LOCUS       NM_138662               5355 bp    mRNA    linear   ROD 07-AUG-2023
DEFINITION  Mus musculus protocadherin alpha 3 (Pcdha3), mRNA.
ACCESSION   NM_138662
VERSION     NM_138662.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5355)
  AUTHORS   Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V,
            Maniatis T, Hasenstaub AR, Stryker MP and Alvarez-Buylla A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5355)
  AUTHORS   Elbert A, Vogt D, Watson A, Levy M, Jiang Y, Brule E, Rowland ME,
            Rubenstein J and Berube NG.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   3  (bases 1 to 5355)
  AUTHORS   Fan L, Lu Y, Shen X, Shao H, Suo L and Wu Q.
  TITLE     Alpha protocadherins and Pyk2 kinase regulate cortical neuron
            migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
            complex in mice
  JOURNAL   Elife 7, e35242 (2018)
   PUBMED   29911975
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5355)
  AUTHORS   Toyoda S, Kawaguchi M, Kobayashi T, Tarusawa E, Toyama T, Okano M,
            Oda M, Nakauchi H, Yoshimura Y, Sanbo M, Hirabayashi M, Hirayama T,
            Hirabayashi T and Yagi T.
  TITLE     Developmental epigenetic modification regulates stochastic
            expression of clustered protocadherin genes, generating single
            neuron diversity
  JOURNAL   Neuron 82 (1), 94-108 (2014)
   PUBMED   24698270
REFERENCE   5  (bases 1 to 5355)
  AUTHORS   Esumi S, Kakazu N, Taguchi Y, Hirayama T, Sasaki A, Hirabayashi T,
            Koide T, Kitsukawa T, Hamada S and Yagi T.
  TITLE     Monoallelic yet combinatorial expression of variable exons of the
            protocadherin-alpha gene cluster in single neurons
  JOURNAL   Nat Genet 37 (2), 171-176 (2005)
   PUBMED   15640798
REFERENCE   6  (bases 1 to 5355)
  AUTHORS   Murata Y, Hamada S, Morishita H, Mutoh T and Yagi T.
  TITLE     Interaction with protocadherin-gamma regulates the cell surface
            expression of protocadherin-alpha
  JOURNAL   J Biol Chem 279 (47), 49508-49516 (2004)
   PUBMED   15347688
REFERENCE   7  (bases 1 to 5355)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 5355)
  AUTHORS   Wu Q, Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M,
            Noonan JP, Zhang MQ, Myers RM and Maniatis T.
  TITLE     Comparative DNA sequence analysis of mouse and human protocadherin
            gene clusters
  JOURNAL   Genome Res 11 (3), 389-404 (2001)
   PUBMED   11230163
REFERENCE   9  (bases 1 to 5355)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   10 (bases 1 to 5355)
  AUTHORS   Wu Q and Maniatis T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020968.3, AC020972.3 and AC020973.3.
            
            On Feb 22, 2019 this sequence version replaced NM_138662.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013761.1, BC141348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2489              AC020968.3         157613-160101
            2490-2548           AC020972.3         11539-11597         c
            2549-2637           AC020972.3         8399-8487           c
            2638-5355           AC020973.3         123819-126536
FEATURES             Location/Qualifiers
     source          1..5355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..5355
                     /gene="Pcdha3"
                     /gene_synonym="mKIAA0345"
                     /note="protocadherin alpha 3"
                     /db_xref="GeneID:192163"
                     /db_xref="MGI:MGI:2447313"
     exon            1..2489
                     /gene="Pcdha3"
