LOCUS       NM_007766               5322 bp    mRNA    linear   ROD 04-FEB-2024
DEFINITION  Mus musculus protocadherin alpha 4 (Pcdha4), mRNA.
ACCESSION   NM_007766 XM_991107
VERSION     NM_007766.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5322)
  AUTHORS   Xu,L., Zheng,Y., Li,X., Wang,A., Huo,D., Li,Q., Wang,S., Luo,Z.,
            Liu,Y., Xu,F., Wu,X., Wu,M. and Zhou,Y.
  TITLE     Abnormal neocortex arealization and Sotos-like syndrome-associated
            behavior in Setd2 mutant mice
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523829
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5322)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5322)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   4  (bases 1 to 5322)
  AUTHORS   Fan,L., Lu,Y., Shen,X., Shao,H., Suo,L. and Wu,Q.
  TITLE     Alpha protocadherins and Pyk2 kinase regulate cortical neuron
            migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
            complex in mice
  JOURNAL   Elife 7, e35242 (2018)
   PUBMED   29911975
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5322)
  AUTHORS   Goodman,K.M., Rubinstein,R., Thu,C.A., Bahna,F., Mannepalli,S.,
            Ahlsen,G., Rittenhouse,C., Maniatis,T., Honig,B. and Shapiro,L.
  TITLE     Structural Basis of Diverse Homophilic Recognition by Clustered
            alpha- and beta-Protocadherins
  JOURNAL   Neuron 90 (4), 709-723 (2016)
   PUBMED   27161523
REFERENCE   6  (bases 1 to 5322)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 5322)
  AUTHORS   Sugino,H., Hamada,S., Yasuda,R., Tuji,A., Matsuda,Y., Fujita,M. and
            Yagi,T.
  TITLE     Genomic organization of the family of CNR cadherin genes in mice
            and humans
  JOURNAL   Genomics 63 (1), 75-87 (2000)
   PUBMED   10662547
REFERENCE   8  (bases 1 to 5322)
  AUTHORS   Senzaki,K., Ogawa,M. and Yagi,T.
  TITLE     Proteins of the CNR family are multiple receptors for Reelin
  JOURNAL   Cell 99 (6), 635-647 (1999)
   PUBMED   10612399
REFERENCE   9  (bases 1 to 5322)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   10 (bases 1 to 5322)
  AUTHORS   Kohmura,N., Senzaki,K., Hamada,S., Kai,N., Yasuda,R., Watanabe,M.,
            Ishii,H., Yasuda,M., Mishina,M. and Yagi,T.
  TITLE     Diversity revealed by a novel family of cadherins expressed in
            neurons at a synaptic complex
  JOURNAL   Neuron 20 (6), 1137-1151 (1998)
   PUBMED   9655502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020968.3, AC020972.3 and AC020973.3.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_007766.3.
            
            On Mar 21, 2007 this sequence version replaced NM_007766.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86916.1, SRR1660813.235044.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2462              AC020968.3         164214-166675
            2463-2521           AC020972.3         11539-11597         c
            2522-2610           AC020972.3         8399-8487           c
            2611-5322           AC020973.3         123819-126530
FEATURES             Location/Qualifiers
     source          1..5322
