LOCUS       NM_138663               5254 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus protocadherin alpha 12 (Pcdha12), mRNA.
ACCESSION   NM_138663
VERSION     NM_138663.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5254)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5254)
  AUTHORS   Xu,L., Zheng,Y., Li,X., Wang,A., Huo,D., Li,Q., Wang,S., Luo,Z.,
            Liu,Y., Xu,F., Wu,X., Wu,M. and Zhou,Y.
  TITLE     Abnormal neocortex arealization and Sotos-like syndrome-associated
            behavior in Setd2 mutant mice
  JOURNAL   Sci Adv 7 (1) (2021)
   PUBMED   33523829
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5254)
  AUTHORS   Mancia Leon,W.R., Spatazza,J., Rakela,B., Chatterjee,A., Pande,V.,
            Maniatis,T., Hasenstaub,A.R., Stryker,M.P. and Alvarez-Buylla,A.
  TITLE     Clustered gamma-protocadherins regulate cortical interneuron
            programmed cell death
  JOURNAL   Elife 9, e55374 (2020)
   PUBMED   32633719
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5254)
  AUTHORS   Elbert,A., Vogt,D., Watson,A., Levy,M., Jiang,Y., Brule,E.,
            Rowland,M.E., Rubenstein,J. and Berube,N.G.
  TITLE     CTCF Governs the Identity and Migration of MGE-Derived Cortical
            Interneurons
  JOURNAL   J Neurosci 39 (1), 177-192 (2019)
   PUBMED   30377227
REFERENCE   5  (bases 1 to 5254)
  AUTHORS   Fan,L., Lu,Y., Shen,X., Shao,H., Suo,L. and Wu,Q.
  TITLE     Alpha protocadherins and Pyk2 kinase regulate cortical neuron
            migration and cytoskeletal dynamics via Rac1 GTPase and WAVE
            complex in mice
  JOURNAL   Elife 7, e35242 (2018)
   PUBMED   29911975
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5254)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   7  (bases 1 to 5254)
  AUTHORS   Sugino,H., Hamada,S., Yasuda,R., Tuji,A., Matsuda,Y., Fujita,M. and
            Yagi,T.
  TITLE     Genomic organization of the family of CNR cadherin genes in mice
            and humans
  JOURNAL   Genomics 63 (1), 75-87 (2000)
   PUBMED   10662547
REFERENCE   8  (bases 1 to 5254)
  AUTHORS   Senzaki,K., Ogawa,M. and Yagi,T.
  TITLE     Proteins of the CNR family are multiple receptors for Reelin
  JOURNAL   Cell 99 (6), 635-647 (1999)
   PUBMED   10612399
REFERENCE   9  (bases 1 to 5254)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   10 (bases 1 to 5254)
  AUTHORS   Kohmura,N., Senzaki,K., Hamada,S., Kai,N., Yasuda,R., Watanabe,M.,
            Ishii,H., Yasuda,M., Mishina,M. and Yagi,T.
  TITLE     Diversity revealed by a novel family of cadherins expressed in
            neurons at a synaptic complex
  JOURNAL   Neuron 20 (6), 1137-1151 (1998)
   PUBMED   9655502
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY013759.1.
