctagaggag
      301 acagacaggg gctctttggt ggggaaccta gcaaaagatt tggggttgag tttaagggag
      361 ttgattacca ggggcgccca gattctttcc aaagggaaca aacagctcct gcagctggag
      421 cagaagagtg gaaatttgct cctgaaagaa aaattggatc gagaggagtt atgcgggagc
      481 accaatccgt gtatcctaca tttccaggtg ttactaaaaa gtccagtgca atttattcaa
      541 ggggaaatac agcttcaaga tgtaaatgat catgccccag aattcatgga agatgaaatt
      601 ctccttaaaa ttttggaaag cagccttcca ggtgccgtgt ttccattgaa aatagctcaa
      661 gatttggatg tggggagcaa cacggttcaa aactatacaa tcagcaccaa cgcccatttc
      721 caccttctca cccgcaatca cagcgacggc aggaaatatc cagagctcgt gctagacaaa
      781 gcactggacc gggaggaaca ggcacagatt agattaacac tcacggctat ggacagtggg
      841 tcacctccca agactgggac tacccaggtt gtcattgtgg tcctggacat taatgacaat
      901 gcccctgaat ttgcccaagg gctctatgag gtgcaagttc aagagaacag tcctgtgggc
      961 tcccttgtcc tcactgtatc cgcaagagat ttagatgctg ggacacacgg agagctctcc
     1021 tattcgcttt ttcaatcatc aaatcaagtt ctacaggctt ttgaagtaaa tacagacacc
     1081 ggagaaatta gagtaagaaa actgttggac tttgaggaaa ttcagtctta ccgcatggaa
     1141 atcgaggcct ctgatggggg aggcctttca ggaaaatgca cagtagtaat acatgtgatg
     1201 gatgtaaatg acaacgctcc tgaactcacc atgtcagtac ttatcagcga aattccagaa
     1261 aactcccctg aaactatagt cgcgattttt ggaatttcag atccagactc tggagacaat
     1321 ggaaaaatgg tgtgctccgt ccaagaccgt cttcctttcc tcttgaaacc taatgaagaa
     1381 aacttctaca cgttggtaac tgaaagagca ctggacagag agagcagagc tgagtacaac
     1441 atcaccatta cggtctcaga catgggcaca cccaggctca caacccagca caccataaca
     1501 gtgcaggtgt ctgacatcaa tgacaacgcc cctgccttca ctcacacctc ctacaccatg
     1561 tttgtccgag aaaacaacag ccctgcattg cacataggca ccatcagcgc cacagactca
     1621 gactcaggct ccaatgccca catcacctac tcgctgctgc ctccccatga cccacaactg
     1681 gccctcaact cgctcatctc catcaacgca gacaatgggc agctgtttgc gctcagggcg
     1741 ctggactatg aggccctgca ggcctttgag ttccatgtgg gcgccacaga tggaggctct
     1801 cccgcgctca gcagccaggc gctggtgcgc gtggtggtgc tggacgacaa tgacaatgcg
     1861 cccttcgtgc tctacccgat gcagaacgct tctgcgcctt gcactgagct gctgcccagg
     1921 gcagcggagc ccggatatct ggtcaccaag gtggtggctg tggaccgcga ctctggacag
     1981 aatgcctggc tgtcattcca actgctcaag accacggagc ctggactgtt cagtgtgtgg
     2041 gcgcacaatg gcgaggtgcg caccaccagg ctgctgagcg agcgcgatgt gcccaagcac
     2101 aggctgctcc tgctggtcaa ggacaatgga gaacctccac actctgccag tgtcacactg
     2161 catgtattgc tggtcgatgg tttctctcag ccctaccttc ctctgccaga ggtggcgcgc
     2221 gaccctgcac aagaagatgt actaacactc tacctggtca ttgccttggc ctctgtgtct
     2281 tctctcttcc tggtgtctgt gctgctgttt gtgggagtaa gactgtgcag gaaggctggg
     2341 gagacttctc tgggtggctg ctctgtgcct gagggacact ttcctggcca cctggtggat
     2401 gttagcggaa ctgggaccct gtcccagagc taccagtatg aggtgtgtct gacgggaggt
     2461 actggaacaa atgagtttaa atttcttaaa ccagtacttc ccaacttttt gaatgaagga
     2521 ggttacagaa acacggagga gaattccaat tttagggatt ctttggggtt tagctaaaag
     2581 tcacatttga ctcgtgtgat gataataaca cgatattagt gatataattt cacaaccatt
     2641 cactcgtgga aagaggtctg cactagcatg atactggtag tcatatttgt agctgattca
     2701 cattgtcgaa tattccttgc attttttgct aactatcttt ccctcaagca cacaatatag
     2761 ctgcaaaatg ttctttcttg gtgggattcg tcttcaacac ttaaaaaaaa aaggtttaaa
     2821 agttaagaga tattttcagg ctcctggttt ctgagcatgt gcattgattt cttttaatca
     2881 cagaactcct gtctcgaaag ttcttgttat tactaggatg aatttaatgc tattgtaaat
     2941 gatggctttc agttttaaaa ataattttca atcaggcaag cattcttttg tgaacttcta
     3001 aatcctatga ttctgttgcc taggtccaag agccctattt tctttcttca aatgaactgt
     3061 tattcgatca ggattatgtt tctaaattaa gtatttcttt caaaatatat aaaagttaat
     3121 taaagtattt ttaacattcc gaaaaactca tctgttatat caaaaatggt ggacttatta
     3181 atacacttgt gactagtttt tcagaaatgg ctttggtatg taaatagtga ttctaactct
     3241 tttaacatga ttgagcaatc atcaatctac atgattaata catacacagt aaacacagag
     3301 acacattagt gtgctttcac aagaaatttg tcataagtca atattactct aaaatacatc
     3361 tactggagct tgaggtgtag ctaaatggaa aaccatgtgt tcagcacgca tgatgccctg
     3421 gatacaacac tcagaacc
//