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..5322
                     /gene="Pcdha4"
                     /gene_synonym="Cnr1; Crnr1"
                     /note="protocadherin alpha 4"
                     /db_xref="GeneID:12936"
                     /db_xref="MGI:MGI:1298406"
     exon            1..2462
                     /gene="Pcdha4"
                     /gene_synonym="Cnr1; Crnr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2921
                     /gene="Pcdha4"
                     /gene_synonym="Cnr1; Crnr1"
                     /note="cadherin-related neuronal receptor 1; PCDH-alpha-4"
                     /codon_start=1
                     /product="protocadherin alpha-4 precursor"
                     /protein_id="NP_031792.1"
                     /db_xref="CCDS:CCDS37776.1"
                     /db_xref="GeneID:12936"
                     /db_xref="MGI:MGI:1298406"
                     /translation="MEFSWGSGQESQRLLLSFLLLAIWEAGNSQIHYSIPEEAKHGTF
                     VGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSAEC
                     SIHLEVIVDRPLQVFHVEVEVRDINDNPPRFPTTQKNLFIAESRPLDTWFPLEGASDA
                     DIGINAVLTYRLSPNDYFSLEKPSNDERVKGLGLVLRKSLDREETPEIILVLTVTDGG
                     KPELTGSVQLLITVLDANDNAPVFDRSLYTVKLPENVPNGTLVVKVNASDLDEGVNGD
                     IMYSFSTDISPNVKYKFHIDPVSGEIIVKGYIDFEECKSYEILIEGIDKGQLPLSGHC
                     KVIVQVEDINDNVPELEFKSLSLPIRENSPVGTVIALISVSDRDTGVNGQVTCSLTSH
                     VPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDGGSPSLWATASVSVEVADVND
                     NAPVFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYV
                     SVHAESGKVFALQPLDHEELELLRFQVSARDAGVPALGSNVTLQVFVLDENDNAPTLL
                     EPEAGVSGGIVSRLVSRSVGAGHVVAKVRAVDADSGYNAWLSYELQSSEGNSRSLFRV
                     GLYTGEISTTRILDEADSPRQRLLVLVKDHGDPAMIVTATVLVSLVENGPVPKAPSRV
                     STSVTHSEASLVDVNVYLIIAICAVSSLLVLTLLLYTALRCSTVPSESVCGPPKPVMV
                     CSSAVGSWSYSQQRRQRVCSGEYPPKTDLMAFSPSLSDSRDREDQLQSAEDSSGKPRQ
                     PNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVG
                     AGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFITFG
                     KKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"
     exon            2463..2521
                     /gene="Pcdha4"
                     /gene_synonym="Cnr1; Crnr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2610
                     /gene="Pcdha4"
                     /gene_synonym="Cnr1; Crnr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..5322
                     /gene="Pcdha4"
                     /gene_synonym="Cnr1; Crnr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgatggacta acggattaga agaattctcc tagctctgag agaatcccta atcagaacaa
       61 agcactgtgc acttgaaatg gaattttcct ggggaagtgg ccaggaatcc cagcgcttgc
      121 ttctttcttt tctgcttctt gcaatctggg aggcagggaa cagccagatc cactactcca
      181 tccctgagga ggccaaacac ggcaccttcg tgggccgcat cgcgcaggac ctggggctgg
      241 agctgacgga gctggtgccc cgcctgttca gagtggcgtc caaggaccgc ggagaccttc
      301 tggaggtaaa tctgcagaat ggcattttgt ttgtgaattc tcggatcgac cgggaggagc
