LOCUS       NM_138661               5341 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus protocadherin alpha 9 (Pcdha9), mRNA.
ACCESSION   NM_138661
VERSION     NM_138661.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5341)
  AUTHORS   Gabriel,G.C., Yagi,H., Tan,T., Bais,A., Glennon,B.J.,
            Stapleton,M.C., Huang,L., Reynolds,W.T., Shaffer,M.G.,
            Ganapathiraju,M., Simon,D., Panigrahy,A., Wu,Y.L. and Lo,C.W.
  TITLE     Mitotic block and epigenetic repression underlie neurodevelopmental
            defects and neurobehavioral deficits in congenital heart disease
  JOURNAL   Nat Commun 16 (1), 469 (2025)
   PUBMED   39774941
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5341)
  AUTHORS   Zhong,J., Wang,C., Zhang,D., Yao,X., Zhao,Q., Huang,X., Lin,F.,
            Xue,C., Wang,Y., He,R., Li,X.Y., Li,Q., Wang,M., Zhao,S.,
            Afridi,S.K., Zhou,W., Wang,Z., Xu,Y. and Xu,Z.
  TITLE     PCDHA9 as a candidate gene for amyotrophic lateral sclerosis
  JOURNAL   Nat Commun 15 (1), 2189 (2024)
   PUBMED   38467605
  REMARK    GeneRIF: PCDHA9 as a candidate gene for amyotrophic lateral
            sclerosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5341)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 5341)
  AUTHORS   Wilson,R.L., Troja,W., Courtney,J., Williams,A. and Jones,H.N.
  TITLE     Placental and fetal characteristics of the Ohia mouse line
            recapitulate outcomes in human hypoplastic left heart syndrome
  JOURNAL   Placenta 117, 131-138 (2022)
   PUBMED   34890862
REFERENCE   5  (bases 1 to 5341)
  AUTHORS   Teekakirikul,P., Zhu,W., Gabriel,G.C., Young,C.B., Williams,K.,
            Martin,L.J., Hill,J.C., Richards,T., Billaud,M., Phillippi,J.A.,
            Wang,J., Wu,Y., Tan,T., Devine,W., Lin,J.H., Bais,A.S.,
            Klonowski,J., Moreau de Bellaing,A., Saini,A., Wang,M.X.,
            Emerel,L., Salamacha,N., Wyman,S.K., Lee,C., Sing Li,H., Miron,A.,
            Zhang,J., Xing,J., McNamara,D.M., Fung,E., Kirshbom,P., Mahle,W.,
            Kochilas,L.K., He,Y., Garg,V., White,P., McBride,K.L., Benson,D.W.,
            Gleason,T.G., Mital,S. and Lo,C.W.
  TITLE     Common deletion variants causing protocadherin-alpha deficiency
            contribute to the complex genetics of BAV and left-sided congenital
            heart disease
  JOURNAL   HGG Adv 2 (3) (2021)
   PUBMED   34888534
REFERENCE   6  (bases 1 to 5341)
  AUTHORS   Murata,Y., Hamada,S., Morishita,H., Mutoh,T. and Yagi,T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   7  (bases 1 to 5341)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   8  (bases 1 to 5341)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 5341)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   10 (bases 1 to 5341)
  AUTHORS   Kohmura,N., Senzaki,K., Hamada,S., Kai,N., Yasuda,R., Watanabe,M.,
            Ishii,H., Yasuda,M., Mishina,M. and Yagi,T.
