LOCUS       NM_201243               5242 bp    mRNA    linear   ROD 20-JUN-2024
DEFINITION  Mus musculus protocadherin alpha 8 (Pcdha8), mRNA.
ACCESSION   NM_201243 XM_991239
VERSION     NM_201243.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5242)
  AUTHORS   Teekakirikul,P., Zhu,W., Gabriel,G.C., Young,C.B., Williams,K.,
            Martin,L.J., Hill,J.C., Richards,T., Billaud,M., Phillippi,J.A.,
            Wang,J., Wu,Y., Tan,T., Devine,W., Lin,J.H., Bais,A.S.,
            Klonowski,J., Moreau de Bellaing,A., Saini,A., Wang,M.X.,
            Emerel,L., Salamacha,N., Wyman,S.K., Lee,C., Sing Li,H., Miron,A.,
            Zhang,J., Xing,J., McNamara,D.M., Fung,E., Kirshbom,P., Mahle,W.,
            Kochilas,L.K., He,Y., Garg,V., White,P., McBride,K.L., Benson,D.W.,
            Gleason,T.G., Mital,S. and Lo,C.W.
  TITLE     Common deletion variants causing protocadherin-alpha deficiency
            contribute to the complex genetics of BAV and left-sided congenital
            heart disease
  JOURNAL   HGG Adv 2 (3) (2021)
   PUBMED   34888534
REFERENCE   2  (bases 1 to 5242)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5242)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 5242)
  AUTHORS   Fan,L., Lu,Y., Shen,X., Shao,H., Suo,L. and Wu,Q.
  TITLE     Alpha protocadherins and Pyk2 kinase regulate cortical neuron
            migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
            complex in mice
  JOURNAL   Elife 7, e35242 (2018)
   PUBMED   29911975
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5242)
  AUTHORS   Toyoda,S., Kawaguchi,M., Kobayashi,T., Tarusawa,E., Toyama,T.,
            Okano,M., Oda,M., Nakauchi,H., Yoshimura,Y., Sanbo,M.,
            Hirabayashi,M., Hirayama,T., Hirabayashi,T. and Yagi,T.
  TITLE     Developmental epigenetic modification regulates stochastic
            expression of clustered protocadherin genes, generating single
            neuron diversity
  JOURNAL   Neuron 82 (1), 94-108 (2014)
   PUBMED   24698270
REFERENCE   6  (bases 1 to 5242)
  AUTHORS   Morishita,H., Murata,Y., Esumi,S., Hamada,S. and Yagi,T.
  TITLE     CNR/Pcdhalpha family in subplate neurons, and developing cortical
            connectivity
  JOURNAL   Neuroreport 15 (17), 2595-2599 (2004)
   PUBMED   15570159
REFERENCE   7  (bases 1 to 5242)
  AUTHORS   Murata,Y., Hamada,S., Morishita,H., Mutoh,T. and Yagi,T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   8  (bases 1 to 5242)
  AUTHORS   Wu,Q., Zhang,T., Cheng,J.F., Kim,Y., Grimwood,J., Schmutz,J.,
            Dickson,M., Noonan,J.P., Zhang,M.Q., Myers,R.M. and Maniatis,T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 5242)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 5242)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY013766.1.