      361 tgtgcgggcg gagcgcggag tgcagcatcc acctggaggt gatcgtggac aggccgttgc
      421 aggttttcca cgtggaggtg gaggtgaggg acattaacga caaccctccc aggttcccaa
      481 caacacaaaa gaatctgttc attgcagaat caaggccact tgacacttgg tttccactag
      541 agggcgcttc agacgcagat atcggaatca atgctgtact gacttacaga ctgagtccaa
      601 atgattactt ttctttggaa aaaccatcca acgacgaacg ggtaaaaggt cttggacttg
      661 tattacggaa atctttagac cgggaggaaa ctccagagat aattttagtg cttactgtca
      721 cggacggagg aaagccagag ctgaccggca gtgttcagtt actcatcact gtgctggatg
      781 ccaatgataa tgctccagtt tttgacagat ctctgtatac cgtgaaatta ccagaaaacg
      841 ttccaaatgg gacattggta gtcaaagtca atgcctcaga tttagacgaa ggggtaaatg
      901 gggatattat gtactcattt tctacagata tttcaccaaa tgtgaaatac aaattccaca
      961 tagaccctgt tagcggagag attattgtaa agggatacat tgattttgaa gaatgcaaat
     1021 cctatgaaat tctcatagag ggaattgaca agggacaact tccactctct gggcactgta
     1081 aagtcattgt acaagttgaa gacatcaacg ataatgttcc agaattggaa ttcaaatctc
     1141 tatcacttcc aatacgagag aattctccag tgggcactgt catcgcactc attagtgtgt
     1201 ctgatcggga cacgggtgtc aacgggcagg tgacctgctc cctgacaagt catgtcccct
     1261 tcaagttggt gtccacattc aagaattact attcgctcgt gctggacagc gccctggaca
     1321 gagagacaac agcggactat aaggtggtgg tgacagcgcg ggatgggggc tctccctcgc
     1381 tgtgggccac ggctagcgtg tctgttgagg ttgctgacgt gaacgacaat gcacctgtgt
     1441 tcgcgcagcc cgaatacacg gtgttcgtga aggagaacaa cccgcctggt gcgcacatct
     1501 tcacggtgtc agcgatggat gcggacgcac aggagaacgc gctggtgtcc tactcgctgg
     1561 tggagcggag ggtgggcgag cgcttgctgt cgagctatgt gtctgtgcac gcggagagcg
     1621 gcaaggtgtt cgcgctgcag cctctggacc atgaggagct ggagctgctg cggttccagg
     1681 tgagcgcgcg ggatgctggt gtacctgccc tgggcagcaa tgtgactctg caggtgtttg
     1741 tgctggacga gaatgacaac gcgcccacac tgctggaacc tgaggcagga gtctctggtg
     1801 gaatcgtgag ccggttggtg tccagatcag tgggtgcagg ccatgtggtg gctaaggtgc
     1861 gcgcggtgga tgcagactct ggctataatg catggctctc ttatgagctg caatcgtcag
     1921 aaggcaattc ccgtagcctt ttccgcgtag gtttgtatac gggcgagatt agtactacgc
     1981 gcatactgga tgaagcagat tcgccacgtc agcgccttct ggtgctggtg aaggaccatg
     2041 gtgacccagc aatgattgtt accgccacag tgttggtgtc tctggtagag aatggcccgg
     2101 taccaaaggc tccatcgcga gtatccacga gtgtcacaca ctctgaggcg tcactggtgg
     2161 atgtcaacgt gtacctgatc attgccatct gtgcagtgtc cagcctgcta gtgctcacgc
     2221 tgctgctgta cacagcgctg cgctgttcca ctgtccccag tgagagcgtg tgcgggcctc
     2281 caaaaccggt aatggtgtgc tccagtgcag tggggagctg gtcatactcc caacaaagga
     2341 ggcaaagggt gtgctctggg gagtacccac ctaagaccga cctcatggcc ttcagcccca
     2401 gtttatctga ttcaagggac agagaggatc aattgcagtc tgcagaggat tcctctggaa
     2461 agccccggca gcccaaccct gactggcgct actctgcctc gctaagagca ggcatgcaca
     2521 gctctgtgca cctggaggag gctggcattc tacgggctgg tccaggaggg cctgatcagc
     2581 agtggccaac agtatccagt gcaacaccag aacctgaggc aggagaggtg tcccctccgg
     2641 tgggcgccgg tgtcaacagc aacagctgga cctttaaata cggaccaggc aaccccaaac
     2701 agtccggtcc cggtgagttg ccagacaaat tcattatccc aggatctcct gcaatcatct
     2761 ccatccggca ggagcctgct aacaaccaaa ttgacaaaag cgattttata accttcggca