                     /gene_synonym="mKIAA0345"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2548
                     /gene="Pcdha3"
                     /gene_synonym="mKIAA0345"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2637
                     /gene="Pcdha3"
                     /gene_synonym="mKIAA0345"
                     /inference="alignment:Splign:2.1.0"
     exon            2638..5355
                     /gene="Pcdha3"
                     /gene_synonym="mKIAA0345"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgtctcag ataaaatggt aacggtaagg tgtttaagat gtgaagaata agaaactaaa
       61 aatatttaag aaattttgga tcggcgagag agcaaccaaa cattcggaag ggacttgcga
      121 tggtgttttc tcagagagaa gatcggcatc tgctgctctg gcttcttctc tttgcagcct
      181 gggaggcagg gagcggccag cttcattact ccgtcccaga ggaggccaaa cacggcacct
      241 ttgtgggacg catcgcgcag gacctggggc tggagctggc tgaactggtg cctcgcctgt
      301 tcagggtggc gtccaaggac cgcggggacc ttctggaggt aaatctgcag aatggcattt
      361 tgtttgtgaa ttctcggatc gaccgggagg agctgtgcgg gcggagcgcg gagtgtagca
      421 tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccacgtggag gtggaggtga
      481 gggacattaa cgacaaccct ccagtatttc cagtagccac aaagaatctt tttatctatg
      541 aatctcggcc gctgggctcc cggttttcgc tagagggcgc atcagatgca gatataggaa
      601 ccaattcgtt gttgtcttac agtcttaact caagtgaata cttttctttg gatgtcaaaa
      661 gaaaagatga ggaaattaag tccctgggac tcgtgttgaa aaaactttta aacagagagg
      721 acattcctga acataattta ttgataactg cagttgatgg tgggaaacct gagctcactg
      781 gcaccactca agtgaagatc actgttctag atgtgaacga caacgcccca gcatttgaga
      841 agacattcta caaagtcaga ttacccgaaa atgctccaaa tggtactgta gtagtggatg
      901 ttgatgcctc tgatttggat gaaggagtaa ataaggacat tgtatattct tttcaccagg
      961 atatgtcact tgaaatcctg tcaaaattcc acttagaccc aatcagtgga tacatcactg
     1021 taaaaggtaa catagatttt gaggaaacca aatcttttga aatccagata gaagcagcag
     1081 acaagggaac ccctccaatg acagatcatt gcacggttct agttgaaatt gtggacgtca
     1141 atgataacgt gcctgaattg gtcatcaagt cattatcact tcctgtgtta gaaaattctg
     1201 cacccagcac tgtcatcgcc ctgatcagtg tgtctgaccg tgactctgga gccaatggac
     1261 aagtgacctg ctctttgacc cctcaggttc ccttcaagct ggtgtccacc tttaagaatt
     1321 actattctct tgtgctggac agtgtcctgg accgagagac catctctaac tacaacgttg
     1381 ttgtgactgc cagggacggg ggctctcctt ctttgtgcac cacggctagc gtgtctgtgg
     1441 aggtggctga cgtgaatgac aatgctcctg catttgcgca gccggagtac acagtgtttg
     1501 taaaggagaa caaccctcct ggcgcgcaca tcttcacggt gtcagcgatg gatgcggacg
     1561 cacaggagaa cgcgctggtg tcctactcgc tggtggagcg gagggtgggc gagcgcttgc
     1621 tgtcgagcta tgtgtccgtg cacgcggaga gcggcaaggt gtttgcgctg cagcctctgg
     1681 accatgagga gctggagctg ctgcagttcc aggtgagcgc gcgggatgct ggtgtgcctg
     1741 ccctgggcag caatgtgact ctgcaggtgt ttgtgctgga tgagaacgac aatgcgccca
     1801 cactgctggg gcctcacgcg ggcagcgcag tgagcgaact ggtgtcacgg acagtgggtg
     1861 cagggcatgt ggtgacgaag gtgcgtgctg tggacgcgga ctctggctac aacgcgtggc
     1921 tctcttatga gctgcagtca gcagcgggca gtggacgtct tcccttccgc gtgggtctgt
     1981 acaccggtga gatcagcacc acacgtgtcc tggatgaaac agatgccccg cgacagcgcc
     2041 tattggtatt ggtgaaggac catggcgagc cggtgctgac agctacagcc accttgcttg
     2101 tgtctctggt ggagagtggg cacacgccaa acaccccatc ccggactttg gtggattctg
     2161 ccggtaggga ggcttcgctt gtagatatca acgtgtacct gatcatcgcc atctgtgccg
     2221 tgtctagcct gttggtgctc acgctgctgc tgtaccttgc actcaggtgc tccacagcgc
     2281 ccacggaggg cggtcctggg aagcccatgc tggtgtgctc cagcgcagtg gggacctggt
     2341 catattcgca gcaaagaaga cagagggtgt gctctggaga gggcccgccc aagaccgatc
     2401 tcatggcctt cagcccaagt cttacaccat gcccagttaa tcaagataaa gaagacaaac
