LOCUS       NM_001003672            5719 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protocadherin alpha subfamily C, 2 (Pcdhac2), mRNA.
ACCESSION   NM_001003672
VERSION     NM_001003672.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5719)
  AUTHORS   Gallerani N and Au E.
  TITLE     Loss of Clustered Protocadherin Diversity Alters the Spatial
            Distribution of Cortical Interneurons in Mice
  JOURNAL   Cereb Cortex Commun 1 (1), tgaa089 (2020)
   PUBMED   34296145
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5719)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5719)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 5719)
  AUTHORS   Fan L, Lu Y, Shen X, Shao H, Suo L and Wu Q.
  TITLE     Alpha protocadherins and Pyk2 kinase regulate cortical neuron
            migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
            complex in mice
  JOURNAL   Elife 7, e35242 (2018)
   PUBMED   29911975
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5719)
  AUTHORS   Katori S, Noguchi-Katori Y, Okayama A, Kawamura Y, Luo W, Sakimura
            K, Hirabayashi T, Iwasato T and Yagi T.
  TITLE     Protocadherin-alphaC2 is required for diffuse projections of
            serotonergic axons
  JOURNAL   Sci Rep 7 (1), 15908 (2017)
   PUBMED   29162883
  REMARK    GeneRIF: Pcdh-alphaC2 (alphaC2), a Pcdh-alpha isoform, was highly
            expressed in serotonergic neurons, and was required for normal
            diffusion in single-axon-level analyses of serotonergic axons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5719)
  AUTHORS   Morishita H, Murata Y, Esumi S, Hamada S and Yagi T.
  TITLE     CNR/Pcdhalpha family in subplate neurons, and developing cortical
            connectivity
  JOURNAL   Neuroreport 15 (17), 2595-2599 (2004)
   PUBMED   15570159
REFERENCE   7  (bases 1 to 5719)
  AUTHORS   Wang X, Su H and Bradley A.
  TITLE     Molecular mechanisms governing Pcdh-gamma gene expression: evidence
            for a multiple promoter and cis-alternative splicing model
  JOURNAL   Genes Dev 16 (15), 1890-1905 (2002)
   PUBMED   12154121
REFERENCE   8  (bases 1 to 5719)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 5719)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 5719)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020972.3 and AC020973.3.
            
            On Feb 22, 2019 this sequence version replaced NM_001003672.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013769.1, SRR1660819.179523.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2853              AC020972.3         21222-24074         c
            2854-2912           AC020972.3         11539-11597         c
            2913-3001           AC020972.3         8399-8487           c
            3002-5719           AC020973.3         123819-126536
FEATURES             Location/Qualifiers
     source          1..5719
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..5719
                     /gene="Pcdhac2"
                     /gene_synonym="CNRc2"
                     /note="protocadherin alpha subfamily C, 2"
                     /db_xref="GeneID:353237"
                     /db_xref="MGI:MGI:1891443"
     exon            1..2853