     2821 aaaaggagga gaccaagaaa aagaagaaaa agaagaaggg taacaagacc caggagaaaa
     2881 aagagaaagg gaacagcacg acggacaaca gtgaccagtg aggccaccaa atggaaacaa
     2941 gccacttagc cagtttttgt aataatggca aatctctccc atgtagcaac tccccgctcc
     3001 tttctcctat gacatgagcc ctcagaaatc tgcagaaagt tccctgtgtc tgtcttgatc
     3061 gcatttaaca ggttttgtct taaaaagctt tcctaagtct ggtgttaact ctctctctct
     3121 ccactctggc ttgttttcag aacctaaaaa gcagacccag gtttcctttc tcccccgccg
     3181 caaaggagaa gcttcccagc cccgccagtg agagttggac tctctgccct gtgcttcaag
     3241 catcctgtct tgatgatatt tgcagggcag gctgaaaggt attcaggttg agcagttggg
     3301 tgtttgtggt cactgggtat gtgtggctac caagagtgtt ggagagcctg gtattggctg
     3361 ggatggtcca gattagacta gttaacacaa ggagggctgg ggctcaaagg cacatcaaca
     3421 ccgggagtct ttcatctgga gggggaaaat gtgaaactta caaggaccag actttctcaa
     3481 tctctcaact agacatatga tggccatcct ctaacagaca aaaccatccc caccggcaaa
     3541 gctttaggag cccctcaagt gtgctggcta taacatcact gtattcaaaa cctgcagtat
     3601 gcacacgagc cagcagttca agcgtttaac aagagggtcg gccagggcaa cagaagcaga
     3661 tctgatgtgt ttcctgtaca cgtccttgtg ctcacgctat taaaaattct tttgcacaca
     3721 atgtttatga aaaggtctca tccttttcca acaacacata tgcaaaagca aaagaaaaac
     3781 ccaagacctc actttatgct gtttgttgtt tgatagattt attaaaaaga aaagagaaag
     3841 tcgatagcta taaatcttta aaggaatatg atgaatacaa tccccccaac cttccctcaa
     3901 aagagaatcc agtctacagc catttgaaat gatcgttgct gctacagaag tgctttaaga
     3961 gaattgcctg gaacatctgt attatcccgg ccacctgcca atcacagctt tactctttca
     4021 ggtcactctg gggctgcctc ttgcatgtat taattactaa atagaaggat ctttctctct
     4081 tttctaagaa aaatgatgtg cactttgatt acacaacctt ctctaaccca cgatatcaag
     4141 acccagaaac tgaagaaaaa tcttgttttc tcatgcatac agtgagcaga cttttcattc
     4201 ctctggttct gtggttgtct cggtgtgcta gcctacacct ccaccttgtt tagctttcct
     4261 tttctagaac actctgaatt gctaacctta ctaacaccta tgatgttacc tgaatcaatc
     4321 tcccatatgt atgctgtatg ctattataag actcctgaga tatacttact ctgtgcttgt
     4381 gtatgtgaat gttaatgcaa ctattaccta gagtgaactt taagctttat tgttgaatgt
     4441 aagcccatta tatttccttt tgtacacctg tggaaaagtg gaatagtgtt ttttttaaaa
     4501 ccattgttaa tcagcttttg tgtatgaaag acacagtaaa atttctttct taaatcaaga
     4561 tgctggtgat tcaaggaatt ttatttatgg tcagccaagg gctgtctctt gccaagaatc
     4621 ctgctggcaa gggaaaatgg ataaagctgg tttttttttt tcctagtaag aattctggaa
     4681 taaatactga agaaagtccc tgagggtatg caagcacaaa attgtaccaa tctgacctct
     4741 ttgaatttgc agactgcttt gaaatgctat ccggaatatc agcttgtaga aagtaataaa
     4801 atttactgtt accataaata agacatttta agtttattgt gcacaactta gatgtttgat
     4861 taattatatt atctacttaa aagcatataa aagaggtagg agtctgtttt aaaaggcata
     4921 aaaaatctca aaaaaaaaaa acctgtcttg tctactttta gcttcattct cccatatttt
     4981 gaagggtgtg taacttcagc tctgcaggat tgcatggggt aaaactcgtt gacagcgcat
     5041 gtgaaccatt gctacattgt aggttgtgat cattttgccc cactgaagcc catgtaactg
     5101 accttacgtg ccttttgaac taggagaatc gggctataat ttattaatga tgataatgat
     5161 aatgtatatg tacagcactt tttaacctta caaagtgctt tccaattcgt gttagttatt
     5221 agttattaca gctgtaagga taaaacacgt catgtggatt catttttaat tggtgctatt
     5281 ggtatttcct ctgttcttgc taataaatgg aaatggtggt gt
//