  TITLE     Diversity revealed by a novel family of cadherins expressed in
            neurons at a synaptic complex
  JOURNAL   Neuron 20 (6), 1137-1151 (1998)
   PUBMED   9655502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY013767.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013767.1, AB008183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..5341
                     /gene="Pcdha9"
                     /note="protocadherin alpha 9"
                     /db_xref="GeneID:192161"
                     /db_xref="MGI:MGI:2447322"
     exon            1..2481
                     /gene="Pcdha9"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2540
                     /gene="Pcdha9"
                     /inference="alignment:Splign:2.1.0"
     exon            2541..2629
                     /gene="Pcdha9"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..5341
                     /gene="Pcdha9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagattag gaaatcgacc agaagatatt agaacttgtg tgcatctcag atggcacatt
       61 catggacttt taagacaaga gaatgcttca gtggtgatct ccaaatgtct gaggcatgga
      121 gcttggcgcc tgctactttg gcttctgctc cttgcaacat gggatgtagg gagcggccag
      181 cttcactact ctgtcccaga ggaggccaaa cacggcacct tcgtgggccg catcgcgcag
      241 gacttggggc tggagctggc tgaactggtg ccccgcctgt tcagggtggt gtccaaggac
      301 cgcggggacc ttctggaggt aaatcttcag aatggcattt tgtttgtgaa ttctcggatc
      361 gaccgggagg agctgtgcgg gcagaacgcg gagtgtagca tccacctgga ggtgatcgtg
      421 gacaggccgc tgcaggtttt ccacgtggag gtggaggtga gggacattaa tgacaaccct
      481 ccgatattct ccgtagcgga acaaaagatc ttggtagctg aatctagact gcttgattct
      541 cgatttccac tagaaggcgc ctctgatgca gatgttggag agaactctat gcttacttac
      601 aaactcagtt caaatgagtt ttttatcctt gatattgtaa acaaaagagg caaaggcaaa
      661 tttccagtgc ttgttcttcg aaaactgata gatcgagaag aaaatcctca gctaaagttg
      721 ctactgacag caaccgatgg aggcaaacct gaatttacgg gatcggtttc tctgttgatc
      781 caggtgttgg atgttaatga caatgctcct gtgtttgaca gatctgttta cgaagttaag
      841 atgtatgaga atcaagagaa taaaacctta gtaatatggc tgaatgctac tgactcagat
      901 gaaggaataa acaaagaagt ggagtattca tttagctctt tagcctcatc gattataaga
      961 cagaaatttc taataaacga aaagactgga gagataaaaa taaacggcgc tattgacttt
     1021 gaggagagta acaattatga aattcacgtg gatgctacag ataaaggata cccacctatg
     1081 gttgctcact gcaccgtact cgtggaaatc ttggatgaaa atgataacgc accggagata
     1141 gtccttactt ctttgtcttt gccggtgaaa gaagatgctc ctttgggctc tgtaatcgcc
     1201 ctgatcagcg tgtcagacaa agactctggt gtcaatggac aggtgacctg ctccttgact
     1261 aaccatgtcc ccttcaagtt ggtgtccacc ttcaagaatt actattccct cgtgctggac
     1321 agcgccctgg accgagagac cacagctgac tataaggtgg tggtgacagc ccgcgacggg
     1381 ggctcgccct ctctgtgggc cacggccagc gtgtccgtgg aggtggctga cgtgaacgac
     1441 aatgctcctg cattcgcaca tcccgaatac acggtgttcg tgaaggagaa caacccgcct
     1501 ggagtgcaca tcttcacagt attggcggtg gatgctgacg cacaggagaa cgcgctggtg
     1561 tcctactcgc tggtggagcg gagggtgggc gagcgcttgc tgtcgagcta tgtgtctgtg
     1621 cacgcggaga gcggcaaggt gttcgcgctg cagcctctgg accatgagga gctggagctg
     1681 ctgcagttcc aggtgagcgc gcgggatgct ggtgtgcctg ccctgggcag caatgtgact
     1741 ctgcaggtgt ttgtgcagga tgagaatgac aatccgccca cgctgctcgg acatcagtca
     1801 ggtggacctg ctggcgaatt tagccagctt gtttcgcggt cagtgggtgc gggacacgtg
     1861 gtgtcaaagg tgcgcgcggt ggatgcggac tccggttaca acgcgtggct gtcttatgag
     1921 ctccacccaa ctgtgggcgc tcgcagccct ttccgtgtcg gtctctacac gggtgagatc
     1981 agcatgaccc gagccctgga tgaatctgat ttaccgcgcc agcgcctatt ggtgttggtg
     2041 aaggaccacg gcgaacctat gttgatcgcc actgccaccg ttttggtgtc cctggtggag
     2101 aacggccagg tgccaaaagc ttcttcccag gggttgccca actcctcccg cagggaggcg
     2161 tcgctgatgg atgtcaatgt atacctgatc attgccattt gcgcagtgtc cagcctgttg
     2221 gtgctcacgc tgctgctata cacagccctg cgctgctcag ctgtgcccat gcaggctggg