                     /gene="Pcdhac2"
                     /gene_synonym="CNRc2"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..3312
                     /gene="Pcdhac2"
                     /gene_synonym="CNRc2"
                     /note="protocadherin alpha C2"
                     /codon_start=1
                     /product="protocadherin alpha-C2 precursor"
                     /protein_id="NP_001003672.1"
                     /db_xref="CCDS:CCDS29168.1"
                     /db_xref="GeneID:353237"
                     /db_xref="MGI:MGI:1891443"
                     /translation="MEQAGARPGATEHPRPLRPLPWLLLLSFRLLLVLLPGPAASQLR
                     YSVPEEQSPGALVGNVARALGLELRRLGPGCLRINHLGAPSPRYLELDLTNGALFVNE
                     RIDREALCEQRPRCLLSLEVLAHNPVAVSAIEVEILDINDNSPRFPRPDYQLQVSESV
                     APGARFHIESAQDPDVGANSVQTYELSPSEHFELDLKPLQENSKVLELVLRKGLDREQ
                     TALHYLVLTAVDGGIPARSGTAQIAVRVLDTNDNSPAFDQSTYRVQLREDAPPGTLVV
                     KLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDVTTGEVRVSGTLDYEESSSYQIYV
                     QATDRGPVPMAGHCKVLVDIIDVNDNAPEVVLTDLYSPVPEDVALNTVVALLSVNDQD
                     SGSNRKVSLGLEASLPFRLNGFGNSYTLVVSGPLDRERVAAYNITVTATDGGVPPLTS
                     QRTLQVEISDINDNPPSFLKDSYSIYIEENNLPGVLLCTVQATDPDQKENAEVTYSLL
                     DREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFFVTVEAQDKGRPPLSSTVTANV
                     YVVDVNDHAPHILYPTSTNTSAAIEMVPRTAPAGYLVTKVIAMDSDSGQNAWLFYHLV
                     PTSDSDLFKVELHTGEIRITRKIGDESGTTFNLTVVVRDNGEPPLSATVAITVAVVDR
                     VSKMLPDTQRHIKSPRTYSEITLYLIIALSTVSFIFLLTIIVLSIIKCYRYTAYGTAC
                     CGGFCGVRERCPAELYKQANNNIDARIPHGLKVQPHFIEVRGNGSLTKTYCYKACLTA
                     GSGSDTFMFYNTGAQTGPGPGGAQASVTDNRQLTGQSRHSTGNLIILKNDAGSQNEPR
                     QPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPV
                     GAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITF
                     GKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"
     exon            2854..2912
                     /gene="Pcdhac2"
                     /gene_synonym="CNRc2"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3001
                     /gene="Pcdhac2"
                     /gene_synonym="CNRc2"
                     /inference="alignment:Splign:2.1.0"
     exon            3002..5719
                     /gene="Pcdhac2"
                     /gene_synonym="CNRc2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccctctcc ttagagcatc agcggcggcg gcggcagctg gcagtcgcag aaaatcgaga
       61 cccgcggacc gcctggaggc gagtggagga gctgggatat ggggagtcag cgggggcggc
      121 agggcccgga gcccttgaga acgcttggga ggggagccgt ctcgggcatt tgtagtgcgt
      181 gagaggtgaa gagcggcgag ggcggaggcg gggcccgggc ccggcgtgga gcaggctgcc
      241 aagccgctgc ctcccgccct gccccggctg cctctgccag ggccggcggc tatggagcag
      301 gcgggagcca gacctggggc gacagagcat ccgcgacccc tgcggccctt gccctggctg
      361 ctgcttctgt ctttccgact gctgctggtg ctgctgccag gcccagcggc ctcccagcta
      421 cgatactccg tgccggagga gcagagcccc ggcgcgctcg tgggcaacgt ggccagagcc
      481 ttggggctag aactgcggcg cttgggacct ggctgtctgc gcatcaacca tttgggtgca
      541 cccagcccgc gctacctgga actggacttg accaatggag cgctcttcgt caacgagcgg