            
            On May 27, 2003 this sequence version replaced NM_138663.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY013759.1, BC141111.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5254
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.46 cM"
     gene            1..5254
                     /gene="Pcdha12"
                     /gene_synonym="Cnr5; Crnr5; Pcdha13"
                     /note="protocadherin alpha 12"
                     /db_xref="GeneID:192164"
                     /db_xref="MGI:MGI:1298370"
     CDS             1..2853
                     /gene="Pcdha12"
                     /gene_synonym="Cnr5; Crnr5; Pcdha13"
                     /note="protocadherin alpha 13; cadherin-related neuronal
                     receptor 5"
                     /codon_start=1
                     /product="protocadherin alpha-12 precursor"
                     /protein_id="NP_619604.1"
                     /db_xref="CCDS:CCDS29166.1"
                     /db_xref="GeneID:192164"
                     /db_xref="MGI:MGI:1298370"
                     /translation="MLLFSQSGPGSRCLLLSFLLLTTWEAGSGQLHYSIPEEAKHGTF
                     VGRIAQDLGLELTELVPRLFRVASKDRGDLLEVNLQNGILFVNSRIDREELCGRSLEC
                     SIHLEVIVDRPLQVFHVEVEVRDINDNPPVFPETNKNIVIAESRPPETRFPLDGASDA
                     DIGVNSALTYRLDPSDYFALDTQNNRERTSSLSLVLKKSLDREEIQEYSLLLTASDGG
                     KPELTGTVQLLITILDVNDNAPEFDRFVYKVKVLEDALNGTLVINLNATDPDEGINGD
                     IIYSFRRPVSPAVVHAFNIDSNSGEVRTKGLLDFEEIKLYEIPVEAVDKGNIPMTGHC
                     TLLVELLDVNDNAPEVTITSLSLPVREDAQPSTVIALVSVSDRDSGDNGQVTCSLTPH
                     LPFKLVSTFKNYYSLVLDSALDRETTADYKVVVTARDRGSPSLWSTASVSVEVADVND
                     NAPAFAQPEYTVFVKENNPPGAHIFTVSAMDADAQENALVSYSLVERRVGERLLSSYV
                     SVHAESGKVFALQPLDHEELELLQFQVSARDAGVPSLGSNVTLQVFVLDENDNAPTLL
                     PHRAVGAVGTVSELVPRSVGSGHVVAKVRAVDADSGYNAWLSYELQLAAGGMRSPFRV
                     GLYTGEISTTRSLDEADAPRQRLLVLVKDHGEPALTATATVLVSLVENGQAPKISSLA
                     SESTASSEASLVTVNVYLIIAICAVSSLLVITLLLYTALRCSARSTDGACAPGKPMLV
                     CSSAVGSWSYSQQRRQRVCSGEGPPKTDLMAFSPSLPPVLGSAEDTCQRERQVEHLKE
                     PRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSP
                     PVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPANNQIDKSDFI
                     TFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ"
     exon            1..2394
                     /gene="Pcdha12"
                     /gene_synonym="Cnr5; Crnr5; Pcdha13"
                     /inference="alignment:Splign:2.1.0"
     exon            2395..2453
                     /gene="Pcdha12"
                     /gene_synonym="Cnr5; Crnr5; Pcdha13"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2542
                     /gene="Pcdha12"
                     /gene_synonym="Cnr5; Crnr5; Pcdha13"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..5254
                     /gene="Pcdha12"
                     /gene_synonym="Cnr5; Crnr5; Pcdha13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgctattat tctcgcaaag cggcccagga tcccggtgcc tcctgctctc gttcctgctc
       61 ctcacaacct gggaggcagg gagcggccag ctccactact ccatcccaga ggaggccaaa