     2281 tgcgggcttg ggaagcccac tctggtgtgc tcaagcgctg tggggacctg gtcatactca
     2341 cagcagagac agcagcgagt atgctcagga gagggtccgc ccaaaaccga cctcatggct
     2401 tttagcccca gtcttacacc ttgcccagtg gccgaagtgg gaatggaaag tcattctgtt
     2461 ggaggagacg tgcccggaaa gccccggcag cccaaccctg actggcgcta ctctgcctcg
     2521 ctaagagcag gcatgcacag ctctgtgcac ctggaggagg ctggcattct acgggctggt
     2581 ccaggagggc ctgatcagca gtggccaaca gtatccagtg caacaccaga acctgaggca
     2641 ggagaggtgt cccctccggt gggcgccggt gtcaacagca acagctggac ctttaaatac
     2701 ggaccaggca accccaaaca gtccggtccc ggtgagttgc cagacaaatt cattatccca
     2761 ggatctcctg caatcatctc catccggcag gagcctgcta acaaccaaat tgacaaaagc
     2821 gattttataa ccttcggcaa aaaggaggag accaagaaaa agaagaaaaa gaagaagggt
     2881 aacaagaccc aggagaaaaa agagaaaggg aacagcacga cggacaacag tgaccagtga
     2941 ggccaccaaa tggaaacaag ccacttagcc agtttttgta ataatggcaa atctctccca
     3001 tgtagcaact ccccgctcct ttctcctatg acatgagccc tcagaaatct gcagaaagtt
     3061 ccctgtgtct gtcttgatcg catttaacag gttttgtctt aaaaagcttt cctaagtctg
     3121 gtgttaactc tctctctctc cactctggct tgttttcaga acctaaaaag cagacccagg
     3181 tttcctttct cccccgccgc aaaggagaag cttcccagcc ccgccagtga gagttggact
     3241 ctctgccctg tgcttcaagc atcctgtctt gatgatattt gcagggcagg ctgaaaggta
     3301 ttcaggttga gcagttgggt gtttgtggtc actgggtatg tgtggctacc aagagtgttg
     3361 gagagcctgg tattggctgg gatggtccag attagactag ttaacacaag gagggctggg
     3421 gctcaaaggc acatcaacac cgggagtctt tcatctggag ggggaaaatg tgaaacttac
     3481 aaggaccaga ctttctcaat ctctcaacta gacatatgat ggccatcctc taacagacaa
     3541 aaccatcccc accggcaaag ctttaggagc ccctcaagtg tgctggctat aacatcactg
     3601 tattcaaaac ctgcagtatg cacacgagcc agcagttcaa gcgtttaaca agagggtcgg
     3661 ccagggcaac agaagcagat ctgatgtgtt tcctgtacac gtccttgtgc tcacgctatt
     3721 aaaaattctt ttgcacacaa tgtttatgaa aaggtctcat ccttttccaa caacacatat
     3781 gcaaaagcaa aagaaaaacc caagacctca ctttatgctg tttgttgttt gatagattta
     3841 ttaaaaagaa aagagaaagt cgatagctat aaatctttaa aggaatatga tgaatacaat
     3901 ccccccaacc ttccctcaaa agagaatcca gtctacagcc atttgaaatg atcgttgctg
     3961 ctacagaagt gctttaagag aattgcctgg aacatctgta ttatcccggc cacctgccaa
     4021 tcacagcttt actctttcag gtcactctgg ggctgcctct tgcatgtatt aattactaaa
     4081 tagaaggatc tttctctctt ttctaagaaa aatgatgtgc actttgatta cacaaccttc
     4141 tctaacccac gatatcaaga cccagaaact gaagaaaaat cttgttttct catgcataca
     4201 gtgagcagac ttttcattcc tctggttctg tggttgtctc ggtgtgctag cctacacctc
     4261 caccttgttt agctttcctt ttctagaaca ctctgaattg ctaaccttac taacacctat
     4321 gatgttacct gaatcaatct cccatatgta tgctgtatgc tattataaga ctcctgagat
     4381 atacttactc tgtgcttgtg tatgtgaatg ttaatgcaac tattacctag agtgaacttt
     4441 aagctttatt gttgaatgta agcccattat atttcctttt gtacacctgt ggaaaagtgg
     4501 aatagtgttt tttttaaaac cattgttaat cagcttttgt gtatgaaaga cacagtaaaa
     4561 tttctttctt aaatcaagat gctggtgatt caaggaattt tatttatggt cagccaaggg
     4621 ctgtctcttg ccaagaatcc tgctggcaag ggaaaatgga taaagctggt tttttttttt
     4681 cctagtaaga attctggaat aaatactgaa gaaagtccct gagggtatgc aagcacaaaa
     4741 ttgtaccaat ctgacctctt tgaatttgca gactgctttg aaatgctatc cggaatatca
     4801 gcttgtagaa agtaataaaa tttactgtta ccataaataa gacattttaa gtttattgtg
     4861 cacaacttag atgtttgatt aattatatta tctacttaaa agcatataaa agaggtagga
     4921 gtctgtttta aaaggcataa aaaatctcaa aaaaaaaaaa cctgtcttgt ctacttttag
     4981 cttcattctc ccatattttg aagggtgtgt aacttcagct ctgcaggatt gcatggggta
     5041 aaactcgttg acagcgcatg tgaaccattg ctacattgta ggttgtgatc attttgcccc
     5101 actgaagccc atgtaactga ccttacgtgc cttttgaact aggagaatcg ggctataatt
     5161 tattaatgat gataatgata atgtatatgt acagcacttt ttaaccttac aaagtgcttt
     5221 ccaattcgtg ttagttatta gttattacag ctgtaaggat aaaacacgtc atgtggattc
     5281 atttttaatt ggtgctattg gtatttcctc tgttcttgct aataaatgga aatggtggtg
     5341 t
//
