LOCUS       NM_053135               2842 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protocadherin beta 10 (Pcdhb10), mRNA.
ACCESSION   NM_053135
VERSION     NM_053135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2842)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2842)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2842)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 2842)
  AUTHORS   Vanhalst,K., Kools,P., Vanden Eynde,E. and van Roy,F.
  TITLE     The human and murine protocadherin-beta one-exon gene families show
            high evolutionary conservation, despite the difference in gene
            number
  JOURNAL   FEBS Lett 495 (1-2), 120-125 (2001)
   PUBMED   11322959
REFERENCE   5  (bases 1 to 2842)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   6  (bases 1 to 2842)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 2842)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY722394.1, AY013771.1 and BM942895.1.
            
            On Sep 1, 2006 this sequence version replaced NM_053135.1.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               BY722394.1         13-211
            200-2593            AY013771.1         1-2394
            2594-2842           BM942895.1         271-519
FEATURES             Location/Qualifiers
     source          1..2842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.49 cM"
     gene            1..2842
                     /gene="Pcdhb10"
                     /gene_synonym="Pcdhb5D; PcdhbJ"
                     /note="protocadherin beta 10"
                     /db_xref="GeneID:93881"
                     /db_xref="MGI:MGI:2136745"
     exon            1..2841
                     /gene="Pcdhb10"
                     /gene_synonym="Pcdhb5D; PcdhbJ"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..2593
                     /gene="Pcdhb10"
                     /gene_synonym="Pcdhb5D; PcdhbJ"
                     /codon_start=1
                     /product="protocadherin beta 10 precursor"
                     /protein_id="NP_444365.1"
                     /db_xref="CCDS:CCDS29177.1"
                     /db_xref="GeneID:93881"
                     /db_xref="MGI:MGI:2136745"
                     /translation="MEMTLAKTPENRQVLFFTILLLLWKSCADAIIYSIPEETESGYL
                     VANLAKDLGLRVGELAIRGARIHYKGNKELLQLDAETGNLFLKEKPDREVLCRATEPC
                     VLHFQIILENPVQFFQTELQLTDINDHSPEFPDRKMLLKIPESAQPGTTFPLKAAQDP
                     DIGSNAVQNYTVSPNLHFHVVTLSRSDGRKYPELVLDRALDREEQPELTLILTALDGG
                     APPRSGTTEVHIEVVDINDNAPQFIQSLYEVQILENSPLDALVATVSARDLDAGIYGK
                     VAYSLFQDDGISQPFVIDEITGEIRLKGALDFEATPYYNMEIVATDPGGFSGKCTVVI
                     QVVDVNDNAPKLTISSLNSSIPENAPETVVAVFSVSDPDSGENGRMVCSIQNELPFLL
                     KSTFENYYTLVTEGTLDRESKAEYNITISVTDLGTPRLTTQHTITVQVSDINDNAPTF
                     TRTSYTMFIRENNSPALHIGTISATDSDAGSNAHITYSLLPPHDPQLTLTSLVSINED
                     NGQLFALRALDYEALRAFEFHVRATDRGSPALSSQALVLVVVLDDNDNEPFVLYPLQN
                     SSAPCKELVPRAAEAGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVR
                     TTRLLSERDAPKHRLLLVVKDNGDPPRSASVTLHVLLVDGFSQPYLPLSEVVQDPAQE
                     GDDALTLYLVIALASVSSLFLISVLLFVGMKLCKRARSPSLGVCSVPEGHFPGHLVDV
                     SGTGTLSQSYQYEVCLSGDSGTGEFKFLKPMISNLMVQDPEREVKESPHCRDSFVFS"
     regulatory      2817..2822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Pcdhb10"
                     /gene_synonym="Pcdhb5D; PcdhbJ"
                     /note="hexamer: AATAAA"
     polyA_site      2839
                     /gene="Pcdhb10"
                     /gene_synonym="Pcdhb5D; PcdhbJ"