            
            On May 4, 2006 this sequence version replaced XM_991239.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013766.1, BC139424.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5242
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..5242
                     /gene="Pcdha8"
                     /note="protocadherin alpha 8"
                     /db_xref="GeneID:353235"
                     /db_xref="MGI:MGI:2681879"
     CDS             1..2841
                     /gene="Pcdha8"
                     /codon_start=1
                     /product="protocadherin alpha-8 precursor"
                     /protein_id="NP_957695.1"
                     /db_xref="CCDS:CCDS79620.1"
                     /db_xref="GeneID:353235"
                     /db_xref="MGI:MGI:2681879"
                     /translation="MLCLGGAVPDDQLLVLSLLLIAVWEVGSGQLHYSIPEEAKHGTF
                     VGRIAQDLELQLPELVPGLFQLDSKGFGDLLEVNLQNGILFVNSRIDREELCGRSAEC
                     SIHLEVIVDRPLQVFHVEVEVRDINDNPPMFPATQKALFIPESRLLDSRFPLEGASDA
                     DVGSNALLTYRLSTNEHFSLDVPPNHEQVKPLGLVLRKPLDREEAAEIRLLLTATDGG
                     KPELTGTVQLLITVLDVNDNAPVFDRSLYTVKLPENVPNGSLVIKVNASDLDEGVNGD
                     VMYSFSSDVSSDIKSKFHMDTVSGEITVIGIIDFEESKAYKIPLEARDKGLPPLIGHC
                     TVLVEVVDANDNAPQLNVKTLWLPVKEDAQLGKIIALISVIDLDSGINGQVTCSLTNH
                     VPFKLVSTFKNYYSLVLDSALDRETISNYDVIVTARDGGSPSLLATASVSVEVADVND
                     NAPAFAQPEYTVFVKENNPPGAHIFTVSAVDADAQENALVSYSLVERRVGERLLSSYV
                     SVHAESGKVFALQPLDHEELELLQFQVSARDAGVPALGSNVTLQVFVLDENDNVPMLL
                     GSGTGGSDGVFNQLLSRSVDPGHVVAKVRAVDADSGYNAWLSYELLSWPGSMRSPFRV
                     GLYTGEISTTRSLDETDGTRQRLLVLVKDHGEPPLTATVTVLVSLVESGQAPKTSSRS
                     SVGVTVPEPSLVDVNVYLIIAICAVSSLLVLTLLLYTALRCSATPTGGACGSGKPMLV
                     CSSAAGTWSYSQQRRQRVCSGEGPPKTDLMAFSPGLPPCPGSAEPSVSLDSSEKPRQP
                     NPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGA
                     GVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFGK
                     KEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"
     exon            1..2382
                     /gene="Pcdha8"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2441
                     /gene="Pcdha8"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2530
                     /gene="Pcdha8"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..5242
                     /gene="Pcdha8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctgtgtt taggcggtgc agtcccagac gaccagcttc tagtgctttc gcttctgctc
       61 atagcagttt gggaggtggg gagcggccag ctccactact ctatccccga ggaggccaaa
      121 cacggcacct tcgtgggccg catcgcgcag gatcttgaac tgcagctgcc ggagctggtt
      181 cctggtcttt ttcagttgga ttcaaagggt tttggggacc ttctggaggt aaatctgcag
      241 aatggcattt tgtttgtgaa ttctcggatc gaccgggagg aactgtgcgg gcggagcgcg
      301 gagtgtagca tccacttgga ggtgatcgtg gacaggccgc tgcaggtttt ccacgtggag
      361 gtagaggtga gggacattaa tgacaaccct cccatgtttc cagcgacaca aaaggctctg