      601 atagatcgcg aggcgctgtg cgagcagcgg cctcgctgcc tgctcagctt ggaagtgctg
      661 gctcacaacc ctgtggcagt gagcgcgatc gaggtggaaa tactggacat caatgacaac
      721 tctccgcgct tcccgcggcc ggattatcag cttcaggtaa gcgaatccgt ggcacctgga
      781 gcgcggtttc acatagagag cgcacaggac cctgacgtcg gtgccaactc agtgcagacc
      841 tacgagctca gccccagcga gcactttgag ctggatctta aacccttgca ggagaatagc
      901 aaggtgctgg agctcgtgct gcggaagggc ctagaccggg agcagactgc cttgcactac
      961 ttggttctca ctgcggtgga tgggggcatc ccagctcgct caggcacagc tcagatcgcc
     1021 gttcgtgtcc tggacacgaa tgacaattct cctgcctttg accaatccac ttaccgcgtc
     1081 cagctgcgag aggatgctcc tccgggcaca ttggtagtga agttgaatgc ctcggacccg
     1141 gatgagggtt ctaacggtga actcaggtac tccttgagca gctacacatc agaccgggag
     1201 agacagctct tcagcatcga tgtgactaca ggggaagtga gagtaagtgg gactctggat
     1261 tatgaggagt cttcctccta ccagatctat gtgcaagcta ctgaccgggg accggtaccc
     1321 atggcgggac actgcaaggt gttggtggac attatagatg tgaatgacaa cgctccagag
     1381 gtggtgctca cagacttata cagcccagtg cctgaggatg ttgccctcaa cactgttgtg
     1441 gcccttctca gtgtgaatga ccaagattca ggctccaaca ggaaagtaag cctgggtctg
     1501 gaggcttcac tgcccttccg gctgaatggc tttggaaact cctataccct ggtggtgagt
     1561 ggcccattgg atcgggagcg ggtagctgcc tacaacatca cagtgacagc tactgatggg
     1621 ggagtaccac cactcacatc tcaaaggaca ttgcaggttg agatctctga cataaatgac
     1681 aatccaccaa gcttcctgaa ggactcctat tccatctaca tcgaggaaaa caatttacca
     1741 ggtgtgttgc tctgcactgt gcaagccaca gacccagatc aaaaggagaa tgcagaggtg
     1801 acctactcac tcctagacag ggagattcaa gggctgccag tcacctccta tgtctccatt
     1861 aacagtgcca gcggcagcct ttatgctgtc aactcctttg actatgagaa atttcgagag
     1921 ttttttgtga ctgtggaggc ccaggataag gggaggccac cactaagcag cactgtgacc
     1981 gccaacgtgt atgtggtgga cgtgaatgac cacgcccccc atattctata ccctacctca
     2041 actaatacat cagcagccat tgaaatggtg ccacggactg cccctgctgg ctacctggtc
     2101 accaaagtca tagccatgga ttcagactct gggcagaatg cttggctctt ttaccattta
     2161 gtcccaacgt ctgactcgga cctttttaaa gtagaacttc acacaggaga aattaggatt
     2221 accaggaaga taggagatga gagtggcacc actttcaacc tgaccgtggt ggtccgtgac
     2281 aatggagagc cacctctatc agctaccgtg gccatcacag tagctgtggt ggacagggtt
     2341 tctaaaatgc tccctgacac tcagagacat ataaagagtc ctcggacata ctctgagatc
     2401 acactttatc tgataatagc attaagcaca gtgtctttta tattcctttt gacaatcatt
     2461 gttctgagca tcattaagtg ctaccgctac actgcttatg gcacggcatg ctgtgggggc
     2521 ttctgtggag tgagggagcg ctgccctgca gagctgtaca agcaggccaa taacaatatc
     2581 gatgccagga taccacatgg cctcaaagta cagcctcact tcattgaggt tcgaggcaat
     2641 ggctccctca ccaagaccta ctgctacaag gcctgcctga cagcaggctc agggagtgat
     2701 actttcatgt tttacaacac aggggcccag acagggccag ggcctggggg agcccaagcc
     2761 tcagtgactg acaacaggca actcaccggc caaagtaggc acagtaccgg gaacctgatt
     2821 atcctaaaaa atgatgctgg ctctcaaaat gagccccggc agcccaaccc tgactggcgc
     2881 tactctgcct cgctaagagc aggcatgcac agctctgtgc acctggagga ggctggcatt
     2941 ctacgggctg gtccaggagg gcctgatcag cagtggccaa cagtatccag tgcaacacca
     3001 gaacctgagg caggagaggt gtcccctccg gtgggcgccg gtgtcaacag caacagctgg
     3061 acctttaaat acggaccagg caaccccaaa cagtccggtc ccggtgagtt gccagacaaa
     3121 ttcattatcc caggatctcc tgcaatcatc tccatccggc aggagcctgc taacaaccaa