      121 cacggcacct tcgtgggccg catcgcgcag gacctggggc tggagctgac ggagctggtg
      181 ccccgcttgt tcagggtggc gtccaaggac cgcggagacc ttctggaggt aaatctgcag
      241 aatggcattt tgtttgtgaa ttctcggatc gaccgggagg agctgtgcgg gcggagcttg
      301 gagtgtagca tccacctgga ggtgatcgtg gacaggccgc tgcaggtttt ccacgtggag
      361 gtggaggtga gggacattaa tgacaatcca cctgtgttcc ctgaaaccaa caaaaacatc
      421 gtgattgccg agtcgagacc tccagaaact agatttccac tagatggcgc atccgatgca
      481 gatatcggag tcaattccgc cttgacctac cgattggatc ccagcgatta tttcgctttg
      541 gacacgcaaa acaatcgtga gcgaacttct tcgttatccc ttgtgttaaa gaaatcatta
      601 gacagagaag aaattcagga gtatagttta ttactaacag ctagtgacgg aggcaaaccg
      661 gaactgactg gcacagttca gctgctgatc accatcctcg atgtgaatga caatgctccg
      721 gagtttgatc ggttcgttta caaagttaaa gtgttagagg atgcacttaa tggaacgttg
      781 gtgattaact taaacgccac agatcctgac gagggtataa atggagatat aatctactcc
      841 ttcagacggc ctgtatcccc tgcggtggtg catgcattta atatagattc caacagtgga
      901 gaagttagga caaaggggct actggatttc gaagaaatta aactatatga gatacccgtg
      961 gaggcagtag acaaaggcaa tattccaatg acaggccatt gtacccttct ggtggaatta
     1021 ctggatgtaa atgataatgc accagaggtc acgattactt ccctgtcact cccagtcaga
     1081 gaagatgctc agccaagcac tgtcatagct ctcgtcagcg tgtctgaccg agactctggt
     1141 gacaacgggc aggtgacttg ctctttgacg cctcacctcc ccttcaagct ggtgtccact
     1201 ttcaagaatt actattcgtt agtgttggac agcgccctgg accgcgaaac caccgctgac
     1261 tataaggtgg tggtgacagc ccgagacagg ggctcaccct cgctgtggtc cacggccagc
     1321 gtgtccgtgg aggtggctga tgtgaacgac aatgctcctg cattcgcgca gcccgaatac
     1381 acggtgtttg tgaaggagaa caacccgcct ggtgcgcaca tcttcacggt gtcagcgatg
     1441 gatgcggatg cgcaggagaa cgcgctggtg tcctactcgc tggtggagcg gagggtgggc
     1501 gagcgcttgc tgtcgagcta tgtgtctgtg cacgcggaga gtggcaaggt gttcgcgctg
     1561 cagcctctgg accatgagga gctggagctg ctgcagttcc aggtgagcgc gcgggatgct
     1621 ggtgtgcctt ccctgggcag taatgtgact ctgcaggtgt ttgtgctgga tgagaatgac
     1681 aatgcgccca cgctattgcc tcacagagcc gttggagctg tcgggacagt gagcgaactt
     1741 gtgcctaggt cagtgggttc agggcatgta gtggcgaagg tgcgggcagt agatgcggac
     1801 tctggttaca atgcgtggct gtcttatgag cttcagttgg cagcaggggg catgcgcagt
     1861 cccttccgcg tgggtctgta cacgggcgag atcagcacga cgcgctccct agacgaagca
     1921 gatgcgccac gccagcgtct gttggtgttg gtgaaggacc acggcgagcc cgcactgacc
     1981 gccacagcca cggtgctggt gtctctggtg gagaatggcc aagcacccaa gatatcttcc
     2041 cttgcttcgg agagcacagc atcttcggag gcgtcgctgg tgactgtcaa cgtgtacctg
     2101 atcattgcta tttgcgcagt gtccagcctg ttagtgatca cgctgctgct ttacactgcg
     2161 ctgcgctgct cagcaaggtc cacagatgga gcctgtgctc cggggaagcc catgctggtg
     2221 tgctccagcg cggtggggag ctggtcatac tcgcagcaga ggagacagag ggtgtgttct
     2281 ggagagggtc cacctaagac cgacctcatg gcctttagtc ctagtctccc tcctgtgtta
     2341 ggctctgcag aggacacatg tcagagagaa aggcaggtag aacatttgaa agagccccgg
     2401 cagcccaacc ctgactggcg ctactctgcc tcgctaagag caggcatgca cagctctgtg
     2461 cacctggagg aggctggcat tctacgggct ggtccaggag ggcctgatca gcagtggcca
     2521 acagtatcca gtgcaacacc agaacctgag gcaggagagg tgtcccctcc ggtgggcgcc
     2581 ggtgtcaaca gcaacagctg gacctttaaa tacggaccag gcaaccccaa acagtccggt
     2641 cccggtgagt tgccagacaa attcattatc ccaggatctc ctgcaatcat ctccatccgg