      421 tttattccgg agtccagact gcttgactcg cggtttccac tagagggcgc gtcagatgca
      481 gatgtcggtt ccaatgctct gctgacttac agactgagca ccaatgaaca tttctctctg
      541 gatgtaccgc ccaaccacga gcaggtgaaa ccccttgggc tcgttttgcg gaaaccttta
      601 gacagagaag aagctgcaga gattcgctta ttgctcacgg ccaccgacgg aggcaaaccg
      661 gagctgacag gcaccgttca attactcatc accgtgctgg atgtcaatga caatgcacca
      721 gtttttgaca gatctctgta tactgtgaaa ttgccagaaa acgttccaaa tggatcattg
      781 gtaatcaaag tcaatgcctc agatttggac gagggcgtga atggggacgt tatgtactca
      841 ttttctagtg atgtttcttc agatataaaa tccaagttcc acatggacac tgtgagtgga
      901 gagattacag ttataggaat tattgatttc gaagagagta aagcttacaa gattccatta
      961 gaggcacgtg ataagggcct cccaccactg attggtcatt gcacggttct tgtggaagtt
     1021 gtagatgcta acgataatgc tccacagctc aatgtcaaaa cactctggct ccctgttaaa
     1081 gaagatgcac aactggggaa aattattgcc ctgatcagtg tgattgatct agactcaggt
     1141 atcaacgggc aggtgacctg ctccttgact aatcatgtcc ccttcaagtt ggtgtccacc
     1201 ttcaagaatt actattctct cgtgctggac agcgccctgg accgagagac catctctaac
     1261 tatgacgtga ttgtgactgc ccgggacggg ggctctccct cgctgctggc tacagccagc
     1321 gtgtccgtgg aggtggctga cgtgaacgac aatgctcctg cattcgcgca gcccgaatac
     1381 acggtgtttg tgaaggagaa caacccgcct ggtgcgcaca tcttcacagt atcagcggtg
     1441 gatgctgatg cgcaggagaa cgcgctggtg tcctactcac tggtggagcg gagggtgggc
     1501 gagcgcttgc tgtcgagcta tgtgtctgtg cacgcggaga gcggcaaggt gttcgcgctg
     1561 cagcctctgg atcatgagga gctggagctg ctgcagttcc aggtgagcgc acgggatgct
     1621 ggtgtgcctg ccctgggcag caatgtgact ctgcaggtgt ttgtgctgga tgagaacgac
     1681 aatgtgccga tgttgcttgg atctgggacg ggtgggtcag atggagtgtt caatcagctg
     1741 ttgtctaggt ccgtggatcc tggtcacgtg gtggcgaagg tgcgcgccgt agatgcagac
     1801 tctggttaca atgcttggct gtcttatgag ctgctctcat ggccaggcag catgcgcagc
     1861 ccatttcgtg taggattata caccggtgag atcagcacca caaggtcttt ggatgaaaca
     1921 gatgggacta gacaacgttt gctggtgctg gtaaaggacc acggtgagcc tccgctgact
     1981 gctacagtca ccgtgctggt gtctctagtg gaaagtggcc aggctccaaa gacctcgtcc
     2041 cgatcctctg tgggtgttac tgtgccagag ccatctttag tggatgtcaa cgtgtacctg
     2101 atcatcgcca tctgtgcagt gtccagcctg ttggtgctca cgctgctgct gtacacagcg
     2161 ctgcgctgct cggcgacacc cactgggggc gcttgtgggt ctgggaagcc catgctggtg
     2221 tgctccagcg ctgcggggac ttggtcttac tcacagcaga gaaggcagag ggtgtgctct
     2281 ggagagggcc caccgaagac cgacctcatg gccttcagcc ccggtctacc tccatgtcct
     2341 ggatctgcag aaccatctgt ttctttggac tcctccgaga agccccggca gcccaaccct
     2401 gactggcgct actctgcctc gctaagagca ggcatgcaca gctctgtgca cctggaggag
     2461 gctggcattc tacgggctgg tccaggaggg cctgatcagc agtggccaac agtatccagt
     2521 gcaacaccag aacctgaggc aggagaggtg tcccctccgg tgggcgccgg tgtcaacagc
     2581 aacagctgga cctttaaata cggaccaggc aaccccaaac agtccggtcc cggtgagttg
     2641 ccagacaaat tcattatccc aggatctcct gcaatcatct ccatccggca ggagcctgct
     2701 aacaaccaaa ttgacaaaag cgattttata accttcggca aaaaggagga gaccaagaaa
     2761 aagaagaaaa agaagaaggg taacaagacc caggagaaaa aagagaaagg gaacagcacg