     3181 attgacaaaa gcgattttat aaccttcggc aaaaaggagg agaccaagaa aaagaagaaa
     3241 aagaagaagg gtaacaagac ccaggagaaa aaagagaaag ggaacagcac gacggacaac
     3301 agtgaccagt gaggccacca aatggaaaca agccacttag ccagtttttg taataatggc
     3361 aaatctctcc catgtagcaa ctccccgctc ctttctccta tgacatgagc cctcagaaat
     3421 ctgcagaaag ttccctgtgt ctgtcttgat cgcatttaac aggttttgtc ttaaaaagct
     3481 ttcctaagtc tggtgttaac tctctctctc tccactctgg cttgttttca gaacctaaaa
     3541 agcagaccca ggtttccttt ctcccccgcc gcaaaggaga agcttcccag ccccgccagt
     3601 gagagttgga ctctctgccc tgtgcttcaa gcatcctgtc ttgatgatat ttgcagggca
     3661 ggctgaaagg tattcaggtt gagcagttgg gtgtttgtgg tcactgggta tgtgtggcta
     3721 ccaagagtgt tggagagcct ggtattggct gggatggtcc agattagact agttaacaca
     3781 aggagggctg gggctcaaag gcacatcaac accgggagtc tttcatctgg agggggaaaa
     3841 tgtgaaactt acaaggacca gactttctca atctctcaac tagacatatg atggccatcc
     3901 tctaacagac aaaaccatcc ccaccggcaa agctttagga gcccctcaag tgtgctggct
     3961 ataacatcac tgtattcaaa acctgcagta tgcacacgag ccagcagttc aagcgtttaa
     4021 caagagggtc ggccagggca acagaagcag atctgatgtg tttcctgtac acgtccttgt
     4081 gctcacgcta ttaaaaattc ttttgcacac aatgtttatg aaaaggtctc atccttttcc
     4141 aacaacacat atgcaaaagc aaaagaaaaa cccaagacct cactttatgc tgtttgttgt
     4201 ttgatagatt tattaaaaag aaaagagaaa gtcgatagct ataaatcttt aaaggaatat
     4261 gatgaataca atccccccaa ccttccctca aaagagaatc cagtctacag ccatttgaaa
     4321 tgatcgttgc tgctacagaa gtgctttaag agaattgcct ggaacatctg tattatcccg
     4381 gccacctgcc aatcacagct ttactctttc aggtcactct ggggctgcct cttgcatgta
     4441 ttaattacta aatagaagga tctttctctc ttttctaaga aaaatgatgt gcactttgat
     4501 tacacaacct tctctaaccc acgatatcaa gacccagaaa ctgaagaaaa atcttgtttt
     4561 ctcatgcata cagtgagcag acttttcatt cctctggttc tgtggttgtc tcggtgtgct
     4621 agcctacacc tccaccttgt ttagctttcc ttttctagaa cactctgaat tgctaacctt
     4681 actaacacct atgatgttac ctgaatcaat ctcccatatg tatgctgtat gctattataa
     4741 gactcctgag atatacttac tctgtgcttg tgtatgtgaa tgttaatgca actattacct
     4801 agagtgaact ttaagcttta ttgttgaatg taagcccatt atatttcctt ttgtacacct
     4861 gtggaaaagt ggaatagtgt tttttttaaa accattgtta atcagctttt gtgtatgaaa
     4921 gacacagtaa aatttctttc ttaaatcaag atgctggtga ttcaaggaat tttatttatg
     4981 gtcagccaag ggctgtctct tgccaagaat cctgctggca agggaaaatg gataaagctg
     5041 gttttttttt ttcctagtaa gaattctgga ataaatactg aagaaagtcc ctgagggtat
     5101 gcaagcacaa aattgtacca atctgacctc tttgaatttg cagactgctt tgaaatgcta
     5161 tccggaatat cagcttgtag aaagtaataa aatttactgt taccataaat aagacatttt
     5221 aagtttattg tgcacaactt agatgtttga ttaattatat tatctactta aaagcatata
     5281 aaagaggtag gagtctgttt taaaaggcat aaaaaatctc aaaaaaaaaa aacctgtctt
     5341 gtctactttt agcttcattc tcccatattt tgaagggtgt gtaacttcag ctctgcagga
     5401 ttgcatgggg taaaactcgt tgacagcgca tgtgaaccat tgctacattg taggttgtga
     5461 tcattttgcc ccactgaagc ccatgtaact gaccttacgt gccttttgaa ctaggagaat
     5521 cgggctataa tttattaatg atgataatga taatgtatat gtacagcact ttttaacctt
     5581 acaaagtgct ttccaattcg tgttagttat tagttattac agctgtaagg ataaaacacg
     5641 tcatgtggat tcatttttaa ttggtgctat tggtatttcc tctgttcttg ctaataaatg
     5701 gaaatggtgg tgtgaaagc
//