                     /note="major polyA site"
ORIGIN      
        1 atacccagaa agccactgaa agctggaaaa cagaacgctt tctactccct agaagaagaa
       61 ggtatttgag cgtgatctag gggagaaatc tccgcgggca gtaagacatt aaagattaaa
      121 ttcaaggata ttttaccata tttctttgtg gattgaaact gactagaaga agaagcgccc
      181 tctggactaa atcagaaaaa tggagatgac actagcaaaa acgccagaga acaggcaagt
      241 cctttttttt actatactat tgctattatg gaagtcttgt gccgatgcaa ttatatattc
      301 tataccagaa gaaacagaga gtggctattt ggtggctaat ttggcaaaag atctggggct
      361 ccgagttgga gagctggcta ttaggggggc acgaatccat tacaaaggaa acaaagagct
      421 cttgcagctg gatgcagaga ctgggaattt attcctgaag gaaaaaccag accgtgaggt
      481 gctgtgcagg gcgacagaac cctgtgtgct gcacttccag atcatactgg aaaaccctgt
      541 gcagttcttc caaactgaac tgcagctcac agatataaat gaccactctc cagagttccc
      601 tgaccggaaa atgctactga aaatccctga gagcgcccag ccagggacaa cgtttcctct
      661 gaaggcagcc caggaccctg acatagggag caatgctgtt cagaactaca cagtcagtcc
      721 caacctccat ttccatgtgg ttactctcag tcgctcagat ggcaggaaat acccagagct
      781 ggtgctggac agagccctgg acagggagga gcagcctgaa ctcactttaa tcctcactgc
      841 tctggatggt ggagctccac ccaggtcagg aaccaccgaa gttcacattg aagtcgtgga
      901 catcaatgat aacgcccccc agtttataca gtcactctat gaggtgcaga ttcttgaaaa
      961 tagccccctt gatgccttag ttgccacagt ctctgccagg gatttagatg ctgggatata
     1021 tggcaaggta gcctactctc tgtttcagga tgatggaata tctcaaccat ttgtaataga
     1081 tgaaatcaca ggagaaattc gtcttaaagg ggcactggat tttgaggcaa ctccgtatta
     1141 taacatggaa attgtagcta cagacccagg aggcttttca ggaaaatgca ctgtggttat
     1201 ccaggtggtg gatgtgaatg acaatgcccc taagctcacc atatcttcac tcaatagttc
     1261 tatcccagaa aatgctcctg agactgtagt ggctgttttc agtgtttctg atccggattc
     1321 tggggaaaat ggaaggatgg tgtgttctat tcagaacgaa cttccatttc ttttgaagtc
     1381 cacatttgag aactattata ctttagtaac agaggggaca cttgatagag agagcaaagc
     1441 tgaatacaac attactatct ccgtcaccga cctgggcacc cccaggctca caacccagca
     1501 caccataaca gtgcaggtgt ctgacatcaa cgataatgcc cccaccttca cccgaacctc
     1561 ctacaccatg ttcatccggg agaacaacag ccctgccctg cacattggca ccatcagcgc
     1621 cacagactca gacgcaggct ccaatgccca catcacatac tcgctgctgc cgccccatga
     1681 tccgcagctg accctcacct ctcttgtctc catcaatgaa gacaatgggc agctgttcgc
     1741 actcagggct ctggactatg aggccctgcg ggccttcgag tttcatgttc gcgccacaga
     1801 ccgtggttca cccgcgctta gcagccaggc tttggtactc gtggtggtgc tggacgacaa
     1861 tgacaatgag cccttcgtgc tctacccgtt gcagaactct tctgcgccct gtaaggagct
     1921 agtacccaga gctgcggagg caggttactt agtcaccaag gtggtggctg tggaccgcga
     1981 ctctggccag aatgcctggc tgtcattcca gttactcaag gccacggagc ccgggctgtt
     2041 cagcgtgtgg gcgcacaatg gggaggtgcg caccaccagg ctgttgagtg agcgagatgc
     2101 acccaagcac aggctgctgc tggtggtcaa ggacaatggg gatcctccgc gctctgccag
     2161 tgtcacactg catgtgttgc tggtggatgg cttctctcag ccctacctgc ctttgtctga
     2221 agtcgtgcag gatcccgctc aggaaggtga tgacgctctc acgctgtact tggtcattgc
     2281 tttggcatct gtgtcttcac ttttcctcat ttctgttctg ctcttcgttg ggatgaagct
     2341 gtgcaagagg gccaggtcgc cttctctggg tgtctgctct gtgcctgagg gccactttcc
     2401 tggccacctg gtggatgtta gcggaactgg gactctgtcc cagagctacc agtatgaggt
     2461 gtgtttatcg ggggactctg ggactggtga gttcaaattc cttaaaccca tgatctccaa
     2521 cttaatggtt caggaccctg agagagaagt gaaggaaagt ccgcactgca gggatagctt
     2581 tgtattcagt taattgtatg ttttagtgaa tttgtttttg atcaatctat tgcaatatgg
     2641 ttctcttaag aaagtgaatc attttaacta agtattagca ctgtagtcaa agtgtatgca
     2701 tgtcctccat taccaaagtg tttacttagt tcacaatatc cactgtactt aatattttta
     2761 attttagtag atattaagga cacaacttat gttttgcttt agctcaagta ttacacaata
     2821 aaattttatg tcttctgggt ta
//