     2821 acggacaaca gtgaccagtg aggccaccaa atggaaacaa gccacttagc cagtttttgt
     2881 aataatggca aatctctccc atgtagcaac tccccgctcc tttctcctat gacatgagcc
     2941 ctcagaaatc tgcagaaagt tccctgtgtc tgtcttgatc gcatttaaca ggttttgtct
     3001 taaaaagctt tcctaagtct ggtgttaact ctctctctct ccactctggc ttgttttcag
     3061 aacctaaaaa gcagacccag gtttcctttc tcccccgccg caaaggagaa gcttcccagc
     3121 cccgccagtg agagttggac tctctgccct gtgcttcaag catcctgtct tgatgatatt
     3181 tgcagggcag gctgaaaggt attcaggttg agcagttggg tgtttgtggt cactgggtat
     3241 gtgtggctac caagagtgtt ggagagcctg gtattggctg ggatggtcca gattagacta
     3301 gttaacacaa ggagggctgg ggctcaaagg cacatcaaca ccgggagtct ttcatctgga
     3361 gggggaaaat gtgaaactta caaggaccag actttctcaa tctctcaact agacatatga
     3421 tggccatcct ctaacagaca aaaccatccc caccggcaaa gctttaggag cccctcaagt
     3481 gtgctggcta taacatcact gtattcaaaa cctgcagtat gcacacgagc cagcagttca
     3541 agcgtttaac aagagggtcg gccagggcaa cagaagcaga tctgatgtgt ttcctgtaca
     3601 cgtccttgtg ctcacgctat taaaaattct tttgcacaca atgtttatga aaaggtctca
     3661 tccttttcca acaacacata tgcaaaagca aaagaaaaac ccaagacctc actttatgct
     3721 gtttgttgtt tgatagattt attaaaaaga aaagagaaag tcgatagcta taaatcttta
     3781 aaggaatatg atgaatacaa tccccccaac cttccctcaa aagagaatcc agtctacagc
     3841 catttgaaat gatcgttgct gctacagaag tgctttaaga gaattgcctg gaacatctgt
     3901 attatcccgg ccacctgcca atcacagctt tactctttca ggtcactctg gggctgcctc
     3961 ttgcatgtat taattactaa atagaaggat ctttctctct tttctaagaa aaatgatgtg
     4021 cactttgatt acacaacctt ctctaaccca cgatatcaag acccagaaac tgaagaaaaa
     4081 tcttgttttc tcatgcatac agtgagcaga cttttcattc ctctggttct gtggttgtct
     4141 cggtgtgcta gcctacacct ccaccttgtt tagctttcct tttctagaac actctgaatt
     4201 gctaacctta ctaacaccta tgatgttacc tgaatcaatc tcccatatgt atgctgtatg
     4261 ctattataag actcctgaga tatacttact ctgtgcttgt gtatgtgaat gttaatgcaa
     4321 ctattaccta gagtgaactt taagctttat tgttgaatgt aagcccatta tatttccttt
     4381 tgtacacctg tggaaaagtg gaatagtgtt ttttttaaaa ccattgttaa tcagcttttg
     4441 tgtatgaaag acacagtaaa atttctttct taaatcaaga tgctggtgat tcaaggaatt
     4501 ttatttatgg tcagccaagg gctgtctctt gccaagaatc ctgctggcaa gggaaaatgg
     4561 ataaagctgg tttttttttt tcctagtaag aattctggaa taaatactga agaaagtccc
     4621 tgagggtatg caagcacaaa attgtaccaa tctgacctct ttgaatttgc agactgcttt
     4681 gaaatgctat ccggaatatc agcttgtaga aagtaataaa atttactgtt accataaata
     4741 agacatttta agtttattgt gcacaactta gatgtttgat taattatatt atctacttaa
     4801 aagcatataa aagaggtagg agtctgtttt aaaaggcata aaaaatctca aaaaaaaaaa
     4861 acctgtcttg tctactttta gcttcattct cccatatttt gaagggtgtg taacttcagc
     4921 tctgcaggat tgcatggggt aaaactcgtt gacagcgcat gtgaaccatt gctacattgt
     4981 aggttgtgat cattttgccc cactgaagcc catgtaactg accttacgtg ccttttgaac
     5041 taggagaatc gggctataat ttattaatga tgataatgat aatgtatatg tacagcactt
     5101 tttaacctta caaagtgctt tccaattcgt gttagttatt agttattaca gctgtaagga
     5161 taaaacacgt catgtggatt catttttaat tggtgctatt ggtatttcct ctgttcttgc
     5221 taataaatgg aaatggtggt gt
//