     2461 tggttggaga cattgatttc tccatcaaac cccggcagcc caaccctgac tggcgctact
     2521 ctgcctcgct aagagcaggc atgcacagct ctgtgcacct ggaggaggct ggcattctac
     2581 gggctggtcc aggagggcct gatcagcagt ggccaacagt atccagtgca acaccagaac
     2641 ctgaggcagg agaggtgtcc cctccggtgg gcgccggtgt caacagcaac agctggacct
     2701 ttaaatacgg accaggcaac cccaaacagt ccggtcccgg tgagttgcca gacaaattca
     2761 ttatcccagg atctcctgca atcatctcca tccggcagga gcctgctaac aaccaaattg
     2821 acaaaagcga ttttataacc ttcggcaaaa aggaggagac caagaaaaag aagaaaaaga
     2881 agaagggtaa caagacccag gagaaaaaag agaaagggaa cagcacgacg gacaacagtg
     2941 accagtgagg ccaccaaatg gaaacaagcc acttagccag tttttgtaat aatggcaaat
     3001 ctctcccatg tagcaactcc ccgctccttt ctcctatgac atgagccctc agaaatctgc
     3061 agaaagttcc ctgtgtctgt cttgatcgca tttaacaggt tttgtcttaa aaagctttcc
     3121 taagtctggt gttaactctc tctctctcca ctctggcttg ttttcagaac ctaaaaagca
     3181 gacccaggtt tcctttctcc cccgccgcaa aggagaagct tcccagcccc gccagtgaga
     3241 gttggactct ctgccctgtg cttcaagcat cctgtcttga tgatatttgc agggcaggct
     3301 gaaaggtatt caggttgagc agttgggtgt ttgtggtcac tgggtatgtg tggctaccaa
     3361 gagtgttgga gagcctggta ttggctggga tggtccagat tagactagtt aacacaagga
     3421 gggctggggc tcaaaggcac atcaacaccg ggagtctttc atctggaggg ggaaaatgtg
     3481 aaacttacaa ggaccagact ttctcaatct ctcaactaga catatgatgg ccatcctcta
     3541 acagacaaaa ccatccccac cggcaaagct ttaggagccc ctcaagtgtg ctggctataa
     3601 catcactgta ttcaaaacct gcagtatgca cacgagccag cagttcaagc gtttaacaag
     3661 agggtcggcc agggcaacag aagcagatct gatgtgtttc ctgtacacgt ccttgtgctc
     3721 acgctattaa aaattctttt gcacacaatg tttatgaaaa ggtctcatcc ttttccaaca
     3781 acacatatgc aaaagcaaaa gaaaaaccca agacctcact ttatgctgtt tgttgtttga
     3841 tagatttatt aaaaagaaaa gagaaagtcg atagctataa atctttaaag gaatatgatg
     3901 aatacaatcc ccccaacctt ccctcaaaag agaatccagt ctacagccat ttgaaatgat
     3961 cgttgctgct acagaagtgc tttaagagaa ttgcctggaa catctgtatt atcccggcca
     4021 cctgccaatc acagctttac tctttcaggt cactctgggg ctgcctcttg catgtattaa
     4081 ttactaaata gaaggatctt tctctctttt ctaagaaaaa tgatgtgcac tttgattaca
     4141 caaccttctc taacccacga tatcaagacc cagaaactga agaaaaatct tgttttctca
     4201 tgcatacagt gagcagactt ttcattcctc tggttctgtg gttgtctcgg tgtgctagcc
     4261 tacacctcca ccttgtttag ctttcctttt ctagaacact ctgaattgct aaccttacta
     4321 acacctatga tgttacctga atcaatctcc catatgtatg ctgtatgcta ttataagact
     4381 cctgagatat acttactctg tgcttgtgta tgtgaatgtt aatgcaacta ttacctagag
     4441 tgaactttaa gctttattgt tgaatgtaag cccattatat ttccttttgt acacctgtgg
     4501 aaaagtggaa tagtgttttt tttaaaacca ttgttaatca gcttttgtgt atgaaagaca
     4561 cagtaaaatt tctttcttaa atcaagatgc tggtgattca aggaatttta tttatggtca
     4621 gccaagggct gtctcttgcc aagaatcctg ctggcaaggg aaaatggata aagctggttt
     4681 ttttttttcc tagtaagaat tctggaataa atactgaaga aagtccctga gggtatgcaa
     4741 gcacaaaatt gtaccaatct gacctctttg aatttgcaga ctgctttgaa atgctatccg
     4801 gaatatcagc ttgtagaaag taataaaatt tactgttacc ataaataaga cattttaagt
     4861 ttattgtgca caacttagat gtttgattaa ttatattatc tacttaaaag catataaaag
     4921 aggtaggagt ctgttttaaa aggcataaaa aatctcaaaa aaaaaaaacc tgtcttgtct
     4981 acttttagct tcattctccc atattttgaa gggtgtgtaa cttcagctct gcaggattgc
     5041 atggggtaaa actcgttgac agcgcatgtg aaccattgct acattgtagg ttgtgatcat
     5101 tttgccccac tgaagcccat gtaactgacc ttacgtgcct tttgaactag gagaatcggg
     5161 ctataattta ttaatgatga taatgataat gtatatgtac agcacttttt aaccttacaa
     5221 agtgctttcc aattcgtgtt agttattagt tattacagct gtaaggataa aacacgtcat
     5281 gtggattcat ttttaattgg tgctattggt atttcctctg ttcttgctaa taaatggaaa
     5341 tggtggtgtg aaagc
//