     2701 caggagcctg ctaacaacca aattgacaaa agcgatttta taaccttcgg caaaaaggag
     2761 gagaccaaga aaaagaagaa aaagaagaag ggtaacaaga cccaggagaa aaaagagaaa
     2821 gggaacagca cgacggacaa cagtgaccag tgaggccacc aaatggaaac aagccactta
     2881 gccagttttt gtaataatgg caaatctctc ccatgtagca actccccgct cctttctcct
     2941 atgacatgag ccctcagaaa tctgcagaaa gttccctgtg tctgtcttga tcgcatttaa
     3001 caggttttgt cttaaaaagc tttcctaagt ctggtgttaa ctctctctct ctccactctg
     3061 gcttgttttc agaacctaaa aagcagaccc aggtttcctt tctcccccgc cgcaaaggag
     3121 aagcttccca gccccgccag tgagagttgg actctctgcc ctgtgcttca agcatcctgt
     3181 cttgatgata tttgcagggc aggctgaaag gtattcaggt tgagcagttg ggtgtttgtg
     3241 gtcactgggt atgtgtggct accaagagtg ttggagagcc tggtattggc tgggatggtc
     3301 cagattagac tagttaacac aaggagggct ggggctcaaa ggcacatcaa caccgggagt
     3361 ctttcatctg gagggggaaa atgtgaaact tacaaggacc agactttctc aatctctcaa
     3421 ctagacatat gatggccatc ctctaacaga caaaaccatc cccaccggca aagctttagg
     3481 agcccctcaa gtgtgctggc tataacatca ctgtattcaa aacctgcagt atgcacacga
     3541 gccagcagtt caagcgttta acaagagggt cggccagggc aacagaagca gatctgatgt
     3601 gtttcctgta cacgtccttg tgctcacgct attaaaaatt cttttgcaca caatgtttat
     3661 gaaaaggtct catccttttc caacaacaca tatgcaaaag caaaagaaaa acccaagacc
     3721 tcactttatg ctgtttgttg tttgatagat ttattaaaaa gaaaagagaa agtcgatagc
     3781 tataaatctt taaaggaata tgatgaatac aatcccccca accttccctc aaaagagaat
     3841 ccagtctaca gccatttgaa atgatcgttg ctgctacaga agtgctttaa gagaattgcc
     3901 tggaacatct gtattatccc ggccacctgc caatcacagc tttactcttt caggtcactc
     3961 tggggctgcc tcttgcatgt attaattact aaatagaagg atctttctct cttttctaag
     4021 aaaaatgatg tgcactttga ttacacaacc ttctctaacc cacgatatca agacccagaa
     4081 actgaagaaa aatcttgttt tctcatgcat acagtgagca gacttttcat tcctctggtt
     4141 ctgtggttgt ctcggtgtgc tagcctacac ctccaccttg tttagctttc cttttctaga
     4201 acactctgaa ttgctaacct tactaacacc tatgatgtta cctgaatcaa tctcccatat
     4261 gtatgctgta tgctattata agactcctga gatatactta ctctgtgctt gtgtatgtga
     4321 atgttaatgc aactattacc tagagtgaac tttaagcttt attgttgaat gtaagcccat
     4381 tatatttcct tttgtacacc tgtggaaaag tggaatagtg ttttttttaa aaccattgtt
     4441 aatcagcttt tgtgtatgaa agacacagta aaatttcttt cttaaatcaa gatgctggtg
     4501 attcaaggaa ttttatttat ggtcagccaa gggctgtctc ttgccaagaa tcctgctggc
     4561 aagggaaaat ggataaagct ggtttttttt tttcctagta agaattctgg aataaatact
     4621 gaagaaagtc cctgagggta tgcaagcaca aaattgtacc aatctgacct ctttgaattt
     4681 gcagactgct ttgaaatgct atccggaata tcagcttgta gaaagtaata aaatttactg
     4741 ttaccataaa taagacattt taagtttatt gtgcacaact tagatgtttg attaattata
     4801 ttatctactt aaaagcatat aaaagaggta ggagtctgtt ttaaaaggca taaaaaatct
     4861 caaaaaaaaa aaacctgtct tgtctacttt tagcttcatt ctcccatatt ttgaagggtg
     4921 tgtaacttca gctctgcagg attgcatggg gtaaaactcg ttgacagcgc atgtgaacca
     4981 ttgctacatt gtaggttgtg atcattttgc cccactgaag cccatgtaac tgaccttacg
     5041 tgccttttga actaggagaa tcgggctata atttattaat gatgataatg ataatgtata
     5101 tgtacagcac tttttaacct tacaaagtgc tttccaattc gtgttagtta ttagttatta
     5161 cagctgtaag gataaaacac gtcatgtgga ttcattttta attggtgcta ttggtatttc
     5221 ctctgttctt gctaataaat ggaaatggtg gtgt
//
